Difference between revisions of "Team:MIT"

Latest revision as of 23:22, 17 October 2018

C R E S T

Caries Reduction

via

Engineered Signal Transduction

92% of the World has Dental Caries

As the world's most prevalent chronic disease, dental caries' (tooth decay) treatments are few and outdated. Our goal is to develop a novel preventative treatment that will function by inhibiting one of the key steps in pathogenesis: biofilm formation mediated by Streptococcus mutans.

During biofilm formation, S. mutans communicate via a two-component quorum sensing pathway, known as the ComCDE system. This system allows them to sense the presence of other bacteria, and upon activation, secrete adhesive proteins that are used to stick to the surface of the teeth.

Our Project:

In order to create a highly specific sense-and-respond system, we ported the ComCDE system into mammalian cells. This grants them the ability to detect the presence of S. mutans and release anti-biofilm proteins preemptively. Our engineered cells will be encapsulated in a hydrogel that will be implanted in the gingival region of patients' gums.

We hope that our technology will help advance the field of dentistry and make dental care more effective, efficient, and modern. Please use the links above to learn more about our project!

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+.w3-yellow,.w3-hover-yellow:hover{color:#000!important;background-color:#ffeb3b!important}
+.w3-white,.w3-hover-white:hover{color:#000!important;background-color:#fff!important}
+.w3-black,.w3-hover-black:hover{color:#fff!important;background-color:#000!important}
+.w3-grey,.w3-hover-grey:hover,.w3-gray,.w3-hover-gray:hover{color:#000!important;background-color:#9e9e9e!important}
+.w3-light-grey,.w3-hover-light-grey:hover,.w3-light-gray,.w3-hover-light-gray:hover{color:#000!important;background-color:#f1f1f1!important}
+.w3-dark-grey,.w3-hover-dark-grey:hover,.w3-dark-gray,.w3-hover-dark-gray:hover{color:#fff!important;background-color:#616161!important}
+.w3-pale-red,.w3-hover-pale-red:hover{color:#000!important;background-color:#ffdddd!important}
+.w3-pale-green,.w3-hover-pale-green:hover{color:#000!important;background-color:#ddffdd!important}
+.w3-pale-yellow,.w3-hover-pale-yellow:hover{color:#000!important;background-color:#ffffcc!important}
+.w3-pale-blue,.w3-hover-pale-blue:hover{color:#000!important;background-color:#ddffff!important}
+.w3-text-amber,.w3-hover-text-amber:hover{color:#ffc107!important}
+.w3-text-aqua,.w3-hover-text-aqua:hover{color:#00ffff!important}
+.w3-text-blue,.w3-hover-text-blue:hover{color:#2196F3!important}
+.w3-text-light-blue,.w3-hover-text-light-blue:hover{color:#87CEEB!important}
+.w3-text-brown,.w3-hover-text-brown:hover{color:#795548!important}
+.w3-text-cyan,.w3-hover-text-cyan:hover{color:#00bcd4!important}
+.w3-text-blue-grey,.w3-hover-text-blue-grey:hover,.w3-text-blue-gray,.w3-hover-text-blue-gray:hover{color:#607d8b!important}
+.w3-text-green,.w3-hover-text-green:hover{color:#4CAF50!important}
+.w3-text-light-green,.w3-hover-text-light-green:hover{color:#8bc34a!important}
+.w3-text-indigo,.w3-hover-text-indigo:hover{color:#3f51b5!important}
+.w3-text-khaki,.w3-hover-text-khaki:hover{color:#b4aa50!important}
+.w3-text-lime,.w3-hover-text-lime:hover{color:#cddc39!important}
+.w3-text-orange,.w3-hover-text-orange:hover{color:#ff9800!important}
+.w3-text-deep-orange,.w3-hover-text-deep-orange:hover{color:#ff5722!important}
+.w3-text-pink,.w3-hover-text-pink:hover{color:#e91e63!important}
+.w3-text-purple,.w3-hover-text-purple:hover{color:#9c27b0!important}
+.w3-text-deep-purple,.w3-hover-text-deep-purple:hover{color:#673ab7!important}
+.w3-text-red,.w3-hover-text-red:hover{color:#f44336!important}
+.w3-text-sand,.w3-hover-text-sand:hover{color:#fdf5e6!important}
+.w3-text-teal,.w3-hover-text-teal:hover{color:#009688!important}
+.w3-text-yellow,.w3-hover-text-yellow:hover{color:#d2be0e!important}
