Difference between revisions of "Team:Fudan-CHINA"

 
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<html>
 
<html>
  
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<div class="column full_size" >
 
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<h1>STEP</h1>
 
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<p>Fudan-CHINA</p>
 
  
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<span id="stepName">S T E P</span>
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<div style="height: 5vh;"></div>
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<span id="fullName">Synthetic Transducer Engineering Platform</span>
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</div>
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<div class="discoverBotton"><a href="#" class="animated-button victoria-one">DISCOVER NOW</a></div>
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<h3>Description</h3>
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</script>
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<div class="trade-title">
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                <div class="theDivTitle learnMore">A BRIEF INTRODUCTION TO STEP</div>  
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            </div>
  
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Synthetic Transducer Engineering Platform (STEP)
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<div id="abstract">
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Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.
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<br><br>
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We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
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<br><br>
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By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
  
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As the primary cause of death, cancer has long been threatening life of human. Modular receptor systems have become a hotspot of cancer therapy, while existing synthetic systems (CAR-T, synNotch, etc) are only capable of recognising membrane protein rather than soluble ligands, which are also important targets. To address this problem, we designed Synthetic Transducer Engineering Platform (STEP), which is aimed to convert extracellular stimulation of soluble ligands into a reporter gene signal. STEP consists of two separate transmembrane chains, one with an intracellular domain of a transcription factor and the other with a protease. Binding of ligands and the two chains will lead to a cleavage event and release the transcription factor, thus triggering desired gene expression, e.g., secretion of drugs. With its extra- and intra-cellular domain being highly programmable, STEP provides a general yet orthogonal platform of ligand recognition, and a new approach of targeting therapy of cancer.  
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</div>
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<div class="videoOutDiv">
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<div class="videoDiv" data-paralasic="0.45">
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</div>
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<div class="videoTitle">Watch Project Video</div>
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<div class="videoCont">Begin the exploration of our STEP system</div>
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<div class="videoPlayI"><i class="fa fa-play"></i></div>
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<div class="teamVideo">
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</video>
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<i class="fa fa-close"></i>
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</div>
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</div>
  
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[[File:T--Fudan-CHINA--Lab01.jpg]]
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<html>
 
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</div>
 
  
  
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<style>
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#abstract{
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font-size:23px;
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text-align:justify;
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<div class="column full_size" >
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<div class="moreInfoma">
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<div class="trade-content" style="overflow: hidden;">
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            <div class="trade-title">
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                <div class="theDivTitle learnMore">LEARN MORE</div>
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            </div>
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            <div class="trade-black">
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                <div class="trade-box">
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                    <div class="trade-box-list">
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                        <div class="trade-box-item itemProject">
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                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Design">
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                                <div class="item-logo">
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                                    <i class="fa fa-cogs"></i>
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                                </div>
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                                <div class="item-title">Project</div>
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                                <div class="item-text">
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                                    Background<br>Design<br>Applied Design
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                                </div>
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                            </a>
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                        </div>
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                        <div class="trade-box-item itemResults">
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                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Results">
 +
                                <div class="item-logo">
 +
                                  <i class="fa fa-flask"></i>
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                                </div>
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                                <div class="item-title">
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                                        Results
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                          </div>
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                                <div class="item-text">
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                                    Overview<br>STEP System Test<br>Receptor Optimisation<br>Demonstrate<br>Interlab
  
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<h3>Before you start</h3>
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                                </div>
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<p> Please read the following pages:</p>
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                            </a>
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<ul>
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                        </div>
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<li> <a href="https://2018.igem.org/Competition">Competition Hub</a> </li>
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<div class="trade-box-item itemModel">
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<li> <a href="https://2018.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Model">
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<li> <a href="https://2018.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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                                <div class="item-logo">
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</ul>
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                                    <i class="fa fa-area-chart"></i>
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</div>
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                                </div>
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                                <div class="item-title">Model</div>
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                                <div class="item-text">
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<div class="clear extra_space"></div>
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                                    Model<br>Software
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<div class="line_divider"></div>
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                                </div>
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<div class="clear extra_space"></div>
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                            </a>
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                        </div>
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                        <div class="trade-box-item itemParts">
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                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Part_List">
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<div class="column full_size" >
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                                <div class="item-logo">
−
<h3> Styling your wiki </h3>
+
                                    <i class="fa fa-puzzle-piece"></i>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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                                </div>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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                                <div class="item-title">
 +
                                            Parts                    </div>
 +
                                <div class="item-text">
 +
                                    Improved Part<br>Best New Basic Part<br>Best New Composite Part<br>Best Part Collection<br>Part List
  
