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<ul id="dropdown1" class="dropdown-content"> | <ul id="dropdown1" class="dropdown-content"> | ||
<li><a href="https://2018.igem.org/Team:Fudan/Demonstrate">Demonstration</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Demonstrate">Demonstration</a></li> | ||
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<li><a href="https://2018.igem.org/Team:Fudan/Results">Transmembrane logic</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Results">Transmembrane logic</a></li> | ||
</ul> | </ul> | ||
<ul id="dropdown2" class="dropdown-content"> | <ul id="dropdown2" class="dropdown-content"> | ||
− | <li><a href="https://2018.igem.org/Team:Fudan/ | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#ribo">Addon: <sub>ENABLE</sub><sup>ribo</sup></a></li> |
− | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#TALE">Addon: <sub>ENABLE</sub><sup>TALE</sup></a></li> | |
− | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#T2">Addon: <sub>ENABLE</sub><sup>T2</sup></a></li> | |
<li><a href="https://2018.igem.org/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> | ||
<li><a href="https://2018.igem.org/Team:Fudan/Model#War_Predictor">Model: war predictor</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Model#War_Predictor">Model: war predictor</a></li> | ||
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<ul> | <ul> | ||
<li><a href="https://2018.igem.org/Team:Fudan/Demonstrate">Demonstration</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Demonstrate">Demonstration</a></li> | ||
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<li><a href="https://2018.igem.org/Team:Fudan/Results">Transmembrane logic</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Results">Transmembrane logic</a></li> | ||
</ul> | </ul> | ||
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− | <li><a href="https://2018.igem.org/Team:Fudan/ | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#ribo">Addon: <sub>ENABLE</sub><sup>ribo</sup></a></li> |
− | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#TALE">Addon: <sub>ENABLE</sub><sup>TALE</sup></a></li> | |
− | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#T2">Addon: <sub>ENABLE</sub><sup>T2</sup></a></li> | |
<li><a href="https://2018.igem.org/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> | ||
<li><a href="https://2018.igem.org/Team:Fudan/Model#War_Predictor">Model: war predictor</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Model#War_Predictor">Model: war predictor</a></li> | ||
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<img class="responsive-img" src="https://static.igem.org/mediawiki/2018/3/31/T--Fudan--sponsor-1.png" style="height:72px" /><br/> | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/3/31/T--Fudan--sponsor-1.png" style="height:72px" /><br/> | ||
<img class="responsive-img" src="https://static.igem.org/mediawiki/2018/5/55/T--Fudan--sponsor-2.png" style="height:68px" /><br/> | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/5/55/T--Fudan--sponsor-2.png" style="height:68px" /><br/> | ||
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/6/6f/T--Fudan--sponsor-3.png" style="height:72px" / > | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/6/6f/T--Fudan--sponsor-3.png" style="height:72px" /> |
</div> | </div> | ||
<div class="sponsor"> | <div class="sponsor"> | ||
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<ul> | <ul> | ||
<li><a href="https://2018.igem.org/Team:Fudan/Demonstrate">Demonstration</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Demonstrate">Demonstration</a></li> | ||
− | + | ||
<li><a href="https://2018.igem.org/Team:Fudan/Results">Transmembrane logic</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Results">Transmembrane logic</a></li> | ||
<li><a href="https://2017.igem.org/Team:Fudan">2017.iGEM</a></li> | <li><a href="https://2017.igem.org/Team:Fudan">2017.iGEM</a></li> | ||
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<span>Dry lab</span> | <span>Dry lab</span> | ||
<ul> | <ul> | ||
− | <li><a href="https://2018.igem.org/Team:Fudan/ | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#ribo">Addon: <sub>ENABLE</sub><sup>ribo</sup></a></li> |
− | <li><a href="https://2018.igem.org/Team:Fudan/ | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#TALE">Addon: <sub>ENABLE</sub><sup>TALE</sup></a></li> |
− | <li><a href="https://2018.igem.org/Team:Fudan/ | + | <li><a href="https://2018.igem.org/Team:Fudan/Addon#T2">Addon: <sub>ENABLE</sub><sup>T2</sup></a></li> |
<li><a href="https://2018.igem.org/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> | ||
<li><a href="https://2018.igem.org/Team:Fudan/Model#War_Predictor">Model: war predictor</a></li> | <li><a href="https://2018.igem.org/Team:Fudan/Model#War_Predictor">Model: war predictor</a></li> | ||
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</ul> | </ul> | ||
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− | <div class="col s12 m4 | + | <div class="col s12 m4"> |
<span>Wet lab</span> | <span>Wet lab</span> | ||
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− | <div class="col s12 m4"> | + | <div class="col s12 m4 active"> |
<span>Team</span> | <span>Team</span> | ||
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<div class="container"> | <div class="container"> | ||
<div class="contactUS row"> | <div class="contactUS row"> | ||
− | <div class="col s12 m6 | + | <div class="col s12 m6 l4"><i class="fa fa-location-arrow"></i> Life Sci Bldg E301, 2005 Songhu Rd, Shanghai |
</div><div class="col s12 m6 l3"><i class="fa fa-envelope-o"></i> igem@fudan.edu.cn | </div><div class="col s12 m6 l3"><i class="fa fa-envelope-o"></i> igem@fudan.edu.cn | ||
</div><div class="col s12 m6 l2"><i class="fa fa-wechat"></i> Fudan_iGEM | </div><div class="col s12 m6 l2"><i class="fa fa-wechat"></i> Fudan_iGEM | ||
− | </div><div class="col s12 m6 | + | </div><div class="col s12 m6 l3"><i class="fa fa-fax"></i> +86-21-31246727 |
</div> | </div> | ||
</div> | </div> |
Revision as of 14:00, 16 October 2018
- Addon: ENABLEribo
- Addon: ENABLETALE
- Addon: ENABLET2
- Model: transcriptional amplifer
- Model: war predictor
- Software
Sponsors
Our sponsors
Crowd backers (10/4/2018 - 10/9/2018)
Abstract
Contact-dependent signaling is critical for multicellular biological events, yet customizing contact-dependent signal transduction between cells remains challenging. Here we have developed the ENABLE toolbox, a complete set of transmembrane binary logic gates. Each gate consists of 3 layers: Receptor, Amplifier, and Combiner. We first optimized synthetic Notch receptors to enable cells to respond to different signals across the membrane reliably. These signals, individually amplified intracellularly by transcription, are further combined for computing. Our engineered zinc finger-based transcription factors perform binary computation and output designed products. In summary, we have combined spatially different signals in mammalian cells, and revealed new potentials for biological oscillators, tissue engineering, cancer treatments, bio-computing, etc. ENABLE is a toolbox for constructing contact-dependent signaling networks in mammals. The 3-layer design principle underlying ENABLE empowers any future development of transmembrane logic circuits, thus contributes a foundational advance to Synthetic Biology.