+.w3-text-white,.w3-hover-text-white:hover{color:#fff!important}
+.w3-text-black,.w3-hover-text-black:hover{color:#000!important}
+.w3-text-grey,.w3-hover-text-grey:hover,.w3-text-gray,.w3-hover-text-gray:hover{color:#757575!important}
+.w3-text-light-grey,.w3-hover-text-light-grey:hover,.w3-text-light-gray,.w3-hover-text-light-gray:hover{color:#f1f1f1!important}
+.w3-text-dark-grey,.w3-hover-text-dark-grey:hover,.w3-text-dark-gray,.w3-hover-text-dark-gray:hover{color:#3a3a3a!important}
+.w3-border-amber,.w3-hover-border-amber:hover{border-color:#ffc107!important}
+.w3-border-aqua,.w3-hover-border-aqua:hover{border-color:#00ffff!important}
+.w3-border-blue,.w3-hover-border-blue:hover{border-color:#2196F3!important}
+.w3-border-light-blue,.w3-hover-border-light-blue:hover{border-color:#87CEEB!important}
+.w3-border-brown,.w3-hover-border-brown:hover{border-color:#795548!important}
+.w3-border-cyan,.w3-hover-border-cyan:hover{border-color:#00bcd4!important}
+.w3-border-blue-grey,.w3-hover-border-blue-grey:hover,.w3-border-blue-gray,.w3-hover-border-blue-gray:hover{border-color:#607d8b!important}
+.w3-border-green,.w3-hover-border-green:hover{border-color:#4CAF50!important}
+.w3-border-light-green,.w3-hover-border-light-green:hover{border-color:#8bc34a!important}
+.w3-border-indigo,.w3-hover-border-indigo:hover{border-color:#3f51b5!important}
+.w3-border-khaki,.w3-hover-border-khaki:hover{border-color:#f0e68c!important}
+.w3-border-lime,.w3-hover-border-lime:hover{border-color:#cddc39!important}
+.w3-border-orange,.w3-hover-border-orange:hover{border-color:#ff9800!important}
+.w3-border-deep-orange,.w3-hover-border-deep-orange:hover{border-color:#ff5722!important}
+.w3-border-pink,.w3-hover-border-pink:hover{border-color:#e91e63!important}
+.w3-border-purple,.w3-hover-border-purple:hover{border-color:#9c27b0!important}
+.w3-border-deep-purple,.w3-hover-border-deep-purple:hover{border-color:#673ab7!important}
+.w3-border-red,.w3-hover-border-red:hover{border-color:#f44336!important}
+.w3-border-sand,.w3-hover-border-sand:hover{border-color:#fdf5e6!important}
+.w3-border-teal,.w3-hover-border-teal:hover{border-color:#009688!important}
+.w3-border-yellow,.w3-hover-border-yellow:hover{border-color:#ffeb3b!important}
+.w3-border-white,.w3-hover-border-white:hover{border-color:#fff!important}
+.w3-border-black,.w3-hover-border-black:hover{border-color:#000!important}
+.w3-border-grey,.w3-hover-border-grey:hover,.w3-border-gray,.w3-hover-border-gray:hover{border-color:#9e9e9e!important}
+.w3-border-light-grey,.w3-hover-border-light-grey:hover,.w3-border-light-gray,.w3-hover-border-light-gray:hover{border-color:#f1f1f1!important}
+.w3-border-dark-grey,.w3-hover-border-dark-grey:hover,.w3-border-dark-gray,.w3-hover-border-dark-gray:hover{border-color:#616161!important}
+.w3-border-pale-red,.w3-hover-border-pale-red:hover{border-color:#ffe7e7!important}.w3-border-pale-green,.w3-hover-border-pale-green:hover{border-color:#e7ffe7!important}
+.w3-border-pale-yellow,.w3-hover-border-pale-yellow:hover{border-color:#ffffcc!important}.w3-border-pale-blue,.w3-hover-border-pale-blue:hover{border-color:#e7ffff!important}
            #contentSub, #footer-box, #catlinks, #search-controls, #p-logo, #sideMenu, #menubar, .logo_2017, .printfooter, .firstHeading,.visualClear {
                 display: none;
@@ Line 13: / Line 267: @@
            #top-section { /*-- styling for default menu bar (edit, page, history, etc.) --*/
                 border: 0 none;
-                height: 14px;
+                height: 3vw;
                 z-index: 100;
                 top: 0;
@@ Line 40: / Line 294: @@
                 padding: 0px;
                 letter-spacing: normal;
-                line-height: 3vw;
-                font-weight: normal;
+                font-weight: light;
            }
@@ Line 52: / Line 306: @@
 .menu {
          list-style-type: none;
-         margin: 0;
+         margin: 0vw;
