Difference between revisions of "Team:TecCEM/Description"

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     <img src="https://static.igem.org/mediawiki/2018/a/aa/T--TecCEM--Cells.gif" alt="Cell Gif">
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    <h1>Description</h1>
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                 <h1>Description</h1>
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</div>
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                 <h2>Creating a better life quality</h2>
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<div class="wrapper">
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                 <p>TecTissue main objective is to provide mexican families an easy way to help in the reduction of medical bills and hospitalization time, make the recovery process easier and also create a chance for a better life quality for the people that had suffered burns..</p>  
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<p>There is one big problem that is common around  the world, this problem is burn lesions and in Mexico is the third cause of infant mortality. (NTX, 2017) Is a problem that has been ignored because of what the healing process requires. Thus, we decided that accelerating this process would have many advantages, not only in a quicker skin regeneration, but also it would have a psychological impact and a reduction in the economic cost.</p>  
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         <div class="sidebar-header">
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<p>The project mainly consisted in skin regeneration but with an improvement. It was the acceleration of this process using recombinant proteins like collagen, composed by non-canonical amino acids. Also, we implemented a growth factor produced by humans called Leptin. This growth factor has been reported in different skin regeneration process. There were some other proteins used in this project: Tenascin and heparin. Both of them, with the company of collagen, compose our scaffold where the encapsulated leptin (encapsulated with chitosan) binds there in order to have an appropriate delivery of it in the skin.</p>  
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             <h3>Project/ Description</h3>
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<p>Because of the time and all the process that consist the development of a drug, our product was proven in fibroblast cell line (L929), which comes from mice.</p>
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        </div>
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<p>To prove our project it was necessary to elaborate a Mini Skin Simulator were the cell lines were provided with the conditions they required in order to get a positive proliferation. This Mini Skin Simulator was automatized to create a friendly device for the manipulation of cells in a culture.  
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            <span data-change="el" class="d-inline-block open"></span>
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            Index
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        </a>
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        <ul class="collapse list-unstyled" id="descriptionSubmenu">
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            <li class="active">
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                 <a href="#background">Background</a>
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            </li>
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            <li>
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                 <a href="#solution">The solution</a>
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        </ul>
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    <div class="content">
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        <div class="container-fluid first-container" id="description">
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            <div class="row" id="background">
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                 <div class="col">
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                    <h1>Background</h1>
 +
                    <p>All over the globe, burns are a huge problem in the health sector, only in Mexico is the third
 +
                        cause of infant mortality and around 120 thousand people per year suffer a burn accident, based
 +
                        in the public health sector However, there isn't the required infrastructure needed to treat
 +
                        third-degree burns, which causes a high mortality rate (NTX, 2017).
 +
                    </p>
 +
                    <p>
 +
                        Furthermore, the rate of child mortality from burns is 7 times higher in locations with low
 +
                        socioeconomic indicators, where each burn case could hit a cost of 141,750 USD due to the lack
 +
                        of specialized equipment and staff required to attend these delicate wounds.
 +
                        This problem has been ignored because of what the healing process implies, high costs and
 +
                        difficulties providing the specialized treatment. Then, we concluded that accelerating this
 +
                        process would have many advantages, not only in a faster skin regeneration but also it would
 +
                        have a psychological impact and reduce the economic cost.
 +
                    </p>
 +
                </div>
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            </div>
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            <div class="row" id="solution">
 +
                <div class="col">
 +
                    <h1>The solution</h1>
 +
                    <p>Thus, we created TecTissue, a novel treatment that is capable of reducing wound healing time,
 +
                        preventing infections and consequently, decreasing mortality rate. We achieved this with
 +
                        synthetic biology, incorporating a growth factor and a scaffold.
 +
                    </p>
 +
                    <p>
 +
                        TecTissue’s main objective is to provide families with a simple way to help in the reduction of
 +
                        medical bills and hospitalization time, make the recovery process easier and also create a
 +
                        chance of better life quality for the people that suffered from burns.
 +
                        We used recombinant proteins like collagen, composed by non-canonical amino acids. We also
 +
                        implemented a growth factor produced by humans called Leptin. This growth factor has been
 +
                        reported to be essential in different skin regeneration processes. There were some other
 +
                        molecules used in our project such as Tenascin and heparin. Both of them, with the company of
 +
                        collagen, compose our scaffold which is encapsulated with leptin in nanoparticles of chitosan,
 +
                        in order to have an efficient delivery in the skin.
 +
                    </p>
 +
                    <p>We tested the development of TecTissue in fibroblast cell line L-929 and human mesenchymal
 +
                        cells. To demonstrate our project it was necessary to elaborate a Mini Skin Simulator were the
 +
                        cell lines were provided with the conditions they required in order to get a positive
 +
                        proliferation. This Mini Skin Simulator was automatized to create a friendly device for the
 +
                        manipulation of cells in a culture and to reduce the possible contamination.
 +
                    </p>
 +
                </div>
 
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{{TecCEM/Footer}}
 
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Revision as of 07:31, 17 October 2018

Cell Gif

Description

Background

All over the globe, burns are a huge problem in the health sector, only in Mexico is the third cause of infant mortality and around 120 thousand people per year suffer a burn accident, based in the public health sector However, there isn't the required infrastructure needed to treat third-degree burns, which causes a high mortality rate (NTX, 2017).

Furthermore, the rate of child mortality from burns is 7 times higher in locations with low socioeconomic indicators, where each burn case could hit a cost of 141,750 USD due to the lack of specialized equipment and staff required to attend these delicate wounds. This problem has been ignored because of what the healing process implies, high costs and difficulties providing the specialized treatment. Then, we concluded that accelerating this process would have many advantages, not only in a faster skin regeneration but also it would have a psychological impact and reduce the economic cost.

The solution

Thus, we created TecTissue, a novel treatment that is capable of reducing wound healing time, preventing infections and consequently, decreasing mortality rate. We achieved this with synthetic biology, incorporating a growth factor and a scaffold.

TecTissue’s main objective is to provide families with a simple way to help in the reduction of medical bills and hospitalization time, make the recovery process easier and also create a chance of better life quality for the people that suffered from burns. We used recombinant proteins like collagen, composed by non-canonical amino acids. We also implemented a growth factor produced by humans called Leptin. This growth factor has been reported to be essential in different skin regeneration processes. There were some other molecules used in our project such as Tenascin and heparin. Both of them, with the company of collagen, compose our scaffold which is encapsulated with leptin in nanoparticles of chitosan, in order to have an efficient delivery in the skin.

We tested the development of TecTissue in fibroblast cell line L-929 and human mesenchymal cells. To demonstrate our project it was necessary to elaborate a Mini Skin Simulator were the cell lines were provided with the conditions they required in order to get a positive proliferation. This Mini Skin Simulator was automatized to create a friendly device for the manipulation of cells in a culture and to reduce the possible contamination.