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We make it compatible on laptop and mobile devices by using Materialize 1.0.0-rc.2. | We make it compatible on laptop and mobile devices by using Materialize 1.0.0-rc.2. | ||
--> | --> | ||
+ | <!-- LC check on 2018-10-24 --> | ||
<head> | <head> | ||
<meta charset="UTF-8"> | <meta charset="UTF-8"> | ||
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<!-- Font-awesome icons 4.7.0 --> | <!-- Font-awesome icons 4.7.0 --> | ||
− | <link href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/font-awesome.css&action=raw&ctype=text/css" rel="stylesheet"> | + | <link href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/font-awesome.css&action=raw&ctype=text/css" rel="stylesheet" /> |
<!-- Materialize 1.0.0-rc.2 (Material Design like) --> | <!-- Materialize 1.0.0-rc.2 (Material Design like) --> | ||
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<!-- Clear default CSS settings; CSS reset --> | <!-- Clear default CSS settings; CSS reset --> | ||
− | <style | + | <style> |
*{margin: 0;padding: 0;list-style: none;} | *{margin: 0;padding: 0;list-style: none;} | ||
/* via: https://blog.csdn.net/weixin_41014370/article/details/79523637 */ | /* via: https://blog.csdn.net/weixin_41014370/article/details/79523637 */ | ||
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} | } | ||
</style> | </style> | ||
+ | <title>2018 iGEM Team:Fudan - Sponsors</title> | ||
</head> | </head> | ||
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<!-- Fudan div at igem.org --> | <!-- Fudan div at igem.org --> | ||
<div id="FudanWrapper" class="white"> | <div id="FudanWrapper" class="white"> | ||
− | <div id="FudanBody" class="white"> | + | <div id="FudanBody" class="white orangeBg"> |
<header> | <header> | ||
<!-- empty bar --> | <!-- empty bar --> | ||
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<div class="nav-wrapper"> | <div class="nav-wrapper"> | ||
<div id="teamLogo" class="brand-logo"> | <div id="teamLogo" class="brand-logo"> | ||
− | <a href="https://2018.igem.org/Team:Fudan" target="_self"><img src="https://static.igem.org/mediawiki/2018/c/c4/T--Fudan--teamLogo.svg"></a> | + | <a href="https://2018.igem.org/Team:Fudan" target="_self"><img alt="2018 team Fudan logo" src="https://static.igem.org/mediawiki/2018/c/c4/T--Fudan--teamLogo.svg"></a> |
</div> | </div> | ||
<ul id="nav-mobile" class="right orangeBorder"> | <ul id="nav-mobile" class="right orangeBorder"> | ||
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<!-- Dropdown and List elements in navigation bar --> | <!-- Dropdown and List elements in navigation bar --> | ||
<ul id="dropdown1" class="dropdown-content"> | <ul id="dropdown1" class="dropdown-content"> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Demonstrate">Demonstration</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Antigen_Receptors">Antigen, Receptors</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Results">Transmembrane logic</a></li> |
</ul> | </ul> | ||
<ul id="dropdown2" class="dropdown-content"> | <ul id="dropdown2" class="dropdown-content"> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Addon#ribo">Addon: ribo</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Addon#TALE">Addon: TALE</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Addon#T2">Addon: T2</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Model#NotchLigandKinetics">Model: Notch-ligand kinetics</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Software">Software</a></li> |
</ul> | </ul> | ||
<ul id="dropdown3" class="dropdown-content"> | <ul id="dropdown3" class="dropdown-content"> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/InterLab">iGEM interLab</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Notebook">Our notebook</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Primers">Primers used</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Protocols">Protocols</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Safety">Safety</a></li> |
</ul> | </ul> | ||
<ul id="dropdown4" class="dropdown-content"> | <ul id="dropdown4" class="dropdown-content"> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Basic_Parts">Basic parts</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Composite_Parts">Composite parts</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Optimization">Optimization</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Parts_Collection">Parts collection</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Improve">Parts improvement</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Measurement">Quantification</a></li> |
</ul> | </ul> | ||