-         padding: 0;
+         padding: .3vw;
          /*overflow: hidden;*/
          background-color: #333;
          position: fixed;
          width: 100%;
+        height: 4.5vw;
          -webkit-box-shadow: 0 8px 6px -6px #2c2c2c;
          -moz-box-shadow: 0 8px 6px -6px #2c2c2c;
@@ Line 68: / Line 323: @@
          font-family: 'Dosis', sans-serif;;
          font-size: 1.5vw;
-        float: left;
+float: left;
+height: 4.5vw;
      }
@@ Line 75: / Line 332: @@
          color: white;
          text-align: center;
-         padding: 15px 30px;
+         padding: 1vw 1.5vw;
          text-decoration: none;
      }
@@ Line 97: / Line 354: @@
          display: none;
          position: absolute;
-         top: 4.2vw;
+         top: 4vw;
          background-color: #2c2c2c;
-         min-width: 160px;
+         min-width: 10vw;
          box-shadow: 0px 8px 16px 0px rgba(0,0,0,0.2);
          z-index: 1;
@@ Line 106: / Line 363: @@
      .dropdown-content a {
          color: white;
-         padding: 12px 16px;
+         padding: .6vw .9vw;
          text-decoration: none;
          display: block;
@@ Line 124: / Line 381: @@
         font-size: 17vw;
          position: absolute;
-         top: 12vw;
+         top: 23vw;
          left: 2vw;
          z-index: 5;
@@ Line 144: / Line 401: @@
          top: 65vw;
          left: 47vw;
+line-height: 2.8vw;
          z-index: 5;
      }
@@ Line 150: / Line 408: @@
          color: #ce9aff;
          font-family: 'Raleway', sans-serif;;
+line-height: 2.8vw;
          font-size: 1.8vw;
@@ Line 160: / Line 419: @@
          font-size: 3.7vw;
          position: absolute;
+line-height: 2.8vw;
          top: 118vw;
          left: 3vw;
@@ Line 169: / Line 429: @@
          font-family: 'Raleway', sans-serif;;
          font-size: 1.8vw;
+line-height: 2.8vw;
          z-index: 5;
      }
@@ Line 176: / Line 436: @@
          font-family: 'Raleway', sans-serif;;
          font-size: 1.5vw;
+line-height: 2.8vw;
      }
@@ Line 197: / Line 458: @@
 <body >
-  <img class="bg" src="[[File:MIThomeBG.png]]" style="width:100%;">
+  <img class="bg" src="https://static.igem.org/mediawiki/2018/f/f8/T--MIT--MITHomeBG.png" style="width:100%;">
   <div class="menu">
-         <div class="sub"><a class="active" href="#home">Home</a></div>
+         <div class="sub"><a class="active" href="https://2018.igem.org/Team:MIT">Home</a></div>
          <div class="dropdown">
-             <div class="sub"><a href="#project">Team</a></div>
+             <div class="sub"><a href="https://2018.igem.org/Team:MIT/Team">Team</a></div>
              <div class="dropdown-content">
-                 <a href="#">Team Members</a>
+                 <a href="https://2018.igem.org/Team:MIT/Team">Team Members</a>
-                 <a href="#">Collaborations</a>
+                 <a href="https://2018.igem.org/Team:MIT/Collaborations">Collaborations</a>
              </div>
          </div>
          <div class="dropdown">
-             <div class="sub"><a href="#project">Project</a></div>
+             <div class="sub"><a href="https://2018.igem.org/Team:MIT/Description">Project</a></div>
              <div class="dropdown-content">
-                 <a href="#">Sensing</a>
+                 <a href="https://2018.igem.org/Team:MIT/Design">Design</a>
-                 <a href="#">Output</a>
+                 <a href="https://2018.igem.org/Team:MIT/Results">Results</a>
-                 <a href="#">Biofilm Assays</a>
+                 <a href="https://2018.igem.org/Team:MIT/InterLab">InterLab</a>
+                <a href="https://2018.igem.org/Team:MIT/Notebook">Notebook</a>
+                <a href="https://2018.igem.org/Team:MIT/Experiments">Protocols</a>
+                <a href ="https://2018.igem.org/Team:MIT/Attributions"> Attributions </a>
              </div>
          </div>
          <div class="dropdown">
-             <div class="sub"><a href="#project">Parts</a></div>
