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<div class="content"> | <div class="content"> | ||
The complexity of genetic circuits has made it difficult for synthetic biologists to design the artificial | The complexity of genetic circuits has made it difficult for synthetic biologists to design the artificial | ||
− | biological systems. In our project, we developed <span class=" | + | biological systems. In our project, we developed <span class="bold">CO-RAD</span>, a <span class="bold">Collaborative |
− | Optimization</span> platform with multiple functions including <span class=" | + | Optimization</span> platform with multiple functions including <span class="bold">Recommendation, |
Analysis and Design</span>. With the help of CO-RAD, users can design genetic circuits easily and cooperate | Analysis and Design</span>. With the help of CO-RAD, users can design genetic circuits easily and cooperate | ||
− | with remote partners <span class=" | + | with remote partners <span class="bold">in real time</span>. |
− | More importantly, the <span class=" | + | More importantly, the <span class="bold">search & recommendation system in CO-RAD</span> were developed to |
− | inspire users with some previous projects and optimize their design <span class=" | + | inspire users with some previous projects and optimize their design <span class="bold">with evolutionary |
− | algorithm</span>. Moreover, <span class=" | + | algorithm</span>. Moreover, <span class="bold"> <a href="javascript:void(0)" goto="Simulation-Circuits"> a |
+ | novel numerical simulation algorithm </a> </span> | ||
for circuit)applied in CO-RAD was developed to predict the expression level of genetic circuits in no time. | for circuit)applied in CO-RAD was developed to predict the expression level of genetic circuits in no time. | ||
− | Through | + | Through in addition, we incorporated self-designed <span class="bold"> <a href="javascript:void(0)" goto="Validation"> |
+ | wet-lab validation </a> </span>into | ||
our project to validate the new results designed by our CO-RAD platform. In conclusion, by assisting in | our project to validate the new results designed by our CO-RAD platform. In conclusion, by assisting in | ||
collaboration and inspiration, CO-RAD makes complex biological systems accessible to researchers who want | collaboration and inspiration, CO-RAD makes complex biological systems accessible to researchers who want | ||
rapid, intuitive, and high-quality | rapid, intuitive, and high-quality | ||
− | accomplish their designs. | + | accomplish their designs. Click here to design in <a href="http://www.sysu-corad.com/">CO-RAD</a> way. |
− | + | ||
</div> | </div> | ||
− | <div class="header2"> | + | <img src="https://static.igem.org/mediawiki/2018/0/06/T--SYSU-Software--coEdit.png" /> |
+ | |||
+ | <div class="header2"> Background </div> | ||
<div class="content"> | <div class="content"> | ||
− | + | The data shows a shift from single-investigator 'little science' to increasingly large, expensive, | |
− | + | multinational, interdisciplinary and interdependent 'big science'. The scientific collaboration among | |
− | experience, it is very difficult for individuals to design a viable circuit alone | + | researchers becomes more pervasive and essential. |
− | + | </div> | |
− | + | <div class="content"> | |
− | + | To synthetic biology, due to the natural complexity of biological systems, genetic circuit design and the | |
− | + | limited personal experience, it is very difficult for individuals to design a viable circuit alone, raising the | |
− | + | demand of effective collaboration methods. Interdisciplinary and engineering-oriented natures on scientific | |
− | + | research make it praticularly open to collaboration, while time and space issues would compromise the | |
− | + | convenience and the efficency to conduct a collaboration. | |
− | + | </div> | |
+ | <div class="content"> | ||
+ | In this case, we developed a software to improve the efficiency in collaboration and help inspire | ||
+ | synbiologists' ideas, assist their work and optimize their design. | ||
</div> | </div> | ||
− | <img src=" | + | <div class="background-data"> |
+ | <img src="https://static.igem.org/mediawiki/2018/8/85/T--SYSU-Software--backgrounddata1.png" /> | ||
+ | <div class="caption">Figure 1: Percentage of multientity publications, 2000–2009 </div> | ||
+ | <img src="https://static.igem.org/mediawiki/2018/9/9f/T--SYSU-Software--backgrounddata2.png" /> | ||
+ | <div class="caption">Figure 2: The percentage of multiinstitutional publications in 22 ESI fields</div> | ||
+ | </div> | ||
<div class="content"> | <div class="content"> | ||
Therefore, we're here to solve the following problems: | Therefore, we're here to solve the following problems: | ||
− | < | + | <ol> |
− | + | <li> | |
− | + | How to make tele-cooperation as convenient as face-to-face collaboration? | |
− | + | </li> | |
+ | <li> | ||
+ | How to encourage users to come up with and share more creative ideas while designing genetic circuits? | ||
+ | </li> | ||
+ | </ol> | ||
</div> | </div> | ||
<div class="header2"> Solution </div> | <div class="header2"> Solution </div> | ||
− | <div class="header3"> | + | <div class="header3">Source of creative ideas</div> |
<div class="ui three cards"> | <div class="ui three cards"> | ||
<div class="card wide-card"> | <div class="card wide-card"> | ||
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</div> | </div> | ||
<div class="content"> | <div class="content"> | ||
− | <div class="ui header">Search & | + | <div class="ui header">Search & Recommendation</div> |
</div> | </div> | ||
