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| − | <div class="index-project-title">Our project this year</div>
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| − | In an island state such as Taiwan or Japan, the aquaculture is an important industry. However, the Vibrio-related
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| − | infection of aquatic animal has been a critical threat for a long time.The Vibrio-related infection leads to
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| − | inestimable financial damage in Taiwan and Japan, thus, exerting huge impact on the global fishery market.
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| − | <br><br>
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| − | Traditionally, in order to solve the problem of Vibrio infection, the fisherman add antibiotics into the fishpond
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| − | directly. But in this way, the abuse of antibiotics will lead to irreversible harm to the Mother Nature.
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| − | <br><br>
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| − | Our goal this year is to design a system which based on the model of succession. Our engineered E. coli will detect
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| − | the chemicals secreted by Vibrio which is called AHL, then it triggers our engineered bacteria LUX system to produce
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| − | an antimicrobial peptide called colicin which is able to kill Vibrio.
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| − | <br><br>
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| − | When the concentration of Vibrio decreases, the LUX system shuts down and triggers the expression of the suicide gene
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| − | Gp2. Moreover, the regulation system is STAR/ anti – STAR system. Thus, it causes the death of our engineered bacteria
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| − | and finally causes the increase of Vibrio concentration. In this way, our engineered bacteria coexist with the Vibrio
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| − | and control the population. Therefore, we can control the Vibrio population and avoid fish and shrimp infection.
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