Difference between revisions of "Team:Fudan-CHINA"

 
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<span id="fullName">Synthetic Transducer Engineering Platform</span>
 
<span id="fullName">Synthetic Transducer Engineering Platform</span>
 
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  <div class="discoverBotton"><a href="#99" class="animated-button victoria-one">DISCOVER NOW</a></div>
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  <div class="discoverBotton"><a href="#" class="animated-button victoria-one">DISCOVER NOW</a></div>
 
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</script>
 
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<div class="trade-title">
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                <div class="theDivTitle learnMore">A BRIEF INTRODUCTION TO STEP</div>
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            </div>
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 +
<div id="abstract">
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Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.
 +
<br><br>
 +
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
 +
<br><br>
 +
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
  
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</div>
 
 
 
<div class="videoOutDiv">
 
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</div>
 
</div>
 
<div class="videoTitle">Watch Project Video</div>
 
<div class="videoTitle">Watch Project Video</div>
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<div class="videoCont">Because I could not stop for death, he kindly stopped for me. The carriage held but just ourselves and immortality.</div>
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<div class="videoCont">Begin the exploration of our STEP system</div>
 
<div class="videoPlayI"><i class="fa fa-play"></i></div>
 
<div class="videoPlayI"><i class="fa fa-play"></i></div>
 
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                                     Background noise a of the a for the
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                                     Background<br>Design<br>Applied Design
 
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                                        Results
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                                     Human Practice
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                                     Overview<br>STEP System Test<br>Receptor Optimisation<br>Demonstrate<br>Interlab
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                                     Overview<br>Silver HP<br>Integrated HP<br>Education &amp; Engagement<br>Collaborations<br>Safety
 
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G604, School of Life Sciences, Fudan University<br/>
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2005 Songhu Road, Yangpu, Shanghai, China
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Latest revision as of 07:13, 30 November 2018

S T E P
Synthetic Transducer Engineering Platform
DISCOVER NOW
A BRIEF INTRODUCTION TO STEP
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.

We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.

By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
Watch Project Video
Begin the exploration of our STEP system
LEARN MORE
Project
Background
Design
Applied Design
Results
Overview
STEP System Test
Receptor Optimisation
Demonstrate
Interlab
Model
Model
Software
Parts
Improved Part
Best New Basic Part
Best New Composite Part
Best Part Collection
Part List
Human Practice
Overview
Silver HP
Integrated HP
Education & Engagement
Collaborations
Safety
Notebook
Notebook
Team
Team
Attributions
Awards
Awards

  Address


G604, School of Life Sciences, Fudan University
2005 Songhu Road, Yangpu, Shanghai, China