Difference between revisions of "Team:XMU-China/Notebook"

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{{XMU-China}}
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    <title>Team:XMU-China/Notebook - 2018.igem.org</title> 
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</head>
  
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<div class="column full_size">
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<body>
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    <div id="container">
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<h1>Notebook</h1>
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        <header>
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<p> Document the dates you worked on your project. This should be a detailed account of the work done each day for your project.</p>
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            <div class="wrapper cf">
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                <nav id="main-nav">
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</div>
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                    <ul class="first-nav">
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<div class="clear"></div>
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                        <li>
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                            <a href="#" target="_blank">Project</a>
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                            <ul>
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                                <li><a href="#">Description</a></li>
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<div class="column two_thirds_size">
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                                <li><a href="#">Design</a></li>
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<h3>What should this page have?</h3>
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                                <li><a href="#">Demonstrate</a></li>
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<ul>
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                                <li><a href="#">Results</a></li>
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<li>Chronological notes of what your team is doing.</li>
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                                <li><a href="#">Applied Design</a></li>
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<li> Brief descriptions of daily important events.</li>
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                                <li><a href="#">Parts</a></li>
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<li>Pictures of your progress. </li>
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                            </ul>
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<li>Mention who participated in what task.</li>
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                        </li>
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</ul>
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                    </ul>
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                    <ul class="second-nav">
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</div>
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                        <li><a href="#">Notebook</a></li>
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                        <li><a href="#">Hardwork</a></li>
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<div class="column third_size">
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                        <li><a href="#">Model</a></li>
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<div class="highlight decoration_A_full">
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                        <li><a href="#">Human Practice</a></li>
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<h3>Inspiration</h3>
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                        <li><a href="#">Other Works</a></li>
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<p>You can see what others teams have done to organize their notes:</p>
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                        <li><a href="#">Team</a></li>
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                    </ul>
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<ul>  
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                </nav>
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<li><a href="https://2014.igem.org/Team:ATOMS-Turkiye/Notebook">2014 ATOMS-Turkiye</a></li>
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                <a class="toggle"><span></span></a>
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<li><a href="https://2014.igem.org/Team:Tec-Monterrey/ITESM14_project.html#tab_notebook">2014 Tec Monterrey</a></li>
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            </div>
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<li><a href="https://2014.igem.org/Team:Kyoto/Notebook/Magnetosome_Formation#title">2014 Kyoto</a></li>
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        </header>
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<li><a href="https://2014.igem.org/Team:Cornell/notebook">2014 Cornell</a></li>
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    </div>
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</ul>
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    <div class="header">
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        <div class="logo">
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            <img src="https://static.igem.org/mediawiki/2018/b/b5/T--XMU-China--singlelogo.png">
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            <img src="https://static.igem.org/mediawiki/2018/3/35/T--XMU-China--iGEM_logo.png">
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        </div>
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        <div class="clear"></div>
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        <div class="nav">
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            <div id="Team">
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                <div class="nav-word">Team</div>
 +
                <ul>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                </ul>
 +
            </div>
 +
            <div id="Other_Works">
 +
                <div class="nav-word">Other Works</div>
 +
                <ul>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                </ul>
 +
            </div>
 +
            <div id="Human_Practice">
 +
                <div class="nav-word">Human Practice</div>
 +
                <ul>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                </ul>
 +
            </div>
 +
            <div id="Model">
 +
                <div class="nav-word">Model</div>
 +
                <ul>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                </ul>
 +
            </div>
 +
            <div id="Hardwork">
 +
                <div class="nav-word">Hardwork</div>
 +
                <ul>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                </ul>
 +
            </div>
 +
            <div id="Notebook">
 +
                <div>
 +
                    <div class="nav-word">Notebook</div>
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                </div>
 +
                <ul>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                    <li>二级目录</li>
 +
                </ul>
 +
            </div>
 +
            <div id="Project">
 +
                <div class="nav-word">Project</div>
 +
                <ul>
 +
                    <li><span>Description</span></li>
 +
                    <li><span>Design</span></li>
 +
                    <li><span>Demonstrate</span></li>
 +
                    <li><span>Results</span></li>
 +
                    <li><span>Applied Design</span></li>
 +
                    <li><span>Parts</span></li>
 +
                </ul>
 +
            </div>
 +
            <div id="jiannan"><img src="https://static.igem.org/mediawiki/2018/6/6f/T--XMU-China--jiannanlogo.png">
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            </div>
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        </div>
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    </div>
 +
    <div class="main">
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        <div class="about_content history">
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            <h2>Timeline</h2>
 +
            <!-- <p class="about_txt">测试</p> -->
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        </div>
 +
        <div class="event_box">
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            <div class="space_div">
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                <p class="left_space"></p>
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                <p class="right_space"></p>
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            </div>
 +
            <div class="parHd clearfix">
 +
                <div class="limited_framework">
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                    <ul>
 +
                        <li class="act"><span></span>week0</li>
 +
                        <li><span></span>week1</li>
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                        <li><span></span>week2</li>
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                        <li><span></span>week3</li>
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                        <li><span></span>week4</li>
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                        <li><span></span>week5</li>
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                        <li><span></span>week6</li>
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                        <li><span></span>week7</li>
 +
                        <li><span></span>week8</li>
 +
                        <li><span></span>week9</li>
 +
                    </ul>
 +
                    <a class="sPrev"><img src="https://static.igem.org/mediawiki/2018/5/59/T--XMU-China--timeline_left.png"></a>
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                    <a class="sNext"><img src="https://static.igem.org/mediawiki/2018/0/01/T--XMU-China--timeline_right.png"></a></div>
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            </div>
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            <div class="parBd clearfix">
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                <div class="slideBox">
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                    <h4>week0</h4>
 +
                    <p>Protein plays a significant role in performing physiological functions[1], however, in diseased cells, protein carrying out a certain function may indicate the proceedings of disease. Such protein could be sorted to biomarkers, which have been regarded as the targets of disease detection and treatment in recent years.</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week1</h4>
 +
                    <p>[2]~[4] Therefore, detecting those biomarkers of protein-type becomes more and more critical to biological and medical fields. There are two main detecting approaches to detect a particular protein in a complex sample. One is direct determination of the content after purification, another is binding assays which include a target recognition probe and a signal transducer.[6]~[9] They are commonly selected from random sequence libraries, using the systematic evolution of ligands by exponential enrichment (SELEX) techniques.[10] Advantages of aptamers over antibodies include longer shelf life, improved thermal stability and ease of modification and conjugation.[11] An interesting binding assay is to use aptamers as the target recognition probes and CRISPR-Cas12a(Cpf1) as the signal amplifier, which is called Aptamer Based Cell-free Detection system(ABCD system, Figure 1). We developed this system to detect those biomarkers of protein-type for the purpose of disease detection or staging.</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week2</h4>
 +
                    <p> The former approach includes gel filtration chromatography, ion exchange chromatography and nickel column and more, but these methods have high costs, strict equipment requirements and other issues, which are not suitable for promotion and application. The enzyme-linked immunosorbent assay (ELISA) is a typical representative of the latter approach, nevertheless, such assays using antibodies as affinity ligands have cross-reactivity of antibodies compromising the specificity to the target of interest.</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week3</h4>
 +
                    <p>[5] What’s worse, the premise of using ELISA is the need to find the corresponding antibodies, but the fact is that not all proteins can find their specific antibody protein, so the use of ELISA is also limited. Binding assays using aptamers as affinity ligands to recognize specific proteins are better than those using antibodies. Aptamers are short, synthetic single stranded oligonucleotides (DNA or RNA) that can bind to target molecules with high affinity and specificity.</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week4</h4>
 +
                    <p>详细信息</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week5</h4>
 +
                    <p>详细信息</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week6</h4>
 +
                    <p>详细信息</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week7</h4>
 +
                    <p>详细信息</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week8</h4>
 +
                    <p>详细信息</p>
 +
                </div>
 +
                <div class="slideBox" style="display: none;">
 +
                    <h4>week9</h4>
 +
                    <p>详细信息</p>
 +
                </div>
 +
            </div>
 +
        </div>
 +
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                <li>Home</li>
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                <li>Basic Part</li>
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                <li>About us</li>
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                <li>Design</li>
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Revision as of 15:15, 25 September 2018

