Difference between revisions of "Team:Fudan/Acknowledgement"

(Created page with "{{Fudan}}")
 
m
 
(32 intermediate revisions by 5 users not shown)
Line 1: Line 1:
 
{{Fudan}}
 
{{Fudan}}
 +
<html lang="en">
 +
<!--
 +
This html document is created by Tian Huang for Team Fudan iGEM 2018.
 +
We make it compatible on laptop and mobile devices by using Materialize 1.0.0-rc.2.
 +
-->
 +
<!-- LC check on 2018-10-18 -->
 +
<head>
 +
    <meta charset="UTF-8">
 +
 +
    <!-- CSS -->
 +
    <link rel="stylesheet" type="text/css" href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/css.css&action=raw&ctype=text/css" />
 +
 +
    <!-- Font-awesome icons 4.7.0 -->
 +
    <link href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/font-awesome.css&action=raw&ctype=text/css" rel="stylesheet" />
 +
 +
    <!-- Materialize 1.0.0-rc.2 (Material Design like) -->
 +
    <link rel="stylesheet" href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/materialize.css&action=raw&ctype=text/css">
 +
 +
    <!-- Clear default CSS settings; CSS reset -->
 +
    <style>
 +
        *{margin: 0;padding: 0;list-style: none;}
 +
        /* via: https://blog.csdn.net/weixin_41014370/article/details/79523637 */
 +
 +
        /** 清除内外边距 **/
 +
        body, h1, h2, h2, h4, h5, h6, hr, p, blockquote, /* structural elements 结构元素 */
 +
        dl, dt, dd, ul, ol, li, /* list elements 列表元素 */
 +
        pre, /* text formatting elements 文本格式元素 */
 +
        form, fieldset, legend, button, input, textarea, /* form elements 表单元素 */
 +
        th, td /* table elements 表格元素 */ {
 +
            margin: 0;
 +
            padding: 0;
 +
        }
 +
 +
        /** 设置默认字体 **/
 +
 +
        h1, h2, h2, h4, h5, h6 { font-size: 100%; }
 +
        address, cite, dfn, em, var { font-style: normal; } /* 将斜体扶正 */
 +
        code, kbd, pre, samp { font-family: courier new, courier, monospace; } /* 统一等宽字体 */
 +
        small { font-size: 12px; } /* 小于 12px 的中文很难阅读，让 small 正常化 */
 +
 +
        /** 重置列表元素 **/
 +
        ul, ol { list-style: none; }
 +
 +
        /** 重置文本格式元素 **/
 +
        a { text-decoration: none; }
 +
        a:hover { text-decoration: underline; }
 +
 +
 +
        /** 重置表单元素 **/
 +
        legend { color: #000; } /* for ie6 */
 +
        fieldset, img { border: 0; } /* img 搭车：让链接里的 img 无边框 */
 +
        button, input, select, textarea { font-size: 100%; } /* 使得表单元素在 ie 下能继承字体大小 */
 +
        /* 注：optgroup 无法扶正 */
 +
 +
        /** 重置表格元素 **/
 +
        table { border-collapse: collapse; border-spacing: 0; }
 +
 +
        #section1 ul li{
 +
            list-style-type: disc;
 +
            margin: 0 0 0 16px;
 +
            font-size: 19px;
 +
            text-align: justify;
 +
        }
 +
        #pageContent .section ul{
 +
            font-size: 19px;
 +
            margin-top: 23px;
 +
        }
 +
        #acknowledgementPhoto>div.row:nth-child(1)>div{
 +
            padding: 0 30px 0 10px;
 +
        }
 +
    </style>
 +
    <title>2018 iGEM Team:Fudan - Acknowledgement</title>
 +
</head>
 +
 +
<body>
 +
<!-- Fudan div at igem.org -->
 +
<div id="FudanWrapper" class="white">
 +
    <div id="FudanBody" class="white orangeBg">
 +
        <header>
 +
            <!-- empty bar -->
 +
            <div id="emptyBar" style="position:relative;width: 100%;"></div>
 +
 +
            <!-- Navigation bar -->
 +
            <nav id="topNav" class="white z-depth-0_5">
 +
                <div class="nav-wrapper">
 +
                    <div id="teamLogo" class="brand-logo">
 +
                        <a href="https://2018.igem.org/Team:Fudan" target="_self"><img alt="2018 team Fudan logo" src="https://static.igem.org/mediawiki/2018/c/c4/T--Fudan--teamLogo.svg"></a>
 +
                    </div>
 +
                    <ul id="nav-mobile" class="right orangeBorder">
 +
                        <li class="hide-on-med-and-down"><a class="dropdown-trigger" data-target="dropdown1">Project</a></li>
 +
                        <li class="hide-on-med-and-down"><a class="dropdown-trigger" data-target="dropdown2">Dry lab</a></li>
 +
                        <li class="hide-on-med-and-down"><a class="dropdown-trigger" data-target="dropdown3">Wet lab</a></li>
 +
                        <li class="hide-on-med-and-down"><a class="dropdown-trigger" data-target="dropdown4">Toolbox</a></li>
 +
                        <li class="hide-on-med-and-down"><a class="dropdown-trigger" data-target="dropdown5">Outreach</a></li>
 +
                        <li class="hide-on-med-and-down"><a class="dropdown-trigger thisPageLink" data-target="dropdown6">Team</a></li>
 +
                        <li>
 +
                            <a id="navList" data-target="slide-out" class="waves-effect waves-light sidenav-trigger right">
 +
                                <i class="fa fa-navicon" style="font-size: 24px"></i>
 +
                            </a>
 +
                        </li>
 +
                    </ul>
 +
                </div>
 +
            </nav>
 +
 +
            <!-- Dropdown and List elements in navigation bar -->
 +
            <ul id="dropdown1" class="dropdown-content">
 +
                <li><a href="/Team:Fudan/Demonstrate">Demonstration</a></li>
 +
                <li><a href="/Team:Fudan/Antigen_Receptors">Antigen, Receptors</a></li>
 +
                <li><a href="/Team:Fudan/Results">Transmembrane logic</a></li>
 +
            </ul>
 +
            <ul id="dropdown2" class="dropdown-content">
 +
                <li><a href="/Team:Fudan/Addon#ribo">Addon: ribo</a></li>
 +
                <li><a href="/Team:Fudan/Addon#TALE">Addon: TALE</a></li>
 +
                <li><a href="/Team:Fudan/Addon#T2">Addon: T2</a></li>
 +
                <li><a href="/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li>
 +
