Difference between revisions of "Team:HZAU-China/Description"

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<h1>Description</h1>
 
<h1>Description</h1>
  
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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<p>Bacterial therapy has unique capabilities that are unachievable with conventional methods in cancer therapeutics. For example, it can target tumors specifically, stay in body for a longer period of time, and move to distal regions. In our project, we redesign Salmonella to act as a delivery vehicle that can target tumor cells and replicate in their cytoplasm. By using inducer to trigger bacterial expression of the N-terminal domain of GasderminD protein, bacteria can be led to lysis and release this protein into the cytoplasm of tumor cell and then induce pyroptosis to the cell by making membrane pores. Along with this process, the released cytokines such as IL-1β attract immune cells to fight the tumor cell. Our project which aims to induce pyroptosis to tumor cells provides a new approach for cancer therapy.</p>
  
 
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<h3>What should this page contain?</h3>
 
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<li> A clear and concise description of your project.</li>
 
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
 
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<li>References and sources to document your research.</li>
 
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<h3>Inspiration</h3>
 
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<p>See how other teams have described and presented their projects: </p>
 
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
 
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
 
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
 
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
 
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<h3>Advice on writing your Project Description</h3>
 
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be concise, accurate, and unambiguous in your achievements.
 
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<h3>References</h3>
 
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
 
  
 
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Revision as of 06:11, 28 June 2018

Description

Bacterial therapy has unique capabilities that are unachievable with conventional methods in cancer therapeutics. For example, it can target tumors specifically, stay in body for a longer period of time, and move to distal regions. In our project, we redesign Salmonella to act as a delivery vehicle that can target tumor cells and replicate in their cytoplasm. By using inducer to trigger bacterial expression of the N-terminal domain of GasderminD protein, bacteria can be led to lysis and release this protein into the cytoplasm of tumor cell and then induce pyroptosis to the cell by making membrane pores. Along with this process, the released cytokines such as IL-1β attract immune cells to fight the tumor cell. Our project which aims to induce pyroptosis to tumor cells provides a new approach for cancer therapy.