Difference between revisions of "Team:ZJUT-China/Achievement2018"

 
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</head>
 
</head>
 
<!-- 导航栏 -->
 
<!-- 导航栏 -->
<div class="topbar">
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  <div class="dropbkgd">
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      <div class="dropposition">
      <div class="dropdown1">
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        <div class="dropdown1">
        <div class="drop">
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          <div class="drop">
          <a href="https://2018.igem.org/Team:ZJUT-China">Home</a>
+
            <a href="https://2018.igem.org/Team:ZJUT-China">Home</a>
 +
          </div>
 
         </div>
 
         </div>
      </div>
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        <div class="dropdown2">
      <div class="dropdown2">
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              Team
            Team
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            <div class="dropdown-content">
          <div class="dropdown-content">
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              <a href="https://2018.igem.org/Team:ZJUT-China/Team">Team Members</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Team">Team Members</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Attributions">Attributions</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Attributions">Attributions</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Collaborations">Collaborations</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Collaborations">Collaborations</a>
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            </div>
 
           </div>
 
           </div>
 
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              Project
            Project
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            <div class="dropdown-content">
          <div class="dropdown-content">
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              <a href="https://2018.igem.org/Team:ZJUT-China/Description" >Description</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Description" >Description</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Design">Design</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Design">Design</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Results">Results</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Results">Results</a>
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              <a href="https://2018.igem.org/Team:ZJUT-China/Demonstrate">Demonstrate</a>
 +
            </div>
 
           </div>
 
           </div>
 
         </div>
 
         </div>
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        <div class="dropdown4">
      <div class="dropdown4">
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          <div class="drop">
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              Parts
            Parts
+
            <div class="dropdown-content">
          <div class="dropdown-content">
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              <a href="https://2018.igem.org/Team:ZJUT-China/Parts">All parts</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Parts">Overview</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Improve">Improve</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Basic_Part">Basic parts</a>
+
             </div>
            <a href="https://2018.igem.org/Team:ZJUT-China/Composite_Part">Composite parts</a>
+
             <a href="https://2018.igem.org/Team:ZJUT-China/Part_Collection" >Part collection</a>
+
 
           </div>
 
           </div>
 
         </div>
 
         </div>
      </div>
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        <div class="dropdown5">
      <div class="dropdown5">
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          <div class="drop">
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            Lab
          Lab
+
            <div class="dropdown-content">
          <div class="dropdown-content">
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Notebook">Notebook</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Notebook">Notebook</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Protocols2018">Protocols</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Protocols2018">Protocols</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Safety">Safety</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Safety">Safety</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/InterLab" >Interlab</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/InterLab" >Interlab</a>
+
            </div>
 
           </div>
 
           </div>
 
         </div>
 
         </div>
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        <div class="dropdown6">
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              Human Practices
            Human Practices
+
            <div class="dropdown-content">
          <div class="dropdown-content">
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              <a href="https://2018.igem.org/Team:ZJUT-China/Human_Practices">Integrated hp</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/Human_Practices">Integrated hp</a>
+
              <a href="https://2018.igem.org/Team:ZJUT-China/Public_Engagement">Public Engagement & Education</a>
            <a href="https://2018.igem.org/Team:ZJUT-China/PublicEngagement2018">Public Engagement</a>
+
             </div>
            <a href="https://2018.igem.org/Team:ZJUT-China/Public_Engagement8">Education</a>
+
             <a href="https://2018.igem.org/Team:ZJUT-China/Collaboration2018">Collaboration</a>
+
 
           </div>
 
           </div>
 
         </div>
 
         </div>
      </div>
+
        <div class="dropdown7">
      <div class="dropdown7">
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          <div class="drop">
        <div class="drop">
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            <a href="https://2018.igem.org/Team:ZJUT-China/Model"> Modeling</a>
          <a href="https://2018.igem.org/Team:ZJUT-China/Model"> Modeling</a>
+
          </div>
 
         </div>
 
         </div>
      </div>
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        <div class="dropdown8">
      <div class="dropdown8">
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          <div class="drop">
        <div class="drop">
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            <a href="https://2018.igem.org/Team:ZJUT-China/Achievement2018"> Judging</a>
          <a href="https://2018.igem.org/Team:ZJUT-China/Achievement2018"> Achievement</a>
+
          </div>
 
         </div>
 
         </div>
 
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   </div>
 
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<!-- 首页大图 -->
 
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<div class="homepage_img">
 
<div class="homepage_img">
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<!-- 主体 -->
 
