Difference between revisions of "Team:New York City/Human Practices"

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<head><style>.social{
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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2018.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2018.igem.org/Judging/Awards"> award listed below</a>. </p>
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2018.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
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<body>
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    <div class="container">
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        <nav class="sticky-top py-3 navbar navbar-expand-lg navbar-light mr-auto">
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            <div class="container d-flex flex-column flex-md-row justify-content-between">
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                <div class="navbar-brand"><a href="https://2018.igem.org/Team:New_York_City">New York City iGEM</a></div>
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                <div class="collapse navbar-collapse" id="navbarSupportedContent">
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                    <ul class="navbar-nav mr-auto">
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                        <li class="nav-item dropdown">
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                            <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarPR"
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                                role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                                Project
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                            </a>
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                            <div class="dropdown-menu" aria-labelledby="navbarPR">
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/HD">What is
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                                    Huntington's?</a>
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Description">Description</a>
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Design">Design</a>
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Model">Model</a>
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/InterLab">InterLab</a>
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                            </div>
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                        </li>
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                                Notebook
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                            </a>
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                            <div class="dropdown-menu" aria-labelledby="navbarNB">
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Notebook">Notebook</a>
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                            </div>
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                        </li>
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                        <li class="nav-item dropdown">
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                            <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarHP"
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                                role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                                Human Practices
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                            </a>
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                            <div class="dropdown-menu" aria-labelledby="navbarHP">
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Human_Practices">Human
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                                    Practices</a>
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Integrated_Practices">Integrated
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                                    Practices</a>
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Public_Engagement">Public
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                                    Engagement</a>
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Collaborations">Collaborations</a>
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                            </div>
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                        </li>
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                        <li class="nav-item dropdown">
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                            <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarT"
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                                role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                                Team
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                            </a>
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                            <div class="dropdown-menu" aria-labelledby="navbarT">
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Team">Team</a>
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                                <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Attributions">Attributions</a>
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                            </div>
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                        </li>
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                    </ul>
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                </div>
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            </div>
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        </nav>
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    </div>
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    <div class="container py-0 align-middle">
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        <h2 align="center">Human Practices</h2>
 +
    </div>
  
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<h1>Human Practices</h1>
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    <div class="container">
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<p>
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        <p><strong>Introduction to Public Engagement:</strong><br />
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At iGEM we believe societal considerations should be upfront and integrated throughout the design and execution of synthetic biology projects. “Human Practices” refers to iGEM teams’ efforts to actively consider how the world affects their work and the work affects the world. Through your Human Practices activities, your team should demonstrate how you have thought carefully and creatively about whether your project is responsible and good for the world. We invite you to explore issues relating (but not limited) to the ethics, safety, security, and sustainability of your project, and to show how this exploration feeds back into your project purpose, design and execution.
+
            Last year, our team focused on developing a modified RNA protein replacement technology for treating Huntington’s Disease. We were motivated to delve further into research at the RNA level after collaborating with the Huntington’s Disease Society of America. Through our collaboration, we realized that current research in Huntington’s Disease was not selective in specifically targeting mutated Huntingtin RNA strands. Instead of targeting mutated strands only, research would try to target both endogenous and mutated strands, thereby stopping all production of the Huntingtin protein and resulting in undesired side effects. To resolve this, our team began developing modified RNA technology that would specifically target mutated Huntingtin mRNA strands through a specific toehold recognition and exchange process, allowing the mutated strands to be replaced by a corrected synthetic mRNA strand. This year our team is taking this research further by testing the efficacy of the modified RNA replacement technology in Huntingtin cell lines to determine whether our treatment decreases the levels of mutated Huntingtin protein.</p>
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</p>
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 +
<p><strong>Music Video</strong><br /> New York City iGEM Team produced a fun video parody of Uptown Funk music video. We placed this video on YouTube and has been spreading it on social media channels to popularize the iGEM and the science. Enjoy! :)</p>
  
