(46 intermediate revisions by 2 users not shown) | |||
Line 1: | Line 1: | ||
+ | {{New_York_City}} | ||
<html lang="en"> | <html lang="en"> | ||
− | <head> | + | <head><style> |
− | < | + | .sponsor{ |
+ | max-width:200px; | ||
+ | max-height:200px; | ||
+ | } | ||
+ | .container { | ||
+ | align-items: center; | ||
+ | max-width: 960px; | ||
+ | } | ||
+ | a{ | ||
+ | color:#7B84ED; | ||
+ | } | ||
+ | .headimage{ | ||
+ | border-radius: 15px; | ||
+ | } | ||
+ | |||
+ | .social{ | ||
+ | max-width: 50px; | ||
+ | max-height: auto; | ||
+ | } | ||
+ | </style> | ||
</head> | </head> | ||
<body> | <body> | ||
− | <div class="container"> | + | <div class="container"> |
− | + | <nav class="sticky-top py-3 navbar navbar-expand-lg navbar-light mr-auto"> | |
− | + | <div class="container d-flex flex-column flex-md-row justify-content-between"> | |
− | + | <div class="navbar-brand"><a href="https://2018.igem.org/Team:New_York_City">New York City iGEM</a></div> | |
− | + | <div class="collapse navbar-collapse" id="navbarSupportedContent"> | |
− | + | <ul class="navbar-nav mr-auto"> | |
− | + | <li class="nav-item dropdown"> | |
− | + | <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarPR" | |
− | + | role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> | |
− | + | Project | |
− | + | </a> | |
− | + | <div class="dropdown-menu" aria-labelledby="navbarPR"> | |
− | + | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/HD">What is | |
− | + | Huntington's?</a> | |
− | + | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Description">Description</a> | |
− | + | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Design">Design</a> | |
− | + | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Model">Model</a> | |
− | + | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/InterLab">InterLab</a> | |
− | + | ||
− | + | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Results">Results</a> | |
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
</div> | </div> | ||
+ | </li> | ||
+ | <li class="nav-item dropdown"> | ||
+ | <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarNB" | ||
+ | role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> | ||
+ | Notebook | ||
+ | </a> | ||
+ | <div class="dropdown-menu" aria-labelledby="navbarNB"> | ||
+ | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Notebook">Notebook</a> | ||
+ | </div> | ||
+ | </li> | ||
+ | <li class="nav-item dropdown"> | ||
+ | <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarHP" | ||
+ | role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> | ||
+ | Human Practices | ||
+ | </a> | ||
+ | <div class="dropdown-menu" aria-labelledby="navbarHP"> | ||
+ | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Human_Practices">Human | ||
+ | Practices</a> | ||
+ | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Integrated_Practices">Integrated | ||
+ | Practices</a> | ||
+ | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Public_Engagement">Public | ||
+ | Engagement</a> | ||
+ | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Collaborations">Collaborations</a> | ||
+ | </div> | ||
+ | </li> | ||
+ | <li class="nav-item dropdown"> | ||
+ | <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarT" | ||
+ | role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> | ||
+ | Team | ||
+ | </a> | ||
+ | <div class="dropdown-menu" aria-labelledby="navbarT"> | ||
+ | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Team">Team</a> | ||
+ | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/Attributions">Attributions</a> | ||
+ | </div> | ||
+ | </li> | ||
+ | </ul> | ||
+ | </div> | ||
+ | </div> | ||
+ | </nav> | ||
+ | </div> | ||
<div class="container text-center" align="center"> | <div class="container text-center" align="center"> | ||
<div class="row"> | <div class="row"> | ||