<ul id="dropdown5" class="dropdown-content"> | <ul id="dropdown5" class="dropdown-content"> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Bio-Art">Bio-Art display</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Collaborations">Collaborations</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Design_Intention">Design intention</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Human_Practices">Human practices</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Public_Engagement">Public engagement</a></li> |
</ul> | </ul> | ||
<ul id="dropdown6" class="dropdown-content"> | <ul id="dropdown6" class="dropdown-content"> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Attributions">Attributions</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Heritage">Heritage</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Team">Members</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Sponsors">Sponsors</a></li> |
</ul> | </ul> | ||
Line 151: | Line 153: | ||
<ul id="slide-out" class="sidenav"> | <ul id="slide-out" class="sidenav"> | ||
<li style="padding: 0"><div class="sidenavBanner"> | <li style="padding: 0"><div class="sidenavBanner"> | ||
− | <div class="background"> | + | <div class="background orangeBg"> |
</div> | </div> | ||
<p style="width: 100%;text-align: center;font-size: 24px"><span class="white-text">Sponsors</span></p> | <p style="width: 100%;text-align: center;font-size: 24px"><span class="white-text">Sponsors</span></p> | ||
Line 162: | Line 164: | ||
<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Demonstrate">Demonstration</a></li> |
− | + | <li><a href="/Team:Fudan/Antigen_Receptors">Antigen, Receptors</a></li> | |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Results">Transmembrane logic</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
Line 172: | Line 174: | ||
<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
− | + | <li><a href="/Team:Fudan/Addon#ribo">Addon: ribo</a></li> | |
− | + | <li><a href="/Team:Fudan/Addon#TALE">Addon: TALE</a></li> | |
− | + | <li><a href="/Team:Fudan/Addon#T2">Addon: T2</a></li> | |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Model#NotchLigandKinetics">Model: Notch-ligand kinetics</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Software">Software</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
Line 185: | Line 187: | ||
<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/InterLab">iGEM interLab</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Notebook">Our notebook</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Primers">Primers used</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Protocols">Protocols</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Safety">Safety</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Basic_Parts">Basic parts</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Composite_Parts">Composite parts</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Optimization">Optimization</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Parts_Collection">Parts collection</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Improve">Parts improvement</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Measurement">Quantification</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Bio-Art">Bio-Art display</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Collaborations">Collaborations</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Design_Intention">Design intention</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Human_Practices">Human practices</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Public_Engagement">Public engagement</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
Line 222: | Line 224: | ||
<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Acknowledgement">Acknowledgement</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Attributions">Attributions</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Heritage">Heritage</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Team">Members</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Sponsors">Sponsors</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<div id="pageContent" style=""> | <div id="pageContent" style=""> | ||
− | + | ||
<!-- @@@@ main content of the page --> | <!-- @@@@ main content of the page --> | ||
<div class="container"> | <div class="container"> | ||
<main style="margin: 0"> | <main style="margin: 0"> | ||
− | <div id="section1" class="section container | + | <div id="section1" class="section container"> |
<h2>Our sponsors</h2> | <h2>Our sponsors</h2> | ||
<div class="sponsor"> | <div class="sponsor"> | ||
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/1/19/T--Fudan--schoolLogo.jpg" style="height: | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/1/19/T--Fudan--schoolLogo.jpg" style="height:160px" alt="Fudan University" /> |
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/4/4d/T--Fudan--schoolOfLifeSciencesIcon.jpeg" style="height: | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/4/4d/T--Fudan--schoolOfLifeSciencesIcon.jpeg" style="height:170px" alt="School of Life Sciences" /> |
