Difference between revisions of "Team:Fudan-CHINA"

 
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{{Fudan-CHINA}}
 
{{Fudan-CHINA}}
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<html>
 
<html>
−
<head>
+
 
−
<meta charset="utf-8">
+
 
−
<style type="text/css">
+
−
.step{font-family:Algerian;
+
−
  font-size: 11em;
+
<!--page-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------->
−
  color: white;
+
<div id="signageDiv">
−
  left: 800px;  
+
<video id="bgVideo" autoplay muted loop>
−
  position: absolute;  
+
    <source  src="https://static.igem.org/mediawiki/2018/f/fd/T--Fudan-CHINA--bgVideo.mp4">
−
  top: 330px;
+
</video>
−
+
 +
<div id="stepDiv">
 +
<span id="stepName">S T E P</span>
 +
<div style="height: 5vh;"></div>
 +
<span id="fullName">Synthetic Transducer Engineering Platform</span>
 +
</div>
 +
<div class="discoverBotton"><a href="#" class="animated-button victoria-one">DISCOVER NOW</a></div>
 +
</div>
 +
 +
<style>
 +
#signageDiv{
 +
position: relative;
 +
top:0;
 +
}
 +
.discoverBotton{
 +
font-family:Constantia, "Lucida Bright", "DejaVu Serif", Georgia, "serif";
 +
position: absolute;
 +
top:70vh;
 +
left: 50%;
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transform: translateX(-50%);
 +
-moz-transform: translateX(-50%);
 +
-ms-transform: translateX(-50%);
 +
-webkit-transform: translateX(-50%);
 +
}
 +
a.animated-button.victoria-one:after {
 +
background: #fff;
 +
-moz-transform: translateX(-50%) translateY(-50%) rotate(-25deg);
 +
-ms-transform: translateX(-50%) translateY(-50%) rotate(-25deg);
 +
-webkit-transform: translateX(-50%) translateY(-50%) rotate(-25deg);
 +
transform: translateX(-50%) translateY(-50%) rotate(-25deg);
 +
}
 +
a.animated-button:link, a.animated-button:visited {
 +
position: relative;
 +
display: block;
 +
margin: 0 auto 0;
 +
padding: 1vw 1.5vw;
 +
color: #fff;
 +
font-size:1.15vw;
 +
font-weight: 900;
 +
text-align: center;
 +
text-decoration: none;
 +
letter-spacing: 0.1vw;
 +
border-radius:1.5vw;
 +
overflow: hidden;
 +
border: 0.1vw solid #fff;
 +
-webkit-transition: all 0.75s ease;
 +
-moz-transition: all 0.75s ease;
 +
-o-transition: all 0.75s ease;
 +
transition: all 0.75s ease;
 +
}
 +
a.animated-button:link:after, a.animated-button:visited:after {
 +
content: "";
 +
position: absolute;
 +
height: 0%;
 +
left: 50%;
 +
top: 50%;
 +
width: 25vw;
 +
z-index: -1;
 +
-webkit-transition: all 0.75s ease 0s;
 +
-moz-transition: all 0.75s ease 0s;
 +
-o-transition: all 0.75s ease 0s;
 +
transition: all 0.75s ease 0s;
 +
}
 +
a.animated-button:link:hover, a.animated-button:visited:hover {
 +
color: rgba(2,17,35,1);
 +
border: 0.1vw solid transparent;
 +
}
 +
a.animated-button:link:hover:after, a.animated-button:visited:hover:after {
 +
height: 20vw;
 +
}
 +
</style>
 +
<script>
 +
$(document).ready(function() {
 +
$("a.animated-button").on('click',function() {
 +
var navHeight=$("#navUl").height();
 +
var barHeight=$("#top_menu_14").height();
 +
var winHeight=$(window).height();
 +
var totalScroll=winHeight-barHeight-navHeight;
 +
$('body,html').animate({"scrollTop":totalScroll+2},1500);
 +
});
 +
});
 +
</script>
 +
<style>
 +
#signageDiv{
 +
width: 100%;
 +
overflow: hidden;
 
}
 
}
−
.abstract{
+
#bgVideo{
−
font-family:Baskerville, "Palatino Linotype", Palatino, "Century Schoolbook L", "Times New Roman", "serif";
+
position: relative;
−
color: white;
+
}
−
font-size: 1.8em;
+
#stepDiv{
 
position: absolute;
 
position: absolute;
−
width: 1400px;
+
text-align: center;
−
left: 250px;
+
width: 100%;
−
top: 580px;
+
top: 50vh;
−
line-height:25px;
+
-webkit-transform: translateX(0) translateY(-50%);
−
text-align: justify;/*两端对齐*/
+
-moz-transform: translateX(0) translateY(-50%);
−
font-weight: 600;/*粗度*/
+
-ms-transform: translateX(0) translateY(-50%);
 +
transform: translateX(0) translateY(-50%);
 +
}
 +
#stepName{
 +
color: white;
 +
font-family: Algerian,_Algerian;
 +
line-height: 10vh;
 +
height: 10vh;
 