Team:XMU-China/Notebook - 2018.igem.org

Team
  • 二级目录
  • 二级目录
  • 二级目录
  • 二级目录
Other Works
  • 二级目录
  • 二级目录
  • 二级目录
  • 二级目录
Human Practice
  • 二级目录
  • 二级目录
  • 二级目录
  • 二级目录
Model
  • 二级目录
  • 二级目录
  • 二级目录
  • 二级目录
Hardwork
  • 二级目录
  • 二级目录
  • 二级目录
  • 二级目录
Notebook
  • 二级目录
  • 二级目录
  • 二级目录
  • 二级目录
Project
  • Description
  • Design
  • Demonstrate
  • Results
  • Applied Design
  • Parts

Timeline

  • week0
  • week1
  • week2
  • week3
  • week4
  • week5
  • week6
  • week7
  • week8
  • week9

week0

Protein plays a significant role in performing physiological functions[1], however, in diseased cells, protein carrying out a certain function may indicate the proceedings of disease. Such protein could be sorted to biomarkers, which have been regarded as the targets of disease detection and treatment in recent years.

  • Home
  • Basic Part
  • About us
  • Composite Part
  • Attribution
  • Design
  • Modeling
  • Engagemen
  • Biosafety
  • Contribution
  • Collaboration
  • Protocols
  • Notebook
  • Description
  • Experiment