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/1/14/T--Fudan--yunfengLogo_colored.png" style="height: | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/1/14/T--Fudan--yunfengLogo_colored.png" style="height:150px" alt="Yunfeng Capital" /> |
</div> | </div> | ||
<div class="sponsor"> | <div class="sponsor"> | ||
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/3/31/T--Fudan--sponsor-1.png" style="height:72px" /><br/> | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/3/31/T--Fudan--sponsor-1.png" style="height:72px" alt="Andor" /><br/> |
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/5/55/T--Fudan--sponsor-2.png" style="height:68px" /><br/> | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/5/55/T--Fudan--sponsor-2.png" style="height:68px" alt="Chiral Chemistry" /><br/> |
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/6/6f/T--Fudan--sponsor-3.png" style="height:72px" / > | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/a/ab/T--Fudan--nikon-sponsors.jpg" style="height:99px" alt="Nikon" /><br/> |
+ | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/1/1d/T--Fudan--LC-snapgene.png" style="height:72px" alt="Snapgene" /><br/> | ||
+ | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/6/6f/T--Fudan--sponsor-3.png" style="height:72px" alt="YZT" /> | ||
</div> | </div> | ||
<div class="sponsor"> | <div class="sponsor"> | ||
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/4/40/T--Fudan--sponsor-5.png" style="height:80px" /><br/> | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/4/40/T--Fudan--sponsor-5.png" style="height:80px" alt="china scuba diving" /><br/> |
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/2/28/T--Fudan--sponsor-4.png" style="height:50px" /> | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/2/28/T--Fudan--sponsor-4.png" style="height:50px" alt="sea i see" /> |
</div> | </div> | ||
− | <h4 style="margin-top:50px;margin-bottom:0;text-align:center;font-weight:bold;color:#F78E41;line-height: | + | <h4 id="crowd" style="margin-top:50px;margin-bottom:0;text-align:center;font-weight:bold;color:#F78E41;line-height:36px;">Crowd backers <sup>(10/4/2018 - 10/9/2018)</sup></h4> |
<div id="sponsor4"> | <div id="sponsor4"> | ||
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/c/cf/T--Fudan--sponsor-6.png" style="margin-bottom:0" /> | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/c/cf/T--Fudan--sponsor-6.png" style="margin-bottom:0" alt="crowdfunding campaign 1" /> |
− | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/f/fa/T--Fudan--sponsor-7.png" style="margin-top:-20px" /> | + | <img class="responsive-img" src="https://static.igem.org/mediawiki/2018/f/fa/T--Fudan--sponsor-7.png" style="margin-top:-20px" alt="crowdfunding campaign 2" /> |
</div> | </div> | ||
</div> | </div> | ||
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<!--Abstract on content page--> | <!--Abstract on content page--> | ||
<div id="abstractContent" class="z-depth-2"> | <div id="abstractContent" class="z-depth-2"> | ||
− | <a href="#!"><img src="https://static.igem.org/mediawiki/2018/9/96/T--Fudan--X.svg"></a> | + | <a href="#!"><img alt="2018 team Fudan abstract" src="https://static.igem.org/mediawiki/2018/9/96/T--Fudan--X.svg"></a> |
<div class="container"> | <div class="container"> | ||
<h2 style="margin: 0;padding: 10px 0;">Abstract</h2> | <h2 style="margin: 0;padding: 10px 0;">Abstract</h2> | ||
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<i class="fa fa-sticky-note" style="font-size: 30px;line-height: 50px"></i> | <i class="fa fa-sticky-note" style="font-size: 30px;line-height: 50px"></i> | ||
</a> | </a> | ||
− | <a href="# | + | <a href="#FudanWrapper" class="btn"> |
<i class="fa fa-angle-up" style="font-size: 48px;line-height: 45px"></i> | <i class="fa fa-angle-up" style="font-size: 48px;line-height: 45px"></i> | ||
</a> | </a> | ||
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<div class="row"> | <div class="row"> | ||
<div id="sponsor" class="col m3 s12 row"> | <div id="sponsor" class="col m3 s12 row"> | ||
− | <a href="https://2018.igem.org/Team:Fudan" target="_blank"><img class="col | + | <a href="https://2018.igem.org/Team:Fudan" target="_blank"><img alt="2018 Team:Fudan logo white" class="col s3 m6 l3" style="position:relative; padding: 0 0.3rem; margin:-0.15rem 0; left: -0.45rem;" src="https://static.igem.org/mediawiki/2018/7/73/T--Fudan--teamLogoWhite.png"> |
− | </a><a href="http://www.fudan.edu.cn/en/" target="_blank"><img class="col | + | </a><a href="http://www.fudan.edu.cn/en/" target="_blank"><img class="col s3 m6 l3" alt="Fudan University" src="https://static.igem.org/mediawiki/2018/f/f7/T--Fudan--schoolLogo.png"> |
