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Revision as of 16:02, 12 October 2018
Description
Engineered probiotics alleviate the inflammatory bowel disease and prevent colorectal cancer
Due to the accelerated urbanization nowadays, the number of patients with inflammatory bowel disease(IBD) is rising in Asia. In addition, patients with IBD have an increased risk of developing colorectal cancer(CRC). Therefore, NEU China A aim to design a biological system against IBD and potential CRC this year. To put out the fire in the gut, E. coli Nissle 1917 is selected as our firemen. We empower it with an anti-inflammatory device including a sensor and an effector. In other hand, we choose Saccharomyces boulardii to be our policemen. It is armed with myrosinase to turn the glucosinolates, a natural component of cruciferous vegetables, to sulphoraphane which has anticancer activity. Integrating probiotic therapy with synthetic biology, we envision that the collaboration between the E. coli and the yeast will greatly help us to overcome the tough situation in the patient’s gut.
