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<html> | <html> | ||
− | < | + | |
− | < | + | |
− | <style | + | |
− | + | ||
− | + | <!--page--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------> | |
+ | <div id="signageDiv"> | ||
+ | <video id="bgVideo" autoplay muted loop> | ||
+ | <source src="https://static.igem.org/mediawiki/2018/f/fd/T--Fudan-CHINA--bgVideo.mp4"> | ||
+ | </video> | ||
+ | |||
+ | <div id="stepDiv"> | ||
+ | <span id="stepName">S T E P</span> | ||
+ | <div style="height: 5vh;"></div> | ||
+ | <span id="fullName">Synthetic Transducer Engineering Platform</span> | ||
+ | </div> | ||
+ | <div class="discoverBotton"><a href="#" class="animated-button victoria-one">DISCOVER NOW</a></div> | ||
+ | </div> | ||
+ | |||
+ | <style> | ||
+ | #signageDiv{ | ||
+ | position: relative; | ||
+ | top:0; | ||
+ | } | ||
+ | .discoverBotton{ | ||
+ | font-family:Constantia, "Lucida Bright", "DejaVu Serif", Georgia, "serif"; | ||
+ | position: absolute; | ||
+ | top:70vh; | ||
+ | left: 50%; | ||
+ | transform: translateX(-50%); | ||
+ | -moz-transform: translateX(-50%); | ||
+ | -ms-transform: translateX(-50%); | ||
+ | -webkit-transform: translateX(-50%); | ||
} | } | ||
+ | a.animated-button.victoria-one:after { | ||
+ | background: #fff; | ||
+ | -moz-transform: translateX(-50%) translateY(-50%) rotate(-25deg); | ||
+ | -ms-transform: translateX(-50%) translateY(-50%) rotate(-25deg); | ||
+ | -webkit-transform: translateX(-50%) translateY(-50%) rotate(-25deg); | ||
+ | transform: translateX(-50%) translateY(-50%) rotate(-25deg); | ||
+ | } | ||
+ | a.animated-button:link, a.animated-button:visited { | ||
+ | position: relative; | ||
+ | display: block; | ||
+ | margin: 0 auto 0; | ||
+ | padding: 1vw 1.5vw; | ||
+ | color: #fff; | ||
+ | font-size:1.15vw; | ||
+ | font-weight: 900; | ||
+ | text-align: center; | ||
+ | text-decoration: none; | ||
+ | letter-spacing: 0.1vw; | ||
+ | border-radius:1.5vw; | ||
+ | overflow: hidden; | ||
+ | border: 0.1vw solid #fff; | ||
+ | -webkit-transition: all 0.75s ease; | ||
+ | -moz-transition: all 0.75s ease; | ||
+ | -o-transition: all 0.75s ease; | ||
+ | transition: all 0.75s ease; | ||
+ | } | ||
+ | a.animated-button:link:after, a.animated-button:visited:after { | ||
+ | content: ""; | ||
+ | position: absolute; | ||
+ | height: 0%; | ||
+ | left: 50%; | ||
+ | top: 50%; | ||
+ | width: 25vw; | ||
+ | z-index: -1; | ||
+ | -webkit-transition: all 0.75s ease 0s; | ||
+ | -moz-transition: all 0.75s ease 0s; | ||
+ | -o-transition: all 0.75s ease 0s; | ||
+ | transition: all 0.75s ease 0s; | ||
+ | } | ||
+ | a.animated-button:link:hover, a.animated-button:visited:hover { | ||
+ | color: rgba(2,17,35,1); | ||
+ | border: 0.1vw solid transparent; | ||
+ | } | ||
+ | a.animated-button:link:hover:after, a.animated-button:visited:hover:after { | ||
+ | height: 20vw; | ||
+ | } | ||
+ | </style> | ||
+ | <script> | ||
+ | $(document).ready(function() { | ||
+ | $("a.animated-button").on('click',function() { | ||
+ | var navHeight=$("#navUl").height(); | ||
+ | var barHeight=$("#top_menu_14").height(); | ||
+ | var winHeight=$(window).height(); | ||
+ | var totalScroll=winHeight-barHeight-navHeight; | ||
+ | $('body,html').animate({"scrollTop":totalScroll+2},1500); | ||
+ | }); | ||
+ | }); | ||
+ | </script> | ||
+ | <style> | ||
+ | #signageDiv{ | ||
+ | width: 100%; | ||
+ | overflow: hidden; | ||
+ | } | ||
+ | #bgVideo{ | ||
+ | position: relative; | ||
+ | } | ||
+ | #stepDiv{ | ||
+ | position: absolute; | ||
+ | text-align: center; | ||
+ | width: 100%; | ||
+ | top: 50vh; | ||
+ | -webkit-transform: translateX(0) translateY(-50%); | ||
+ | -moz-transform: translateX(0) translateY(-50%); | ||