}
 
}
−
.fullname{
+
#fullName{
−
font-family:Cambria, "Hoefler Text", "Liberation Serif", Times, "Times New Roman", "serif";
+
 
color: white;
 
color: white;
−
    font-size: 2em;
+
font-family:"Lucida Calligraphy",_LucidaCalligraphy;
−
position: absolute;
+
}
−
left:800px;
+
</style>
−
top:430px;
+
 +
<script>
 +
function signageDivFun(){
 +
var videoWidth=1920;
 +
var videoHeight=1080;
 +
var winWidth=$(window).width();
 +
var winHeight=$(window).height();
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$("#signageDiv").css("height",winHeight);
 +
if (winWidth*videoHeight>winHeight*videoWidth ){
 +
$("#bgVideo").css("width",winWidth);
 +
$("#bgVideo").css("top",0.5*(winHeight-videoHeight*winWidth/videoWidth));
 +
$("#bgVideo").css("Height",videoHeight*winWidth/videoWidth);
 +
$("#bgVideo").css("left",0);
 +
}
 +
else{
 +
$("#bgVideo").css("Height",winHeight);
 +
$("#bgVideo").css("left",0.5*(winWidth-videoWidth*winHeight/videoHeight));
 +
$("#bgVideo").css("width",videoWidth*winHeight/videoHeight);
 +
$("#bgVideo").css("top",0);
 +
}
 
 
 +
if (winWidth/winHeight>21/8.5){
 +
$("#stepName").css("font-size","21vh");
 +
}
 +
else{
 +
$("#stepName").css("font-size","8.5vw");
 +
}
 +
if (winWidth/winHeight>5/2.2){
 +
$("#fullName").css("font-size","5vh");
 +
}
 +
else{
 +
$("#fullName").css("font-size","2.2vw");
 +
}
 
}
 
}
−
body{  
+
signageDivFun();
−
background-image:url("https://static.igem.org/mediawiki/2018/9/92/T--Fudan-CHINA--bgpicture1.jpeg");
+
$(window).resize(function(){
−
        background-repeat:no-repeat;
+
signageDivFun();
−
background-position:center top;
+
});
 +
 
 +
</script>
 +
 +
<div class="trade-title">
 +
                <div class="theDivTitle learnMore">A BRIEF INTRODUCTION TO STEP</div>
 +
            </div>
 +
 
 +
<div id="abstract">
 +
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.
 +
<br><br>
 +
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
 +
<br><br>
 +
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
 +
 
 +
</div>
 +
 +
<div class="videoOutDiv">
 +
<div class="videoDiv" data-paralasic="0.45">
 +
</div>
 +
<div class="videoTitle">Watch Project Video</div>
 +
<div class="videoCont">Begin the exploration of our STEP system</div>
 +
<div class="videoPlayI"><i class="fa fa-play"></i></div>
 +
</div>
 +
<div class="teamVideo">
 +
<video id="example_video_1" controls controlsList="nodownload" preload="auto">
 +
    <source src="https://static.igem.org/mediawiki/2018/5/54/T--Fudan-CHINA--pjVideo.mp4" type="video/mp4" />
 +
</video>
 +
<div class="closeVideo">
 +
<i class="fa fa-close"></i>
 +
</div>
 +
</div>
 +
 
