Difference between revisions of "Team:NAU-CHINA/testh"

 
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Precise targeted therapy for solid tumors
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Overview
EGFR (epidermal growth factor receptor) is a protein that exists on the surface of both normal cells and cancer cells. EGFR is very important for cell growth and differentiation. When a cell's ligand binds to EGFR, EGFR will be activated, which will send a signal to the inside of the cell to control cell growth through the cell pathway.
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We developed iGEMCloud to solve some of iGEM's current problems, with its immediacy, openness and interactivity. At present, all the information about iGEM comes from many websites. They are scattered, cluttered and unfriendly to personal user.
However, compared with normal cells, many cancer cells have mutations that overexpress EGFR. When the ligand is attached to the mutated EGFR, this signal will remain " sent" all the time, resulting in uncontrolled cell growth and response. Different EGFR mutations lead to different kinds of cancers, such as non-small cell lung cancer, pancreatic cancer, breast cancer, medullary thyroid cancer, head and neck squamous cell cancer, colorectal cancer, chordoma, and malignant glioma.
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Because the traditional cancer treatment methods, such as radiotherapy and chemotherapy, can kill all the rapidly growing cells while killing the cancer cells, there will be great side effects. Targeted therapy may also have certain side effects because the target also exists in normal cells. Immunotherapy may also damage normal cells due to the strong immune response of the modified T cells, so it is necessary to use an immune checkpoint inhibitor to adjust the intensity of the immune response. However, the use of immunosuppressive agents can also do some harm to the human body.
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So we have created this application(So far, it is android based, and we hope to launch the iOS version in the future) , which is hoped to be a information gathering platform that receives the latest information of iGEM, a micro-blog that allows all users to participate in discussions in group or individual, and a community that built for iGEMers all around the world.
If we replace the upstream extracellular domain of our subject with EGFR antibodies, our design can accurately identify EGFR with different densities on the cell membrane surface, and judge whether the cells change according to the density of EGFR, thus realizing the recognition of cancer cells. Moreover, we can adjust the immune strength of the engineered immune cells and the threshold value of EGFR recognition by adjusting the promoter strength and the type of recombinase, so as to accurately distinguish normal cells with low density EGFR from cancerous cells with high density EGFR, protect normal cells to the maximum extent, and recognize and kill cancerous cells. We come up with two strategies to achieve this.
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1. Make the whole set of switch final secretion PD - 1 antibodies and PD - L1 antibodies, such as MPDL3280A, MEDI4736 BMS - 936559, Nivolumab and Pembrolizumab, so as to make the T cells through other surface molecules to identify and kill cancer cells. Compared with the direct use of antibodies for injection therapy, our method of modifying T cells makes the antibody therapy more targeted and minimizes the damage to other immune cells in the body.
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Instructions
2. Make the whole set of switch finally secrete some molecules such as IL-12, CCL21 and so on. These molecules have the function of collecting T cells, thus strengthening the ability of T cells to kill cancer cells.
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1.Register an account with your email address, enter the verify code, and use this address to log in.
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2.In the application, you can receive official news, notifications, etc. And so that you can get the latest news of iGEM events in a timely, convenient and accurate way.
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3.Users can write blog posts in the discussion forum for all users to browse. The blog post is in the form of pictures + text. The blog posts are classified into different sections, such as experiment, seek help, etc. And so that you can share your ideas with all iGEM participants.
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Excellent blog posts will be tagged so that they are discovered by users. At the same time, users who see the blog posts written by you can comment or reply to you. The content of the reply is in the form of image + text. When you find a nice blog post, click on the star symbol in the upper right to bookmark it for later reading.
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4.If you want to remind specific users to view the content you have posted, you can remind the user to view this blog post or comment by "@" + "user nickname".
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5.You can search for blog posts in one or more keywords in the app, and sort the search results by time, number of view , and collection. You can also search for users or teams.
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6.You can follow the teams or users that you think are worthy of attention so that you can view their published content more easily in the future.
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7.Each user can create or join a team, become a member, and use their team space. The team creator is the captain who can edit the team information in the team space for others to join and show the team research direction. Only members of the team can post in the team space, but everyone can view it. Also, the captain can add albums in the team space,where members of the team can post photos.
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8.This app has built-in gadgets that may be needed for the lab and more other features will be added in the future...
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What it could be
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An information gathering platform:
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We will gather information from other website to release, and we hope to build contact with some organization to get instant and accurate information. The user of this app can share their information in it. If it is valuable and reliable, we will push it to everyone.
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A platform for interaction between teams:
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Through the form of the team space, each team can easily interact with other teams. This will strengthen the connection between iGEM teams and cause countless positive possibilities.
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An iGEM community:
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Each iGEMer could leave a footprint here and show themselves here. Everyone here is part of the iGEM.
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The App we conceived can provide comprehensive information on the release of events, each team to register their own team home page, various activities related to iGEM, question answer and experience sharing , topic discussion, experimental supplies, and more.

Latest revision as of 10:05, 17 October 2018

Overview We developed iGEMCloud to solve some of iGEM's current problems, with its immediacy, openness and interactivity. At present, all the information about iGEM comes from many websites. They are scattered, cluttered and unfriendly to personal user.

So we have created this application(So far, it is android based, and we hope to launch the iOS version in the future) , which is hoped to be a information gathering platform that receives the latest information of iGEM, a micro-blog that allows all users to participate in discussions in group or individual, and a community that built for iGEMers all around the world.

Instructions 1.Register an account with your email address, enter the verify code, and use this address to log in.

2.In the application, you can receive official news, notifications, etc. And so that you can get the latest news of iGEM events in a timely, convenient and accurate way.

3.Users can write blog posts in the discussion forum for all users to browse. The blog post is in the form of pictures + text. The blog posts are classified into different sections, such as experiment, seek help, etc. And so that you can share your ideas with all iGEM participants.

Excellent blog posts will be tagged so that they are discovered by users. At the same time, users who see the blog posts written by you can comment or reply to you. The content of the reply is in the form of image + text. When you find a nice blog post, click on the star symbol in the upper right to bookmark it for later reading.

4.If you want to remind specific users to view the content you have posted, you can remind the user to view this blog post or comment by "@" + "user nickname".

5.You can search for blog posts in one or more keywords in the app, and sort the search results by time, number of view , and collection. You can also search for users or teams.

6.You can follow the teams or users that you think are worthy of attention so that you can view their published content more easily in the future.

7.Each user can create or join a team, become a member, and use their team space. The team creator is the captain who can edit the team information in the team space for others to join and show the team research direction. Only members of the team can post in the team space, but everyone can view it. Also, the captain can add albums in the team space,where members of the team can post photos.

8.This app has built-in gadgets that may be needed for the lab and more other features will be added in the future...

What it could be An information gathering platform: We will gather information from other website to release, and we hope to build contact with some organization to get instant and accurate information. The user of this app can share their information in it. If it is valuable and reliable, we will push it to everyone.

A platform for interaction between teams: Through the form of the team space, each team can easily interact with other teams. This will strengthen the connection between iGEM teams and cause countless positive possibilities.

An iGEM community: Each iGEMer could leave a footprint here and show themselves here. Everyone here is part of the iGEM.

The App we conceived can provide comprehensive information on the release of events, each team to register their own team home page, various activities related to iGEM, question answer and experience sharing , topic discussion, experimental supplies, and more.