+ | -ms-transform: translateX(0) translateY(-50%); | ||
+ | transform: translateX(0) translateY(-50%); | ||
+ | } | ||
+ | #stepName{ | ||
+ | color: white; | ||
+ | font-family: Algerian,_Algerian; | ||
+ | line-height: 10vh; | ||
+ | height: 10vh; | ||
+ | } | ||
+ | #fullName{ | ||
+ | color: white; | ||
+ | font-family:"Lucida Calligraphy",_LucidaCalligraphy; | ||
+ | } | ||
+ | </style> | ||
+ | |||
+ | <script> | ||
+ | function signageDivFun(){ | ||
+ | var videoWidth=1920; | ||
+ | var videoHeight=1080; | ||
+ | var winWidth=$(window).width(); | ||
+ | var winHeight=$(window).height(); | ||
+ | $("#signageDiv").css("height",winHeight); | ||
+ | if (winWidth*videoHeight>winHeight*videoWidth ){ | ||
+ | $("#bgVideo").css("width",winWidth); | ||
+ | $("#bgVideo").css("top",0.5*(winHeight-videoHeight*winWidth/videoWidth)); | ||
+ | $("#bgVideo").css("Height",videoHeight*winWidth/videoWidth); | ||
+ | $("#bgVideo").css("left",0); | ||
+ | } | ||
+ | else{ | ||
+ | $("#bgVideo").css("Height",winHeight); | ||
+ | $("#bgVideo").css("left",0.5*(winWidth-videoWidth*winHeight/videoHeight)); | ||
+ | $("#bgVideo").css("width",videoWidth*winHeight/videoHeight); | ||
+ | $("#bgVideo").css("top",0); | ||
+ | } | ||
+ | |||
+ | if (winWidth/winHeight>21/8.5){ | ||
+ | $("#stepName").css("font-size","21vh"); | ||
+ | } | ||
+ | else{ | ||
+ | $("#stepName").css("font-size","8.5vw"); | ||
+ | } | ||
+ | if (winWidth/winHeight>5/2.2){ | ||
+ | $("#fullName").css("font-size","5vh"); | ||
+ | } | ||
+ | else{ | ||
+ | $("#fullName").css("font-size","2.2vw"); | ||
+ | } | ||
+ | } | ||
+ | signageDivFun(); | ||
+ | $(window).resize(function(){ | ||
+ | signageDivFun(); | ||
+ | }); | ||
+ | |||
+ | </script> | ||
+ | |||
+ | <div class="trade-title"> | ||
+ | <div class="theDivTitle learnMore">A BRIEF INTRODUCTION TO STEP</div> | ||
+ | </div> | ||
+ | |||
+ | <div id="abstract"> | ||
+ | Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application. | ||
+ | <br><br> | ||
+ | We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application. | ||
+ | <br><br> | ||
+ | By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential. | ||
+ | |||
+ | </div> | ||
+ | |||
+ | <div class="videoOutDiv"> | ||
+ | <div class="videoDiv" data-paralasic="0.45"> | ||
+ | </div> | ||
+ | <div class="videoTitle">Watch Project Video</div> | ||
+ | <div class="videoCont">Begin the exploration of our STEP system</div> | ||
+ | <div class="videoPlayI"><i class="fa fa-play"></i></div> | ||
+ | </div> | ||
+ | <div class="teamVideo"> | ||
+ | <video id="example_video_1" controls controlsList="nodownload" preload="auto"> | ||
+ | <source src="https://static.igem.org/mediawiki/2018/5/54/T--Fudan-CHINA--pjVideo.mp4" type="video/mp4" /> | ||
+ | </video> | ||
+ | <div class="closeVideo"> | ||
+ | <i class="fa fa-close"></i> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <style> | ||
+ | video::-webkit-media-controls-panel{ | ||
+ | background: rgba(35,35,35,0.8); | ||
+ | |||
+ | } | ||
+ | video::-webkit-media-controls-play-button,video::-webkit-media-controls-mute-button,video::-webkit-media-controls-fullscreen-button{ | ||
+ | filter: brightness(2); | ||
+ | } | ||
+ | video::-webkit-media-controls-current-time-display{ | ||
+ | color: rgba(255,255,255,0.6); | ||
+ | } | ||
+ | video::-webkit-media-controls-time-remaining-display{ | ||
+ | color: rgba(255,255,255,0.6); | ||
+ | } | ||
+ | #example_video_1{ | ||
+ | display: inline-block; | ||
+ | position: relative; | ||
+ | top:50%; | ||
+ | transform: translateY(-50%); | ||
+ | } | ||
+ | .teamVideo{ | ||
+ | position: fixed; | ||
+ | width: 100%; | ||
+ | height: 100%; | ||
