Difference between revisions of "Team:Warwick"

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<html lang="en">
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<html>
  <head>
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<head>
    <meta charset="UTF-8">
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<meta charset="UTF-8">
    <title>WISB iGEM</title>
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          <h1 style="margin-left: 10%; margin-right: 10%; text-align: center">
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            Welcome To The <span>WISB</span> iGEM Wiki Page<br><br>
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              <div class="numbertext">1 / 5</div>
 
              <img alt='' class='imgs' src="https://static.igem.org/mediawiki/2018/8/8a/T--Warwick--gibbethill.png" style="width:100%">
 
              <div class="text" id='text1'>WISB and iGEM <br>
 
                <div class='text_inner'>
 
                  <br>
 
                 
 
                  <h3>The International Genetically Engineered Machine (iGEM) Competition</h3>
 
                  iGEM is an international genetic engineering competition that fosters scientific research and
 
                  education by creating a community of young student researchers, and by operating the Registry
 
                  of Standard Biological parts – an open source repository of DNA parts freely accessible to the
 
                  participating teams and labs.  You can find out more on the iGEM website.
 
                  Teams are made up of undergraduate students from a number of disciplines – typically engineering,
 
                  physics, chemistry, mathematics, computer science and biology.  Teams design their own project,
 
                  implement it during the summer, and travel to Boston to present their results at the iGEM “Jamboree”.
 
                  <br><br>
 
                 
 
                  <h3>iGEM at the University of Warwick</h3>
 
                  Undergraduate students at the University of Warwick have participated in the iGEM competition
 
                  for the past three years, winning two Gold medals and one Silver medal. In 2016 Warwick’s team
 
                  were also nominated for best software tool.
 
                  <br>
 
                  Professor Alfonso Jaramillo leads the Warwick iGEM initiative, with support from WISB Post
 
                  Doctoral Research Assistants and Principal Investigators.
 
  
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                 <script>
              <div class="numbertext">2 / 5</div>
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              <img alt='' class='imgs' src="https://static.igem.org/mediawiki/2018/thumb/4/4d/T--Warwick--igem_team_2018.png/800px-T--Warwick--igem_team_2018.png" style="width:100%">
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              <div class="text" id='text2'>Our Team <br>
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                 <div class='text_inner'>
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                  <br>
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                  <h3>The Team</h3>
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                  This year our iGEM team consists of students from Biochemistry, Biomedical Sciences,
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                  Medical Microbiology & Virology, Life Sciences with Global Sustainable Development,
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                  and for the first time students from other disciplinaries; Computer Science, and Law.
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                  <br><br>
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                  The iGEM team will be assisted by
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                  <a class='aca-links' href='https://warwick.ac.uk/fac/sci/chemistry/research/corre/'>Dr. Christopher Corre</a>,
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                  <a class='aca-links' href='https://www.wisb-uow.co.uk/people/corinne-hanlon/'>Dr. Corinne Hanlon</a>, and
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                  <a class='aca-links' href='https://warwick.ac.uk/fac/sci/lifesci/people/ajaramillo/'>Dr.Alfonso Jaramillo</a>
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                  and many other academics from within the University of Warwick.
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                  <br><br>
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                      <span>Meet the Team</span>
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              <div class="text" id='text3'>Our Plan <br>
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                <div class='text_inner'>
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                  <br>
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                  <h3>Our Goal</h3>
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                  Our goal is to create a better future using synthetic biology to solve problems
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                  currently faced by the world today. For example, last year our iGEM team used
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                  E.coli to produce a biopolymer, which then in turn was used as the bio-ink for
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                  their 3D printer. Over the course of the summer months, the team relentlessly
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                  worked away in many labs around the campus to use this system for the creation of
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                  surface coatings with improved biocompatibility and osseointegration.<br><br>
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function goToAttributions(){
              <div class="numbertext">4 / 5</div>
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}
              <div class="text" id='text4'>Lab Diary <br><br>
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                <div class='text_inner'>
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                <h3>Development Diary</h3>
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                Our iGEM team has kept records of everything we have achieved so far, ranging from the
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                first meetings to what will become the final product. An up to date diary of these events
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                can be found below.
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                <br><br><br>
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 +
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                  <span>Lab Diary</span>
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function goToDescription(){
              <div class="numbertext">5 / 5</div>
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}
              <div class="text" id='text5'>Results <br>
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                <div class='text_inner'>
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                  <br><br>
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                  When we have some you'll be the first to know!
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                </div>
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              </div>
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            </div>
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          <br><br>
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            <h3>
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            Project Description
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<p>
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The theme of our iGEM entry this year is water safety. In particular, we will focus on using synthetic biology to achieve two goals. The first of these goals is to develop a novel method for detecting Legionella spp. in water systems, with the ability to distinguish between live and dead bacteria. Legionella is the bacteria that is responsible for causing Legionnaire’s disease in humans – a disease that causes pneumonia. It lives only in aquatic environments, usually as an intracellular parasite of protozoa such as amoebas. Legionnaire’s disease currently has no vaccine, so prevention relies on maintenance of Legionella spp. free water supplies. Currently we are looking at detecting Legionella mRNA using a complementary guide RNA that activates dCas9 when binding, to express GFP on a plasmid.
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</p>
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<p>
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Our second goal is to develop and sequence a strain of E. coli that can utilise oestrogen as a source of carbon. Modern practises of society including agriculture and pharmaceuticals have increased the level of oestrogen in natural water sources such as rivers and lakes. This poses a large risk to aquatic species, especially fish, and has been shown to cause collapse of fish populations. We aim to investigate genetically modified bacteria as a potential starting point for a solution to this problem. By using directed evolution, we aim to synthesise a strain of E. coli that has the ability to use oestrogen as a carbon source, and then use sequencing to observe and study the genetic changes that allow it to do so.
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</p>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/0/0e/T--Warwick--WISB.png">
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/8/8b/T--Warwick--SEB.png">
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/9/9a/T--Warwick--WCTrust.png">
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                    <td>
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                    </td>
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                    <td>
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/b/bb/T--Warwick--WSFG.png">
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                <tr>
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                    <td>
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/f/fb/T--Warwick--NEbiolabs.png">
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/c/c4/T--Warwick--snapgene.png">
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                <tr>
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                    <td>
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/1/1f/T--Warwick--Wsoe.png">
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/a/a9/T--Warwick--wchem.png">
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                    </td>
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                </tr>
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                <tr>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/c/c0/T--Warwick--igemExeter.png">
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/d/d7/T--Warwick--igemNottingham.png">
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                    </td>
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                    <td>
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/4/4e/T--Warwick--cardiff.png">
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                    </td>
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         <div style="float: right; width: 20%;">
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function goToMedals(){
          <p>&#9400; WISB iGEM Team, <br>University of Warwick 2018</p>
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         window.location = 'https://2018.igem.org/Team:Warwick/Medals';
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        slides[slideIndex-1].style.display = "block";
+
        dots[slideIndex-1].className += " active";
+
      }
+
    </script>
+
  
