Difference between revisions of "Team:Austin LASA/Description"

Revision as of 20:12, 17 October 2018

const r = i => h('a', {href: '#ref_' + i}, i);
h(g.Page, {title: 'Description', prev: 'https://2018.igem.org/Team:Austin_LASA/Collaborations', next: 'https://2018.igem.org/Team:Austin_LASA/Design', selector: [2, 0]},
  h(g.Section, {title: 'Why HIV Detection in Infants?'},
    h('p', null, 'HIV diagnosis of infants in the developing world continues to pose many problems. It is estimated that there are approximately 1500 new cases of HIV infection in children under the age of 15, 90% of which occur in the developing world and contracted HIV at birth [', r(1), ']. Infants often show symptoms of HIV very early on, and in some cases, HIV can rapidly evolve into AIDS [', r(2), ']. As such, it is imperative that infants with HIV are diagnosed as early as possible.'),
    h('p', null, 'The WHO has stated that earlier diagnosis of HIV in infants and children:'),
    h('ul', null,
      h('li', null, 'enables the early identification of who have HIV-infection, as a first step in securing their treatment and care'),
      h('li', null, 'enables the identification of those who are HIV-exposed but uninfected, facilitating follow-up care and prevention measures that will help to ensure that they remain uninfected'),
      h('li', null, 'assists in the effective use of essential resources by targeting ART on children who need treatment'),
      h('li', null, 'improves the psychosocial well-being of families and children, reducing potential stigma, discrimination and psychological distress for HIV-uninfected children and increasing the chances of adoption for orphans'),
      h('li', null, 'facilitates life-planning for parents and/or children who have HIV [', r(3), ']')
    )
  ),
  h(g.Section, {title: 'References'},
    h('p', null, '[', h('a', {id: 'ref_1'}, '1'), '] W. (2011, February 03). Antiretroviral therapy of HIV infection in infants and children. Retrieved October 16, 2018, from ', h('a', {href: 'http://www.who.int/hiv/pub/paediatric/infants/en/'}, 'http://www.who.int/hiv/pub/paediatric/infants/en/')),
    h('p', null, '[', h('a', {id: 'ref_2'}, '2'), '] Krist, A. H., & Crawford-Faucher, A. (2002, May 15). Management of Newborns Exposed to Maternal HIV Infection. Retrieved October 16, 2018, from ', h('a', {href: 'https://www.aafp.org/afp/2002/0515/p2049.html'}, 'https://www.aafp.org/afp/2002/0515/p2049.html')),
    h('p', null, '[', h('a', {id: 'ref_3'}, '3'), '] Damet, G., & Vercauteren, G. (n.d.). Early detection of HIV infection in infants and children [PDF]. Geneva: WHO.'),
    h('p', null, '[', h('a', {id: 'ref_4'}, '4'), '] Diagnosis of HIV Infection in Infants and Children Pediatric ARV. (2017, November 15). Retrieved October 16, 2018, from ', h('a', {href: 'https://aidsinfo.nih.gov/guidelines/html/2/pediatric-arv/55/diagnosis-of-hiv-infection-in-infants-and-children'}, 'https://aidsinfo.nih.gov/guidelines/html/2/pediatric-arv/55/diagnosis-of-hiv-infection-in-infants-and-children')),
    h('p', null, '[', h('a', {id: 'ref_5'}, '5'), '] Shafiee, H., Wang, S., Inci, F., Toy, M., Henrich, T. J., Kuritzkes, D. R., & Demirci, U. (2015). Emerging technologies for point-of-care management of HIV infection. Annual review of medicine, 66, 387-405.'),
    h('p', null, '[', h('a', {id: 'ref_6'}, '6'), '] Gootenberg, J. S., Abudayyeh, O. O., Kellner, M. J., Joung, J., Collins, J. J., & Zhang, F. (2018). Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6. Science, 360(6387), 439-444.'),
    h('p', null, '[', h('a', {id: 'ref_7'}, '7'), '] Chen, J. S., Ma, E., Harrington, L. B., Da Costa, M., Tian, X., Palefsky, J. M., & Doudna, J. A. (2018). CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity. Science, 360(6387), 436-439.')
  )
);

@@ Line 6: / Line 6: @@
    h(g.Section, {title: 'Why HIV Detection in Infants?'},
      h('p', null, 'HIV diagnosis of infants in the developing world continues to pose many problems. It is estimated that there are approximately 1500 new cases of HIV infection in children under the age of 15, 90% of which occur in the developing world and contracted HIV at birth [', r(1), ']. Infants often show symptoms of HIV very early on, and in some cases, HIV can rapidly evolve into AIDS [', r(2), ']. As such, it is imperative that infants with HIV are diagnosed as early as possible.'),
-     h('p', null, 'The WHO has stated that earlier diagnosis of HIV in infants and children:')
+     h('p', null, 'The WHO has stated that earlier diagnosis of HIV in infants and children:'),
      h('ul', null,
        h('li', null, 'enables the early identification of who have HIV-infection, as a first step in securing their treatment and care'),
@@ Line 12: / Line 12: @@
        h('li', null, 'assists in the effective use of essential resources by targeting ART on children who need treatment'),
        h('li', null, 'improves the psychosocial well-being of families and children, reducing potential stigma, discrimination and psychological distress for HIV-uninfected children and increasing the chances of adoption for orphans'),
+      h('li', null, 'facilitates life-planning for parents and/or children who have HIV [', r(3), ']')
      )
    ),