<!-- 主体 -->
 
<div class="container">
 
<div class="container">
<!-- 8张图片导航 -->
+
   <div class="col-10">
   <div>
+
     <div class="judg">
     <div class="homeindex">
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       <h1>Bronze Medal</h1>
       <a href="https://2018.igem.org/Team:ZJUT-China">
+
      <p>★ Attend the Giant Jamboree★</p>
        <img src="https://static.igem.org/mediawiki/2018/f/f2/T--ZJUT-China--%E6%9A%82%E6%97%B6.png" alt="" width=256px height=390px>
+
      <p>We can't wait to participate in jamboree!</p>
       </a>
+
      <p>★ wiki ★</p>
    </div>
+
      <p>As you can see, we have built our own wiki.</p>
    <div class="homeindex">
+
      <p>★ poster ★</p>
       <a href="https://2018.igem.org/Team:ZJUT-China/Team2018">
+
      <p>Yes, we made a poster.</p>
        <img src="https://static.igem.org/mediawiki/2018/f/f2/T--ZJUT-China--%E6%9A%82%E6%97%B6.png" alt="" width=256px height=390px>
+
      <p>★ presentation ★</p>
      </a>
+
      <p>Yes, we have prepared our presentation.</p>
    </div>
+
       <p>★ judging form ★</p>
    <div class="homeindex">
+
      <p>Judging form has been submitted on time</p>
       <a href="https://2018.igem.org/Team:ZJUT-China/Description2018">
+
      <p>★ Attribution ★</p>
        <img src="https://static.igem.org/mediawiki/2018/f/f2/T--ZJUT-China--%E6%9A%82%E6%97%B6.png" alt="" width=256px height=390px>
+
       <p><a href="https://2018.igem.org/Team:ZJUT-China/Attributions">Click here to gain more details</a></p>
      </a>
+
      <p>★ InterLab Study ★</p>
    </div>
+
      <p>Our InterLab date has been accepted,<br><a href="https://2018.igem.org/Team:ZJUT-China/InterLab"> Click here to gain more details</a></p>
    <div class="homeindex">
+
      <h1>Silver Medal</h1>
       <a href="https://2018.igem.org/Team:ZJUT-China/overview201">
+
      <p>★ Validated Part ★</p>
        <img src="https://static.igem.org/mediawiki/2018/f/f2/T--ZJUT-China--%E6%9A%82%E6%97%B6.png" alt="" width=256px height=390px>
+
       <p>We have designed more than one part and documented the experimental characterization on that Part's Main Page. <br><a href="https://2018.igem.org/Team:ZJUT-China/Parts">Click here to gain more details</a>
       </a>
+
      </p>
    </div>
+
      <p>★ Collaboration ★ </p>
    <div class="homeindex">
+
      <p>We have collaboration with several teams on wetlab, drylab and human practices. <br><a href="https://2018.igem.org/Team:ZJUT-China/Collaborations">Click here to gain more details</a>
       <a href="https://2018.igem.org/Team:ZJUT-China/notebook2018">
+
      </p>
        <img src="https://static.igem.org/mediawiki/2018/f/f2/T--ZJUT-China--%E6%9A%82%E6%97%B6.png" alt="" width=256px height=390px>
+
      <p>★ Human Practices ★</p>
       </a>
+
       <p>We have done a lot of work on Human Practices and have greatly advanced the progress of our project. <br> <a href="https://2018.igem.org/Team:ZJUT-China/Human_Practices">Click here to gain more details</a>
    </div>
+
       </p>
    <div class="homeindex">
+
      <h1>Gold Medal</h1>
       <a href="https://2018.igem.org/Team:ZJUT-China/HumanPractices2018">
+
      <p>★ Integrated Human Practices ★</p>
        <img src="https://static.igem.org/mediawiki/2018/f/f2/T--ZJUT-China--%E6%9A%82%E6%97%B6.png" alt="" width=256px height=390px>
+
       <p>Our project has changed based upon our human practices work. <br><a href="https://2018.igem.org/Team:ZJUT-China/Human_Practices"> Click here to gain more details</a>
      </a>
+
       </p>
    </div>
+
      <p>★ Improve a Previous Part ★</p>
    <div class="homeindex">
+
       <p>Our new part <a href="http://parts.igem.org/Part:BBa_K2277000"> BBa_K2556051</a>has a functional improvement upon <a href="http://parts.igem.org/Part:BBa_K2556051">BBa_K2277000</a>. <br> <a href="https://2018.igem.org/Team:ZJUT-China/Improve">Click here to gain more details</a>
      <a href="https://2018.igem.org/Team:ZJUT-China/Modelling2018">
+
       </p>
        <img src="https://static.igem.org/mediawiki/2018/f/f2/T--ZJUT-China--%E6%9A%82%E6%97%B6.png" alt="" width=256px height=390px>
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      <p>★ Model ★</p>
       </a>
+
       <p>We have used some data of our BioBricks to build model of our system. <br><a href="https://2018.igem.org/Team:ZJUT-China/Model">Click here to gain more details</a>
    </div>
+
       </p>
    <div class="homeindex">
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       <a href="https://2018.igem.org/Team:ZJUT-China/Achievement2018">
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        <img src="https://static.igem.org/mediawiki/2018/f/f2/T--ZJUT-China--%E6%9A%82%E6%97%B6.png" alt="" width=256px height=390px>
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   <!-- 正文 -->
 
