Difference between revisions of "Team:Cornell"

 
(43 intermediate revisions by 3 users not shown)
Line 14: Line 14:
 
         #content {
 
         #content {
 
             background: #0d1c38;
 
             background: #0d1c38;
−
             padding:0px;
+
             padding: 0px;
−
             width:100% !important;
+
             width: 100% !important;
−
             margin-top:-26px;
+
             margin-top: 0px;
−
             margin-left:0px ;
+
             margin-left: 0px ;
 
         }
 
         }
  
Line 23: Line 23:
 
         #HQ_page p {
 
         #HQ_page p {
 
             font-family: 'Opens Sans', sans-serif;
 
             font-family: 'Opens Sans', sans-serif;
−
            font-size: 14px;
 
−
            text-align: center;
 
 
         }
 
         }
  
Line 31: Line 29:
 
             margin: 0;
 
             margin: 0;
 
         }
 
         }
 +
 +
        /* removes bullets from Toolkit dropdown menu */
 +
        ul {
 +
            list-style-image: none;
 +
        }
 +
 
     </style>
 
     </style>
 
     <title>Team:Cornell - 2018.igem.org</title>
 
     <title>Team:Cornell - 2018.igem.org</title>
Line 37: Line 41:
 
     <link rel="stylesheet" type="text/css" href="https://2018.igem.org/Team:Cornell/grids?action=raw&ctype=text/css">
 
     <link rel="stylesheet" type="text/css" href="https://2018.igem.org/Team:Cornell/grids?action=raw&ctype=text/css">
 
     <!-- JS -->
 
     <!-- JS -->
−
     <script src="https://2018.igem.org/Team:Cornell/jquerymin?action=raw&ctype=text/javascript"></script></script>
+
     <script src="https://2018.igem.org/Team:Cornell/jquerymin?action=raw&ctype=text/javascript"></script>
−
     <script src="https://2018.igem.org/Team:Cornell/mainJS?action=raw&ctype=text/javascript"></script></script>
+
     <script src="https://2018.igem.org/Team:Cornell/mainJS?action=raw&ctype=text/javascript"></script>
 
</head>
 
</head>
 
<body>
 
<body>
Line 47: Line 51:
 
                 <div>
 
                 <div>
 
                     <div class="nav-bar-logo">
 
                     <div class="nav-bar-logo">
−
                         <a href="home"><img src="https://static.igem.org/mediawiki/2018/6/63/T--Cornell--OscillateLogo.jpg" alt="Oscillate"></a>
+
                         <a href="https://2018.igem.org/Team:Cornell"><img src="https://static.igem.org/mediawiki/2018/a/af/T--Cornell--OscillateLogo.png" alt="Oscillate"></a>
 
                     </div>
 
                     </div>
 
                     <div class="nav-bar-main-menu">
 
                     <div class="nav-bar-main-menu">
−
                        <div class="dropdown">
+
                    <div class="dropdown">
−
                            <button class="dropbtn">TEAM</button>
+
                        <button class="dropbtn">TEAM</button>
−
                            <div class="dropdown-content team-dropdown-content">
+
                        <div class="dropdown-content team-dropdown-content">
−
                                <a href="https://2018.igem.org/Team:Cornell/Team">BIOS</a>
+
                            <a href="https://2018.igem.org/Team:Cornell/Team">BIOS</a>
−
                                <a href="https://2018.igem.org/Team:Cornell/Sponsors">SPONSORS</a>
+
                            <a href="https://2018.igem.org/Team:Cornell/Sponsors">SPONSORS</a>
−
                                <a href="https://2018.igem.org/Team:Cornell/Attributions">ATTRIBUTIONS</a>
+
                            <a href="https://2018.igem.org/Team:Cornell/Attributions">ATTRIBUTIONS</a>
−
                            </div>
+
 
                         </div>
 
                         </div>
−
                        <div class="dropdown">
+
                    </div>
−
                            <button class="dropbtn">OUTREACH</button>
+
                    <div class="dropdown">
−
                            <div class="dropdown-content outreach-dropdown-content">
+
                        <button class="dropbtn">OUTREACH</button>
−
                                <a href="#">COLLABORATIONS</a>
+
                        <div class="dropdown-content outreach-dropdown-content">
−
                                <a href="#">PUBLIC ENGAGEMENT</a>
+
                            <a href="https://2018.igem.org/Team:Cornell/Collaborations">COLLABORATIONS</a>
−
                            </div>
+
                            <a href="https://2018.igem.org/Team:Cornell/Public_Engagement">PUBLIC ENGAGEMENT</a>
 