                <li><a href="/Team:Fudan/Model#NotchLigandKinetics">Model: Notch-ligand&nbsp;kinetics</a></li>
 +
                <li><a href="/Team:Fudan/Software">Software</a></li>
 +
            </ul>
 +
            <ul id="dropdown3" class="dropdown-content">
 +
                <li><a href="/Team:Fudan/InterLab">iGEM interLab</a></li>
 +
                <li><a href="/Team:Fudan/Notebook">Our notebook</a></li>
 +
                <li><a href="/Team:Fudan/Primers">Primers used</a></li>
 +
                <li><a href="/Team:Fudan/Protocols">Protocols</a></li>
 +
                <li><a href="/Team:Fudan/Safety">Safety</a></li>
 +
            </ul>
 +
            <ul id="dropdown4" class="dropdown-content">
 +
                <li><a href="/Team:Fudan/Basic_Parts">Basic parts</a></li>
 +
                <li><a href="/Team:Fudan/Composite_Parts">Composite parts</a></li>
 +
                <li><a href="/Team:Fudan/Optimization">Optimization</a></li>
 +
                <li><a href="/Team:Fudan/Parts_Collection">Parts collection</a></li>
 +
                <li><a href="/Team:Fudan/Improve">Parts improvement</a></li>
 +
                <li><a href="/Team:Fudan/Measurement">Quantification</a></li>
 +
            </ul>
 +
            <ul id="dropdown5" class="dropdown-content">
 +
                <li><a href="/Team:Fudan/Bio-Art">Bio-Art display</a></li>
 +
                <li><a href="/Team:Fudan/Collaborations">Collaborations</a></li>
 +
                <li><a href="/Team:Fudan/Design_Intention">Design intention</a></li>
 +
                <li><a href="/Team:Fudan/Human_Practices">Human practices</a></li>
 +
                <li><a href="/Team:Fudan/Public_Engagement">Public engagement</a></li>
 +
            </ul>
 +
            <ul id="dropdown6" class="dropdown-content">
 +
                <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li>
 +
                <li><a href="/Team:Fudan/Attributions">Attributions</a></li>
 +
                <li><a href="/Team:Fudan/Heritage">Heritage</a></li>
 +
                <li><a href="/Team:Fudan/Team">Members</a></li>
 +
                <li><a href="/Team:Fudan/Sponsors">Sponsors</a></li>
 +
            </ul>
 +
 +
            <!-- Slide-out navigator contents -->
 +
            <ul id="slide-out" class="sidenav">
 +
                <li style="padding: 0"><div class="sidenavBanner">
 +
                    <div class="background orangeBg">
 +
                    </div>
 +
                    <p style="width: 100%;text-align: center;font-size: 24px"><span class="white-text">Acknowledgement</span></p>
 +
                </div></li>
 +
                <li>
 +
                    <ul class="collapsible expandable">
 +
                        <li>
 +
                            <div class="collapsible-header">Project</div>
 +
                            <div class="collapsible-body">
 +
                                <ul>
 +
                                    <li><a href="/Team:Fudan/Demonstrate">Demonstration</a></li>
 +
                <li><a href="/Team:Fudan/Antigen_Receptors">Antigen, Receptors</a></li>
 +
                                    <li><a href="/Team:Fudan/Results">Transmembrane logic</a></li>
 +
                                </ul>
 +
                            </div>
 +
                        </li>
 +
                        <li>
 +
                            <div class="collapsible-header">Dry Lab</div>
 +
                            <div class="collapsible-body">
 +
                                <ul>
 +
                                  <li><a href="/Team:Fudan/Addon#ribo">Addon: ribo</a></li>
 +
                <li><a href="/Team:Fudan/Addon#TALE">Addon: TALE</a></li>
 +
                <li><a href="/Team:Fudan/Addon#T2">Addon: T2</a></li>
 +
                                    <li><a href="/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li>
 +
                                    <li><a href="/Team:Fudan/Model#NotchLigandKinetics">Model: Notch-ligand&nbsp;kinetics</a></li>
 +
                                    <li><a href="/Team:Fudan/Software">Software</a></li>
 +
                                </ul>
 +
                            </div>
 +
                        </li>
 +
                        <li>
 +
                            <div class="collapsible-header">Wet Lab</div>
 +
                            <div class="collapsible-body">
 +
                                <ul>
 +
                                    <li><a href="/Team:Fudan/InterLab">iGEM interLab</a></li>
 +
                                    <li><a href="/Team:Fudan/Notebook">Our notebook</a></li>
 +
                                    <li><a href="/Team:Fudan/Primers">Primers used</a></li>
 +
                                    <li><a href="/Team:Fudan/Protocols">Protocols</a></li>
 +
                                    <li><a href="/Team:Fudan/Safety">Safety</a></li>
 +
                                </ul>
 +
                            </div>
 +
                        </li>
 +
                        <li>
 +
                            <div class="collapsible-header">Toolbox</div>
 +
                            <div class="collapsible-body">
 +
                                <ul>
 +
                                    <li><a href="/Team:Fudan/Basic_Parts">Basic parts</a></li>
 +
                                    <li><a href="/Team:Fudan/Composite_Parts">Composite parts</a></li>
 +
                                    <li><a href="/Team:Fudan/Optimization">Optimization</a></li>
 +
                                    <li><a href="/Team:Fudan/Parts_Collection">Parts collection</a></li>
 +
                                    <li><a href="/Team:Fudan/Improve">Parts improvement</a></li>
 +
                                    <li><a href="/Team:Fudan/Measurement">Quantification</a></li>
