As a new therapy project, developing a reliable solution and putting it into practice and making a positive impact on society in a responsible way is what we have long pursued. However, no one can guarantee that our plan is perfect in our research process, which will not only affect the public's interests in a continuous way, but also contribute to the sustainable development of society. Hence, we designed an integrated human practice project to answer the following three questions:

(1) How to make Human Practice consolidate into our cycle of debug and development, improving our iterative and evolutionary process?
(2) How to response the doubt of safety and policy problems, preserves and promotes public confidence to synthetic biology and its applications?
(3) How to establish an effective interaction with the community, stakeholders and society, to reach a consensus and create responsible usage by a virtuous cycle?

In response to the challenges of these three issues and questions, from the beginning, we proposed a set of ideas named CERE cycle (communicating-engagement-reflection-evolution) to guide our integrated human practice. Also, we affiliate the Human practice with entire project closely and actively, for addressing some of the great challenges humanity or our health is facing.

As many teams have mentioned and be put into practice, working by the framework of engineering cycles can make human practice effectively contribute to project development and help reflect on many aspects of the entire project. As we will show below, we are trying to put forward a human practice model which is simple and easy to implement in different cultural environments, and we will analyzes in detail how our integrated human practices have a beneficial impact to the entire project, and in interaction with the outside world, Establish an output-input positive and negative feedback mechanism.

We believe that we should communicate with different people before we start designing the entire project. They may be experts, researchers, potential consumers, manufacturers and stakeholders, even who are interested in our project. The process is called part of early engagement. In our integrated Human Practice, we divided the communication into the following four modules: Interview, Survey, Additional activities and collaboration. It should be noted that these four modules are not isolated, but have intrinsic logical connection: we get expert opinions through interviews; listen to the public's ideas through questionnaires; and draw on experience from R&D industrial practices through additional activities. Finally we exchanged our ideas with peers to boost the improvement of our project.