+ | background-color: rgba(0,0,0,1); | ||
+ | top: 0; | ||
+ | left: 0; | ||
+ | z-index: 900; | ||
+ | text-align: center; | ||
+ | display: none; | ||
+ | } | ||
+ | .videoDiv{ | ||
+ | width:100%; | ||
+ | height:28vw; | ||
+ | background-image: url('https://static.igem.org/mediawiki/2018/c/ce/T--Fudan-CHINA--pjbgImg.jpg'); | ||
+ | background-position: center top; | ||
+ | background-repeat: no-repeat; | ||
+ | background-size: 100%; | ||
+ | text-align: center; | ||
+ | filter: brightness(0.5); | ||
+ | } | ||
+ | .videoTitle{ | ||
+ | color: white; | ||
+ | font-size:3vw; | ||
+ | font-family: Cambria, "Hoefler Text", "Liberation Serif", Times, "Times New Roman", "serif"; | ||
+ | text-align:center; | ||
+ | position: relative; | ||
+ | top:-19vw; | ||
+ | font-weight: 900; | ||
+ | } | ||
+ | .videoCont{ | ||
+ | color: white; | ||
+ | font-size:1.2vw; | ||
+ | font-family:; | ||
+ | text-align:center; | ||
+ | position: relative; | ||
+ | top:-17vw; | ||
+ | font-weight: 100; | ||
+ | } | ||
+ | .videoOutDiv{ | ||
+ | position: relative; | ||
+ | text-align: center; | ||
+ | margin: 3vw 0 -5vw 0; | ||
+ | } | ||
+ | .videoPlayI{ | ||
+ | position: relative; | ||
+ | top:-13vw; | ||
+ | } | ||
+ | .videoPlayI i{ | ||
+ | font-size:2.7vw; | ||
+ | color: white; | ||
+ | border: 2px solid white; | ||
+ | width: 3vw; | ||
+ | height: 3vw; | ||
+ | padding: 1.3vw 0.9vw 0.9vw 1.3vw; | ||
+ | border-radius: 50%; | ||
+ | cursor: pointer; | ||
+ | } | ||
+ | |||
+ | .closeVideo{ | ||
+ | position: fixed; | ||
+ | top:2vw; | ||
+ | right: 2vw; | ||
+ | color:rgba(211,211,211,0.8); | ||
+ | font-size: 2.5vw; | ||
+ | cursor: pointer; | ||
+ | transition: all 0.3s ease; | ||
+ | } | ||
+ | .closeVideo:hover{ | ||
+ | color: rgba(211,211,211,1); | ||
+ | } | ||
+ | </style> | ||
+ | <script> | ||
+ | $(".videoPlayI i").mouseenter(function(){ | ||
+ | $(this).stop().animate({"color":"rgba(135,206,250)","borderColor":"rgba(135,206,250)"},200); | ||
+ | }) | ||
+ | $(".videoPlayI i").mouseleave(function(){ | ||
+ | $(this).stop().animate({"color":"white","borderColor":"white"},200); | ||
+ | }) | ||
+ | |||
+ | videoSizeAdj(); | ||
+ | $(window).resize(function(){ | ||
+ | videoSizeAdj(); | ||
+ | }); | ||
+ | |||
+ | function videoSizeAdj(){ | ||
+ | var winHeight=$(window).height(); | ||
+ | var winWidth=$(window).width(); | ||
+ | if (winWidth/winHeight>16/9){ | ||
+ | $("#example_video_1").width(winHeight/9*16); | ||
+ | $("#example_video_1").height(winHeight); | ||
+ | } | ||
+ | else{ | ||
+ | $("#example_video_1").width(winWidth); | ||
+ | $("#example_video_1").height(winWidth/16*9); | ||
+ | } | ||
+ | } | ||
+ | $(".videoPlayI").click(function(){ | ||
+ | $(".teamVideo").fadeIn(); | ||
+ | $("#top_menu_14").fadeOut(); | ||
+ | $("#example_video_1")[0].play(); | ||
+ | }) | ||
+ | $(".closeVideo").click(function(){ | ||
+ | $("#top_menu_14").fadeIn(); | ||
+ | $(".teamVideo").fadeOut(); | ||
+ | $("#example_video_1")[0].pause(); | ||
+ | }); | ||
+ | |||
+ | |||
+ | $(window).scroll(function() { | ||
+ | var scrollTop = $(window).scrollTop(); | ||
+ | var videoDivTop=$(".videoDiv").offset().top; | ||
+ | var winHeight=$(window).height(); | ||
+ | var videoDivValue = $('.videoDiv').attr('data-paralasic'); | ||
+ | if (scrollTop+winHeight-videoDivTop>0){ | ||
+ | $('.videoDiv').css('background-position', 'center top -' + (scrollTop+winHeight-videoDivTop)*videoDivValue + 'px'); | ||
+ | } | ||
+ | }); | ||
+ | </script> | ||
+ | |||
+ | |||
+ | |||
+ | <style> | ||
+ | #abstract{ | ||
+ | font-size:23px; | ||
+ | text-align:justify; | ||
+ | line-height:35px; | ||
+ | margin-left:10%; | ||
+ | margin-right:10%; | ||
+ | margin-top:3%; | ||
