Difference between revisions of "Team:New York City/Description"

(Prototype team page)
 
 
(8 intermediate revisions by 2 users not shown)
Line 1: Line 1:
 
{{New_York_City}}
 
{{New_York_City}}
−
<html>
+
<html lang="en">
−
 
+
<head><style>
−
 
+
.social{
−
 
+
            max-width: 50px;
−
<div class="column full_size">
+
            max-height: auto;
−
<h1>Description</h1>
+
        }
−
 
+
        .container {
−
<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
+
            align-items: center;
−
 
+
            max-width: 960px;
 +
        }
 +
        a{
 +
            color:#7B84ED;
 +
        }
 +
        p{
 +
            font-size: 120%;
 +
        }
 +
        .shiny{
 +
            color:#7B84ED;
 +
        }
 +
        .headimage{
 +
            border-radius: 15px;
 +
        }
 +
img {max-width: 40%;}
 +
    </style>
 +
</head>
 +
<body>
 +
    <div class="container">
 +
        <nav class="sticky-top py-3 navbar navbar-expand-lg navbar-light mr-auto">
 +
            <div class="container d-flex flex-column flex-md-row justify-content-between">
 +
                <div class="navbar-brand"><a href="https://2018.igem.org/Team:New_York_City">New York City iGEM</a></div>
 +
                <div class="collapse navbar-collapse" id="navbarSupportedContent">
 +
                    <ul class="navbar-nav mr-auto">
 +
                        <li class="nav-item dropdown">
 +
                            <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarPR"
 +
                                role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
 +
                                Project
 +
                            </a>
 +
                            <div class="dropdown-menu" aria-labelledby="navbarPR">
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/HD">What is
 +
                                    Huntington's?</a>
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Description">Description</a>
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Design">Design</a>
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Model">Model</a>
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/InterLab">InterLab</a>
 +
                            </div>
 +
                        </li>
 +
                        <li class="nav-item dropdown">
 +
                            <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarNB"
 +
                                role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
 +
                                Notebook
 +
                            </a>
 +
                            <div class="dropdown-menu" aria-labelledby="navbarNB">
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Notebook">Notebook</a>
 +
                            </div>
 +
                        </li>
 +
                        <li class="nav-item dropdown">
 +
                            <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarHP"
 +
                                role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
 +
                                Human Practices
 +
                            </a>
 +
                            <div class="dropdown-menu" aria-labelledby="navbarHP">
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Human_Practices">Human
 +
                                    Practices</a>
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Integrated_Practices">Integrated
 +
                                    Practices</a>
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Public_Engagement">Public
 +
                                    Engagement</a>
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Collaborations">Collaborations</a>
 +
                            </div>
 +
                        </li>
 +
                        <li class="nav-item dropdown">
 +
                            <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarT"
 +
                                role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
 +
                                Team
 +
                            </a>
 +
                            <div class="dropdown-menu" aria-labelledby="navbarT">
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Team">Team</a>
 +
                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Attributions">Attributions</a>
 +
                            </div>
 +
                        </li>
 +
                    </ul>
 +
                </div>
 +
            </div>
 +
        </nav>
 +
    </div>
 +
<div class="container py-0 align-middle">
 +
    <h2 align="center">Our Motivation</h2>
 
</div>
 
</div>
  
−
 
+
<div class="container">
−
 
+
    <p class="lead">Huntington's Disease (HD) is an autosomal dominant genetic disorder, meaning that if one allele out
−
<div class="column two_thirds_size">
+
        of two carries the HTT mutation the HD gene will produce the faulty protein of Huntingtin. Therefore, the
−
<h3>What should this page contain?</h3>
+
        children of an individual suffering from HD will have a 50/50 chance of carrying the faulty gene if they do
−
<ul>
+
        not express it themselves. According to the Huntington's Disease Society of America, the "quintessential family
−
<li> A clear and concise description of your project.</li>
+
        disease" and the ability of this disease to wreak such devastating and overarching damage on an individual and
−
<li>A detailed explanation of why your team chose to work on this particular project.</li>
+
        all those around them are one of the root reasons our team has chosen to tackle HD. For instance, HD is
−
<li>References and sources to document your research.</li>
+
        adult-onset (30s to 50s) and many individuals go about their lives and form families without the knowledge of
−
<li>Use illustrations and other visual resources to explain your project.</li>
+
        the storm looming on the horizon. At the time of their diagnosis, their children will be revealed to be at risk
−
</ul>
+
        of inheriting the disease. HD robs a patient of their life, eventually leaving them physically, cognitively, and
 +
        behaviorally inept to continue their daily tasks and responsibilities. Although HD is classified as a rare
 +
        disorder, the tragic and frightful effects it has upon patients, carriers, and families call for a resolution
 +
        to be developed in the near future.</p>
 
</div>
 
</div>
−
 
+
<div align="center">
−
<div class="column third_size" >
+
<img src="https://static.igem.org/mediawiki/2018/0/0b/T--New_York_City--desc.jpg" />
−
<div class="highlight decoration_A_full">
+
−
<h3>Inspiration</h3>
+
−
<p>See how other teams have described and presented their projects: </p>
+
−
 
+
−
<ul>
+
−
<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
+
−
<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
+
−
<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
+
−
<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
+
−
</ul>
+
 
