Difference between revisions of "Team:UBonn HBRS"

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{{UBonn_HBRS/header|title=iGEM Bonn|active-start=active|class-sideNav=d-none|class-main=col-lg-12}}
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<img src="//2018.igem.org/wiki/images/b/be/T--UBonn_HBRS--Startpage-Title.png" class="img-fluid d-block mx-auto" alt="iGEM Bonn 2018 - Molecular Mouthwash" />
  
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We are working on a way to prevent caries. The major cariogenic bacterium is <em class="fat-blue">Streptococcus mutans</em>. Its pathogenicity originates from its attachment to the tooth surface and the formation of biofilms on it.
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<img src="//2017.igem.org/wiki/images/1/15/T--UBonn_HBRS--Startpage-Tooth_s_mutans.png" class="img-fluid d-block mx-auto" alt="Development of Caries" />
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<img src="//2017.igem.org/wiki/images/0/00/T--UBonn_HBRS--Startpage-Spacer.png" class="img-fluid d-block mx-auto" alt=".................................................." />
  
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<h1> Welcome to iGEM 2018! </h1>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<img src="//2017.igem.org/wiki/images/0/0f/T--UBonn_HBRS--Startpage-SMutans-Pellicle.png" class="img-fluid d-block float-left" alt="SMutans Pellicle Attachment Proteins" />
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First, we identified <span class="fat-blue">proteins</span> that are responsible for the attachment, biofilm formation and thus pathogenicity of <em>S. mutans</em>. After that we synthesized the genes coding for them by IDT. In the next step we express these proteins.
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<img src="//2017.igem.org/wiki/images/0/00/T--UBonn_HBRS--Startpage-Spacer.png" class="img-fluid d-block mx-auto" alt=".................................................." />
  
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Once expression is successful, we perform <span class="fat-blue">SELEX</span> against them to find aptamers, that potentially inhibit the formation of plaques. <span class="fat-blue">Aptamers</span> are short nucleic acids, which can perform functions similiar to proteins.
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<img src="//2018.igem.org/wiki/images/d/d5/T--UBonn_HBRS--Startpage-SELEX.png" class="img-fluid d-block float-right" alt="SELEX" />
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<img src="//2017.igem.org/wiki/images/0/00/T--UBonn_HBRS--Startpage-Spacer.png" class="img-fluid d-block mx-auto" alt=".................................................." />
  
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At last we screen the selected aptamers for their ability to prevent the formation of a biofilm.
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<img src="//2017.igem.org/wiki/images/4/4b/T--UBonn_HBRS--Startpage-Products.png" class="img-fluid d-block mx-auto" alt="Adding our aptamers to everyday products" />
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<h3>Before you start</h3>
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<img src="//2017.igem.org/wiki/images/0/00/T--UBonn_HBRS--Startpage-Spacer.png" class="img-fluid d-block mx-auto" alt=".................................................." />
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<p> Please read the following pages:</p>
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<li>  <a href="https://2018.igem.org/Competition">Competition Hub</a> </li>
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<li> <a href="https://2018.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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<img src="//2017.igem.org/wiki/images/e/e1/T--UBonn_HBRS--Startpage-Tooth_aptamers.png" class="img-fluid d-block mx-auto" alt="Aptamer protects the teeth from caries" />
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An important part of our project has been to introduce Synthetic Biology to the public through various <span class="fat-blue">Human practices</span> events.
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<img src="//2017.igem.org/wiki/images/7/7e/T--UBonn_HBRS--Startpage-Human_Practices.png" class="img-fluid d-block mx-auto" alt="Human Practices: Survey, Science Slam, School visits, Conferences, City booth, Panels" />
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<h2>We thank our Institutions and our sponsors for their support</h2>
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<h3> Styling your wiki </h3>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<h3> Uploading pictures and files </h3>
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<p> You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. </p>
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<p>When you upload, set the "Destination Filename" to <b> T--YourOfficialTeamName--NameOfFile.jpg</b>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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<h3> Wiki template information </h3>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p>Use WikiTools - Edit in the black menu bar to edit this page</p>
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<h3>Tips</h3>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2018.igem.org/Calendar">iGEM 2018 calendar</a> </li>
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<li>Have lots of fun! </li>
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<h3>Inspiration</h3>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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Revision as of 11:26, 19 June 2018

iGEM Bonn

iGEM Bonn 2018 - Molecular Mouthwash
We are working on a way to prevent caries. The major cariogenic bacterium is Streptococcus mutans. Its pathogenicity originates from its attachment to the tooth surface and the formation of biofilms on it.
Development of Caries
..................................................
SMutans Pellicle Attachment Proteins
First, we identified proteins that are responsible for the attachment, biofilm formation and thus pathogenicity of S. mutans. After that we synthesized the genes coding for them by IDT. In the next step we express these proteins.
..................................................
Once expression is successful, we perform SELEX against them to find aptamers, that potentially inhibit the formation of plaques. Aptamers are short nucleic acids, which can perform functions similiar to proteins.
SELEX
..................................................
At last we screen the selected aptamers for their ability to prevent the formation of a biofilm.
Adding our aptamers to everyday products
..................................................
Aptamer protects the teeth from caries
An important part of our project has been to introduce Synthetic Biology to the public through various Human practices events.
Human Practices: Survey, Science Slam, School visits, Conferences, City booth, Panels

We thank our Institutions and our sponsors for their support


© iGEM Team Bonn 2018 Top ↑