Difference between revisions of "Team:NTHU Formosa/test03"

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{{NTHU_Formosa}}
 
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<h1>Welcome to NTHU_Formosa! </h1>
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<br><img src="https://static.igem.org/mediawiki/2018/8/82/T--NTHU_Formosa--Logo.jpg" align="middle" width=100%>
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<h4> Autonomous cell reporter system for non-invasive real-time blood diagnosis </h4>
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<p style="text-align:justify;"> People around the world are growing awareness to their health condition. To monitor the health condition, a wide range of biomarkers-- special substances in the bloodstream representing the physiological and pathological states-- has been used in clinical
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diagnoses1. Blood test is one of the most common way for detecting biomarkers but it suffers from several inevitable drawbacks such as invasiveness, time-consuming procedure, demand for medical staff service, non real-time tracking and so on. These
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disadvantages may discourage people from the periodic medical checkup. Indeed, according to a survey (of 1862 samples) pulled by our team, nearly half of the participants took blood test less than once a five-year frequency (Fig. 1), which is impractical
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for early detection and early treatment of diseases. In terms of non-invasive real-time health monitoring, great varieties of wearable devices and smartwatches, working as personal daily fitness trackers, have been developed. The global market of wearable
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medical devices is estimated to reach $35 billion USD soon. However, most of the current devices are only capable of measuring heart rate, steps taken, calories, quality of sleep and a few other personal metrics. These limited diagnosis information
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provided by current devices cannot precisely represent the physiological states relating to many diseases. To address this long-standing worldwide issue, we aim to develop a new tool, a non-invasive or minimally-invasive real-time tracking system for
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the level of specific biomarkers in bloodstream.
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<br><img src="https://static.igem.org/mediawiki/2018/2/28/T--NTHU_Formosa--circle_2.png" height="400" width="610" align="middle">
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To achieve the goal, our team proposed Biowatcher, comprising of a bioluminescence-detecting watch (Biowatch) and most importantly engineered reporter cells that enable detection and autonomous report of the level of almost all kinds of biomarkers in
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bloodstream. The sensing parts of the reporter cells are powered by nanobodies, the single-domain antibody that can be engineered to detect different biomarkers2. Binding of biomarkers on nanobodies triggers our synthetic gene circuits and in turn induces
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autonomous bioluminescent system3 as a readout for wearable devices to detect. Our real-time bioluminescence-detecting watch, Biowatch, will track the level of risk factors by measuring the bioluminescence intensity and record the data as numbers and
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graphs. It will send alert to users once the level of the risk factors is too high. Meanwhile, there will be suggestions of nearby hospitals according to the users’ location. The system will also upload and attribute the data to public health analysis
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under the users’ consent. (Fig. 2)
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<br><img src="https://static.igem.org/mediawiki/2018/9/90/T--NTHU_Formosa--project_model.png" height="600" width="400" align="middle">
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<h3>Before you start</h3>
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<p> Please read the following pages:</p>
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<ul>
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<li>  <a href="https://2018.igem.org/Competition">Competition Hub</a> </li>
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<li> <a href="https://2018.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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<li> <a href="https://2018.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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<h3> Styling your wiki </h3>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<h3> Uploading pictures and files </h3>
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<p> You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. </p>
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<p>When you upload, set the "Destination Filename" to <b> T--YourOfficialTeamName--NameOfFile.jpg</b>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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UPLOAD FILES
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<h3> Wiki template information </h3>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<h3> Editing your wiki </h3>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p>Use WikiTools - Edit in the black menu bar to edit this page</p>
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<a href="https://2018.igem.org/wiki/index.php?title=Team:NTHU_Formosa&action=edit">
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EDIT PAGE
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<h3>Tips</h3>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2018.igem.org/Calendar">iGEM 2018 calendar</a> </li>
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<li>Have lots of fun! </li>
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<h3>Inspiration</h3>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<ul>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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</ul>
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Revision as of 08:24, 27 September 2018

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