Difference between revisions of "Team:Fudan-CHINA"

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                <div class="theDivTitle learnMore">A BRIEF INTRODUCTION TO STEP</div>
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            </div>
  
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<div id="abstract">
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Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.
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<br><br>
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We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
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<br><br>
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By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
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<div class="videoTitle">Watch Project Video</div>
 
<div class="videoTitle">Watch Project Video</div>
<div class="videoCont">Because I could not stop for death, he kindly stopped for me. The carriage held but just ourselves and immortality.</div>
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<div class="videoCont">Begin the exploration of our STEP system</div>
 
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<div class="trade-title">
 
                <div class="theDivTitle learnMore">A BRIEF INTRODUCTION TO STEP</div>
 
            </div>
 
  
<div id="abstract">
 
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.
 
<br><br>
 
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
 
<br><br>
 
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
 
 
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                                 <div class="item-title">Project</div>
 
                                 <div class="item-title">Project</div>
 
                                 <div class="item-text">
 
                                 <div class="item-text">
<a href="https://2018.igem.org/Team:Fudan-CHINA/Background"> Background </a> <br>
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                                    Background<br>Design<br>Applied Design
<a https://2018.igem.org/Team:Fudan-CHINA/Design">Design</a> <br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Applied_Design"> Applied Design</a>
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                                 </div>
 
                                 </div>
 
                             </a>
 
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                           </div>
 
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                                 <div class="item-text">
                                     Overview</a><br>
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                                     Overview<br>STEP System Test<br>Receptor Optimisation<br>Demonstrate<br>Interlab
<a href="https://2018.igem.org/Team:Fudan-CHINA/Results_STEP">STEP System Test</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Results_PR">Receptor Optimisation</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Demonstrate">Demonstrate</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/InterLab">Interlab</a>
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                                 </div>
 
                                 </div>
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                                 <div class="item-title">Model</div>
 
                                 <div class="item-title">Model</div>
 
                                 <div class="item-text">
 
                                 <div class="item-text">
<a href="https://2018.igem.org/Team:Fudan-CHINA/Model">Model</a><br>
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                                    Model<br>Software
<a href="https://2018.igem.org/Team:Fudan-CHINA/Software">Software</a>
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                                 </div>
 
                                 </div>
 
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                         <div class="trade-box-item itemParts">
                             <a href="https://2018.igem.org/Team:Fudan-CHINA/Improve">
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                             <a href="https://2018.igem.org/Team:Fudan-CHINA/Part_List">
 
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                                     <i class="fa fa-puzzle-piece"></i>
 
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                                             Parts                    </div>
 
                                             Parts                    </div>
 
                                 <div class="item-text">
 
                                 <div class="item-text">
<a href="https://2018.igem.org/Team:Fudan-CHINA/Improve">Improved Part</a><br>
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                                    Improved Part<br>Best New Basic Part<br>Best New Composite Part<br>Best Part Collection<br>Part List
<a href="https://2018.igem.org/Team:Fudan-CHINA/Basic_Part">Best New Basic Part</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Composite_Part">Best New Composite Part</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Part_Collection">Best Part Collection</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Part_List">Part List</a>
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                                 </div>
 
                                 </div>
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                                 <div class="item-title">Human Practice</div>
 
                                 <div class="item-title">Human Practice</div>
 
                                 <div class="item-text">
 
                                 <div class="item-text">
<a href="https://2018.igem.org/Team:Fudan-CHINA/Human_Practices">Overview</a><br>
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                                    Overview<br>Silver HP<br>Integrated HP<br>Education &amp; Engagement<br>Collaborations<br>Safety
<a href="https://2018.igem.org/Team:Fudan-CHINA/Human_Practices#mainTitle2">Silver HP</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Human_Practices#mainTitle3">Integrated HP</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Collaborations">Education &amp; Engagement</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Collaborations">Collaborations</a><br>
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<a href="https://2018.igem.org/Team:Fudan-CHINA/Safety">Safety</a>
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                                 </div>
 
                                 </div>
 
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                                 <div class="item-title">Notebook</div>
 
                                 <div class="item-title">Notebook</div>
 
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                                 <div class="item-text">
                                     <a href="https://2018.igem.org/Team:Fudan-CHINA/Notebook">Notebook</a>
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                                     Notebook
 
                                 </div>
 
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                                 <div class="item-title">Team</div>
 
                                 <div class="item-title">Team</div>
 
                                 <div class="item-text">
 
                                 <div class="item-text">
<a href="https://2018.igem.org/Team:Fudan-CHINA/Team">Team</a><br>
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                                    Team<br>Attributions
<a href="https://2018.igem.org/Team:Fudan-CHINA/Attributions">Attributions</a>
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                                 <div class="item-title">Awards</div>
 
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                                     <a href="https://2018.igem.org/Team:Fudan-CHINA/Awards">Awards</a>
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                                     Awards
 
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                                 </div>
 
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Latest revision as of 07:13, 30 November 2018

S T E P
Synthetic Transducer Engineering Platform
A BRIEF INTRODUCTION TO STEP
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.

We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.

By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
Watch Project Video
Begin the exploration of our STEP system

  Address



G604, School of Life Sciences, Fudan University
2005 Songhu Road, Yangpu, Shanghai, China