+ | margin-bottom:5%; | ||
+ | font-family:"Gill Sans", "Gill Sans MT", "Myriad Pro", "DejaVu Sans Condensed", Helvetica, Arial, "sans-serif"; | ||
+ | } | ||
+ | </style> | ||
+ | |||
+ | <div class="moreInfoma"> | ||
+ | <div class="trade-content" style="overflow: hidden;"> | ||
+ | <div class="trade-title"> | ||
+ | <div class="theDivTitle learnMore">LEARN MORE</div> | ||
+ | </div> | ||
+ | <div class="trade-black"> | ||
+ | <div class="trade-box"> | ||
+ | <div class="trade-box-list"> | ||
+ | <div class="trade-box-item itemProject"> | ||
+ | <a href="https://2018.igem.org/Team:Fudan-CHINA/Design"> | ||
+ | <div class="item-logo"> | ||
+ | <i class="fa fa-cogs"></i> | ||
+ | </div> | ||
+ | <div class="item-title">Project</div> | ||
+ | <div class="item-text"> | ||
+ | Background<br>Design<br>Applied Design | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="trade-box-item itemResults"> | ||
+ | <a href="https://2018.igem.org/Team:Fudan-CHINA/Results"> | ||
+ | <div class="item-logo"> | ||
+ | <i class="fa fa-flask"></i> | ||
+ | </div> | ||
+ | <div class="item-title"> | ||
+ | Results | ||
+ | </div> | ||
+ | <div class="item-text"> | ||
+ | Overview<br>STEP System Test<br>Receptor Optimisation<br>Demonstrate<br>Interlab | ||
+ | |||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="trade-box-item itemModel"> | ||
+ | <a href="https://2018.igem.org/Team:Fudan-CHINA/Model"> | ||
+ | <div class="item-logo"> | ||
+ | <i class="fa fa-area-chart"></i> | ||
+ | </div> | ||
+ | <div class="item-title">Model</div> | ||
+ | <div class="item-text"> | ||
+ | Model<br>Software | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="trade-box-item itemParts"> | ||
+ | <a href="https://2018.igem.org/Team:Fudan-CHINA/Part_List"> | ||
+ | <div class="item-logo"> | ||
+ | <i class="fa fa-puzzle-piece"></i> | ||
+ | </div> | ||
+ | <div class="item-title"> | ||
+ | Parts </div> | ||
+ | <div class="item-text"> | ||
+ | Improved Part<br>Best New Basic Part<br>Best New Composite Part<br>Best Part Collection<br>Part List | ||
+ | |||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="trade-content" style="overflow: hidden;"> | ||
+ | <div class="trade-black"> | ||
+ | <div class="trade-box"> | ||
+ | <div class="trade-box-list"> | ||
+ | <div class="trade-box-item itemHP"> | ||
+ | <a href="https://2018.igem.org/Team:Fudan-CHINA/Human_Practices"> | ||
+ | <div class="item-logo"> | ||
+ | <i class="fa fa-h-square"></i> | ||
+ | </div> | ||
+ | <div class="item-title">Human Practice</div> | ||
+ | <div class="item-text"> | ||
+ | Overview<br>Silver HP<br>Integrated HP<br>Education & Engagement<br>Collaborations<br>Safety | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="trade-box-item itemNotebook"> | ||
+ | <a href="https://2018.igem.org/Team:Fudan-CHINA/Notebook"> | ||
+ | <div class="item-logo"> | ||
+ | <i class="fa fa-book"></i> | ||
+ | </div> | ||
+ | <div class="item-title">Notebook</div> | ||
+ | <div class="item-text"> | ||
+ | Notebook | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="trade-box-item itemTeam"> | ||
+ | <a href="https://2018.igem.org/Team:Fudan-CHINA/Team"> | ||
+ | <div class="item-logo"> | ||
+ | <i class="fa fa-users"></i> | ||
+ | </div> | ||
+ | <div class="item-title">Team</div> | ||
+ | <div class="item-text"> | ||
+ | Team<br>Attributions | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="trade-box-item itemAwards"> | ||
+ | <a href="https://2018.igem.org/Team:Fudan-CHINA/Awards"> | ||
+ | <div class="item-logo"> | ||
+ | <i class="fa fa-lightbulb-o"></i> | ||
+ | </div> | ||
+ | <div class="item-title">Awards</div> | ||
+ | <div class="item-text"> | ||
+ | Awards | ||
+ | </div> | ||