 +
                                </ul>
 +
                            </div>
 +
                        </li>
 +
                        <li>
 +
                            <div class="collapsible-header">Outreach</div>
 +
                            <div class="collapsible-body">
 +
                                <ul>
 +
                                    <li><a href="/Team:Fudan/Bio-Art">Bio-Art display</a></li>
 +
                                    <li><a href="/Team:Fudan/Collaborations">Collaborations</a></li>
 +
                                    <li><a href="/Team:Fudan/Design_Intention">Design intention</a></li>
 +
                                    <li><a href="/Team:Fudan/Human_Practices">Human practices</a></li>
 +
                                    <li><a href="/Team:Fudan/Public_Engagement">Public engagement</a></li>
 +
                                </ul>
 +
                            </div>
 +
                        </li>
 +
                        <li>
 +
                            <div class="collapsible-header">Team</div>
 +
                            <div class="collapsible-body">
 +
                                <ul>
 +
                                    <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li>
 +
                                    <li><a href="/Team:Fudan/Attributions">Attributions</a></li>
 +
                                    <li><a href="/Team:Fudan/Heritage">Heritage</a></li>
 +
                                    <li><a href="/Team:Fudan/Team">Members</a></li>
 +
                                    <li><a href="/Team:Fudan/Sponsors">Sponsors</a></li>
 +
                                </ul>
 +
                            </div>
 +
                        </li>
 +
                    </ul>
 +
 +
                </li>
 +
                <li><div class="placeHolder"></div></li>
 +
            </ul>
 +
        </header>
 +
 +
        <div id="pageContent" style="">
 +
            <div id="contentBanner" class="figureBanner orangeBg">
 +
                <div class="row">
 +
                    <div class="col s12 m6 valign-wrapper hide-on-med-and-up">
 +
                        <h1>Acknowledgement</h1>
 +
                    </div>
 +
                    <div class="col s12 m6 valign-wrapper hide-on-med-and-up">
 +
                        <span>Let us express the most sincere thanks to those
 +
                            who rendered their warm help to us. A successful
 +
                            team can’t be constructed without them.</span>
 +
                    </div>
 +
                </div>
 +
                <div id="figureBannerTitle" class="hide-on-small-only">
 +
                    <h1 style="word-break: break-all;font-size: 50px;">Acknowledgement</h1>
 +
                    <p><span>Let us express the most sincere thanks to those
 +
                            who rendered their warm help to us. A successful
 +
                            team can’t be constructed without them.</span></p>
 +
                </div>
 +
                <div class="hide-on-small-only">
 +
                    <img alt="2018 team Fudan title acknowledgement" src="https://static.igem.org/mediawiki/2018/1/1e/T--Fudan--title_ack.jpg">
 +
<svg width="10" height="10" xmlns="http://www.w3.org/2000/svg" style="position:absolute; left:0;top:0; width: 4%;height: 100%;">
 +
                        <defs>
 +
                            <linearGradient y2="0%" x2="100%" y1="0%" x1="0%" id="blackgraleft">
 +
                                <stop stop-color="rgb(0,0,0)" stop-opacity="1" offset="0%"/>
 +
                                <stop stop-color="rgb(0,0,0)" stop-opacity="0" offset="100%"/>
 +
                            </linearGradient>
 +
                        </defs>
 +
                        <g>
 +
                            <rect id="svg_1" fill="url(#blackgraleft)" height="100%" width="100%"/>
 +
                        </g>
 +
                    </svg>
 +
                    <svg width="10" height="10" xmlns="http://www.w3.org/2000/svg" style="position:absolute; right:0;top:0; width: 4%;height: 100%;">
 +
                        <defs>
 +
                            <linearGradient y2="0%" x2="100%" y1="0%" x1="0%" id="blackgraright">
 +
                                <stop stop-color="rgb(0,0,0)" stop-opacity="0" offset="0%"/>
 +
                                <stop stop-color="rgb(0,0,0)" stop-opacity="1" offset="100%"/>
 +
                            </linearGradient>
 +
                        </defs>
 +
                        <g>
 +
                            <rect id="svg_2" fill="url(#blackgraright)" height="100%" width="100%"/>
 +
                        </g>
 +
                    </svg>
 +
                </div>
 +
            </div>
 +
 +
            <!-- main content of the page -->
 +
            <div class="container">
 +
                <main style="margin-right:0;">
 +
                    <div id="section1" class="section container">
 +
                        <h2>Acknowledgement</h2>
 +
                        <ul>
 +
                            <!--li>
 +
                                We thank <a href="https://2017.igem.org/Team:Fudan/Teamers" target="_blank">Zijie Yang</a> for his practical guidance in <a href="/protocols">molecular cloning</a>,
 +
                                <a href="/primers">primers design</a>, <a href="/protocols">cell culture</a> and <a href="/measurements">flow data analysis</a>.
 +
                                He also helped us to start the <a href="/measurements">FACS</a> Jazz machine whenever we need.
 +
                            </li-->
 +
                            <li>
 +