                         </div>
 
                         </div>
−
                        <div class="dropdown">
+
                    </div>
−
                            <button class="dropbtn">HUMAN-CENTERED DESIGN</button>
+
                    <div class="dropdown">
−
                            <div class="dropdown-content human-dropdown-content">
+
                        <button class="dropbtn">HUMAN-CENTERED DESIGN</button>
−
                                <a href="#">PRACTICES</a>
+
                        <div class="dropdown-content human-dropdown-content">
−
                                <a href="#">POLICIES</a>
+
                            <a href="https://2018.igem.org/Team:Cornell/Human_Practices">PRACTICES</a>
−
                                <a href="https://2018.igem.org/Team:Cornell/Entrepreneurship">ENTREPRENEURSHIP</a>
+
                            <a href="https://2018.igem.org/Team:Cornell/Policies">POLICIES</a>
−
                            </div>
+
                            <a href="https://2018.igem.org/Team:Cornell/Entrepreneurship">ENTREPRENEURSHIP</a>
 
                         </div>
 
                         </div>
−
                        <div class="dropdown">
+
                    </div>
−
                            <button class="dropbtn">MODELING</button>
+
                    <div class="dropdown">
−
                            <div class="dropdown-content modeling-dropdown-content">
+
                        <button class="dropbtn">MODELING</button>
−
                                <a href="https://2018.igem.org/Team:Cornell/Model">MODEL</a>
+
                        <div class="dropdown-content modeling-dropdown-content">
−
                                <a href="https://2018.igem.org/Team:Cornell/Software">SOFTWARE</a>
+
                            <a href="https://2018.igem.org/Team:Cornell/Model">MODELING</a>
−
                                <a href="https://2018.igem.org/Team:Cornell/Design">DESIGN</a>
+
                            <a href="https://2018.igem.org/Team:Cornell/Testing">TESTING</a>
−
                            </div>
+
 
                         </div>
 
                         </div>
−
                        <div class="dropdown">
+
                    </div>
−
                            <button class="dropbtn">TOOLKIT</button>
+
                    <div class="dropdown">
−
                            <div class="dropdown-content toolkit-dropdown-content">
+
                        <button class="dropbtn">TOOLKIT</button>
−
                                <ul>
+
                        <div class="dropdown-content toolkit-dropdown-content">
−
                                    <div class="nav-first-col">
+
                            <ul>
−
                                        <li class = "wet-lab-list-title"><b>WET LAB</b></li>
+
                                <div class="nav-first-col">
−
                                        <li><a href="https://2018.igem.org/Team:Cornell/Foundations">FOUNDATIONS</a></li>
+
                                    <li class = "wet-lab-list-title"><b>WET LAB</b></li>
−
                                        <li><a href="https://2018.igem.org/Team:Cornell/Demonstrate">DEMONSTRATE</a></li>
+
                                    <li><a href="https://2018.igem.org/Team:Cornell/Foundations">FOUNDATIONS</a></li>
−
                                        <li><a href="https://2018.igem.org/Team:Cornell/InterLab">INTERLAB</a></li>
+
                                    <li><a href="https://2018.igem.org/Team:Cornell/Demonstrate">DEMONSTRATE</a></li>
−
                                        <li><a href="hhttps://2018.igem.org/Team:Cornell/Parts">PARTS</a></li>
+
                                    <li><a href="https://2018.igem.org/Team:Cornell/InterLab">INTERLAB</a></li>
−
                                        </li>
+
                                    <li><a href="https://2018.igem.org/Team:Cornell/Parts">PARTS</a></li>
−
                                     </div>
+
                                     <li><a href="https://2018.igem.org/Team:Cornell/Basic_Part">BASIC PARTS</a></li>
−
 
+
                                    <li><a href="https://2018.igem.org/Team:Cornell/Composite_Part">COMPOSITE PARTS</a></li>
−
                                    <div class="nav-second-col">
+
                                    </li>
−
                                        <li class = "doc-list-title"><b>DOCUMENTATION</b></li>
+
                                </div>
−
                                        <li><a href="https://2018.igem.org/Team:Cornell/Notebook">NOTEBOOK</a></li>
+
                                 <div class="nav-second-col">
−
                                        <li><a href="https://2018.igem.org/Team:Cornell/Safety">SAFETY</a></li>
+
                                    <li class = "doc-list-title"><b>DOCUMENTATION</b></li>
−
                                        </li>
+
                                    <li><a href="https://2018.igem.org/Team:Cornell/Notebook">NOTEBOOK</a></li>
−
                                    </div>
+
                                    <li><a href="https://2018.igem.org/Team:Cornell/Safety">SAFETY</a></li>
−
                                 </ul>
+
                                    </li>
−
                            </div>
+
                                </div>
−
                        </div>
+
                            </ul>
−
                        <div class="dropdown">
+
−
                            <button class="dropbtn" onclick="location.href='https://2018.igem.org/Team:Cornell/Description '">ABOUT</button>
+
−
                        </div>
+
−
                        <div class="dropdown">
+
−
                            <button class="dropbtn active-page" onclick="location.href='https://2018.igem.org/Team:Cornell'">HOME</button>
+
 