  </body>
+
    switch(newTeam){
 +
    case 0:
 +
    h3content.html("Biological");
 +
    pcontent.html("Riboswitches used to find RNA from Legionella allowing reliable confirmation of the presence of the live bacteria.");
 +
    break;
 +
    case 1:
 +
h3content.html("Organic");
 +
    pcontent.html("Utilising bacteria, specifically E.coli, to degrade Oestrogen from water to help out wildlife.");
 +
    break;
 +
    case 2:
 +
h3content.html("Inorganic");
 +
    pcontent.html("Utilisting the lead absorbing properties of B.subtilis bacteria to collect lead from water and with a newly injected gas vesicle gene to make the bacteria float to the surface for easy collection.");
 +
    break;
 +
    }
  
 +
    previousTeam = newTeam;
 +
}
 +
 +
function reset(){
 +
$("#BottNav").hide();
 +
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 +
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 +
<title>Ripple</title>
 +
<link rel="icon" href="images/RippleLogo.ico">
 +
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 +
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<body>
 +
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<div id='Navbar'>
 +
<div id='TopNav'>
 +
<ul><!--
 +
  --><li><span class='topnavs' id='topnav0' onmouseenter="changeNavBar(0)">Project</span></li><!--
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                                  --><li><span class='topnavs' id='topnav2' onmouseenter="changeNavBar(2)">Human Practices</span></li><!--
 +
  --><li><span class='topnavs' id='topnav3' onmouseenter="changeNavBar(3)">The Team</span></li><!--
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  --><li><span class='topnavs' id='topnav4' onmouseenter="changeNavBar(4)">Contact Us</span></li>
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</ul>
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 +
        <h3 id='WelcomeH3'>Ripple</h3>
 +
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 +
        </div> <br><br>
 +
 +
        <div class='WelcomeDivs' id='WDText'><br>
 +
<span id='WDT0'>Biological</span>
 +
    <br><br><br><br><br>
 +
    <span id='WDT1'>Organic</span>
 +
    <br><br><br><br><br>
 +
    <span id='WDT2'>Inorganic</span>
 +
    <br><br><br><br><br>
 +
    <span id='WDT3'>Solutions to clean water</span>
 +
    </div>
 +
 +
    </div>
 +
</div>
 +
</div>
 +
 +
<div class='contentDivs' id='CDiv1'>
 +
<h1>Why water safety?</h1>
 +
<p>Access to safe water is among the many crises we face as a growing population. The WHO estimates that 2.1 billion people lack access to safely managed drinking water services (http://www.un.org/en/sections/issues-depth/water/) , and it is estimated that $260B lost globally each year due to lack of basic water. <a href='https://water.org/our-impact/water-crisis/'>source</a><br><br>When we tried to break down this problem, we were overwhelmed by the many different types of contaminants in water, each of which require different approaches to their removal. We decided to look into how to remove on of each in three main sub-categories of contaminants: Biological, Organic and Inorganic.<br><br>Looking into this event, we realised there were many different types of contaminants in water, each of which require different approaches to their removal. We decided to look into how to remove on of each in three main sub-categories of contaminants: Biological, Organic and Inorganic.</p>
 +
</div>
 +
 +
<div class='contentDivs' id='CDiv2'>
 +
<h1>Three very different problems: Lead, Legionella and Oestrogen.</h1>
 +
<p>We are tackling the bioremediation of waters, focusing on three water pollutants in particular: the organic (oestrogen), inorganic (lead) and biological (legionella). Core concepts of synthetic biology were used create circuits which degrade, remove and detect these pollutants respectively.<br><br>Our projects are ambitious and attempt to solve a wide range of problems that aren’t connected to each other by a unified solution, and that’s not what we are trying to come up with. Each of these areas we have invested in were chosen based on the resources we had as a university in terms of expertise, equipment and experience.</p>
 +
</div>
 +
 +
<div class='imageDivs' id='greywhitesplit'></div>
 +
 +
<div class='' id='BOIStriangle'>
 +
 +
<div id='BOISContent'>
 +
<h1 id='BCTitle'>Click one</h3>
 +
<p id='BCText'></p>
 +
</div>
 +
 +