                                We thank <a href="https://2017.igem.org/Team:Fudan/Teamers" target="_blank">Yiheng Wang</a> for teaching us to model
 +
                                <a href="/model#1">DNA and transcription factor binding</a> using his previous <a href="https://2017.igem.org/Team:Fudan/Model" target="blank">model</a>.
 +
                            </li>
 +
                            <li>
 +
                                We thank <a href="https://2017.igem.org/Team:Fudan_China/Member" target="_blank">Tian Huang</a> for providing us with a <a href="https://materializecss.com/" target="_blank">Materialize</a>
 +
                                based wiki template and teaching us with basic knowledge about HTML and CSS.
 +
                            </li>
 +
                            <li>
 +
                                We thank <a href="https://2017.igem.org/Team:Fudan/Teamers" target="_blank">Yiming Cai</a> for giving us
 +
                                advice on purifying EGFP protein, which was used in the beads assay at the early
 +
                                stage of the project.
 +
                            </li>
 +
                            <li>
 +
                                We thank <a href="https://2017.igem.org/Team:Fudan/Teamers" target="_blank">Yijie Pan</a> for giving us practical suggestions
 +
                                on <a href="/Team:Fudan/Protocols" target="_blank">repeated fragment</a> molecular cloning and <a href="/Team:Fudan/Parts_Collection" target=_blank>BioBrick parts</a> documentation.
 +
                            </li>
 +
                            <li>We thank <a href="https://2017.igem.org/Team:Fudan/Teamers" target="_blank">Xinxuan Xiong</a> and <a href="https://2017.igem.org/Team:Fudan_China/Member" target="_blank">Xinyi Xu</a>
 +
                                for giving us useful advice about the <a href="https://2017.igem.org/Team:Fudan/Bio-Art" target="_blank">Bio-ART</a> display and actively helping us in preparation for the display.
 +
                            </li>
 +
                            <li>
 +
                                We thank <a href="https://2017.igem.org/Team:Fudan/Teamers" target="_blank">Ao Feng</a> for helpful discussions on human practice.
 +
                            </li><li>We thank Jingyi Hu for helping us taking bacteria on the morning, and playing an active role in some of our <a href="/Team:Fudan/Human_Practices" target="_blank">human practice</a>.
 +
                            </li><li>We thank Haotian Guo for incisive comments on refining our presentation during and immediately after <a href="https://2018.igem.org/Team:ShanghaiTech/Collaborations" target="_blank">CCiC</a>.
 +
                            </li><li>We thank Professor Xu Wei’s advice on performing flow cytometry and doing the flow data analysis.
 +
                            </li><li>We thank Professor <a href="http://life.fudan.edu.cn/Data/View/1456" target="_blank">Yufang Zheng</a> for helpful discussions on the known Notch regulation and unpublished insight from her study with metalloprotease [ADAM10] and [ADAM17].
 +
                            </li><li>We thank Professor <a href="https://www.ki.si/en/departments/d12-department-of-synthetic-biology-and-immunology/" target=_blank>Roman Jerala</a> on email and face-to-face discussions on designing TALE based logic gates.
 +
                            </li><li>We thank Professor <a href="https://blacklow.hms.harvard.edu/" target="_blank">Stephen Blacklow</a> on email and face-to-face discussions on engineered Notch receptor optimization.
 +
                            </li><li>We thank Doctor Lixin Yang, Doctor Ganjun Yu, Doctor Xiaoying Bi, and Doctor Pengfei Luo for sparing precise time to have the discussion on <a href="/Team:Fudan/Human_Practices#section1" target="_blank">Interview doctors</a>.
 +
                            </li><li>We thank Professor Xin Yuan, in the Department of Philosophy, for attending our Bio-Ethic debate and his comments enriched our understanding.
 +
                            </li><li>We thank Professor  <a href="http://life.fudan.edu.cn/Data/View/1457" target="_blank">Jiang Zhong</a>, Professor <a href="http://life.fudan.edu.cn/Data/View/1335" target="_blank">Xiaoming Ding</a>, Professor <a href="http://life.fudan.edu.cn/Data/View/1475" target="_blank">Qiang Huang</a>, and Professor  <a href="http://life.fudan.edu.cn/Data/View/1391" target="_blank">Ting Ni</a> for giving us valuable suggestions and feeds at different stages of the project, from the initial brainstorm to the middle project progress and the pre-departure presentations.
 +
                            </li><li>We thank the Club of FDU Bertalanffy Society for helping to rent the space for  <a href="/Team:Fudan/Bio-Art" target="_blank">Bio-ART</a> display.
 +
                            </li><li>We thank teachers in <a href="http://www.shedunews.com/jymp_qbdht.html" target="_blank">Qibao Dwight High School</a>, <a href="http://www.jincai.sh.cn/web/JCZX/273001.htm" target="_blank">Shanghai Jincai High School</a>, <a href="https://www.fdfz.cn/ " target="_blank">the High School Affiliated to Fudan University</a> for offering us with opportunities to implement <a href="/Team:Fudan/Human_Practices" target="_blank">our HP</a>.
 +
                            </li><li>We thank <a href="https://2018.igem.org/Team:Fudan-CHINA" target="_blank">Team:Fudan_China</a> for teaching us how to use the plate reader.
 +
                            </li>
 +
                        </ul>
 +
 +
                        <h2>Photos</h2>
 +
                        <div id="acknowledgementPhoto">
 +
                            <h4>People</h4>
 +
                            <p style="margin-left: 10px">Listed by alphabetical order of surnames.</p>