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                                </div>
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                            </a>
 +
                        </div>
 +
                    </div>
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                </div>
 +
            </div>
 
</div>
 
</div>
 +
<div class="trade-content" style="overflow: hidden;">
 +
            <div class="trade-black">
 +
                <div class="trade-box">
 +
                    <div class="trade-box-list">
 +
                      <div class="trade-box-item itemHP">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Human_Practices">
 +
                                <div class="item-logo">
 +
                                  <i class="fa fa-h-square"></i>
 +
                                </div>
 +
                                <div class="item-title">Human Practice</div>
 +
                                <div class="item-text">
 +
                                    Overview<br>Silver HP<br>Integrated HP<br>Education &amp; Engagement<br>Collaborations<br>Safety
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                                </div>
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                            </a>
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                        </div>
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                        <div class="trade-box-item itemNotebook">
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                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Notebook">
 +
                                <div class="item-logo">
 +
                                    <i class="fa fa-book"></i>
 +
                                </div>
 +
                                <div class="item-title">Notebook</div>
 +
                                <div class="item-text">
 +
                                    Notebook
 +
                                </div>
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                            </a>
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                        </div>
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                        <div class="trade-box-item itemTeam">
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                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Team">
 +
                                <div class="item-logo">
 +
                                  <i class="fa fa-users"></i>
 +
                                </div>
 +
                                <div class="item-title">Team</div>
 +
                                <div class="item-text">
 +
                                    Team<br>Attributions
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
                        <div class="trade-box-item itemAwards">
 +
                            <a href="https://2018.igem.org/Team:Fudan-CHINA/Awards">
 +
                                <div class="item-logo">
 +
                                    <i class="fa fa-lightbulb-o"></i>
 +
                                </div>
 +
                                <div class="item-title">Awards</div>
 +
                                <div class="item-text">
 +
                                    Awards
 +
                                </div>
 +
                            </a>
 +
                        </div>
 +
                    </div>
 +
                </div>
 +
            </div>
 +
        </div>
 +
      </div>
  
 +
<style>
 +
.theDivTitle{
 +
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 +
font-family: "Verlag Book",Arial,Helvetica;
 +
font-weight: 400;
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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−
<div class="clear extra_space"></div>
+
.trade-box-item a {
 +
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 +
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 +
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 +
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 +
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 +
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 +
    top: 0;
 +
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 +
.trade-box {
 +
    width: 85% !important;
 +
    margin: 0 auto;
 +
    position: relative;
 +
    transition: all .3s ease;
 +
}
  
−
<div class="column third_size" >
+
.trade-box-list {
 +
    display: flex;
 +
    flex-direction: row;
 +
    justify-content: center;
 +
    align-items: center;
 +
}
  
−
<h3> Uploading pictures and files </h3>
+
.trade-box-item {
−
<p> You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. </p>
+
    flex: 1;
 +
    text-align: center;
 +
    position: relative;
 +
    height: 26vw;
 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
    background-color: rgba(0,0,0,.6);
 +
    transition: all .4s cubic-bezier(.4, 0, .2, 1);
 +
}
  
−
<p>When you upload, set the "Destination Filename" to <b> T--YourOfficialTeamName--NameOfFile.jpg</b>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
+
.item-logo {
 +
    margin: 0 auto;
 +
    display: block;
 +
}
  