+ | </a> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <style> | ||
+ | .theDivTitle{ | ||
+ | color: rgba(6,34,82,1); | ||
+ | font-family: "Verlag Book",Arial,Helvetica; | ||
+ | font-weight: 400; | ||
+ | font-size: 3vw; | ||
+ | padding:0; | ||
+ | margin: 1vw; | ||
+ | position: relative; | ||
+ | } | ||
+ | .theDivTitle:after { | ||
+ | content: ""; | ||
+ | position: absolute; | ||
+ | width: 4vw; | ||
+ | height: 0.06vw; | ||
+ | background-color: rgba(6,34,82,1); | ||
+ | top:3.4vw; | ||
+ | left: 50%; | ||
+ | transform: translateX(-50%); | ||
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+ | .trade-content{ | ||
+ | padding:0 0 0 0; | ||
+ | margin: 0; | ||
+ | } | ||
+ | .trade-title { | ||
+ | color: #333; | ||
+ | text-align: center; | ||
+ | padding: 3.5vw 0 1vw 0; | ||
+ | margin: 0 0 3vw 0; | ||
+ | position: relative; | ||
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+ | |||
+ | |||
+ | |||
+ | .trade-box-item a { | ||
+ | text-decoration: none; | ||
+ | color: #000; | ||
+ | position: absolute; | ||
+ | width: 100%; | ||
+ | height: 100%; | ||
+ | left: 0; | ||
+ | top: 0; | ||
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+ | |||
+ | |||
+ | .trade-box { | ||
+ | width: 85% !important; | ||
+ | margin: 0 auto; | ||
+ | position: relative; | ||
+ | transition: all .3s ease; | ||
+ | } | ||
+ | |||
+ | .trade-box-list { | ||
+ | display: flex; | ||
+ | flex-direction: row; | ||
+ | justify-content: center; | ||
+ | align-items: center; | ||
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+ | |||
+ | .trade-box-item { | ||
+ | flex: 1; | ||
+ | text-align: center; | ||
+ | position: relative; | ||
+ | height: 26vw; | ||
+ | background: no-repeat center; | ||
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+ | |||
+ | .trade-content .trade-box-item:before { | ||
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+ | position: absolute; | ||
+ | width: 100%; | ||
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+ | |||
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+ | background-image: url("https://static.igem.org/mediawiki/2018/1/1a/T--Fudan-CHINA--projectBgImg1.png"); | ||
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Latest revision as of 07:13, 30 November 2018
S T E P
Synthetic Transducer Engineering Platform
A BRIEF INTRODUCTION TO STEP
Troubling the world for years, cancer has long been a major threat to people's health. The rapidly developing cell therapy has proved its potential for cancer treatment, but all of the current biosensors, from CAR to SynNotch, lack either programmability or orthogonality, which could significantly restrict its clinical application.
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
We provide our own solution to the problem, the Synthetic Transducer Engineering Platform (STEP). Consisting of two transmembrane chains with ligand receptor on the extracellular domain and protease/transcription factor pair on the intracellular domain, it can achieve high modularity as well as orthogonality in both upstream and downstream. Through our experiments and models, we've successfully proved the reliability and tunability of STEP, and are trying to find the best condition for its real application.
By using STEP in clinical researches and practices, treatment best suited for cancer patients can be developed. With further researches and optimisation, we believe it will reveal its full potential.
Watch Project Video
Begin the exploration of our STEP system
Address
G604, School of Life Sciences, Fudan University
2005 Songhu Road, Yangpu, Shanghai, China
2005 Songhu Road, Yangpu, Shanghai, China
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