Difference between revisions of "Team:Fudan-CHINA"
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| + | <div class="theDivTitle learnMore">A BRIEF INTRODUCTION TO STEP</div> | ||
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| + | Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application. | ||
| + | <br><br> | ||
| + | We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application. | ||
| + | <br><br> | ||
| + | By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential. | ||
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<div class="videoTitle">Watch Project Video</div> | <div class="videoTitle">Watch Project Video</div> | ||
| − | <div class="videoCont"> | + | <div class="videoCont">Begin the exploration of our STEP system</div> |
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Latest revision as of 07:13, 30 November 2018
S T E P
Synthetic Transducer Engineering Platform
A BRIEF INTRODUCTION TO STEP
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
Watch Project Video
Begin the exploration of our STEP system
SPONSORS
Address
G604, School of Life Sciences, Fudan University
2005 Songhu Road, Yangpu, Shanghai, China
2005 Songhu Road, Yangpu, Shanghai, China