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    <br />
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<p>For more information, please see the <a href="https://2018.igem.org/Human_Practices">Human Practices Hub</a>. There you will find:</p>
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<div align="center">
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    <video height="320" width="auto" controls>
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<ul>
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        <source src="https://static.igem.org/mediawiki/2018/0/06/T--New_York_City--Video.mp4" type="video/mp4">
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<li> an <a href="https://2018.igem.org/Human_Practices/Introduction">introduction</a> to Human Practices at iGEM </li>
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        </video>
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<li>tips on <a href="https://2018.igem.org/Human_Practices/How_to_Succeed">how to succeed</a> including explanations of judging criteria and advice about how to conduct and document your Human Practices work</li>
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<li>descriptions of <a href="https://2018.igem.org/Human_Practices/Examples">exemplary work</a> to inspire you</li>
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<li>links to helpful <a href="https://2018.igem.org/Human_Practices/Resources">resources</a></li>
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<li>And more! </li>
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</ul>
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<p>On this page, your team should document all of your Human Practices work and activities. You should write about the Human Practices topics you considered in your project, document any activities you conducted to explore these topics (such as engaging with experts and stakeholders), describe why you took a particular approach (including referencing any work you built upon), and explain if and how you integrated takeaways from your Human Practices work back into your project purpose, design and/or execution. </p>
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<p>If your team has gone above and beyond in work related to safety, then you should document this work on your Safety wiki page and provide a description and link on this page. If your team has developed education and public engagement efforts that go beyond a focus on your particular project, and for which would like to nominate your team for the Best Education and Public Engagement Special Prize, you should document this work on your Education and Education wiki page and provide a description and link here. </p>
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</div>
 
</div>
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<br/>
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<div class="clear"></div>
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<div class="column full_size">
 
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<div class="highlight decoration_background">
 
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<p>The iGEM judges will review this page to assess whether you have met the Silver and/or Gold medal requirements based on the Integrated Human Practices criteria listed below. If you nominate your team for the <a href="https://2018.igem.org/Judging/Awards">Best Integrated Human Practices Special Prize</a> by filling out the corresponding field in the <a href="https://2018.igem.org/Judging/Judging_Form">judging form</a>, the judges will also review this page to consider your team for that prize.
 
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</p>
 
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</div>
 
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</div>
 
  
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<div class="clear extra_space"></div>
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<p><strong>October 18, 2018:</strong><br />
 +
            New York City iGEM Team registered to join HDSA Research Webinar with Julia Alterman, a PhD student at the University of Massachusetts, presents her work on RNA interference strategies for huntingtin-lowering in HD. TOPIC: RNAi-based huntingtin lowering in the central nervous system: a new potential Huntington's disease therapeutic. </p>
  
 +
        <div align="center"><img
 +
                    src="https://static.igem.org/mediawiki/2018/8/8f/T--New_York_City--hdsaweb.jpg" />
 +
        </div>
  
 +
<p><strong>October 15, 2018:</strong><br />
 +
            We had a great opportunity to present HD Resolution iGEM project to Stuyvesant High School community of students, student leaders and teachers. Thanks to Hedy, Selena, Julia, Erica, Jennifer for organizing this event. Stuyvesant students also filled out our two questionnaires about their knowledge about Huntington's disease and Ethics.</p>
  
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<div class="column full_size">
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        <div align="center">
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<a href="https://stuy.enschool.org/"><img
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<h3>Silver Medal Criterion #3</h3>
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                    src="https://static.igem.org/mediawiki/2018/f/fc/T--New_York_City--stuy1.jpg" /></a>
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<p>Convince the judges you have thought carefully and creatively about whether your work is responsible and good for the world. Document how you have investigated these issues and engaged with your relevant communities, why you chose this approach, and what you have learned. Please note that surveys will not fulfill this criteria unless you follow scientifically valid methods. </p>
+
<a href="https://stuy.enschool.org/"><img
 +
                    src="https://static.igem.org/mediawiki/2018/c/cc/T--New_York_City--stuy2.jpg" /></a>
 +
<a href="https://stuy.enschool.org/"><img
 +
                    src="https://static.igem.org/mediawiki/2018/9/99/T--New_York_City--stuy3.jpg" /></a>
 +
<a href="https://stuy.enschool.org/"><img
 +
                    src="https://static.igem.org/mediawiki/2018/b/b6/T--New_York_City--stuy4.jpg" /></a>
 +
        </div>
 +
<br>
 +
    <div id="pdf" align="center">
 +
        <object data="https://static.igem.org/mediawiki/2018/2/21/T--New_York_City--stuy.pdf" type="application/pdf" width="900" height="1200"> alt : <a href="https://static.igem.org/mediawiki/2018/2/21/T--New_York_City--stuy.pdf">Stuyvesant</a></object>
 +
    </div>
  
 +
<br/>
 +
        <p><strong>September 15 2018:</strong><br />
 +
            New York City iGEM Team started fundraising for Huntington's Disease Society of America Team Hope Walk in
 +
            New York City and joined New York City HDSA Team Hope on Hudson River Park - River 46 on Saturday September
 +
            15.</p>
  