 +
                            <div class="row">
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="doctor Bi" src="https://static.igem.org/mediawiki/2018/9/9f/T--Fudan--Xiaoying_Bi.jpg">
 +
                                    <span>Xiaoying Bi</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Blacklow S" src="https://static.igem.org/mediawiki/2018/d/d7/T--Fudan--Stephen_Blacklow.jpg">
 +
                                    <span>Stephen Blacklow</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Cai" src="https://static.igem.org/mediawiki/2018/7/72/T--Fudan--Yiming_Cai.jpg">
 +
                                    <span>Yiming Cai</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Ding" src="https://static.igem.org/mediawiki/2018/4/4a/T--Fudan--Xiaoming_Ding.jpg">
 +
                                    <span>Xiaoming Ding</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Feng" src="https://static.igem.org/mediawiki/2018/d/dc/T--Fudan--fengao.jpg">
 +
                                    <span>Ao Feng</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Guo" src="https://static.igem.org/mediawiki/2018/5/5c/T--Fudan--Haotian_Guo.jpg">
 +
                                    <span>Haotian Guo</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Hu" src="https://static.igem.org/mediawiki/2018/a/a6/T--Fudan--Jingyi_Hu.jpg">
 +
                                    <span>Jingyi Hu</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Huang Q" src="https://static.igem.org/mediawiki/2018/c/c7/T--Fudan--Qiang_Huang.jpg">
 +
                                    <span>Qiang Huang</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Huang T" src="https://static.igem.org/mediawiki/2018/3/3d/T--Fudan--Tian_Huang.jpg">
 +
                                    <span>Tian Huang</span>
 +
                                </div>
 +
<div class="col s12 m3 l2">
 +
    <img alt="Jerala" src="https://static.igem.org/mediawiki/2018/9/99/T--Fudan--LC--Roman_Jerala.jpg" />
 +
    <span>Jerala Roman</span>
 +
</div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Luo" src="https://static.igem.org/mediawiki/2018/6/65/T--Fudan--Pengfei_Luo.jpg">
 +
                                    <span>Pengfei Luo</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Ni" src="https://static.igem.org/mediawiki/2018/2/20/T--Fudan--Ting_Ni.jpg">
 +
                                    <span>Ting Ni</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Pan" src="https://static.igem.org/mediawiki/2018/3/3f/T--Fudan--Yijie_Pan.jpg">
 +
                                    <span>Yijie Pan</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Wang" src="https://static.igem.org/mediawiki/2018/1/11/T--Fudan--Yiheng_Wang.jpg">
 +
                                    <span>Yiheng Wang</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Xiong" src="https://static.igem.org/mediawiki/2018/8/80/T--Fudan--Xinxuan_Xiong.jpg">
 +
                                    <span>Xinxuan Xiong</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Xu W" src="https://static.igem.org/mediawiki/2018/1/16/T--Fudan--Wei_Xu.jpg">
 +
                                    <span>Wei Xu</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Xu X" src="https://static.igem.org/mediawiki/2018/a/a0/T--Fudan--Xinyi_Xu.jpg">
 +
                                    <span>Xinyi Xu</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="doctor Yang L" src="https://static.igem.org/mediawiki/2018/4/4e/T--Fudan--Lixing_Yang.jpg">
 +
                                    <span>Lixing Yang</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="doctor Yang S" src="https://static.igem.org/mediawiki/2018/5/57/T--Fudan--Shunhua_Yang.jpg">
 +
                                    <span>Shunhua Yang</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="doctor Yu" src="https://static.igem.org/mediawiki/2018/6/6f/T--Fudan--Ganjun_Yu.jpg">
 +
                                    <span>Ganjun Yu</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="doctor Yuan" src="https://static.igem.org/mediawiki/2018/6/6e/T--Fudan--Xin_Yuan.jpg">
 +
                                    <span>Xin Yuan</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Zhong" src="https://static.igem.org/mediawiki/2018/c/c6/T--Fudan--Jiang_Zhong.jpg">
 +
                                    <span>Jiang Zhong</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Zheng" src="https://static.igem.org/mediawiki/2018/7/79/T--Fudan--Yufang_Zheng.jpg">
 +
                                    <span>Yufang Zheng</span>
 +
                                </div>
 +
                            </div>
 +
                            <h4>Labs, Organizations & Schools</h4>
 +
                            <div class="row">
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Changhai" src="https://static.igem.org/mediawiki/2018/f/fd/T--Fudan--Changhai_Hospital.jpg">
 +
                                    <span>Changhai Hospital</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Jincai" src="https://static.igem.org/mediawiki/2018/7/7f/T--Fudan--Jincai_High_School.png">
 +
                                    <span>Jincai High School</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Fuzhong" src="https://static.igem.org/mediawiki/2018/a/a7/T--Fudan--Fudanfuzhong.jpg">
 +
                                    <span>High School Affiliated to Fudan University</span>
 +
                                </div>
 +
                                <div class="col s12 m3 l2">
 +
                                    <img alt="Qibao" src="https://static.igem.org/mediawiki/2018/f/f1/T--Fudan--Qibao_Dwight.jpg">
 +
                                    <span>Shanghai Qibao Dwight High School</span>