 +
<style>
 +
video::-webkit-media-controls-panel{
 +
background: rgba(35,35,35,0.8);
 +
 +
}
 +
video::-webkit-media-controls-play-button,video::-webkit-media-controls-mute-button,video::-webkit-media-controls-fullscreen-button{
 +
filter: brightness(2);
 +
}
 +
video::-webkit-media-controls-current-time-display{
 +
color: rgba(255,255,255,0.6);
 +
}
 +
video::-webkit-media-controls-time-remaining-display{
 +
color: rgba(255,255,255,0.6);
 +
}
 +
#example_video_1{
 +
display: inline-block;
 +
position: relative;
 +
top:50%;
 +
transform: translateY(-50%);
 +
}
 +
.teamVideo{
 +
position: fixed;
 +
width: 100%;
 +
height: 100%;
 +
background-color: rgba(0,0,0,1);
 +
top: 0;
 +
left: 0;
 +
z-index: 900;
 +
text-align: center;
 +
display: none;
 +
}
 +
.videoDiv{
 +
width:100%;
 +
height:28vw;
 +
background-image: url('https://static.igem.org/mediawiki/2018/c/ce/T--Fudan-CHINA--pjbgImg.jpg');
 +
background-position: center top;
 +
background-repeat: no-repeat;
 +
background-size: 100%;
 +
text-align: center;
 +
filter: brightness(0.5);
 +
}
 +
.videoTitle{
 +
color: white;
 +
font-size:3vw;
 +
font-family: Cambria, "Hoefler Text", "Liberation Serif", Times, "Times New Roman", "serif";
 +
text-align:center;
 +
position: relative;
 +
top:-19vw;
 +
font-weight: 900;
 +
}
 +
.videoCont{
 +
color: white;
 +
font-size:1.2vw;
 +
font-family:;
 +
text-align:center;
 +
position: relative;
 +
top:-17vw;
 +
font-weight: 100;
 +
}
 +
.videoOutDiv{
 +
position: relative;
 +
text-align: center;
 +
margin: 3vw 0 -5vw 0;
 +
}
 +
.videoPlayI{
 +
position: relative;
 +
top:-13vw;
 +
}
 +
.videoPlayI i{
 +
font-size:2.7vw;
 +
color: white;
 +
border: 2px solid white;
 +
width: 3vw;
 +
height: 3vw;
 +
padding: 1.3vw 0.9vw 0.9vw 1.3vw;
 +
border-radius: 50%;
 +
cursor: pointer;
 +
}
 +
 +
.closeVideo{
 +
position: fixed;
 +
top:2vw;
 +
right: 2vw;
 +
color:rgba(211,211,211,0.8);
 +
font-size: 2.5vw;
 +
cursor: pointer;
 +
transition: all 0.3s ease;
 +
}
 +
.closeVideo:hover{
 +
color: rgba(211,211,211,1);
 
}
 
}
 
</style>
 
</style>
−
</head>
+
<script>
 +
$(".videoPlayI i").mouseenter(function(){
 +
$(this).stop().animate({"color":"rgba(135,206,250)","borderColor":"rgba(135,206,250)"},200);
 +
})
 +
$(".videoPlayI i").mouseleave(function(){
 +
$(this).stop().animate({"color":"white","borderColor":"white"},200);
 +
})
 +
 
 +
videoSizeAdj();
 +
$(window).resize(function(){
 +
videoSizeAdj();
 +
});
 
