Difference between revisions of "Team:Purdue/Human Practices"

 
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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2018.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2018.igem.org/Judging/Awards"> award listed below</a>. </p>
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<div class='title'>Human Practices</div>
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2018.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
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<h1>Overview</h1>
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<h1>Human Practices</h1>
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<p>Our work in human practices focused on answering two questions: will our diagnostic test responsibly impact the world in a positive way, and if so how can we best tailor our design to the needs of those seeking to use it. To answer these questions, we sought the advice of professionals specializing in paper-based assays and the opinions of those who would feasibly come into contact with the test at each step of the diagnostic process. The insight we gained from these interactions demonstrated that Yeast ID has a high potential to responsibly improve the lives of those suffering from yeast infections. By listening to feedback from these key stakeholders we were also able to identify and correct previously unforeseen problems in assay design, propelling us closer to our goal of making as large and positive as possible. Our human practices process consists of six basic steps.</p>
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At iGEM we believe societal considerations should be upfront and integrated throughout the design and execution of synthetic biology projects. “Human Practices” refers to iGEM teams’ efforts to actively consider how the world affects their work and the work affects the world. Through your Human Practices activities, your team should demonstrate how you have thought carefully and creatively about whether your project is responsible and good for the world. We invite you to explore issues relating (but not limited) to the ethics, safety, security, and sustainability of your project, and to show how this exploration feeds back into your project purpose, design and execution.
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<h1 style="margin-bottom:0;padding-bottom:0;">Step 1</h1>
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<p>For more information, please see the <a href="https://2018.igem.org/Human_Practices">Human Practices Hub</a>. There you will find:</p>
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<h2 style="text-align: center;margin-top:0;padding-top:0;">Doing research on the problem and learning diagnosis and treatment processes</h2>
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<p>Follow up on findings from literature review by investigating diagnosis and treatment processes first hand.</p>
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<li> an <a href="https://2018.igem.org/Human_Practices/Introduction">introduction</a> to Human Practices at iGEM </li>
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<li>tips on <a href="https://2018.igem.org/Human_Practices/How_to_Succeed">how to succeed</a> including explanations of judging criteria and advice about how to conduct and document your Human Practices work</li>
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<li>descriptions of <a href="https://2018.igem.org/Human_Practices/Examples">exemplary work</a> to inspire you</li>
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<li>links to helpful <a href="https://2018.igem.org/Human_Practices/Resources">resources</a></li>
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<li>And more! </li>
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<p>Who we talked to:</p>
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<p>On this page, your team should document all of your Human Practices work and activities. You should write about the Human Practices topics you considered in your project, document any activities you conducted to explore these topics (such as engaging with experts and stakeholders), describe why you took a particular approach (including referencing any work you built upon), and explain if and how you integrated takeaways from your Human Practices work back into your project purpose, design and/or execution. </p>
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<p>If your team has gone above and beyond in work related to safety, then you should document this work on your Safety wiki page and provide a description and link on this page. If your team has developed education and public engagement efforts that go beyond a focus on your particular project, and for which would like to nominate your team for the Best Education and Public Engagement Special Prize, you should document this work on your Education and Education wiki page and provide a description and link here. </p>
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<h3 style="margin-top:0;">Practicing OBGYN: Dr. Lisa Yang</h3>
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<p>On any given day, Dr. Lisa Yang could expect to visit with regular patients for checkups, perform surgeries, coach a future mother through labor, and deliver multiple babies. Dr. Yang additionally oversees surgeries and tests performed by residents in training. Apart from answering our questions pertaining to current diagnostics for yeast infections (see problem page), Dr. Yang described the ideal yeast infection diagnostic. The ideal diagnostic has the following characteristics:</p>
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<p>The iGEM judges will review this page to assess whether you have met the Silver and/or Gold medal requirements based on the Integrated Human Practices criteria listed below. If you nominate your team for the <a href="https://2018.igem.org/Judging/Awards">Best Integrated Human Practices Special Prize</a> by filling out the corresponding field in the <a href="https://2018.igem.org/Judging/Judging_Form">judging form</a>, the judges will also review this page to consider your team for that prize.  
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<li>Able to produce results in the office without the use of specialized lab equipment</li>
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<li>If her staff is able to perform the test because she either has to conduct the test herself or send it into a lab</li>
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<h3>Silver Medal Criterion #3</h3>
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<p>Convince the judges you have thought carefully and creatively about whether your work is responsible and good for the world. Document how you have investigated these issues and engaged with your relevant communities, why you chose this approach, and what you have learned. Please note that surveys will not fulfill this criteria unless you follow scientifically valid methods. </p>
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<h3>Gold Medal Criterion #1</h3>