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<h3>Gold Medal Criterion #1</h3>
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        <div align="center"><a href="https://hdsa.donordrive.com/index.cfm?fuseaction=donorDrive.participant&participantID=48528"><img
−
<p>Expand on your silver medal activity by demonstrating how you have integrated the investigated issues into the purpose, design and/or execution of your project. Document how your project has changed based upon your human practices work.
+
                    src="https://static.igem.org/mediawiki/2018/a/a4/T--New_York_City--hdsa.png" /></a>
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</p>
+
        </div>
 +
<div align="center">
 +
<a href="https://hdsa.donordrive.com/index.cfm?fuseaction=donorDrive.participant&participantID=48528"><img
 +
                    src="https://static.igem.org/mediawiki/2018/b/b8/T--New_York_City--walk2.png" /></a>
 +
</div>
 +
<div align="center">
 +
<a href="https://hdsa.donordrive.com/index.cfm?fuseaction=donorDrive.participant&participantID=48528"><img
 +
                    src="https://static.igem.org/mediawiki/2018/3/3d/T--New_York_City--walk3.png" /></a>
 +
</div>
 +
<div align="center">
 +
<a href="https://hdsa.donordrive.com/index.cfm?fuseaction=donorDrive.participant&participantID=48528"><img
 +
                    src="https://static.igem.org/mediawiki/2018/c/cb/T--New_York_City--walk1.png" /></a>      
 
</div>
 
</div>
  
 +
        <p><strong>September 11, 2018:</strong><br />
 +
            New York City iGEM Team registered for HSG 2018: Unlocking HD Nov. 8-10, 2018, Hotel ZaZa, Museum District,
 +
            Houston, Texas
 +
            25th Anniversary Celebration
  
 +
            Over the past 20 years, the Huntington Study Group (HSG) has hosted an annual, internationally recognized
 +
            forum for training and education of Huntington disease (HD) researchers and for presentation of new
 +
            research findings and treatments to the worldwide community, plus much more…</p>
  
−
<div class="clear extra_space"></div>
+
        <div align="center"><a href="https://huntingtonstudygroup.org/about/our-annual-meeting/"><img src="https://static.igem.org/mediawiki/2018/a/a8/T--New_York_City--hgsa.png" /></a>
 +
        </div>
  
 +
        <p><strong>September 9 2018:</strong><br />
 +
            New York City iGEM Team is excited to volunteer and support Huntington's Disease Society of America NY Team
 +
            Hope Walk in Long Island NY tomorrow Sunday Sep 9.</p>
 +
        <div align="center"><a href="https://hdsa.donordrive.com/index.cfm?fuseaction=donordrive.participant&participantID=48526"><img
 +
                    src="https://static.igem.org/mediawiki/2018/e/e4/T--New_York_City--walk.png" /></a>
 +
        </div>
  
 +
        <p><strong>September 8 2018:</strong><br />
 +
            New York City iGEM Team joined as a member to Huntington Study Group, a world leader in facilitating
 +
            high-quality clinical research trials and studies in Huntington disease (HD). We have the first and largest
 +
            HD clinical research network of over 400 active and compassionate investigators, coordinators, scientists
 +
            and HD experts at over 120 HSG Credentialed Research Sites across the globe dedicated to seeking treatments
 +
            that make a difference and improving the quality of life and outcomes for families affected by HD.</p>
  
−
<div class="column full_size">
+
        <div align="center"><a href="https://huntingtonstudygroup.org/"><img src="https://static.igem.org/mediawiki/2018/7/77/T--New_York_City--hsg.png" /></a>
−
<h3>Best Integrated Human Practices Special Prize</h3>
+
        </div>
  
−
<p>To compete for the Best Integrated Human Practices prize, please describe your work on this page and also fill out the description on the judging form. </p>
+
        <p><strong>August 20, 2018</strong><br />
 +
            New York City iGEM Team joined Steptember campaign of Cerebral Palsy Alliance Research Foundation a non
 +
            profit organization to fund the world's best research to treat, prevent and ultimately find a cure for
 +
            cerebral palsy (a generic brain disorder)</p>
  