 +
                                </div>
 +
                            </div>
 +
                            <h4>iGEM Teams</h4>
 +
                            <div class="row">
 +
                                <div class="col s12 m4 l3">
 +
                                    <img alt="2018 Fudan-CHINA" src="https://static.igem.org/mediawiki/2018/6/65/T--Fudan--Fudan_China.jpg">
 +
                                    <span>Fudan-CHINA 2018</span>
 +
                                </div>
 +
                                <div class="col s12 m4 l3">
 +
                                    <img alt="2017 Fudan" src="https://static.igem.org/mediawiki/2018/f/fa/T--Fudan--team_Fudan.png">
 +
                                    <span>Fudan 2017</span>
 +
                                </div>
 +
                                <div class="col s12 m4 l3">
 +
                                    <img alt="2017 Fudan_China" src="https://static.igem.org/mediawiki/2018/4/4f/T--Fudan--Team_Fudan_China2017.png">
 +
                                    <span>Fudan_China 2017</span>
 +
                                </div>
 +
                            </div>
 +
                        </div>
 +
                    </div>
 +
                </main>
 +
            </div>
 +
 +
            <!--Abstract on content page-->
 +
            <div id="abstractContent" class="z-depth-2">
 +
                <a href="#!"><img alt="2018 team Fudan abstract" src="https://static.igem.org/mediawiki/2018/9/96/T--Fudan--X.svg"></a>
 +
                <div class="container">
 +
                    <h2 style="margin: 0;padding: 10px 0;">Abstract</h2>
 +
                    <p style="margin: 0">Contact-dependent signaling is critical for multicellular biological
 +
                        events, yet customizing contact-dependent signal transduction between
 +
                        cells remains challenging. Here we have developed the ENABLE toolbox, a
 +
                        complete set of transmembrane binary logic gates. Each gate consists of
 +
                        3 layers: Receptor, Amplifier, and Combiner. We first optimized synthetic
 +
                        Notch receptors to enable cells to respond to different signals across the
 +
                        membrane reliably. These signals, individually amplified intracellularly by
 +
                        transcription, are further combined for computing. Our engineered zinc finger-based
 +
                        transcription factors perform binary computation and output designed products.
 +
                        In summary, we have combined spatially different signals in mammalian cells,
 +
                        and revealed new potentials for biological oscillators, tissue engineering,
 +
                        cancer treatments, bio-computing, etc. ENABLE is a toolbox for constructing
 +
                        contact-dependent signaling networks in mammals. The 3-layer design principle
 +
                        underlying ENABLE empowers any future development of transmembrane logic circuits,
 +
                        thus contributes a foundational advance to Synthetic Biology.
 +
                    </p>
 +
                </div>
 +
            </div>
 +
 +
            <!-- Floating Btns -->
 +
            <div class="floatingBtn">
 +
                <a href="#!" id="abstractBtn" class="btn">
 +
                    <i class="fa fa-sticky-note" style="font-size: 30px;line-height: 50px"></i>
 +
                </a>
 +
                <a href="#FudanWrapper" class="btn">
 +
                    <i class="fa fa-angle-up" style="font-size: 48px;line-height: 45px"></i>
 +
                </a>
 +
            </div>
 +
 +
            <!-- Footer with sponsors and contact methods -->
 +
            <footer id="FudanFooter" class="page-footer grey">
 +
                <div class="container">
 +
                    <div class="row">
 +
                        <div id="sponsor" class="col m3 s12 row">
 +
                            <a href="https://2018.igem.org/Team:Fudan" target="_blank"><img alt="2018 team Fudan logo" class="col s3 m6 l3" style="position:relative; padding: 0 0.3rem; margin:-0.15rem 0; left: -0.45rem;" src="https://static.igem.org/mediawiki/2018/7/73/T--Fudan--teamLogoWhite.png">
 +
                            </a><a href="http://www.fudan.edu.cn/en/" target="_blank"><img class="col s3 m6 l3" alt="Fudan University" src="https://static.igem.org/mediawiki/2018/f/f7/T--Fudan--schoolLogo.png">
 +
                        </a><a href="http://life.fudan.edu.cn/" target="_blank"><img class="col s3 m6 l3" style="margin-bottom: 4%;/* 该图比其他小一点，排版需要 */" alt="School of Life Sciences, Fudan University" src="https://static.igem.org/mediawiki/2018/1/1d/T--Fudan--schoolOfLifeSciencesIcon.png">
 +
                        </a><a href="http://www.yfc.cn/en/" target="_blank"><img class="col s3 m6 l3" style="padding: 0.15rem 0.9rem;" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2018/e/e2/T--Fudan--yunfengLogo.png">
 +
                        </a>
 +
                            <h3 class="col s12" style="text-align: left; color: rgba(255, 255, 255, 0.8); font-size: 18px">ENABLE: making cells even smarter</h3>
 +
                        </div>
 +
                        <div id="usefulLinks" class="col m9 s12 row">
 +
                            <div class="col s12 l6 row">
 +
                                <div class="col s12 m4">
 +
                                    <span>Project</span>
 +
                                    <ul>
 +
                                        <li><a href="/Team:Fudan/Demonstrate">Demonstration</a></li>
 +
 +
                <li><a href="/Team:Fudan/Antigen_Receptors">Antigen, Receptors</a></li>