                         </div>
 
                         </div>
 
                     </div>
 
                     </div>
 +
                    <div class="dropdown">
 +
                        <button class="dropbtn" onclick="location.href='https://2018.igem.org/Team:Cornell/About'">ABOUT</button>
 +
                    </div>
 +
                    <div class="dropdown">
 +
                        <button class="dropbtn active-page" onclick="location.href='https://2018.igem.org/Team:Cornell'">HOME</button>
 +
                    </div>
 +
                </div>
 
                 </div>
 
                 </div>
 
             </div>
 
             </div>
Line 190: Line 194:
 
             <div class="home-banner-wrapper">
 
             <div class="home-banner-wrapper">
 
                 <div class="home-banner-content-wrapper">
 
                 <div class="home-banner-content-wrapper">
−
                     <img class="home-banner-logo" src="https://static.igem.org/mediawiki/2018/6/63/T--Cornell--OscillateLogo.jpg">
+
                     <img class="home-banner-logo" src="https://static.igem.org/mediawiki/2018/a/af/T--Cornell--OscillateLogo.png">
−
                     <p class="home-banner-caption">Introducing novelty through a frequency-based biological band-pass filter.</p>
+
                     <div class="home-banner-caption">Introducing a novel frequency-based biological band-pass filter.</div>
 
                     <div class="home-banner-chevron-wrapper">
 
                     <div class="home-banner-chevron-wrapper">
 
                         <a id="chevron-button" href="#home-description"><img class="home-banner-chevron" src="https://static.igem.org/mediawiki/2018/d/d0/T--Cornell--RedChevron.jpg"></a>
 
                         <a id="chevron-button" href="#home-description"><img class="home-banner-chevron" src="https://static.igem.org/mediawiki/2018/d/d0/T--Cornell--RedChevron.jpg"></a>
Line 207: Line 211:
 
             <hr class="yellow-accent-line-center">
 
             <hr class="yellow-accent-line-center">
 
             <div class="home-description">
 
             <div class="home-description">
−
                 We are building a <span id="home-description-emphasis-words">biological band-pass filter</span>. While biological band pass filters have been developed before, none respond to frequency-based inputs but instead respond to amplitude based inputs.
+
                 At Cornell iGEM, we look to the future to build now what synthetic biology needs next. We developed our project with the synthetic biology community in mind, and built a tool that the field can use for years to come. Our project shifts the paradigm of cellular signaling to a frequency-based signal and is an innovative step in mimicking digital systems.  <br><br><div><span id="home-description-emphasis-words"><i>Come explore the future with us.</i></span></div>  
−
                By controlling the rates of degradation of the components of our system, we are putting together a <span id="home-description-emphasis-words">frequency-response</span> low-pass and high-pass filter to create a <span id="home-description-emphasis-words">novel</span>           band-pass filter.
+
−
                <br><br> Our filter would allow bacteria to respond only to certain frequency-based inputs, and give it even more <span id="home-description-emphasis-words">digital logic-like</span> character, long a goal of synthetic biology. Moving forward,
+
−
                our project could be an important tool for scientists as synthetic biology branches into increasingly diverse fields.
+
 
             </div>
 
             </div>
 
             <div class="home-red-frequency-wrapper">
 
             <div class="home-red-frequency-wrapper">
Line 223: Line 224:
 
                 <div class="home-sub-description-left-content">
 
                 <div class="home-sub-description-left-content">
 
                     <div class="sub-description-sub-heading-left">
 
                     <div class="sub-description-sub-heading-left">
−
                         Ideation.
+
                         Wet Lab
 