− | <div class="ui bottom attached button detail-btn" data-id="4">View Detail</div> | + | <div class="ui bottom attached button detail-btn button-override" data-id="4">View Detail</div> |
</div> | </div> | ||
<div class="card wide-card"> | <div class="card wide-card"> | ||
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</div> | </div> | ||
<div class="content"> | <div class="content"> | ||
− | <div class="ui header">Analysis & | + | <div class="ui header">Analysis & Simulation</div> |
</div> | </div> | ||
− | <div class="ui bottom attached button detail-btn" data-id="5">View Detail</div> | + | <div class="ui bottom attached button detail-btn button-override" data-id="5">View Detail</div> |
</div> | </div> | ||
<div class="card wide-card"> | <div class="card wide-card"> | ||
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</div> | </div> | ||
<div class="content"> | <div class="content"> | ||
− | <div class="ui header">Guide the | + | <div class="ui header">Guide the Design</div> |
</div> | </div> | ||
− | <div class="ui bottom attached button detail-btn" data-id="6">View Detail</div> | + | <div class="ui bottom attached button detail-btn button-override" data-id="6">View Detail</div> |
</div> | </div> | ||
</div> | </div> | ||
<div class="ui modal" id="modal-4"> | <div class="ui modal" id="modal-4"> | ||
− | <div class="header">Search & | + | <div class="header">Search & Recommendaion</div> |
<div class="image content"> | <div class="image content"> | ||
<div class="ui medium image"> | <div class="ui medium image"> | ||
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</div> | </div> | ||
<div class="description"> | <div class="description"> | ||
− | + | Search engine in CO-RAD is powerful for users to quickly gain their desired projects and papers, from which new and creative ideas originate. | |
− | + | ||
</div> | </div> | ||
</div> | </div> | ||
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</div> | </div> | ||
<div class="ui modal" id="modal-5"> | <div class="ui modal" id="modal-5"> | ||
− | <div class="header">Analysis & | + | <div class="header">Analysis & Simulation</div> |
<div class="image content"> | <div class="image content"> | ||
<div class="ui medium image"> | <div class="ui medium image"> | ||
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</div> | </div> | ||
<div class="description"> | <div class="description"> | ||
− | + | CO-RAD can not only analyses circuits and compute the values of CG and CAI, but builds mathematical models to simulate the circuits and predict the expression levels. | |
− | + | ||
− | + | ||
</div> | </div> | ||
</div> | </div> | ||
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</div> | </div> | ||
<div class="ui modal" id="modal-6"> | <div class="ui modal" id="modal-6"> | ||
− | <div class="header">Guide the | + | <div class="header">Guide the Design</div> |
<div class="image content"> | <div class="image content"> | ||
<div class="ui medium image"> | <div class="ui medium image"> | ||
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</div> | </div> | ||
<div class="description"> | <div class="description"> | ||
− | Through an algorithm that simulates evolution, users can get optimal kinetic parameters for circuits, | + | Through an algorithm that simulates evolution, users can get optimal kinetic parameters for circuits, which can assist users in modifying their circuits to reach the expected behavior. |
− | + | ||
</div> | </div> | ||
</div> | </div> | ||
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</div> | </div> | ||
</div> | </div> | ||
− | |||
− | |||
<br /> | <br /> | ||
+ | <div class="header3">Enhancement on Collaboration</div> | ||
<div class="ui three cards"> | <div class="ui three cards"> | ||
<div class="card wide-card"> | <div class="card wide-card"> | ||
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</div> | </div> | ||
<div class="content"> | <div class="content"> | ||
− | <div class="ui header"> | + | <div class="ui header">Collaborative Platform</div> |
</div> | </div> | ||
− | <div class="ui bottom attached button detail-btn" data-id="1">View Detail</div> | + | <div class="ui bottom attached button detail-btn button-override" data-id="1">View Detail</div> |
</div> | </div> | ||
<div class="card wide-card"> | <div class="card wide-card"> | ||
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</div> | </div> | ||
<div class="content"> | <div class="content"> | ||
− | <div class="ui header"> | + | <div class="ui header">Synchronization Sketchpad</div> |
</div> | </div> | ||
− | <div class="ui bottom attached button detail-btn" data-id="2">View Detail</div> | + | <div class="ui bottom attached button detail-btn button-override" data-id="2">View Detail</div> |
</div> | </div> | ||
<div class="card wide-card"> | <div class="card wide-card"> | ||
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</div> | </div> | ||
<div class="content"> | <div class="content"> | ||
− | <div class="ui header">SBOL | + | <div class="ui header">SBOL Support</div> |
</div> | </div> | ||
− | <div class="ui bottom attached button detail-btn" data-id="3">View Detail</div> | + | <div class="ui bottom attached button detail-btn button-override" data-id="3">View Detail</div> |
</div> | </div> | ||
</div> | </div> | ||
<div class="ui modal" id="modal-1"> | <div class="ui modal" id="modal-1"> | ||
− | <div class="header"> | + | <div class="header">Collaborative Platform</div> |
<div class="image content"> | <div class="image content"> | ||
<div class="ui medium image"> | <div class="ui medium image"> | ||
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</div> | </div> | ||
<div class="description"> | <div class="description"> | ||