   <!-- 正文 -->
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    <h1> Project Descriptions </h1>
 
    <h2>Background</h2>
 
    <p>Antibiotics have played an important role in safeguarding human health and promoting the development of animal husbandry for a long time. However, in recent years, the overuse of antibiotics has aroused widespread concern, mainly focusing on the emerging problems of antibiotic-resistant bacteria and resistance genes. Antibiotic and antibiotic resistance genes are new pollutants, and antibiotic contamination does not accumulate in the body, 70% - 80% of antibiotics will be discharged into the environment with urine, the impact on microorganisms in the environment. Antibiotics enable microorganisms in the environment to screen resistance genes, enhance resistance, and possibly form superbacteria. Resistance genes are also likely to spread and spread in the environment, threatening public health, food and drinking water safety, thereby causing direct health hazards to our human beings.
 
    <br><br>Antibiotic resistance: Global Surveillance Report released by the World Health Organization in 2014 shows that 63,000 people die each year from super-resistant bacteria in the United States and 25,000 in the European Union. The number of deaths caused by superbugs in the United States far exceeds that of HIV infected deaths. If the global spread of superbacteria is not effectively curbed, the resulting death toll could increase by 10 million annually. To cope with the spread of superbug, the world needs to spend 100 trillion dollars by 2050[1]. Therefore, it is necessary and urgent to carry out the related research on antibiotic resistance genes and reveal the diffusion and transmission of antibiotic resistance genes in the environment for assessing the ecological risk of antibiotic resistance genes.
 
    <br><br>Existing treatment technologies can only deal with some of the genetic contaminants that have been diffused into the environment, but can not eliminate the source of pollution from the source. Therefore, we expect to construct a controllable genetic engineering bacteria with self-eliminating ability of resistant genes by using CRISSPR/Cas9 technology with high efficiency of gene editing and optical control system, that is, to solve the problem of bacterial resistance from the source, and to provide a possible and effective way to solve the problem of resistant gene pollution and protect the ecological environment.
 
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        【1】World Health Organization. Antibiotic resistance: global report on surveillance 2014[R]. Geneva: World Health Organization, 2014.
 
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    <h2>CRISPR/Cas</h2>
 
    <p>
 
      CRISPR/Cas is the abbreviation of Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9. CRISPR/Cas system is the immune system of prokaryotic organism, when guided by gRNA, Cas protein can cut the target DNA and cause a double-strain break. Now this system has become an efficient, fast and accurate genome editing tool.
 
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    <div class="note">Picture origin: Wikipedia  Author: marius walter, 25 Sept. 2017)</div>
 
    <p>Basically, the CRISPR/Cas9 genome editing system needs two plasmids, one expresses Cas9 protein, the other provides sgRNA which is rea human-designed gRNA. Antibiotics resistance has become a global health issue. Till today, almost all of microbiology labs and fermentation factory use antibiotics resistance gene as selective marker.  Our project creates a plasmid that include both Cas9 gene and sgRNA sequence. When induced by light of a certain wave length, it cuts the antibiotics resistance genes in the bacteria preventing them from leaking into the environment.</p>
 
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Latest revision as of 20:48, 17 October 2018

Team:ZJUT-China - 2018.igem.org

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Team:ZJUT-China

Bronze Medal

★ Attend the Giant Jamboree★

We can't wait to participate in jamboree!

★ wiki ★

As you can see, we have built our own wiki.

★ poster ★

Yes, we made a poster.

★ presentation ★

Yes, we have prepared our presentation.

★ judging form ★

Judging form has been submitted on time

★ Attribution ★

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★ InterLab Study ★

Our InterLab date has been accepted,
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Silver Medal

★ Validated Part ★

We have designed more than one part and documented the experimental characterization on that Part's Main Page.
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★ Collaboration ★

We have collaboration with several teams on wetlab, drylab and human practices.
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★ Human Practices ★

We have done a lot of work on Human Practices and have greatly advanced the progress of our project.
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Gold Medal

★ Integrated Human Practices ★

Our project has changed based upon our human practices work.
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★ Improve a Previous Part ★

Our new part BBa_K2556051has a functional improvement upon BBa_K2277000.
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★ Model ★

We have used some data of our BioBricks to build model of our system.
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