</div>
 
</div>
 +
<div class="container py-0 align-middle">
 +
    <h2 align="center">Abstract</h2>
 
</div>
 
</div>
  
 +
<div class="container">
 +
    <p class="lead">Huntington's Disease (HD) is an autosomal dominant disorder that leads to the progressive
 +
        degeneration of neurons in the brain, which currently has no cure. HD is typically adult-onset and is
 +
        characterized by a variety of symptoms including memory loss, involuntary movements, poor coordination,
 +
        and impaired decision-making. Mutation in the huntingtin (HTT) gene causes HD, specifically a trinucleotide
 +
        repeat of CAG that is abnormally repeated over 40 times. The goal of our project was to test the effectiveness
 +
        of the plasmid that we generated last year, which targets and blocks endogenous faulty mRNA and releases a
 +
        corrected RNA strand for proper protein synthesis of the HTT gene. The efficacy of this plasmid was tested
 +
        on huntingtin cell lines, specifically the HeLa/polyQ-mCFP cell line. The effectiveness of this treatment was
 +
        tested by evaluating whether the quantity of mutated HTT protein decreases after transfecting cells with the
 +
        engineered plasmid.</p>
 +
</div>
  
−
 
+
<div align="center">
−
 
+
<img src="https://static.igem.org/mediawiki/2018/2/2a/T--New_York_City--abstract.jpg" />
−
<div class="column two_thirds_size" >
+
−
<h3>Advice on writing your Project Description</h3>
+
−
 
+
−
<p>
+
−
We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be concise, accurate, and unambiguous in your achievements.  
+
−
</p>
+
−
 
+
 
</div>
 
</div>
  
−
<div class="column third_size">
+
<div class="container">
−
<h3>References</h3>
+
    <p class="lead">Sources:</p>
−
<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
+
    <ol>
−
 
+
        <li><a href="https://ghr.nlm.nih.gov/condition/huntington-disease#synonyms">ghr.nlm.nih.gov</a></li>
 +
        <li><a href="https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Huntingtons-Disease-Hope-Through#3137_14">ninds.nih.gov</a></li>
 +
        <li><a href="http://hdsa.org/what-is-hd/">hdsa.org</a></li>
 +
    </ol>
 
</div>
 
</div>
−
 
+
    <div class="container" align="center">
−
 
+
        <div class="row" align="center">
−
 
+
            <div class="col-sm-3">
−
 
+
            </div>
−
 
+
            <div class="col-sm-2">
−
 
+
                <a href="https://www.facebook.com/HDResolution/"><img class="social" src="https://static.igem.org/mediawiki/2018/6/61/T--New_York_City--fb.png"></a>
 +
            </div>
 +
            <div class="col-sm-2">
 +
                <a href="https://twitter.com/HDNYC_iGEM"><img class="social" src="https://static.igem.org/mediawiki/2018/4/46/T--New_York_City--twit.png"></a>
 +
            </div>
 +
            <div class="col-sm-2">
 +
                <a href="https://www.instagram.com/nyc_igem/"><img class="social" src="https://static.igem.org/mediawiki/2018/0/0a/T--New_York_City--ig.png"></a>
 +
            </div>
 +
            <div class="col-sm-3">
 +
            </div>
 +
        </div>
 +
        <br />
 +
    </div>
 +
</body>
 
</html>
 
</html>

Latest revision as of 01:37, 17 October 2018

Our Motivation

Huntington's Disease (HD) is an autosomal dominant genetic disorder, meaning that if one allele out of two carries the HTT mutation the HD gene will produce the faulty protein of Huntingtin. Therefore, the children of an individual suffering from HD will have a 50/50 chance of carrying the faulty gene if they do not express it themselves. According to the Huntington's Disease Society of America, the "quintessential family disease" and the ability of this disease to wreak such devastating and overarching damage on an individual and all those around them are one of the root reasons our team has chosen to tackle HD. For instance, HD is adult-onset (30s to 50s) and many individuals go about their lives and form families without the knowledge of the storm looming on the horizon. At the time of their diagnosis, their children will be revealed to be at risk of inheriting the disease. HD robs a patient of their life, eventually leaving them physically, cognitively, and behaviorally inept to continue their daily tasks and responsibilities. Although HD is classified as a rare disorder, the tragic and frightful effects it has upon patients, carriers, and families call for a resolution to be developed in the near future.

Abstract

Huntington's Disease (HD) is an autosomal dominant disorder that leads to the progressive degeneration of neurons in the brain, which currently has no cure. HD is typically adult-onset and is characterized by a variety of symptoms including memory loss, involuntary movements, poor coordination, and impaired decision-making. Mutation in the huntingtin (HTT) gene causes HD, specifically a trinucleotide repeat of CAG that is abnormally repeated over 40 times. The goal of our project was to test the effectiveness of the plasmid that we generated last year, which targets and blocks endogenous faulty mRNA and releases a corrected RNA strand for proper protein synthesis of the HTT gene. The efficacy of this plasmid was tested on huntingtin cell lines, specifically the HeLa/polyQ-mCFP cell line. The effectiveness of this treatment was tested by evaluating whether the quantity of mutated HTT protein decreases after transfecting cells with the engineered plasmid.

Sources:

  1. ghr.nlm.nih.gov
  2. ninds.nih.gov
  3. hdsa.org