                     </div>
 
                     </div>
 
                     <hr class="yellow-accent-line-left-sub">
 
                     <hr class="yellow-accent-line-left-sub">
−
                     <p>We are building a <span id="home-description-emphasis-words">biological band-pass filter</span>. While biological band pass filters have been developed before, none respond to frequency-based inputs but instead respond to amplitude based inputs. By controlling the rates of degradation of the components of our system, we are putting together a <span id="home-description-emphasis-words">frequency-response</span> low-pass and high-pass filter to create a <span id="home-description-emphasis-words">novel</span> band-pass filter.</p>
+
                     <div>But how? We rely on sensory elements to allow cells to respond to frequency signals, while combining them with tunable protein degradation tags to control the kinetics of protein expression. This has allowed us to develop a tunable gene-expression system developed to respond to controlled and defined stimuli. This further acts as a template for development of systems responsive to various frequency input signals, from heat to light to sound.</div>
 
                 </div>
 
                 </div>
 
                 <div class="home-sub-description-right-image">
 
                 <div class="home-sub-description-right-image">
−
                 <img src="https://static.igem.org/mediawiki/2018/7/73/T--Cornell--Rahul.jpg">
+
                 <img src="https://static.igem.org/mediawiki/2018/5/56/T--Cornell--SnehaInLab.jpg">
 
                 </div>
 
                 </div>
 
             </div>
 
             </div>
Line 235: Line 236:
 
                 <div class="home-sub-description-right-content">
 
                 <div class="home-sub-description-right-content">
 
                 <div class="sub-description-sub-heading-right">
 
                 <div class="sub-description-sub-heading-right">
−
                     Ideation.
+
                     Modeling
 
                 </div>
 
                 </div>
 
                 <hr class="yellow-accent-line-right-sub">
 
                 <hr class="yellow-accent-line-right-sub">
−
                 <p>We are building a <span id="home-description-emphasis-words">biological band-pass filter</span>. While biological band pass filters have been developed before, none respond to frequency-based inputs but instead respond to amplitude based inputs. By controlling the rates of degradation of the components of our system, we are putting together a <span id="home-description-emphasis-words">frequency-response</span> low-pass and high-pass filter to create a <span id="home-description-emphasis-words">novel</span> band-pass filter.</p>
+
                 <div>Innovative modeling serves as a critical component of our toolkit and as a modular tool that other teams can use in the future. We developed advanced deterministic and stochastic models using a unique proof-based approach. Further, we were able to draw from Degree Theory in mathematics to construct formal proofs regarding the nature of our dynamical system independent of specific parameter values to create a robust modeling framework.</div>
 
                 </div>
 
                 </div>
 
                 <div class="home-sub-description-left-image">
 
                 <div class="home-sub-description-left-image">
−
                 <img src="https://static.igem.org/mediawiki/2018/7/73/T--Cornell--Rahul.jpg">
+
                 <img src="https://static.igem.org/mediawiki/2018/f/f6/T--Cornell--modelingIcon.jpg">
 
                 </div>
 
                 </div>
 
             </div>
 
             </div>
Line 248: Line 249:
 
                 <div class="home-sub-description-left-content">
 
                 <div class="home-sub-description-left-content">
 
                     <div class="sub-description-sub-heading-left">
 
                     <div class="sub-description-sub-heading-left">
−
                         Ideation.
+
                         Human Practices
 
                     </div>
 
                     </div>
 
                     <hr class="yellow-accent-line-left-sub">
 
                     <hr class="yellow-accent-line-left-sub">
−
                     <p>We are building a <span id="home-description-emphasis-words">biological band-pass filter</span>. While biological band pass filters have been developed before, none respond to frequency-based inputs but instead respond to amplitude based inputs. By controlling the rates of degradation of the components of our system, we are putting together a <span id="home-description-emphasis-words">frequency-response</span> low-pass and high-pass filter to create a <span id="home-description-emphasis-words">novel</span> band-pass filter.</p>
+
                     <div>As a team, we always try to keep in mind the impact of our projects as well as the considerations we make in their design. We spoke with other iGEM teams and synthetic biologists to learn more about how to design our system, and where it could go in the future. We further integrated ourselves in the local and national communities, leading workshops and teaching local students about the growing field of synthetic biology and the exciting possibilities it can have!</div>
 