− | </a><a href="http://life.fudan.edu.cn/" target="_blank"><img class="col | + | </a><a href="http://life.fudan.edu.cn/" target="_blank"><img class="col s3 m6 l3" style="margin-bottom: 4%;/* 该图比其他小一点,排版需要 */" alt="School of Life Sciences, Fudan University" src="https://static.igem.org/mediawiki/2018/1/1d/T--Fudan--schoolOfLifeSciencesIcon.png"> |
− | </a><a href="http://www.yfc.cn/en/" target="_blank"><img class="col | + | </a><a href="http://www.yfc.cn/en/" target="_blank"><img class="col s3 m6 l3" style="padding: 0.15rem 0.9rem;" alt="Yunfeng Capital" src="https://static.igem.org/mediawiki/2018/e/e2/T--Fudan--yunfengLogo.png"> |
</a> | </a> | ||
<h3 class="col s12" style="text-align: left; color: rgba(255, 255, 255, 0.8); font-size: 18px">ENABLE: making cells even smarter</h3> | <h3 class="col s12" style="text-align: left; color: rgba(255, 255, 255, 0.8); font-size: 18px">ENABLE: making cells even smarter</h3> | ||
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<span>Project</span> | <span>Project</span> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Demonstrate">Demonstration</a></li> |
− | + | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Antigen_Receptors">Antigen, Receptors</a></li> |
+ | <li><a href="/Team:Fudan/Results">Transmembrane logic</a></li> | ||
<li><a href="https://2017.igem.org/Team:Fudan">2017.iGEM</a></li> | <li><a href="https://2017.igem.org/Team:Fudan">2017.iGEM</a></li> | ||
</ul> | </ul> | ||
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<span>Dry lab</span> | <span>Dry lab</span> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Addon#ribo">Addon: ribo</a></li> |
− | + | <li><a href="/Team:Fudan/Addon#TALE">Addon: TALE</a></li> | |
− | + | <li><a href="/Team:Fudan/Addon#T2">Addon: T2</a></li> | |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Model#NotchLigandKinetics">Model: Notch-ligand kinetics</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Software">Software</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
− | <div class="col s12 m4 | + | <div class="col s12 m4"> |
<span>Wet lab</span> | <span>Wet lab</span> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/InterLab">iGEM interLab</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Notebook">Our notebook</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Primers">Primers used</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Protocols">Protocols</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Safety">Safety</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<span>Toolbox</span> | <span>Toolbox</span> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Basic_Parts">Basic parts</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Composite_Parts">Composite parts</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Optimization">Optimization</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Parts_Collection">Parts collection</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Improve">Parts improvement</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Measurement">Quantification</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<span>Outreach</span> | <span>Outreach</span> | ||
<ul> | <ul> | ||
− | <li><a href=" | + | <li><a href="/Team:Fudan/Bio-Art">Bio-Art display</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Collaborations">Collaborations</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Design_Intention">Design intention</a></li> |
− | <li><a href=" | + | <li><a href="/Team:Fudan/Human_Practices">Human practices</a></li> |
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Latest revision as of 15:28, 7 November 2018
- Addon: ribo
- Addon: TALE
- Addon: T2
- Model: transcriptional amplifer
- Model: Notch-ligand kinetics
- Software
Sponsors
Our sponsors
Crowd backers (10/4/2018 - 10/9/2018)
Abstract
Contact-dependent signaling is critical for multicellular biological events, yet customizing contact-dependent signal transduction between cells remains challenging. Here we have developed the ENABLE toolbox, a complete set of transmembrane binary logic gates. Each gate consists of 3 layers: Receptor, Amplifier, and Combiner. We first optimized synthetic Notch receptors to enable cells to respond to different signals across the membrane reliably. These signals, individually amplified intracellularly by transcription, are further combined for computing. Our engineered zinc finger-based transcription factors perform binary computation and output designed products. In summary, we have combined spatially different signals in mammalian cells, and revealed new potentials for biological oscillators, tissue engineering, cancer treatments, bio-computing, etc. ENABLE is a toolbox for constructing contact-dependent signaling networks in mammals. The 3-layer design principle underlying ENABLE empowers any future development of transmembrane logic circuits, thus contributes a foundational advance to Synthetic Biology.