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<p>Expand on your silver medal activity by demonstrating how you have integrated the investigated issues into the purpose, design and/or execution of your project. Document how your project has changed based upon your human practices work.
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<h1 style="margin-bottom:0;padding-bottom:0;">Step 2</h1>
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<h2 style="text-align: center;margin-top:0;padding-top:0;">Developing our Paper-Based Assay</h2>
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<p>Throughout the process of building our paper-based assay, we consulted professionals who helped us change our assay to better fit the needs of healthcare professionals and patients everywhere.</p>
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<p>Who we talked to:</p>
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<p>To compete for the Best Integrated Human Practices prize, please describe your work on this page and also fill out the description on the judging form. </p>
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<p>How does your project affect society and how does society influence the direction of your project? How might ethical considerations and stakeholder input guide your project purpose and design and the experiments you conduct in the lab? How does this feedback enter into the process of your work all through the iGEM competition? Document a thoughtful and creative approach to exploring these questions and how your project evolved in the process to compete for this award!</p>
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<p>You must also delete the message box on the top of this page to be eligible for this prize.</p>
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<h3 style="margin-top:0;">Dr. Linnes</h3>
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<p>Dr. Linnes is an assistant professor in Biomedical Engineering at Purdue University who specializes in developing paper-based assays. She helped our team greatly by providing examples of paper-based assays, identifying important variables in assay design, and allowing our assay designer to use materials and equipment in her lab. Because of her large contribution, it is difficult to narrow down discrete changes she provoked in our design; that being said, we directly implemented her suggestion to have a 3-step maximum on our assay.</p>
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<h1 style="margin-bottom:0;padding-bottom:0;">Step 3</h1>
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<h2 style="text-align: center;margin-top:0;padding-top:0;">Learn how to Relay our research to the public</h2>
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<p>Communicating our research and transporting or assay to the public is important when making our assay more globally accessible. </p>
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<p>Dr. Cooky is an associate professor of American Studies and Women’s, Gender, and Sexuality Studies at Purdue University. During our project she helped us in focusing in on how we can help the general public understand our research. She also brought to light that yeast infections are “a relatively minor medical issue that creates a disproportionate impact on women’s lives.”</p>
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<p>Throughout our talk with her she brought to our attention:</p>
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<li>How the youth is getting educated on sexual health and what their programs entail</li>
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<li>Whether or not sexual health education programs are teach about infections like vulvovaginal candidiasis</li>
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<li>Different misconceptions that surround women’s health and the implications of what going to get treatment for infections like vulvovaginal candidiasis entail</li>
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<li>How different cultures view women’s health and the challenges women face in obtaining a test and getting treatment</li>
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<li>Make sure our test is something women could do by themselves by keeping it simple and accessible</li>
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<li>Consider a global reach with our test</li>
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<p>Dr. Clase is the director of the Biotechnology Innovation and Regulatory Science Center and also a professor in Agricultural and Biological Engineering as well as Technology Leadership and Innovation. She works extensively with building programs to help secure access to medicine in Africa and developing nations. Dr. Clase helped us by answering questions about bringing our assay to the global market. From talking with her she answered our questions about international healthcare and suggested we find out how people learn about healthcare and where people go if there is no doctor or nurse.</p>
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<p>We had the opportunity to work with Purdue University Libraries in creating an event called DIYBio and Maker, where we educated the Purdue community about synthetic biology and our project. During the event we interacted with students and shed light on the importance of synthetic biology and the implications of our research.</p>
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<h1 style="margin-bottom:0;padding-bottom:0;">Step 4</h1>
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<p>The most important stakeholder for any diagnostic test is the user, the person tasked with completing the necessary steps and analyzing the results. Unfortunately, the stigma associated with yeast infections and the difficulty of finding a large diverse population of potential users make collecting data from this key demographic challenging. Thankfully Amazon Mechanical Turk, an online survey distribution platform, was able to help us circumvent these problems. After working with the Purdue Statistics Department to eliminate biases from our survey questions and receiving IRB approval, the survey was distributed and completed by 239 potential users. The survey allowed us to collect data on the habits of those with potential yeast infections and determine minimums for assay cost and speed among other metrics. Because users preferred the test have two sample channels instead of the one channel offered by our paper-based assay at the time, we updated our test design. To view our survey questions and full findings, click the link below,</p>
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<p>A truly accessible assay can be shipped anywhere with minimal shipping accommodations. To test how shipping and dormancy would affect the functionality of our assay we shipped prototypes to the Northwestern iGEM Team for experimentation. Although we were unable to characterize the impact of shipping on test effectiveness, the interaction demonstrated that our assay instructions needed to be more specific and that sample loading areas should be labelled. The updated design can be found on our hardware page. To view more details of our collaboration, click the link below.</p>
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Latest revision as of 00:21, 18 October 2018

