Difference between revisions of "Team:New York City/Description"

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{{New_York_City}}
 
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<h1>Description</h1>
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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        <div class="container d-flex flex-column flex-md-row justify-content-between">
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            <div class="navbar-brand"><a href="https://2018.igem.org/Team:New_York_City">HD Resolution</a></div>
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            <div class="collapse navbar-collapse" id="navbarSupportedContent">
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                <ul class="navbar-nav mr-auto">
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                    <li class="nav-item dropdown">
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                        <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarPR" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                            Project
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                        </a>
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                        <div class="dropdown-menu" aria-labelledby="navbarPR">
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                            <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/HD">What is HD?</a>
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                            <a class="dropdown-item" href="">Coming Soon</a>
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                        <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarNB" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                            Notebook
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                        </a>
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                        <div class="dropdown-menu" aria-labelledby="navbarNB">
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                            <a class="dropdown-item" href="">Coming Soon</a>
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                        </div>
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                    </li>
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                        <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarHP" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                            Human Practices
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                        </a>
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                        <div class="dropdown-menu" aria-labelledby="navbarHP">
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                            <a class="dropdown-item" href="">Coming Soon</a>
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                        </div>
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                    </li>
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                    <li class="nav-item">
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                        <a class="nav-link" href="#">Team</a>
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                    </li>
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                </ul>
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            </div>
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        </div>
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    </nav>
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    <h2 align="center">Our Motivation</h2>
 
</div>
 
</div>
  
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    <p class="lead">Huntington's Disease (HD) is an autosomal dominant genetic disorder, meaning that if one allele out
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        of two carries the HTT mutation the HD gene will produce the faulty protein of Huntingtin. Therefore, the
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<h3>What should this page contain?</h3>
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        children of an individual suffering from HD will have a 50/50 chance of carrying the faulty gene if they do
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<ul>
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        not express it themselves. According to the Huntington's Disease Society of America, the "quintessential family
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<li> A clear and concise description of your project.</li>
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        disease" and the ability of this disease to wreak such devastating and overarching damage on an individual and
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
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        all those around them are one of the root reasons our team has chosen to tackle HD. For instance, HD is
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<li>References and sources to document your research.</li>
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        adult-onset (30s to 50s) and many individuals go about their lives and form families without the knowledge of
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<li>Use illustrations and other visual resources to explain your project.</li>
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        the storm looming on the horizon. At the time of their diagnosis, their children will be revealed to be at risk
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</ul>
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        of inheriting the disease. HD robs a patient of their life, eventually leaving them physically, cognitively, and
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        behaviorally inept to continue their daily tasks and responsibilities. Although HD is classified as a rare
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        disorder, the tragic and frightful effects it has upon patients, carriers, and families call for a resolution
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        to be developed in the near future.</p>
 
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    <h2 align="center">Abstract</h2>
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<h3>Inspiration</h3>
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<p>See how other teams have described and presented their projects: </p>
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
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<div class="container">
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    <p class="lead">Huntington's disease (HD) is an autosomal dominant genetic disorder that causes the breakdown of
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        nerve cells in the brain and currently has no cure, which is why we're aiming to find one! HD, which is usually
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        adult-onset, is particularly devastating because it includes symptoms such as amnesia, involuntary movements,
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<h3>Advice on writing your Project Description</h3>
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        and physical incoordination, giving a patient a lifespan of only ten years after onset. The primary cause of
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        this disease is a trinucleotide repeat of CAG in the huntingtin gene, where a repeat of 40 or more can cause
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<p>
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        the manifestation of the disease. Our goal is to create a synthetic RNA strand displacement technology that
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be concise, accurate, and unambiguous in your achievements.  
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        consists of the corrected RNA strand and a "guide" strand. The guide strand will bond with endogenous, faulty
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        messenger RNA and release the corrected RNA strand for proper protein synthesis of the huntingtin protein,
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        while disposing of the repeating CAG sequence. Ultimately, once such technologies are developed to overcome
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        endocytosis and blood brain barrier traversal, an injectable cure can be produced.</p>
 
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<h3>References</h3>
 
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
 
  
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    <p class="lead">Sources:</p>
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    <ol>
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        <li><a href="https://ghr.nlm.nih.gov/condition/huntington-disease#synonyms">ghr.nlm.nih.gov</a></li>
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        <li><a href="https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Huntingtons-Disease-Hope-Through#3137_14">ninds.nih.gov</a></li>
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        <li><a href="http://hdsa.org/what-is-hd/">hdsa.org</a></li>
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    </ol>
 
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Revision as of 07:21, 31 August 2018

Our Motivation

Huntington's Disease (HD) is an autosomal dominant genetic disorder, meaning that if one allele out of two carries the HTT mutation the HD gene will produce the faulty protein of Huntingtin. Therefore, the children of an individual suffering from HD will have a 50/50 chance of carrying the faulty gene if they do not express it themselves. According to the Huntington's Disease Society of America, the "quintessential family disease" and the ability of this disease to wreak such devastating and overarching damage on an individual and all those around them are one of the root reasons our team has chosen to tackle HD. For instance, HD is adult-onset (30s to 50s) and many individuals go about their lives and form families without the knowledge of the storm looming on the horizon. At the time of their diagnosis, their children will be revealed to be at risk of inheriting the disease. HD robs a patient of their life, eventually leaving them physically, cognitively, and behaviorally inept to continue their daily tasks and responsibilities. Although HD is classified as a rare disorder, the tragic and frightful effects it has upon patients, carriers, and families call for a resolution to be developed in the near future.

Abstract

Huntington's disease (HD) is an autosomal dominant genetic disorder that causes the breakdown of nerve cells in the brain and currently has no cure, which is why we're aiming to find one! HD, which is usually adult-onset, is particularly devastating because it includes symptoms such as amnesia, involuntary movements, and physical incoordination, giving a patient a lifespan of only ten years after onset. The primary cause of this disease is a trinucleotide repeat of CAG in the huntingtin gene, where a repeat of 40 or more can cause the manifestation of the disease. Our goal is to create a synthetic RNA strand displacement technology that consists of the corrected RNA strand and a "guide" strand. The guide strand will bond with endogenous, faulty messenger RNA and release the corrected RNA strand for proper protein synthesis of the huntingtin protein, while disposing of the repeating CAG sequence. Ultimately, once such technologies are developed to overcome endocytosis and blood brain barrier traversal, an injectable cure can be produced.

Sources:

  1. ghr.nlm.nih.gov
  2. ninds.nih.gov
  3. hdsa.org