Difference between revisions of "Team:BGU Israel"

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    <title>OriginALS</title>
  
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<li> <a href="https://2018.igem.org/Competition">Competition Hub</a> </li>
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<li> <a href="https://2018.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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            <h1 class="section-heading  text-center animated fadeInLeft">Abstarct</h1>
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            <p style="margin:0px !important; padding:0!important;"  class="mb-4 justified animated fadeInRight">Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons. <br><br>
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</div>
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Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach: </p>
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              <ol class="mb-4 justified animated fadeInRight">
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                <li> We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.</li>
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                <li>We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.</li>
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              </ol>
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              <p  class="mb-4 justified animated fadeInRight">
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In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.</p>
  
  
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            <h1 class="section-heading">Contact Us</h1>
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            <p class="mb-5 text-faded">Feel free to follow and contact us for more information on:</p>
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        <div class="row">
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          <div class="col-lg-3 col-md-6 ml-auto text-center text-faded ">
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            <a href="https://www.facebook.com/iGEMBGU/" target="_blank"  class="text-faded"><i class="fa fa-facebook fa-3x mb-3 sr-contac hvr-bob"></i>
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            <p>iGEM BGU</p></a>
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          <div class="col-lg-3 col-md-6 mr-auto text-center text-faded ">
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            <a href="https://twitter.com/originalsbgu" target="_blank" class="text-faded"><i class="fa fa-twitter fa-3x mb-3 sr-contact hvr-bob"></i>
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            <p>
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              @OrignialsBGU
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            </p></a>
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            <a href="https://www.instagram.com/igem_2018_bgu/" target="_blank" class="text-faded"><i class="fa fa-instagram fa-3x mb-3 sr-contact  hvr-bob"></i>
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                <p>@iGEM_2018_BGU</p></a>
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          </div>
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          <div class="col-lg-3 col-md-6 mr-auto text-center text-faded">
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            <a href="mailto:originalbgu@gmail.com" target="_blank" class="text-faded"><i class="fa fa-envelope-o fa-3x mb-3 sr-contact  hvr-bob"></i>
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            <p>
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              originalbgu@gmail.com
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            </p></a>
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          </div>
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  <nav class="navbar navbar-expand-md navbar-dark bg-dark">
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                <a class="nav-link" href="#">Ben-Gurion University of the Negev<br>
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Ben Gurion 1, Beer Sheva 8410501, Israel</a>
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                <a class="nav-link" href="#">Copyright &copy; 2018 OriginALS. All Rights Reserved.</a>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<p> You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. </p>
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<p>When you upload, set the "Destination Filename" to <b> T--YourOfficialTeamName--NameOfFile.jpg</b>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2018.igem.org/Calendar">iGEM 2018 calendar</a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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Revision as of 13:28, 16 June 2018

a OriginALS

<!DOCTYPE html> OriginALS

Abstarct

Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons.

Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach:

  1. We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.
  2. We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.

In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.

Contact Us

Feel free to follow and contact us for more information on:

iGEM BGU

@OrignialsBGU

@iGEM_2018_BGU

originalbgu@gmail.com