Difference between revisions of "Team:NUS Singapore-A"

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    <h3 id='Overview'>Eco-friendly Bio-manufacturing of Flavonoid Dyes in Escherichia coli via Computer-mediated Optogenetic Regulation</h2>
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<div class="text-box-description">Biomanufacturing opens up possibilities for sustainable production of useful materials. We, Team NUSGEM, created Coup Dyetat, an environmentally-friendly platform, advancing biomanufacturing. Discover our project
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  <div class="text-box-design">Current biomanufacturing platforms are chemical-intensive and expensive. Coup Dyetat is more environmentally friendly and potentially cheaper. Find out how
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  <div class="text-box-ihp">Integrating findings from our human practices has helped us make sure that our platform is relevant to biomanufacturers. Find out who we spoke to</div>
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  <div class="text-box-results">Did you know that textile dyeing and dyestuff production industry is the second most pollutive industry? Our biomanufacturing platform can help alleviate this problem. To prove that the platform works, we decided to produce flavonoids to be used as dyes.</div>
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  <div class="text-box-modeling">No system would work without its support. Find out what we did to complete our system</div>
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    <p style="margin: 0 5%"> Natural dyes are increasingly considered as an eco-friendly solution to the serious water pollution generated by the textile and dye industries. Traditional production of natural dyes from plants heavily exhausts land and labour. While bio-manufacturing is an attractive alternative, it remains costly and chemically-intensive. We aim to develop a new bio-manufacturing method of producing flavonoids in E. coli for use as natural dyes. To eliminate the use of expensive chemical inducers to switch from growth to production phase and allow dynamic gene regulation, we designed an optogenetic circuit using a blue light repressible promoter for flavonoid biosynthesis. As it is critical to monitor cellular metabolic burden for efficient production, we introduced a stress-sensing fluorescence reporter. To optimize operations, a computer-aided system was developed to regulate gene expression using light according to the feedback from the stress sensor. To demonstrate this approach, we produced Luteolin, a natural yellow dye.
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  <div class="text-box-team">Our team of 13 is made up intensely motivated students across all disciplines. Find out who we are</div>
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Revision as of 10:54, 15 October 2018

CONNECT WITH US

Biomanufacturing opens up possibilities for sustainable production of useful materials. We, Team NUSGEM, created Coup Dyetat, an environmentally-friendly platform, advancing biomanufacturing. Discover our project
Current biomanufacturing platforms are chemical-intensive and expensive. Coup Dyetat is more environmentally friendly and potentially cheaper. Find out how
Integrating findings from our human practices has helped us make sure that our platform is relevant to biomanufacturers. Find out who we spoke to
Did you know that textile dyeing and dyestuff production industry is the second most pollutive industry? Our biomanufacturing platform can help alleviate this problem. To prove that the platform works, we decided to produce flavonoids to be used as dyes.
No system would work without its support. Find out what we did to complete our system
Our team of 13 is made up intensely motivated students across all disciplines. Find out who we are


HEAR OUR STORY

We’re using synthetic biology to change the way the world thinks and functions.

We’re a little disruptive, dangerous and maybe a tad too bold. But the world needs some shaking up every now and then, and we think we’re just the right people for that.

Together we’re going to engineer biology and create something awesome.

CONTACT US

nusigem@gmail.com

21 Lower Kent Ridge Rd, Singapore 119077