Protein scaffolds for star-shaped antimicrobial peptides
StarCores are a new type of star-shaped Antimicrobial Peptide (AMP). Like antibiotics, AMPs can be used to kill harmful bacteria. But because AMPs attack bacteria differently than conventional antibiotics, killing bacteria with AMPs slows down the evolution of antibiotic resistance.
We designed StarCores in response to the specific needs of veterinarians, farmers, and policymakers in France. Our goal was to provide a specific solution for killing Gram-negative bacteria on pig farms. Over the summer, we successfully designed, produced, tested and optimized a novel class of bacteria-killing peptides with high activity and reduced toxicity.
The story of our project unfolds sequentially. For the best experience of our wiki, we invite you to read the sections below in order, starting with Integrated Design.