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- Biosynthesis plays a significant role in industrial production while enzymatic reaction rate is one of the key factors in an efficient production. and concentration of enzymes is a widely employed solution. Here we engineered yeast cells to express enzymes for producing carotene, which would then be integrated into a protein scaffold based on the interaction between SUMO and SIM modules. The oligomerization of these modules could induce the proximity of enzymes, which enhances the speed of enzymatic reactions and the yield rate of products significantly.