(25 intermediate revisions by 2 users not shown) | |||
Line 89: | Line 89: | ||
var winHeight=$(window).height(); | var winHeight=$(window).height(); | ||
var totalScroll=winHeight-barHeight-navHeight; | var totalScroll=winHeight-barHeight-navHeight; | ||
− | $('body,html').animate({"scrollTop":totalScroll+2}, | + | $('body,html').animate({"scrollTop":totalScroll+2},1500); |
}); | }); | ||
}); | }); | ||
Line 163: | Line 163: | ||
</script> | </script> | ||
+ | <div class="trade-title"> | ||
+ | <div class="theDivTitle learnMore">A BRIEF INTRODUCTION TO STEP</div> | ||
+ | </div> | ||
+ | |||
+ | <div id="abstract"> | ||
+ | Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application. | ||
+ | <br><br> | ||
+ | We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application. | ||
+ | <br><br> | ||
+ | By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential. | ||
+ | </div> | ||
<div class="videoOutDiv"> | <div class="videoOutDiv"> | ||
Line 169: | Line 180: | ||
</div> | </div> | ||
<div class="videoTitle">Watch Project Video</div> | <div class="videoTitle">Watch Project Video</div> | ||
− | <div class="videoCont"> | + | <div class="videoCont">Begin the exploration of our STEP system</div> |
<div class="videoPlayI"><i class="fa fa-play"></i></div> | <div class="videoPlayI"><i class="fa fa-play"></i></div> | ||
</div> | </div> | ||
Line 319: | Line 330: | ||
} | } | ||
}); | }); | ||
− | </script> | + | </script> |
+ | |||
+ | |||
+ | |||
+ | <style> | ||
+ | #abstract{ | ||
+ | font-size:23px; | ||
+ | text-align:justify; | ||
+ | line-height:35px; | ||
+ | margin-left:10%; | ||
+ | margin-right:10%; | ||
+ | margin-top:3%; | ||
+ | margin-bottom:5%; | ||
+ | font-family:"Gill Sans", "Gill Sans MT", "Myriad Pro", "DejaVu Sans Condensed", Helvetica, Arial, "sans-serif"; | ||
+ | } | ||
+ | </style> | ||
<div class="moreInfoma"> | <div class="moreInfoma"> | ||
Line 330: | Line 356: | ||
<div class="trade-box-list"> | <div class="trade-box-list"> | ||
<div class="trade-box-item itemProject"> | <div class="trade-box-item itemProject"> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:Fudan-CHINA/Design"> |
<div class="item-logo"> | <div class="item-logo"> | ||
<i class="fa fa-cogs"></i> | <i class="fa fa-cogs"></i> | ||
Line 336: | Line 362: | ||
<div class="item-title">Project</div> | <div class="item-title">Project</div> | ||
<div class="item-text"> | <div class="item-text"> | ||
− | Background | + | Background<br>Design<br>Applied Design |
</div> | </div> | ||
</a> | </a> | ||
</div> | </div> | ||
<div class="trade-box-item itemResults"> | <div class="trade-box-item itemResults"> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:Fudan-CHINA/Results"> |
<div class="item-logo"> | <div class="item-logo"> | ||
<i class="fa fa-flask"></i> | <i class="fa fa-flask"></i> | ||
</div> | </div> | ||
− | <div class="item-title">Results</div> | + | <div class="item-title"> |
+ | Results | ||
+ | </div> | ||
<div class="item-text"> | <div class="item-text"> | ||
− | + | Overview<br>STEP System Test<br>Receptor Optimisation<br>Demonstrate<br>Interlab | |
+ | |||
</div> | </div> | ||
</a> | </a> | ||
Line 358: | Line 387: | ||
<div class="item-title">Model</div> | <div class="item-title">Model</div> | ||
<div class="item-text"> | <div class="item-text"> | ||
− | Model | + | Model<br>Software |
</div> | </div> | ||
</a> | </a> | ||
</div> | </div> | ||