 +
                                        <li><a href="/Team:Fudan/Results">Transmembrane logic</a></li>
 +
                                        <li><a href="https://2017.igem.org/Team:Fudan">2017.iGEM</a></li>
 +
                                    </ul>
 +
                                </div>
 +
                                <div class="col s12 m4">
 +
                                    <span>Dry lab</span>
 +
                                    <ul>
 +
                                    <li><a href="/Team:Fudan/Addon#ribo">Addon: ribo</a></li>
 +
                <li><a href="/Team:Fudan/Addon#TALE">Addon: TALE</a></li>
 +
                <li><a href="/Team:Fudan/Addon#T2">Addon: T2</a></li>
 +
                                        <li><a href="/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li>
 +
                                        <li><a href="/Team:Fudan/Model#NotchLigandKinetics">Model: Notch-ligand&nbsp;kinetics</a></li>
 +
                                        <li><a href="/Team:Fudan/Software">Software</a></li>
 +
                                    </ul>
 +
                                </div>
 +
                                <div class="col s12 m4">
 +
                                    <span>Wet lab</span>
 +
                                    <ul>
 +
                                        <li><a href="/Team:Fudan/InterLab">iGEM interLab</a></li>
 +
                                        <li><a href="/Team:Fudan/Notebook">Our notebook</a></li>
 +
                                        <li><a href="/Team:Fudan/Primers">Primers used</a></li>
 +
                                        <li><a href="/Team:Fudan/Protocols">Protocols</a></li>
 +
                                        <li><a href="/Team:Fudan/Safety">Safety</a></li>
 +
                                    </ul>
 +
                                </div>
 +
                            </div>
 +
                            <div class="col s12 l6 row">
 +
                                <div class="col s12 m4">
 +
                                    <span>Toolbox</span>
 +
                                    <ul>
 +
                                        <li><a href="/Team:Fudan/Basic_Parts">Basic parts</a></li>
 +
                                        <li><a href="/Team:Fudan/Composite_Parts">Composite parts</a></li>
 +
                                        <li><a href="/Team:Fudan/Optimization">Optimization</a></li>
 +
                                        <li><a href="/Team:Fudan/Parts_Collection">Parts collection</a></li>
 +
                                        <li><a href="/Team:Fudan/Improve">Parts improvement</a></li>
 +
                                        <li><a href="/Team:Fudan/Measurement">Quantification</a></li>
 +
                                    </ul>
 +
                                </div>
 +
                                <div class="col s12 m4">
 +
                                    <span>Outreach</span>
 +
                                    <ul>
 +
                                        <li><a href="/Team:Fudan/Bio-Art">Bio-Art display</a></li>
 +
                                        <li><a href="/Team:Fudan/Collaborations">Collaborations</a></li>
 +
                                        <li><a href="/Team:Fudan/Design_Intention">Design intention</a></li>
 +
                                        <li><a href="/Team:Fudan/Human_Practices">Human practices</a></li>
 +
                                        <li><a href="/Team:Fudan/Public_Engagement">Public engagement</a></li>
 +
                                    </ul>
 +
                                </div>
 +
                                <div class="col s12 m4 active">
 +
                                    <span>Team</span>
 +
                                    <ul>
 +
                                        <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li>
 +
                                        <li><a href="/Team:Fudan/Attributions">Attributions</a></li>
 +
                                        <li><a href="/Team:Fudan/Heritage">Heritage</a></li>
 +
                                        <li><a href="/Team:Fudan/Team">Members</a></li>
 +
                                        <li><a href="/Team:Fudan/Sponsors">Sponsors</a></li>
 +
                                    </ul>
 +
                                </div>
 +
                            </div>
 +
                        </div>
 +
                    </div>
 +
                </div>
 +
                <div class="footer-copyright">
 +
                    <div class="container">
 +
                        <div class="contactUS row">
 +
                          <div class="col s12 m6 l4"><i class="fa fa-location-arrow"></i> Life Sci Bldg E301, 2005 Songhu Rd, Shanghai
 +
                          </div><div class="col s12 m6 l2"><i class="fa fa-fax"></i> +86-21-31246727
 +
                          </div><div class="col s12 m6 l2"><i class="fa fa-envelope-o"></i> igem@fudan.edu.cn
 +
                          </div><div class="col s12 m6 l4"><i class="fa fa-twitter"></i> <i class="fa fa-wechat"></i> Fudan_iGEM
 +
                          </div>
 +
                        </div>
 +
                    </div>
 +
                </div>
 +
            </footer>
 +
 +
        </div>
 +
    </div>
 +
</div>
 +
<!-- Javascript files -->
 +
<!-- Materialize 1.0.0-rc.2 -->
 +
<script src="https://2018.igem.org/wiki/index.php?title=Template:Fudan/materialize.js&action=raw&ctype=text/javascript"></script>
 +
 +
<!-- Javascript -->
 +
<script src="https://2018.igem.org/wiki/index.php?title=Template:Fudan/js.js&action=raw&ctype=text/javascript"></script>
 +
 +
 +
</body>
 +
</html>