<img src='https://static.igem.org/mediawiki/2018/b/b5/T--Warwick--Biological.svg' id='bioIMG' onclick="rotate(0)">
 +
<img src='https://static.igem.org/mediawiki/2018/a/aa/T--Warwick--Organic.svg' id='orgIMG'  onclick="rotate(1)">
 +
<img src='https://static.igem.org/mediawiki/2018/0/0e/T--Warwick--Inorganic.svg' id='inorgIMG'  onclick="rotate(2)">
 +
</div>
 +
 +
<div class='imageDivs' id='labDiv'>
 +
<div class='imageDivs' id='whitegreysplit'></div>
 +
<img src='https://static.igem.org/mediawiki/2018/6/69/T--Warwick--lab2.png' id='labIMG'>
 +
<div id='imageFilter'>
 +
<div class='contentOnImages'>
 +
<h2 style='font-size: 1.5vw; color: white'>Ripple is</h2>
 +
<h1 style='font-size: 3vw;'>
 +
<span style='font-weight: 400; color: white; line-height: normal;'>Making water <span style='font-weight: 700;'>safe</span> again,</span>
 +
<span style='font-weight: 300; color: white;'> one step at a time</span>
 +
</h1><br>
 +
<p style='font-weight: 300; font-size: 1.5vw; width: 60%; margin: 0 auto'>
 +
Here on the Ripple iGEM team we are dedicating ourselves to making water safe again; not just for the ourselves, but for the surrounding environments and wildlife too.
 +
</p>
 +
<br>
 +
<button onclick="goToDescription()">Find out more here</button>
 +
</div>
 +
</div>
 +
</div>
 +
 +
<div id='footer'>
 +
 +
<div id='leftFoot'>
 +
<h1 class='FooterTitle' style='margin: 15px auto'>Contact Us</h1>
 +
<div id='socialmedia'>
 +
<h1 style='color: white; font-weight: 300; font-size: 1.5vw;'>igem@warwick.ac.uk</h1>
 +
<br>
 +
            <a class='socialMedia' style='margin-left: 5%' href="https://www.youtube.com/channel/UCHhLKgvGJFkdSmwgGPvN9PA">
 +
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 +
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 +
<h1 class='FooterTitle' style='color: black'>Sponsors</h1>
 +
        <table id='theSponsors'>
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 +
                    <td>
 +
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                        <img class='sponsorimages' src="https://static.igem.org/mediawiki/2018/f/fb/T--Warwick--NEbiolabs.png">
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                    </td>
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            <table id='theSponsors'>
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                <tr>
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</body>
 
</html>
 
</html>

Latest revision as of 02:10, 18 October 2018

Ripple

Ripple




Biological




Organic




Inorganic




Solutions to clean water

Why water safety?

Access to safe water is among the many crises we face as a growing population. The WHO estimates that 2.1 billion people lack access to safely managed drinking water services (http://www.un.org/en/sections/issues-depth/water/) , and it is estimated that $260B lost globally each year due to lack of basic water. source

When we tried to break down this problem, we were overwhelmed by the many different types of contaminants in water, each of which require different approaches to their removal. We decided to look into how to remove on of each in three main sub-categories of contaminants: Biological, Organic and Inorganic.

Looking into this event, we realised there were many different types of contaminants in water, each of which require different approaches to their removal. We decided to look into how to remove on of each in three main sub-categories of contaminants: Biological, Organic and Inorganic.

Three very different problems: Lead, Legionella and Oestrogen.

We are tackling the bioremediation of waters, focusing on three water pollutants in particular: the organic (oestrogen), inorganic (lead) and biological (legionella). Core concepts of synthetic biology were used create circuits which degrade, remove and detect these pollutants respectively.

Our projects are ambitious and attempt to solve a wide range of problems that aren’t connected to each other by a unified solution, and that’s not what we are trying to come up with. Each of these areas we have invested in were chosen based on the resources we had as a university in terms of expertise, equipment and experience.

Click one

Ripple is

Making water safe again, one step at a time


Here on the Ripple iGEM team we are dedicating ourselves to making water safe again; not just for the ourselves, but for the surrounding environments and wildlife too.