−
<div class="button_link">
+
.trade-content .trade-box-item .item-logo {
−
<a href="https://2018.igem.org/Special:Upload">
+
    position: relative;
−
UPLOAD FILES
+
    margin-top: 8vw;
−
</a>
+
    transition: all .4s cubic-bezier(.4, 0, .2, 1);
−
</div>
+
}
  
−
</div>
+
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 +
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 +
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 +
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 +
color: white;
 +
font-size: 3.5vw;
 +
}
  
−
<div class="column third_size" >
+
.item-title {
−
<h3> Wiki template information </h3>
+
    font-size: 1.8vw;
−
<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
+
    font-weight:700;
 +
    color: #fff;
 +
    padding: 0.7vw 0;
 +
    position: relative;
 +
font-family:"Gill Sans", "Gill Sans MT", "Myriad Pro", "DejaVu Sans Condensed", Helvetica, Arial, "sans-serif";
 +
}
  
−
</div>
+
.trade-content .item-title:before {
 +
    content: "";
 +
    position: relative;
 +
    display: block;
 +
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 +
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 +
    margin: 0 auto 2vw;
 +
    transition: all .4s cubic-bezier(.4, 0, .2, 1);
 +
}
  
 +
.item-text {
 +
    position: relative;
 +
    transition: all .4s cubic-bezier(.4, 0, .2, 1);
 +
    opacity: 0;
 +
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 +
color: #fff;
 +
    font-size: 1.5vw;
 +
    line-height:1.8vw;
 +
font-family: Cambria, "Hoefler Text", "Liberation Serif", Times, "Times New Roman", "serif";
 +
}
  
  
−
<div class="column third_size" >
+
.trade-content .itemProject {
−
<div class="highlight decoration_B_full">
+
    background-image: url("https://static.igem.org/mediawiki/2018/1/1a/T--Fudan-CHINA--projectBgImg1.png");
−
<h3> Editing your wiki </h3>
+
}
−
<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
+
−
<p>Use WikiTools - Edit in the black menu bar to edit this page</p>
+
.trade-content .itemResults {
 +
    background-image: url("https://static.igem.org/mediawiki/2018/0/0e/T--Fudan-CHINA--ResultBgImg.jpg");
 +
filter: brightness(1.1);
 +
}
  
−
<div class="button_link">
+
.trade-content .itemModel {
−
<a href="https://2018.igem.org/wiki/index.php?title=Team:Fudan-CHINA&action=edit">
+
    background-image: url("https://static.igem.org/mediawiki/2018/2/2b/T--Fudan-CHINA--modelBgImg1.png");
−
EDIT PAGE
+
}
−
</a>
+
−
</div>
+
.trade-content .itemParts {
 +
    background-image: url("https://static.igem.org/mediawiki/2018/1/18/T--Fudan-CHINA--partsBgImg.jpg");
 +
}
  
 +
.trade-content .itemHP {
 +
    background-image: url("https://static.igem.org/mediawiki/2018/1/12/T--Fudan-CHINA--hpBgImg2.png");
 +
}
 +
.trade-content .itemNotebook {
 +
    background-image: url("https://static.igem.org/mediawiki/2018/2/26/T--Fudan-CHINA--NotebookBgImg.png");
 +
}
  
−
</div>
+
.trade-content .itemAwards {
−
</div>
+
    background-image: url("https://static.igem.org/mediawiki/2018/2/2a/T--Fudan-CHINA--awardBgImg2.png");
 +
}
  
 +
.trade-content .itemTeam {
 +
    background-image: url("https://static.igem.org/mediawiki/2018/6/64/T--Fudan-CHINA--teamBgImg1.png");
 +
}
  
 +
.trade-content .trade-box-item:hover .item-text {
 +
    display: block;
 +
    opacity: 1;
 +
    margin-top: 0;
 +
}
  
 +
.trade-content .trade-box-item:hover:before {
 +
    background-color: rgba(50,143,189,0.90);
 +
}
  