−
<p>How does your project affect society and how does society influence the direction of your project? How might ethical considerations and stakeholder input guide your project purpose and design and the experiments you conduct in the lab? How does this feedback enter into the process of your work all through the iGEM competition? Document a thoughtful and creative approach to exploring these questions and how your project evolved in the process to compete for this award!</p>
+
        <div align="center"> <a href="https://www.steptember.us/"><img src="https://static.igem.org/mediawiki/2018/3/3e/T--New_York_City--stepb.png" /></a>
−
<p>You must also delete the message box on the top of this page to be eligible for this prize.</p>
+
        </div>
 +
    </div>
 +
    <br />
 +
    <div class="container" align="center">
 +
        <div class="row" align="center">
 +
            <div class="col-sm-3">
 +
            </div>
 +
            <div class="col-sm-2">
 +
                <a href="https://www.facebook.com/HDResolution/"><img class="social" src="https://static.igem.org/mediawiki/2018/6/61/T--New_York_City--fb.png"></a>
 +
            </div>
 +
            <div class="col-sm-2">
 +
                <a href="https://twitter.com/HDNYC_iGEM"><img class="social" src="https://static.igem.org/mediawiki/2018/4/46/T--New_York_City--twit.png"></a>
 +
            </div>
 +
            <div class="col-sm-2">
 +
                <a href="https://www.instagram.com/nyc_igem/"><img class="social" src="https://static.igem.org/mediawiki/2018/0/0a/T--New_York_City--ig.png"></a>
 +
            </div>
 +
            <div class="col-sm-3">
 +
            </div>
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        </div>
 +
        <br />
 +
    </div>
 +
</body>
  
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Latest revision as of 17:23, 17 October 2018

Human Practices

Introduction to Public Engagement:
Last year, our team focused on developing a modified RNA protein replacement technology for treating Huntington’s Disease. We were motivated to delve further into research at the RNA level after collaborating with the Huntington’s Disease Society of America. Through our collaboration, we realized that current research in Huntington’s Disease was not selective in specifically targeting mutated Huntingtin RNA strands. Instead of targeting mutated strands only, research would try to target both endogenous and mutated strands, thereby stopping all production of the Huntingtin protein and resulting in undesired side effects. To resolve this, our team began developing modified RNA technology that would specifically target mutated Huntingtin mRNA strands through a specific toehold recognition and exchange process, allowing the mutated strands to be replaced by a corrected synthetic mRNA strand. This year our team is taking this research further by testing the efficacy of the modified RNA replacement technology in Huntingtin cell lines to determine whether our treatment decreases the levels of mutated Huntingtin protein.

Music Video
New York City iGEM Team produced a fun video parody of Uptown Funk music video. We placed this video on YouTube and has been spreading it on social media channels to popularize the iGEM and the science. Enjoy! :)



October 18, 2018:
New York City iGEM Team registered to join HDSA Research Webinar with Julia Alterman, a PhD student at the University of Massachusetts, presents her work on RNA interference strategies for huntingtin-lowering in HD. TOPIC: RNAi-based huntingtin lowering in the central nervous system: a new potential Huntington's disease therapeutic.

October 15, 2018:
We had a great opportunity to present HD Resolution iGEM project to Stuyvesant High School community of students, student leaders and teachers. Thanks to Hedy, Selena, Julia, Erica, Jennifer for organizing this event. Stuyvesant students also filled out our two questionnaires about their knowledge about Huntington's disease and Ethics.


alt : Stuyvesant

September 15 2018:
New York City iGEM Team started fundraising for Huntington's Disease Society of America Team Hope Walk in New York City and joined New York City HDSA Team Hope on Hudson River Park - River 46 on Saturday September 15.

September 11, 2018:
New York City iGEM Team registered for HSG 2018: Unlocking HD Nov. 8-10, 2018, Hotel ZaZa, Museum District, Houston, Texas 25th Anniversary Celebration Over the past 20 years, the Huntington Study Group (HSG) has hosted an annual, internationally recognized forum for training and education of Huntington disease (HD) researchers and for presentation of new research findings and treatments to the worldwide community, plus much more…

September 9 2018:
New York City iGEM Team is excited to volunteer and support Huntington's Disease Society of America NY Team Hope Walk in Long Island NY tomorrow Sunday Sep 9.

September 8 2018:
New York City iGEM Team joined as a member to Huntington Study Group, a world leader in facilitating high-quality clinical research trials and studies in Huntington disease (HD). We have the first and largest HD clinical research network of over 400 active and compassionate investigators, coordinators, scientists and HD experts at over 120 HSG Credentialed Research Sites across the globe dedicated to seeking treatments that make a difference and improving the quality of life and outcomes for families affected by HD.

August 20, 2018
New York City iGEM Team joined Steptember campaign of Cerebral Palsy Alliance Research Foundation a non profit organization to fund the world's best research to treat, prevent and ultimately find a cure for cerebral palsy (a generic brain disorder)