Difference between revisions of "Team:Austin LASA/Human Practices"

Revision as of 03:52, 18 October 2018

h(g.Section, {title: 'Lindsey Dawson'},
    'Associate Director, HIV Policy',
    h('br'),
    'Kaiser Family Foundation',
    h('p', null, 'Ms. t will accompany our kit'),
    h('ul', null,
      h('li', null, 'She details on how understanding the importance of detection is important, but how it is equally important to consider the steps that should be taken to get treatment afterward (eg. antiretroviral treatment)'),
      h('li', null, 'Sent the following information (even though the CDC material is focused on US primarily)',
        h('ul', null,
          h('li', null, h('a', {href: 'https://stacks.cdc.gov/view/cdc/23447'}, 'CDC recommendations on Lab testing for HIV')),
          h('li', null, h('a', {href: 'https://www.cdc.gov/hiv/pdf/testing/hiv-tests-laboratory-use.pdf'}, 'Lab tests')),
          h('li', null, h('a', {href: 'https://www.cdc.gov/hiv/pdf/testing/rapid-hiv-tests-non-clinical.pdf'}, 'Rapid tests')),
          h('li', null, h('a', {href: 'https://www.cdc.gov/hiv/pdf/testing/hiv-tests-advantages-disadvantages_1.pdf   '}, 'Advantages/Disadvantages to different HIV tests')),
          h('li', null, h('a', {href: 'https://stacks.cdc.gov/view/cdc/50872'}, 'Recommended testing algorithm')),
          h('li', null, h('a', {href: 'https://www.cdc.gov/hiv/testing/laboratorytests.html'}, 'More info here (incl. all the above links)')),
          h('li', null, h('a', {href: 'http://www.oraquick.com/What-is-OraQuick/OraQuick-In-Home-HIV-Test'}, 'OraSure’s home test')),
          h('li', null, h('a', {href: 'http://aidsinfo.unaids.org/'}, 'To see hardest hit countries, including where share of people unaware of their HIV status is highest (i.e. undiagnosed)'))
        )
      )
    )
  ),

h(g.Section, {title: 'Christopher R Singh'},
    'Biological Safety Officer, MS, Ph.D.',
    h('br'),
    'The University of Texas at Austin',
    h('br'),
    'Environmental Health and Safety',
    h('p', null, 'Dr. Singh served as our guide for various safety concerns and was able to provide us information on various regulations as follows.'),
    h('ul', null,
      h('li', null, 'Based on the procedures and information provided, are there specific clearances or hazards that we need to be aware of?'),
      h('li', null, 'What is the best way to handle blood spots or DNA samples when using a detection kit? What are things that we should keep in mind for creating the most aseptic and safe kit?'),
      h('li', null, 'What are the best disposal or packaging methods when the goal is to use kits such as these overseas in non-lab environments?',
        h('ul', null,
          h('li', null, 'For the research side of things there would need to be approvals for working with human material, blood, cells etc. and working with HIV or the potential components, depending on the research there may be several groups that will look at the work including the IBC.  Research would need to be done in a BSL-2 space hopefully equipped with a biosafety cabinet.  The hazards with the research would of course be the human material as well as the virus or viral components. In the field there would be little opportunity for working aseptically unless the plan would be for a mobile lab to be in place. The best you can do there would be best practice or universal precautions, the idea being that you would treat all samples as potentially pathogenic or infectious, but there would likely not be an opportunity to set up a BSC or any type of clean work space.  You would want proper PPE which at a minimum would be clothes that cover skin (long sleeve etc.) gloves, eye protection and a lab coat.  Depending on how samples will be obtained there may be additional requirements needed.  All the waste should be hazardous material/biowaste, this means for the research side it will need to be autoclaved or disposed of in biohazard boxes.  For field work you would need to check country regulations since they often differ, but you would still want to consider it hazardous waste. Please let me know if I missed something or if anything needs clarification or if there is anything else I can help with.')
        )
      )
    )
  )

)
  ),
  h(g.Section, {title: 'Human Practices in Our Kit'},
    h('p', null, 'We integrated human practices into our project throughout the iGEM season. Below we’ve summarized how our integrated human practices fits the requirements for the Gold Medal Integrated Human Practices criterion and the Best Integrated Human Practices Award.'),
    h('p', null, 'For a much more detailed reference on the development of our kit and how our human practices played a role in that, please see our Kit Considerations page. For a much more detailed reference on how our human practices impact our wet lab work, please see our Design, Development, and Results page.')
  )
);

