Difference between revisions of "Team:Montpellier"

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<h3>Why is it crucial to find a new approach to contraception ?</h3>
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Hormonal contraception has a lot of side effects for women (such as weight gain or acne), a pill is easy to forget, and there is an environmental impact since water can be contaminated by hormones. Moreover, some women cannot take pills because of
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cardiovascular problems and family history.
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Despite the huge progress made for contraception since the beginning of the 20th century, contraception still needs improvement.
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We want to use microbicide with a spermicidal effect as a new way of contraception: safe and affordable, with a long term effect.
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<h3> How do we do that ? </h3>
 
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We decided to focus on making a new kind of contraceptive using <i>Lactobacillus jensenii</i>, which is one of the most represented bacteria in the vaginal flora. This hormone-free contraception uses a designed <i>L. jensenii</i> that has the ability to immobilize spermatozoa in the vagina.
 
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How does it really work ? Our goal is to create bacteria capable of having a “switch effect” : when a woman decides to turn it on, bacteria will have a spermicidal effect and will allow in situ contraception. Otherwise, bacteria will be in “off mode”, and spermatozoa will be able to pass. <br/>
 
  
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Several studies have demonstrated that many molecules have spermicidal activity, we are focusing on some of them such as Nisin, Subtilosin ... (for more information : <a href = "https://2018.igem.org/Team:Montpellier/Description"> Description of the projet</a>).
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The idea is to introduce the genes that are coding the spermicidal peptids and antibodies into <i>Lactobacillus jensenii</i> and then to apply a colony of these designed bacteria into the vagina for long-term contraception.  
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<h3> <i>Lactobacillus jensenii</I> : a little-known bacteria </h3>
 
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<i>Lactobacillus jensenii</i> is a little studied bacteria. We can find it in the vagina (23% of vaginal microflora), on the skins of grapes at the time of their harvest. Moreover, in the industry <i>L. jensenii</i> is sometimes used in producing fermented foods. </br> </br>
 
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A part of our project is to establish a toolbox of <i>L. jensenii</i> by integrating experiments, bioinformatic tools and modelisation. Indeed <i>L. jensenii</i> is essential for the vagina health. 
 
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We hope that a better knowledge of this bacterium, essential to the proper functioning of the female genital tract, will help a better understanding of certain diseases such as fungal and urinary tract infections.
 
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Revision as of 09:45, 20 August 2018

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