Latest revision as of 15:06, 7 November 2018

2018 iGEM Team:Fudan - Acknowledgement

Acknowledgement

Let us express the most sincere thanks to those who rendered their warm help to us. A successful team can’t be constructed without them.

Acknowledgement

Let us express the most sincere thanks to those who rendered their warm help to us. A successful team can’t be constructed without them.

2018 team Fudan title acknowledgement

Acknowledgement

  • We thank Yiheng Wang for teaching us to model DNA and transcription factor binding using his previous model.
  • We thank Tian Huang for providing us with a Materialize based wiki template and teaching us with basic knowledge about HTML and CSS.
  • We thank Yiming Cai for giving us advice on purifying EGFP protein, which was used in the beads assay at the early stage of the project.
  • We thank Yijie Pan for giving us practical suggestions on repeated fragment molecular cloning and BioBrick parts documentation.
  • We thank Xinxuan Xiong and Xinyi Xu for giving us useful advice about the Bio-ART display and actively helping us in preparation for the display.
  • We thank Ao Feng for helpful discussions on human practice.
  • We thank Jingyi Hu for helping us taking bacteria on the morning, and playing an active role in some of our human practice.
  • We thank Haotian Guo for incisive comments on refining our presentation during and immediately after CCiC.
  • We thank Professor Xu Wei’s advice on performing flow cytometry and doing the flow data analysis.
  • We thank Professor Yufang Zheng for helpful discussions on the known Notch regulation and unpublished insight from her study with metalloprotease [ADAM10] and [ADAM17].
  • We thank Professor Roman Jerala on email and face-to-face discussions on designing TALE based logic gates.
  • We thank Professor Stephen Blacklow on email and face-to-face discussions on engineered Notch receptor optimization.
  • We thank Doctor Lixin Yang, Doctor Ganjun Yu, Doctor Xiaoying Bi, and Doctor Pengfei Luo for sparing precise time to have the discussion on Interview doctors.
  • We thank Professor Xin Yuan, in the Department of Philosophy, for attending our Bio-Ethic debate and his comments enriched our understanding.
  • We thank Professor Jiang Zhong, Professor Xiaoming Ding, Professor Qiang Huang, and Professor Ting Ni for giving us valuable suggestions and feeds at different stages of the project, from the initial brainstorm to the middle project progress and the pre-departure presentations.
  • We thank the Club of FDU Bertalanffy Society for helping to rent the space for Bio-ART display.
  • We thank teachers in Qibao Dwight High School, Shanghai Jincai High School, the High School Affiliated to Fudan University for offering us with opportunities to implement our HP.
  • We thank Team:Fudan_China for teaching us how to use the plate reader.

Photos

People

Listed by alphabetical order of surnames.

doctor Bi Xiaoying Bi
Blacklow S Stephen Blacklow
Cai Yiming Cai
Ding Xiaoming Ding
Feng Ao Feng
Guo Haotian Guo
Hu Jingyi Hu
Huang Q Qiang Huang
Huang T Tian Huang
Jerala Jerala Roman
Luo Pengfei Luo
Ni Ting Ni
Pan Yijie Pan
Wang Yiheng Wang
Xiong Xinxuan Xiong
Xu W Wei Xu
Xu X Xinyi Xu
doctor Yang L Lixing Yang
doctor Yang S Shunhua Yang
doctor Yu Ganjun Yu
doctor Yuan Xin Yuan
Zhong Jiang Zhong
Zheng Yufang Zheng

Labs, Organizations & Schools

Changhai Changhai Hospital
Jincai Jincai High School
Fuzhong High School Affiliated to Fudan University
Qibao Shanghai Qibao Dwight High School

iGEM Teams

2018 Fudan-CHINA Fudan-CHINA 2018
2017 Fudan Fudan 2017
2017 Fudan_China Fudan_China 2017
2018 team Fudan abstract

Abstract

Contact-dependent signaling is critical for multicellular biological events, yet customizing contact-dependent signal transduction between cells remains challenging. Here we have developed the ENABLE toolbox, a complete set of transmembrane binary logic gates. Each gate consists of 3 layers: Receptor, Amplifier, and Combiner. We first optimized synthetic Notch receptors to enable cells to respond to different signals across the membrane reliably. These signals, individually amplified intracellularly by transcription, are further combined for computing. Our engineered zinc finger-based transcription factors perform binary computation and output designed products. In summary, we have combined spatially different signals in mammalian cells, and revealed new potentials for biological oscillators, tissue engineering, cancer treatments, bio-computing, etc. ENABLE is a toolbox for constructing contact-dependent signaling networks in mammals. The 3-layer design principle underlying ENABLE empowers any future development of transmembrane logic circuits, thus contributes a foundational advance to Synthetic Biology.