<div class="trade-box-item itemParts"> | <div class="trade-box-item itemParts"> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:Fudan-CHINA/Part_List"> |
<div class="item-logo"> | <div class="item-logo"> | ||
<i class="fa fa-puzzle-piece"></i> | <i class="fa fa-puzzle-piece"></i> | ||
</div> | </div> | ||
− | <div class="item-title">Parts</div> | + | <div class="item-title"> |
+ | Parts </div> | ||
<div class="item-text"> | <div class="item-text"> | ||
− | + | Improved Part<br>Best New Basic Part<br>Best New Composite Part<br>Best Part Collection<br>Part List | |
+ | |||
</div> | </div> | ||
</a> | </a> | ||
Line 382: | Line 413: | ||
<div class="trade-box-list"> | <div class="trade-box-list"> | ||
<div class="trade-box-item itemHP"> | <div class="trade-box-item itemHP"> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:Fudan-CHINA/Human_Practices"> |
<div class="item-logo"> | <div class="item-logo"> | ||
<i class="fa fa-h-square"></i> | <i class="fa fa-h-square"></i> | ||
Line 388: | Line 419: | ||
<div class="item-title">Human Practice</div> | <div class="item-title">Human Practice</div> | ||
<div class="item-text"> | <div class="item-text"> | ||
− | + | Overview<br>Silver HP<br>Integrated HP<br>Education & Engagement<br>Collaborations<br>Safety | |
</div> | </div> | ||
</a> | </a> | ||
</div> | </div> | ||
<div class="trade-box-item itemNotebook"> | <div class="trade-box-item itemNotebook"> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:Fudan-CHINA/Notebook"> |
<div class="item-logo"> | <div class="item-logo"> | ||
<i class="fa fa-book"></i> | <i class="fa fa-book"></i> | ||
Line 399: | Line 430: | ||
<div class="item-title">Notebook</div> | <div class="item-title">Notebook</div> | ||
<div class="item-text"> | <div class="item-text"> | ||
− | + | Notebook | |
</div> | </div> | ||
</a> | </a> | ||
</div> | </div> | ||
<div class="trade-box-item itemTeam"> | <div class="trade-box-item itemTeam"> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:Fudan-CHINA/Team"> |
<div class="item-logo"> | <div class="item-logo"> | ||
<i class="fa fa-users"></i> | <i class="fa fa-users"></i> | ||
Line 410: | Line 441: | ||
<div class="item-title">Team</div> | <div class="item-title">Team</div> | ||
<div class="item-text"> | <div class="item-text"> | ||
− | + | Team<br>Attributions | |
</div> | </div> | ||
</a> | </a> | ||
</div> | </div> | ||
<div class="trade-box-item itemAwards"> | <div class="trade-box-item itemAwards"> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:Fudan-CHINA/Awards"> |
<div class="item-logo"> | <div class="item-logo"> | ||
<i class="fa fa-lightbulb-o"></i> | <i class="fa fa-lightbulb-o"></i> | ||
Line 555: | Line 586: | ||
color: #fff; | color: #fff; | ||
font-size: 1.5vw; | font-size: 1.5vw; | ||
+ | line-height:1.8vw; | ||
font-family: Cambria, "Hoefler Text", "Liberation Serif", Times, "Times New Roman", "serif"; | font-family: Cambria, "Hoefler Text", "Liberation Serif", Times, "Times New Roman", "serif"; | ||
} | } | ||
Line 675: | Line 707: | ||
</script> | </script> | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
</html> | </html> | ||
+ | {{Fudan-CHINA/ContactUs}} |
Latest revision as of 07:13, 30 November 2018
S T E P
Synthetic Transducer Engineering Platform
A BRIEF INTRODUCTION TO STEP
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
Watch Project Video
Begin the exploration of our STEP system
Address
G604, School of Life Sciences, Fudan University
2005 Songhu Road, Yangpu, Shanghai, China
2005 Songhu Road, Yangpu, Shanghai, China