@@ Line 18: / Line 18: @@
      p('We investigated the struggles of HIV diagnosis by talking to someone who had traveled to Malawi and had experienced that environment. In our opinion, her direct experience was one of the best ways to investigate the issue. She discussed how the device must be relatively simple to use and be fast, as often people leave the clinic before they get the results back. The more we spoke to people, the more evident it was that a quick and simple kit was something that was an actual necessity. More details on these investigations can be found in the “Engaging with Experts” section of this page.'),
      p('We also engaged with people who are vital to the process of HIV-1 diagnosis and an integral part of that community. We spoke to someone involved in HIV policy in order to help us understand the complexities of building a kit and how to ensure that it was truly beneficial in diagnosis. We also spoke to a biological safety officer in order to understand the disposal techniques and packaging methods in order to ensure that our kit would be used responsibly and have no negative effects that were preventable. More details on this HIV and safety community engagement can be found in the “Engaging with Experts” section of this page.'),
-     p('We chose this approach of interviewing people who had actually traveled to locations where our kit was needed because we thought that it would be the best way to get feedback that was personal and genuine. We feel as if we were successful in this, as the information they provided us was seemed much more personal than information gained from papers or other resources. We also interviewed safety and policy officials, as we felt like they would be able to provide a fresh perspective on our project. The team ourselves would not be able to catch every single minute detail that may have a negativeWe focused on contacting people who have experience in diagnosing HIV-1 in the field because we knew that we would not have the opportunity to experience this ourselves, but the input from these individuals was still exceptionally valuable. We wanted to know what this diagnostic process was like and what the struggles were from someone who has spent time in that environment. We also contacted a people involved with policy and safety because HIV-1 is a dangerous disease and we realized that the kit and the process of using it (hypothetically) may have complications that we may not be able to see at first glance.
+     p('We chose this approach of interviewing people who had actually traveled to locations where our kit was needed because we thought that it would be the best way to get feedback that was personal and genuine. We feel as if we were successful in this, as the information they provided us was seemed much more personal than information gained from papers or other resources. We also interviewed safety and policy officials, as we felt like they would be able to provide a fresh perspective on our project. The team ourselves would not be able to catch every single minute detail that may have a negative impact considering we are not experts in the field. Therefore, we talked to experts who were able to make sure that our work was truly responsible and would have a positive impact.')
- impact considering we are not experts in the field. Therefore, we talked to experts who were able to make sure that our work was truly responsible and would have a positive impact.')
    ),
    h(g.Section, {title: 'GOLD MEDAL CRITERIA'},
-     p('Utilizing the information thatWe focused on contacting people who have experience in diagnosing HIV-1 in the field because we knew that we would not have the opportunity to experience this ourselves, but the input from these individuals was still exceptionally valuable. We wanted to know what this diagnostic process was like and what the struggles were from someone who has spent time in that environment. We also contacted a people involved with policy and safety because HIV-1 is a dangerous disease and we realized that the kit and the process of using it (hypothetically) may have complications that we may not be able to see at first glance.
+     p('Utilizing the information that we gained from various experts, we were able to finalize our laboratory protocols and decided to focus on protocols that did not require specific machinery. By doing so, we were able to divert from depending on large central labs, to doing detection within small rural hospitals, thereby increasing communication between the technicians and family. In response to sterility, we created a resource to establish a standard for universal precautions. To see a more detailed description of the designing and implementation please refer to the Integration section.')
- we gained from various experts, we were able to finalize our laboratory protocols and decided to focus on protocols that did not require specific machinery. By doing so, we were able to divert from depending on large central labs, to doing detection within small rural hospitals, thereby increasing communication between the technicians and family. In response to sterility, we created a resource to establish a standard for universal precautions. To see a more detailed description of the designing and implementation please refer to the Integration section.')
    ),
    h(g.Section, {title: 'BEST INTEGRATED HUMAN PRACTICES SPECIAL PRIZE'},
@@ Line 39: / Line 37: @@
            h('li', null, 'The second annual Austin STEM Day, led by the American Heart Association, Abbott and Texas Mutual Insurance Company, will engage 40 high-school students in a day-long conference. The program aimed to inspire students, encourage innovative thinking and demonstrate that not only are STEM careers critical to the health of our communities but also, they can be fun!'),
            h('li', null, 'Volunteers engaged with other students during the conference from 8:30-12 p.m on July 21, 2018 and participated in various STEM related activities with mentors to to help inspire future students.')