+             <div class="sub"><a href="https://2018.igem.org/Team:MIT/Parts">Parts</a></div>
              <div class="dropdown-content">
-                 <a href="#">Basic Parts</a>
+                 <a href="https://2018.igem.org/Team:MIT/Basic_Part">Basic Parts</a>
-                 <a href="#">Composite Parts</a>
+                 <a href="https://2018.igem.org/Team:MIT/Composite_Part">Composite Parts</a>
              </div>
          </div>
-         <div class="sub"><a href="#safety">Safety</a></div>
+         <div class="sub"><a href="https://2018.igem.org/Team:MIT/Safety">Safety</a></div>
          <div class="dropdown">
-             <div class="sub"><a href="#project">Human Practices</a></div>
+             <div class="sub"><a href="https://2018.igem.org/Team:MIT/Human_Practices">Human Practices</a></div>
              <div class="dropdown-content">
-                 <a href="#">Integrated Human Practices</a>
+                 <a href="https://2018.igem.org/Team:MIT/Human_Practices">Integrated Human Practices</a>
-                 <a href="#">Public Engagement</a>
+                 <a href="https://2018.igem.org/Team:MIT/Public_Engagement">Public Engagement</a>
              </div>
          </div>
-         <div class="sub"><a href="#awards">Awards</a></div>
+         <div class="sub"><a href="https://2018.igem.org/Team:MIT/Model">Model</a></div>
      </div>
@@ Line 237: / Line 502: @@
          <div class="w3-content w3-section" style="max-width:2000px">
-             <img class="mySlides" src="https://i.imgur.com/YQp3tfB.png" style="width:100%;">
+             <img class="mySlides" src="https://static.igem.org/mediawiki/2018/f/fb/T--MIT--slide1.png" style="width:100%;">
-             <img class="mySlides" src="https://i.imgur.com/M7DzQQI.png" style="width:100%;">
+             <img class="mySlides" src="https://static.igem.org/mediawiki/2018/7/7f/T--MIT--slide2.png" style="width:100%;">
-             <img class="mySlides" src="https://i.imgur.com/HX3uCmE.png" style="width:100%;">
+             <img class="mySlides" src="https://static.igem.org/mediawiki/2018/7/73/T--MIT--slide3.png" style="width:100%;">
-             <img class="mySlides" src="https://i.imgur.com/vSxrkvL.png" style="width:100%;">
+             <img class="mySlides" src="https://static.igem.org/mediawiki/2018/2/26/T--MIT--slide4.png" style="width:100%;">
          </div>
      </div>
@@ Line 248: / Line 513: @@
      </div>
      <div>
-         <div class = "subtitle" style="position: absolute; top: 32vw; left: 2vw;">Caries  Reduction</div> <div class="p5" style="position: absolute; top: 34.25vw; left: 21.5vw;">via</div>
+         <div class = "subtitle" style="position: absolute; top: 35vw; left: 2vw;">Caries  Reduction</div> <div class="p5" style="position: absolute; top: 35vw; left: 21.5vw;">via</div>
-         <div class = "subtitle" style="position: absolute; top: 32vw; left: 24vw;">Engineered Signal Transduction</div>
+         <div class = "subtitle" style="position: absolute; top: 35vw; left: 24vw;">Engineered Signal Transduction</div>
      </div>
     <div>
          <div class="h3">92% of the World has Dental Caries</div>
          <div class="text1" style ="position: absolute;
-         top: 73vw;
+         top: 72vw;
          margin-right: 3vw;
          left: 47vw;">As the world's most prevalent chronic disease, dental caries' (tooth decay) treatments are few and outdated.
@@ Line 260: / Line 525: @@
          pathogenesis: biofilm formation mediated by Streptococcus mutans. </div>
          <div class="text1" style =" position: absolute; margin-right: 3vw;
-         top: 90vw;
+         top: 89vw;
          left: 47vw;">During biofilm formation, S. mutans communicate via a two-component quorum sensing pathway, known as the ComCDE
              system. This system allows them to sense the presence of other bacteria, and upon activation, secrete