− | A | + | A collaborative platform with visual circuit designer and management studio, where multiple users can work together, just like (and even better than!) working face to face. |
− | + | ||
</div> | </div> | ||
</div> | </div> | ||
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</div> | </div> | ||
<div class="ui modal" id="modal-2"> | <div class="ui modal" id="modal-2"> | ||
− | <div class="header"> | + | <div class="header">Synchronization Sketchpad</div> |
<div class="image content"> | <div class="image content"> | ||
<div class="ui medium image"> | <div class="ui medium image"> | ||
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</div> | </div> | ||
<div class="description"> | <div class="description"> | ||
− | A | + | A magical board that connects everyone, with which users can share their real-time performances on visual designer. |
− | + | ||
</div> | </div> | ||
</div> | </div> | ||
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</div> | </div> | ||
<div class="ui modal" id="modal-3"> | <div class="ui modal" id="modal-3"> | ||
− | <div class="header">SBOL | + | <div class="header">SBOL Support</div> |
<div class="image content"> | <div class="image content"> | ||
<div class="ui medium image"> | <div class="ui medium image"> | ||
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</div> | </div> | ||
<div class="description"> | <div class="description"> | ||
− | Our system is compatible | + | Our system is compatible to SBOL, the most common data format in the field of synthetic biology, which means circuits edited on other software can be quickly imported into our software without re-editing. |
− | + | ||
− | + | ||
</div> | </div> | ||
</div> | </div> |
Latest revision as of 22:26, 17 October 2018
Project
Welcome to CO-RAD!
The complexity of genetic circuits has made it difficult for synthetic biologists to design the artificial biological systems. In our project, we developed CO-RAD, a Collaborative Optimization platform with multiple functions including Recommendation, Analysis and Design. With the help of CO-RAD, users can design genetic circuits easily and cooperate with remote partners in real time. More importantly, the search & recommendation system in CO-RAD were developed to inspire users with some previous projects and optimize their design with evolutionary algorithm. Moreover, <a href="javascript:void(0)" goto="Simulation-Circuits"> a novel numerical simulation algorithm </a> for circuit)applied in CO-RAD was developed to predict the expression level of genetic circuits in no time. Through in addition, we incorporated self-designed <a href="javascript:void(0)" goto="Validation"> wet-lab validation </a> into our project to validate the new results designed by our CO-RAD platform. In conclusion, by assisting in collaboration and inspiration, CO-RAD makes complex biological systems accessible to researchers who want rapid, intuitive, and high-quality accomplish their designs. Click here to design in <a href="http://www.sysu-corad.com/">CO-RAD</a> way.
<img src="" />
Background
The data shows a shift from single-investigator 'little science' to increasingly large, expensive, multinational, interdisciplinary and interdependent 'big science'. The scientific collaboration among researchers becomes more pervasive and essential.
To synthetic biology, due to the natural complexity of biological systems, genetic circuit design and the limited personal experience, it is very difficult for individuals to design a viable circuit alone, raising the demand of effective collaboration methods. Interdisciplinary and engineering-oriented natures on scientific research make it praticularly open to collaboration, while time and space issues would compromise the convenience and the efficency to conduct a collaboration.
In this case, we developed a software to improve the efficiency in collaboration and help inspire synbiologists' ideas, assist their work and optimize their design.
<img src="" />
<img src="" />
Therefore, we're here to solve the following problems:
- How to make tele-cooperation as convenient as face-to-face collaboration?
- How to encourage users to come up with and share more creative ideas while designing genetic circuits?
Solution
Source of creative ideas
<img src="" />
Search & Recommendation
<img src="" />
Analysis & Simulation
<img src="" />
Guide the Design
Search & Recommendaion
<img src="" />
Search engine in CO-RAD is powerful for users to quickly gain their desired projects and papers, from which new and creative ideas originate.
Analysis & Simulation
<img src="" />
CO-RAD can not only analyses circuits and compute the values of CG and CAI, but builds mathematical models to simulate the circuits and predict the expression levels.
Guide the Design
<img src="" />
Through an algorithm that simulates evolution, users can get optimal kinetic parameters for circuits, which can assist users in modifying their circuits to reach the expected behavior.
Enhancement on Collaboration
<img src="" />
Collaborative Platform
<img src="" />
Synchronization Sketchpad
<img src="" />
SBOL Support
Collaborative Platform
<img src="" />
A collaborative platform with visual circuit designer and management studio, where multiple users can work together, just like (and even better than!) working face to face.
Synchronization Sketchpad
<img src="" />
A magical board that connects everyone, with which users can share their real-time performances on visual designer.
SBOL Support
<img src="" />
Our system is compatible to SBOL, the most common data format in the field of synthetic biology, which means circuits edited on other software can be quickly imported into our software without re-editing.
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