Team:Nottingham

Clostridium dTox Project

Project description Abstract

Human Practices

Overview Silver Gold Safety and Ethics

Public Engagement

Discovery day School workshops Media

Lab

Ideas Design Results Conclusion Future Work Interlab Labfolder

Modelling

Introduction Summary Lytic Phage Models Temporate Phage Models Comparsion of all three models Methodology Parameters References

Collaborations

The University of Warwick Team BioMarvel- Korea The University of Warwick and Imperial College London UK Meetups

Achievements

Medal Criteria Parts Improved parts Demonstrate General conclusion

Team

Students Supervisors Principal Investigators

Attributions

iGEM 2018

Clostridium dTox

It's not so difficile

What is C. difficile infection?

Clostridium difficile infection is the most common cause of antibiotic-associated diarrhoea in the Western World and is a big problem in hospitals and care-facilities.

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What is the problem?

A consequence of antibiotic misuse and the capability of bacteria to readily evolve has allowed antibiotic resistance to become a worldwide major dilemma.

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What are we going to do?

The goal of our project is to engineer a phage which will infect C. difficile and express genetic constructs designed to suppress toxin production.

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About our sponsors