                 </div>
 
                 </div>
 
                 <div class="home-sub-description-right-image">
 
                 <div class="home-sub-description-right-image">
−
                 <img src="https://static.igem.org/mediawiki/2018/7/73/T--Cornell--Rahul.jpg">
+
                 <img src="https://static.igem.org/mediawiki/2018/b/ba/T--Cornell--humanPracticesIcon.JPG">
−
                </div>
+
−
            </div>
+
−
            <div class="home-sub-description-right2">
+
−
                <div class="home-sub-description-right-content">
+
−
                <div class="sub-description-sub-heading-right">
+
−
                    Ideation.
+
−
                </div>
+
−
                <hr class="yellow-accent-line-right-sub">
+
−
                <p>We are building a <span id="home-description-emphasis-words">biological band-pass filter</span>. While biological band pass filters have been developed before, none respond to frequency-based inputs but instead respond to amplitude based inputs. By controlling the rates of degradation of the components of our system, we are putting together a <span id="home-description-emphasis-words">frequency-response</span> low-pass and high-pass filter to create a <span id="home-description-emphasis-words">novel</span> band-pass filter.</p>
+
−
                </div>
+
−
                <div class="home-sub-description-left-image">
+
−
                <img src="https://static.igem.org/mediawiki/2018/7/73/T--Cornell--Rahul.jpg">
+
 
                 </div>
 
                 </div>
 
             </div>
 
             </div>
Line 276: Line 265:
 
             <div class="footer-wrapper">
 
             <div class="footer-wrapper">
 
                 <div class="icon-wrapper">
 
                 <div class="icon-wrapper">
−
                     <a class="icon" href=""><img src="https://static.igem.org/mediawiki/2018/3/30/T--Cornell--Facebook.jpg"></a>
+
                     <a class="icon" href="http://facebook.com/cornelligem"><img src="https://static.igem.org/mediawiki/2018/3/30/T--Cornell--Facebook.jpg"></a>
 
                 </div>
 
                 </div>
 
                 <div class="icon-wrapper">
 
                 <div class="icon-wrapper">
−
                     <a class="icon" href=""><img src="https://static.igem.org/mediawiki/2018/0/02/T--Cornell--Twitter.jpg"></a>
+
                     <a class="icon" href="http://twitter.com/cugem"><img src="https://static.igem.org/mediawiki/2018/0/02/T--Cornell--Twitter.jpg"></a>
 
                 </div>
 
                 </div>
 
                 <div class="icon-wrapper">
 
                 <div class="icon-wrapper">
−
                     <a class="icon" href=""><img src="https://static.igem.org/mediawiki/2018/a/ae/T--Cornell--Instagram.jpg"></a>
+
                     <a class="icon" href="https://www.instagram.com/cugem/"><img src="https://static.igem.org/mediawiki/2018/a/ae/T--Cornell--Instagram.jpg"></a>
 
                 </div>
 
                 </div>
 
                 <div class="icon-wrapper icon-wrapper-last">
 
                 <div class="icon-wrapper icon-wrapper-last">
−
                     <a class="icon" href=""><img src="https://static.igem.org/mediawiki/2018/7/77/T--Cornell--Youtube.jpg"></a>
+
                     <a class="icon" href="https://www.youtube.com/channel/UCJt-5JfyoucUJXC1EsTllhg"><img src="https://static.igem.org/mediawiki/2018/7/77/T--Cornell--Youtube.jpg"></a>
 
                 </div>
 
                 </div>
 
             </div>
 
             </div>

Latest revision as of 19:40, 21 November 2018

Team:Cornell - 2018.igem.org

Introducing a novel frequency-based biological band-pass filter.
At Cornell iGEM, we look to the future to build now what synthetic biology needs next. We developed our project with the synthetic biology community in mind, and built a tool that the field can use for years to come. Our project shifts the paradigm of cellular signaling to a frequency-based signal and is an innovative step in mimicking digital systems.

Come explore the future with us.
Wet Lab
But how? We rely on sensory elements to allow cells to respond to frequency signals, while combining them with tunable protein degradation tags to control the kinetics of protein expression. This has allowed us to develop a tunable gene-expression system developed to respond to controlled and defined stimuli. This further acts as a template for development of systems responsive to various frequency input signals, from heat to light to sound.
Modeling
Innovative modeling serves as a critical component of our toolkit and as a modular tool that other teams can use in the future. We developed advanced deterministic and stochastic models using a unique proof-based approach. Further, we were able to draw from Degree Theory in mathematics to construct formal proofs regarding the nature of our dynamical system independent of specific parameter values to create a robust modeling framework.
Human Practices
As a team, we always try to keep in mind the impact of our projects as well as the considerations we make in their design. We spoke with other iGEM teams and synthetic biologists to learn more about how to design our system, and where it could go in the future. We further integrated ourselves in the local and national communities, leading workshops and teaching local students about the growing field of synthetic biology and the exciting possibilities it can have!