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<h2> Project: Cerberus </h2>
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<p>In this era of developing innovative materials, functionalizing cellulose paves the way towards interesting perspectives. Even though it is used in medicine, textile and stationery, new innovations may still be applied to this material with many known and applied properties. Simplifying the conjugation of bioactive molecules to cellulose would allow new perspectives to be explored. From conductive paper to pathogenic infection preventing hygienic devices, our design of a three headed linker protein named Cerberus (in reference to the greek mythological dog) will enable a wide range of chemicals to be fixated. This design is based on the fusion of three fixating protein structures representing the three heads of the system. The first head is a protein domain of the type 3 Carbohydrates Binding Modules (CBM3) family. The second is one of the strongest linkage systems of the living realm: streptavidin, with its high affinity for biotin. The last of the heads features a non-natural amino acid, azidophenylalanine, catalysing covalent bonds by click chemistry. This thought-out linker will allow a large variety of biological, organic and inorganic molecules to conjugate with cellulose.</p>
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<p style="font-size:2.5rem !important; color: white">How can Synthetic Biology lead to the creation of new materials? </p>
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<p ALIGN=RIGHT style="font-size:2rem !important; color:white;">More details on our <a href='https://2018.igem.org/Team:Toulouse-INSA-UPS/Description' style="color:lightblue">Description page</a></p>
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<p style="font-size:2.5rem !important; color: white">To answer this challenge, we designed a versatile molecular binding platform that we named <em>Cerberus</em></p>
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<p ALIGN=RIGHT style="font-size:2rem !important; color:white;">More details on our <a href='https://2018.igem.org/Team:Toulouse-INSA-UPS/Design' style="color:lightblue">Design page</a></p>
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<p style="font-size:2.5rem !important; color: white">We characterised our system and gave new properties to cellulose</p>
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<p ALIGN=RIGHT style="font-size:2rem !important; color:white;">Take a look at the <a href='https://2018.igem.org/Team:Toulouse-INSA-UPS/Results' style="color:lightblue" >Results page</a></p>
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<p style="font-size:2.5rem !important; color: white">Meet the pack that achieved it!</p>
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<p ALIGN=RIGHT style="font-size:2rem !important; color:white;">Check out our <a href='https://2018.igem.org/Team:Toulouse-INSA-UPS/Team' style="color:lightblue" >Team page</a></p>
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Latest revision as of 13:49, 16 October 2018

How can Synthetic Biology lead to the creation of new materials?

More details on our Description page

To answer this challenge, we designed a versatile molecular binding platform that we named Cerberus

More details on our Design page

We characterised our system and gave new properties to cellulose

Take a look at the Results page

Meet the pack that achieved it!

Check out our Team page

No dogs were harmed over the course of this iGEM project.

INSA Toulouse UPS LISBP TWB Defi Adisseo Foundation ESF Catalyses


The content provided on this website is the fruit of the work of the Toulouse INSA-UPS iGEM Team. As a deliverable for the iGEM Competition, it falls under the Creative Commons Attribution 4.0. Thus, all content on this wiki is available under the Creative Commons Attribution 4.0 license (or any later version). For futher information, please consult the official website of Creative Commons.

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