-         ) We focused on contacting people who have experience in diagnosing HIV-1 in the field because we knew that we would not have the opportunity to experience this ourselves, but the input from these individuals was still exceptionally valuable. We wanted to know what this diagnostic process was like and what the struggles were from someone who has spent time in that environment. We also contacted a people involved with policy and safety because HIV-1 is a dangerous disease and we realized that the kit and the process of using it (hypothetically) may have complications that we may not be able to see at first glance.
+         )
-We focused on contacting people who have experience in diagnosing HIV-1 in the field because we knew that we would not have the opportunity to experience this ourselves, but the input from these individuals was still exceptionally valuable. We wanted to know what this diagnostic process was like and what the struggles were from someone who has spent time in that environment. We also contacted a people involved with policy and safety because HIV-1 is a dangerous disease and we realized that the kit and the process of using it (hypothetically) may have complications that we may not be able to see at first glance.
        ),
        h('li', null, 'The LASA iGEM Team led mini science experiment-labs at The Thinkery Museum (8/10/18, 8/25/18, and 9/15/18)',
@@ Line 70: / Line 66: @@
            h('p', null, 'Will helping a student filter their mixture in order to remove chunks. The kids enjoyed seeing the DNA form after rubbing alcohol was added.')
          )
-       )  h(g.Section, {title: 'OUR APPROACH'},
+       )
-    p('The reason why we chose to focus so heavily on education of younger students in our human practices is because we believe that a public educated in biotechnology and genetics starts at its roots. This meant attempting to spark some inspiration in younger students, which we believe we were successful in. They were so incredibly fascinated with the results of their experiments, and we believe that this is going to be a motivator for them the persue expanding their own knowledge.'),
-    p('We focused on contacting people who have experience in diagnosing HIV-1 in the field because we knew that we would not have the opportunity to experience this ourselves, but the input from these individuals was still exceptionally valuable. We wanted to know what this diagnostic process was like and what the struggles were from someone who has spent time in that environment. We also contacted a people involved with policy and safety because HIV-1 is a dangerous disease and we realized that the kit and the process of using it (hypothetically) may have complications that we may not be able to see at first glance.')
-  ),
      )
    ),
    h(g.Section, {title: 'Engaging with Experts'},
-     p('In order to learn more about the diagnosi  h(g.Section, {title: 'OUR APPROACH'},
+     p('In order to learn more about the diagnosis of HIV and biosafety, we interviewed several experts in the field and have included the information they gave us below.'),
-    p('The reason why we chose to focus so heavily on education of younger students in our human practices is because we believe that a public educated in biotechnology and genetics starts at its roots. This meant attempting to spark some inspiration in younger students, which we believe we were successful in. They were so incredibly fascinated with the results of their experiments, and we believe that this is going to be a motivator for them the persue expanding their own knowledge.'),
-    p('We focused on contacting people who have experience in diagnosing HIV-1 in the field because we knew that we would not have the opportunity to experience this ourselves, but the input from these individuals was still exceptionally valuable. We wanted to know what this diagnostic process was like and what the struggles were from someone who has spent time in that environment. We also contacted a people involved with policy and safety because HIV-1 is a dangerous disease and we realized that the kit and the process of using it (hypothetically) may have complications that we may not be able to see at first glance.')
-  ),s of HIV and biosafety, we interviewed several experts in the field and have included the information they gave us below.'),
    h(g.Section, {title: 'Dr. Veronica Leautaud, Ph. D.'},
      'Director of Education',
      h('br'),
-     'Rice 360 Institute for Global Health',  h(g.Section, {title: 'OUR APPROACH'},
+     'Rice 360 Institute for Global Health',
-    p('The reason why we chose to focus so heavily on education of younger students in our human practices is because we believe that a public educated in biotechnology and genetics starts at its roots. This meant attempting to spark some inspiration in younger students, which we believe we were successful in. They were so incredibly fascinated with the results of their experiments, and we believe that this is going to be a motivator for them the persue expanding their own knowledge.'),
-    p('We focused on contacting people who have experience in diagnosing HIV-1 in the field because we knew that we would not have the opportunity to experience this ourselves, but the input from these individuals was still exceptionally valuable. We wanted to know what this diagnostic process was like and what the struggles were from someone who has spent time in that environment. We also contacted a people involved with policy and safety because HIV-1 is a dangerous disease and we realized that the kit and the process of using it (hypothetically) may have complications that we may not be able to see at first glance.')
-  ),
      h('p', null, 'Dr. Leautaud is a professor at the Rice 360 Institute for Global Health and was able to provide the following feedback on our project and kit.'),
      h('ul', null,
@@ Line 226: / Line 213: @@
    )
    ),
    h(g.Section, {title: 'Human Practices in Our Kit'},
      h('p', null, 'We integrated human practices into our project throughout the iGEM season. Below we’ve summarized how our integrated human practices fits the requirements for the Gold Medal Integrated Human Practices criterion and the Best Integrated Human Practices Award.'),