 +
.trade-content .trade-box-item:hover .item-logo {
 +
    margin-top: 5vw;
 +
}
  
−
<div class="clear extra_space"></div>
+
.trade-content .trade-box-item:hover .item-title:before {
−
<div class="line_divider"></div>
+
    opacity: 0;
−
<div class="clear extra_space"></div>
+
    margin-bottom: 0;
 +
}
 +
</style>
 +
 +
 +
  
−
 
+
<div id="sponsor">
−
 
+
<div class="theDivTitle">SPONSORS</div>
−
<div class="column two_thirds_size" >
+
<div style="font-size: 0;position: relative;margin: 4vw;">
−
<h3>Tips</h3>
+
<a href="http://life.fudan.edu.cn/" style="font-size: 0;">
−
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
+
<img class="spImg" id="spImg1" src="https://static.igem.org/mediawiki/2018/7/74/T--Fudan-CHINA--sp2.png" />
−
<ul>
+
</a>
−
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
+
<a href="http://medicine.fudan.edu.cn/" style="font-size: 0;">
−
<li>Be clear about what you are doing and how you plan to do this.</li>
+
<img class="spImg" id="spImg2" src="https://static.igem.org/mediawiki/2018/d/d1/T--Fudan-CHINA--sp3.png" />
−
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
+
</a>
−
<li>Make sure information is easy to find; nothing should be more than 3 clicks away. </li>
+
<a href="http://www.yfc.cn/cn/index.html" style="font-size: 0;">
−
<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
+
<img class="spImg" id="spImg4" src="https://static.igem.org/mediawiki/2018/7/7b/T--Fudan-CHINA--sp4.png" />
−
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2018.igem.org/Calendar">iGEM 2018 calendar</a> </li>
+
</a>
−
<li>Have lots of fun! </li>
+
<a href="https://sg.idtdna.com/pages" style="font-size: 0">
−
</ul>  
+
<img class="spImg" id="spImg3" style="position: relative;left:15.3px;" src="https://static.igem.org/mediawiki/2018/e/eb/T--Fudan-CHINA--sp7.png" /></a>
 +
<a href="http://www.snapgene.com/" style="font-size: 0;">
 +
<img class="spImg" id="spImg5" src="https://static.igem.org/mediawiki/2018/f/fb/T--Fudan-CHINA--sp5.png" />
 +
</a>
 +
<a href="https://www.mathworks.com/" style="font-size: 0;">
 +
<img class="spImg" id="spImg6" src="https://static.igem.org/mediawiki/2018/c/c4/T--Fudan-CHINA--sp6.png" />
 +
</a>
 +
</div>
 
</div>
 
</div>
 +
<style>
 +
#sponsor{
 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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−
<div class="column third_size">
+
−
<div class="highlight decoration_A_full">
+
−
<h3>Inspiration</h3>
+
−
<p> You can also view other team wikis for inspiration! Here are some examples:</p>
+
−
<ul>
+
−
<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
+
−
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
+
−
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
+
−
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
+
−
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
+
−
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
+
−
</ul>
+
−
</div>
+
−
</div>
+
−
 
+
−
 
+
−
 
+
−
 
+
 
</html>
 
</html>
 +
{{Fudan-CHINA/ContactUs}}

Latest revision as of 07:13, 30 November 2018

S T E P
Synthetic Transducer Engineering Platform
DISCOVER NOW
A BRIEF INTRODUCTION TO STEP
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.

We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.

By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
Watch Project Video
Begin the exploration of our STEP system
LEARN MORE
Project
Background
Design
Applied Design
Results
Overview
STEP System Test
Receptor Optimisation
Demonstrate
Interlab
Model
Model
Software
Parts
Improved Part
Best New Basic Part
Best New Composite Part
Best Part Collection
Part List
Human Practice
Overview
Silver HP
Integrated HP
Education & Engagement
Collaborations
Safety
Notebook
Notebook
Team
Team
Attributions
Awards
Awards

  Address


G604, School of Life Sciences, Fudan University
2005 Songhu Road, Yangpu, Shanghai, China