Bootstrap Example

Human Practices

Overview

Our work in human practices focused on answering two questions: will our diagnostic test responsibly impact the world in a positive way, and if so how can we best tailor our design to the needs of those seeking to use it. To answer these questions, we sought the advice of professionals specializing in paper-based assays and the opinions of those who would feasibly come into contact with the test at each step of the diagnostic process. The insight we gained from these interactions demonstrated that Yeast ID has a high potential to responsibly improve the lives of those suffering from yeast infections. By listening to feedback from these key stakeholders we were also able to identify and correct previously unforeseen problems in assay design, propelling us closer to our goal of making as large and positive as possible. Our human practices process consists of six basic steps.

Step 1

Doing research on the problem and learning diagnosis and treatment processes

Follow up on findings from literature review by investigating diagnosis and treatment processes first hand.

Who we talked to:

Step 2

Developing our Paper-Based Assay

Throughout the process of building our paper-based assay, we consulted professionals who helped us change our assay to better fit the needs of healthcare professionals and patients everywhere.

Who we talked to:

Step 3

Learn how to Relay our research to the public

Communicating our research and transporting or assay to the public is important when making our assay more globally accessible.

Who we talked to:

Integrated HP:

Step 4

IRB-approved survey

The most important stakeholder for any diagnostic test is the user, the person tasked with completing the necessary steps and analyzing the results. Unfortunately, the stigma associated with yeast infections and the difficulty of finding a large diverse population of potential users make collecting data from this key demographic challenging. Thankfully Amazon Mechanical Turk, an online survey distribution platform, was able to help us circumvent these problems. After working with the Purdue Statistics Department to eliminate biases from our survey questions and receiving IRB approval, the survey was distributed and completed by 239 potential users. The survey allowed us to collect data on the habits of those with potential yeast infections and determine minimums for assay cost and speed among other metrics. Because users preferred the test have two sample channels instead of the one channel offered by our paper-based assay at the time, we updated our test design. To view our survey questions and full findings, click the link below,

Click here to learn more

Step 5

Collaboration

A truly accessible assay can be shipped anywhere with minimal shipping accommodations. To test how shipping and dormancy would affect the functionality of our assay we shipped prototypes to the Northwestern iGEM Team for experimentation. Although we were unable to characterize the impact of shipping on test effectiveness, the interaction demonstrated that our assay instructions needed to be more specific and that sample loading areas should be labelled. The updated design can be found on our hardware page. To view more details of our collaboration, click the link below.

Click here to learn more

Special Thanks

to all those that made this possible

Follow Us On

Contact Us

igem@purdue.edu

Kevin Fitzgerald, B025

1203 W State St.

West Lafayette, IN 47906