Team:Tsinghua
About Us
Abstract
NEON COLI - WIDE-DYNAMIC-RANGE, FINE-TUNED QUORUM SENSING POSITIVE FEEDBACK CIRCUIT
Neon Coli is an acronym of our slogan: Necessary Expression ONly! What we built is a controllable positive feedback device. We combined the lux quorum sensing system from Vibrio Fischeri with CRISPRi to design our own NEON system. NEON system is a great improvement to preexisting artificial positive feedback devices. It has the advantages of positive feedback loops—sensitive, extraordinarily high output and wide-dynamic-range. It can also avoid their shortages of uncontrollable leakage. We built this device with the initial intention to control a leaky generator. However with the help of other iGEMer we realized the potential of our NEON system. NEON system can be integrated into other iGEM projects as expression optimizer and assist in signal transduction processes. It may also lead to new applications in synthetic biological computations, and circuits that require fine control of gene expression.
Team
Here is our energetic team!
Huang Tianze
Team Leader
Wang Xuan
Team Advisor
Han Jianing
Team Advisor
Zhou Siyan
Team Advisor
Chen Jiani
Team Member
Chen Xinyi
Team Member
Ge Xiaofei
Team Member
Hao Yuejun
Team Member
Li Yibo
Team Member
Mao Zeping
Team Member
Shen Yunhao
Team Member
Wang Tingxuan
Team Member
Wu Yan
Team Member
Yan Qi
Team Member
Yao Liang
Team Member
Zheng Kaiyu
Team Member
Zhou Manxuan
Team Member
Zhou Liqun
Team Member
Chen Guoqiang
Supervisor
Liu Dong
SupervisorMedals
We had an wonderful time in Boston and come away with gold medals, a nomination forBest Information Processing!