 
 +
function videoSizeAdj(){
 +
var winHeight=$(window).height();
 +
var winWidth=$(window).width();
 +
if (winWidth/winHeight>16/9){
 +
$("#example_video_1").width(winHeight/9*16);
 +
$("#example_video_1").height(winHeight);
 +
}
 +
else{
 +
$("#example_video_1").width(winWidth);
 +
$("#example_video_1").height(winWidth/16*9);
 +
}
 +
}
 +
$(".videoPlayI").click(function(){
 +
$(".teamVideo").fadeIn();
 +
$("#top_menu_14").fadeOut();
 +
$("#example_video_1")[0].play();
 +
})
 +
$(".closeVideo").click(function(){
 +
$("#top_menu_14").fadeIn();
 +
$(".teamVideo").fadeOut();
 +
$("#example_video_1")[0].pause();
 +
});
 +
 +
 +
$(window).scroll(function() {
 +
var scrollTop = $(window).scrollTop();
 +
var videoDivTop=$(".videoDiv").offset().top;
 +
var winHeight=$(window).height();
 +
var videoDivValue = $('.videoDiv').attr('data-paralasic');
 +
if (scrollTop+winHeight-videoDivTop>0){
 +
$('.videoDiv').css('background-position', 'center top -' + (scrollTop+winHeight-videoDivTop)*videoDivValue + 'px');
 +
}
 +
});
 +
</script>
 +
 +
 +
 +
<style>
 +
#abstract{
 +
font-size:23px;
 +
text-align:justify;
 +
line-height:35px;
 +
margin-left:10%;
 +
margin-right:10%;
 +
margin-top:3%;
 +
margin-bottom:5%;
 +
font-family:"Gill Sans", "Gill Sans MT", "Myriad Pro", "DejaVu Sans Condensed", Helvetica, Arial, "sans-serif";
 +
}
 +
</style>
 +
 +
<div class="moreInfoma">
 +
<div class="trade-content" style="overflow: hidden;">
 +
            <div class="trade-title">
 +
                <div class="theDivTitle learnMore">LEARN MORE</div>
 +
            </div>
 +
            <div class="trade-black">
 +
                <div class="trade-box">
 +
                    <div class="trade-box-list">
 +
                        <div class="trade-box-item itemProject">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Design">
 +
                                <div class="item-logo">
 +
                                    <i class="fa fa-cogs"></i>
 +
                                </div>
 +
                                <div class="item-title">Project</div>
 +
                                <div class="item-text">
 +
                                    Background<br>Design<br>Applied Design
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
                        <div class="trade-box-item itemResults">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Results">
 +
                                <div class="item-logo">
 +
                                  <i class="fa fa-flask"></i>
 +
                                </div>
 +
                                <div class="item-title">
 +
                                        Results
 +
                          </div>
 +
                                <div class="item-text">
 +
                                    Overview<br>STEP System Test<br>Receptor Optimisation<br>Demonstrate<br>Interlab
 +
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
<div class="trade-box-item itemModel">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Model">
 +
                                <div class="item-logo">
 +
                                    <i class="fa fa-area-chart"></i>
 +
                                </div>
 +
                                <div class="item-title">Model</div>
 +
                                <div class="item-text">
 +
                                    Model<br>Software
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
                        <div class="trade-box-item itemParts">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Part_List">
 +
                                <div class="item-logo">
 +
                                    <i class="fa fa-puzzle-piece"></i>
 +
                                </div>
 +
                                <div class="item-title">
 +
                                            Parts                    </div>
 +
                                <div class="item-text">
 +
                                    Improved Part<br>Best New Basic Part<br>Best New Composite Part<br>Best Part Collection<br>Part List
 +
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
                    </div>
 +
                </div>
 +
            </div>
 +
</div>
 +
<div class="trade-content" style="overflow: hidden;">
 +
            <div class="trade-black">
 +
                <div class="trade-box">
 +
                    <div class="trade-box-list">
 +
                      <div class="trade-box-item itemHP">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Human_Practices">
 +
                                <div class="item-logo">
 +
                                  <i class="fa fa-h-square"></i>
 +
                                </div>
 +
                                <div class="item-title">Human Practice</div>
 +
                                <div class="item-text">
 +
                                    Overview<br>Silver HP<br>Integrated HP<br>Education &amp; Engagement<br>Collaborations<br>Safety
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
                        <div class="trade-box-item itemNotebook">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Notebook">
 +
                                <div class="item-logo">
 +
                                    <i class="fa fa-book"></i>
 +
                                </div>
 +
                                <div class="item-title">Notebook</div>
 +
                                <div class="item-text">
 +
                                    Notebook
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
                        <div class="trade-box-item itemTeam">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Team">
 +
                                <div class="item-logo">
 +
                                  <i class="fa fa-users"></i>
 +
                                </div>
 +
                                <div class="item-title">Team</div>
 +
                                <div class="item-text">
 +
                                    Team<br>Attributions
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
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Cell therapy has shown great potential in cancer treatment these years, while the existing CAR-T cell therapy can only target on cell surface antigens. However, there are also many tumour markers free in the blood, also being important targets marking the location of tumour. <br><br>
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Here we manage to construct a brand new transducer system, named STEP, to recognise small, soluble tumour markers (e.g. VEGF, AFP, TSGF). For that purpose, we adapt and optimise a newly developed system to transduce the input (free ligands) into release of a transcription factor and expression of desired drugs. To increase the recognition ability, we use Rosetta to redesign the interface between ligand and receptor in order to enhance the binding affinity.<br><br>  
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Our STEP system can be applied for detecting tumour markers in blood and secrete drug in real time to appropriate tissues, providing a new yet practical approach for cell therapy and cancer treatment.<br><br>
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Synthetic Transducer Engineering Platform
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{{Fudan-CHINA/ContactUs}}

Latest revision as of 07:13, 30 November 2018

S T E P
Synthetic Transducer Engineering Platform
DISCOVER NOW
A BRIEF INTRODUCTION TO STEP
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.

We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.

By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
Watch Project Video
Begin the exploration of our STEP system
LEARN MORE
Project
Background
Design
Applied Design
Results
Overview
STEP System Test
Receptor Optimisation
Demonstrate
Interlab
Model
Model
Software
Parts
Improved Part
Best New Basic Part
Best New Composite Part
Best Part Collection
Part List
Human Practice
Overview
Silver HP
Integrated HP
Education & Engagement
Collaborations
Safety
Notebook
Notebook
Team
Team
Attributions
Awards
Awards

  Address


G604, School of Life Sciences, Fudan University
2005 Songhu Road, Yangpu, Shanghai, China