− | <div class="col-sm- | + | <div class="col-sm-12" align="center"> |
− | <h1 | + | <h1 class="display-4">Testing the efficacy of mRNA displacement technique in huntingtin cell lines to |
+ | treat Huntington's Disease</h1> | ||
+ | <br/> | ||
</div> | </div> | ||
− | <div class="col-sm- | + | </div> |
− | <img src="https://static.igem.org/mediawiki/2018/1/1c/T--New_York_City--logo.PNG" width=100%/> | + | <div class="row"> |
+ | <div class="col-sm-12" align="center"> | ||
+ | <img class="headimage" src="https://static.igem.org/mediawiki/2018/1/1c/T--New_York_City--logo.PNG" width=100%/> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | <br/> | ||
+ | <div align="center"> | ||
+ | <video height="320" width="auto" controls> | ||
+ | <source src="https://static.igem.org/mediawiki/2018/9/9c/T--New_York_City--nyc_presentation.mp4"> | ||
+ | </video> | ||
+ | </div> | ||
+ | <br/> | ||
+ | <div align="center"> | ||
+ | <div class="container row teamRow text-center"> | ||
+ | <div class="col-sm-4"> | ||
+ | <img class="card-img-top head" src="https://static.igem.org/mediawiki/2018/2/20/T--New_York_City--nyc_5.jpg"> | ||
+ | </div> | ||
+ | <div class="col-sm-4"> | ||
+ | |||
+ | <img class="card-img-top head" src="https://static.igem.org/mediawiki/2018/2/20/T--New_York_City--nyc_1.jpg"> | ||
+ | |||
+ | </div> | ||
+ | <div class="col-sm-4"> | ||
+ | |||
+ | <img class="card-img-top head" src="https://static.igem.org/mediawiki/2018/e/e0/T--New_York_City--nyc_2.jpg"> | ||
+ | |||
+ | </div> | ||
+ | </div> | ||
+ | <br/> | ||
+ | <div class="container row teamRow text-center"> | ||
+ | <div class="col-sm-4"> | ||
+ | |||
+ | <img class="card-img-top head" src="https://static.igem.org/mediawiki/2018/4/4e/T--New_York_City--nyc_3.jpg"> | ||
+ | |||
+ | </div> | ||
+ | <div class="col-sm-4"> | ||
+ | |||
+ | <img class="card-img-top head" src="https://static.igem.org/mediawiki/2018/f/f2/T--New_York_City--bronze.jpg"> | ||
+ | |||
+ | </div> | ||
+ | <div class="col-sm-4"> | ||
+ | |||
+ | <img class="card-img-top head" src="https://static.igem.org/mediawiki/2018/2/20/T--New_York_City--nyc_4.jpg"> | ||
+ | |||
</div> | </div> | ||
</div> | </div> | ||
Line 57: | Line 147: | ||
<div class="col-sm-4"> | <div class="col-sm-4"> | ||
<div class="container"> | <div class="container"> | ||
− | <h2>WHAT</h2> | + | <h2 class="display-4">WHAT</h2> |
− | <p align="left">Huntington's Disease (HD) is a genetic disorder that results in the breakdown of nerve cells in the | + | <p align="left" class="lead">Huntington's Disease (HD) is a genetic disorder that results in the breakdown of nerve cells in the |
brain. Although the disease affects the whole brain, the basal ganglia, which plays a critical role in | brain. Although the disease affects the whole brain, the basal ganglia, which plays a critical role in | ||
motor functions and behavior, is most severely affected. Thus, symptoms of HD include involuntary | motor functions and behavior, is most severely affected. Thus, symptoms of HD include involuntary | ||
Line 66: | Line 156: | ||
<br> | <br> | ||
<div class="container"> | <div class="container"> | ||
− | <h2>WHY</h2> | + | <h2 class="display-4">WHY</h2> |
− | <p align="left">HD is a result of a specific mutation in the huntingtin (HTT) gene, which results in a faulty production | + | <p align="left" class="lead">HD is a result of a specific mutation in the huntingtin (HTT) gene, which results in a faulty production |
of the HTT protein, mHTT. The mutation is a trinucleotide repeat of the codon CAG, where 40 or more will | of the HTT protein, mHTT. The mutation is a trinucleotide repeat of the codon CAG, where 40 or more will | ||
lead to the expression of HD.</p> | lead to the expression of HD.</p> | ||
Line 77: | Line 167: | ||
<div class="col-sm-4"> | <div class="col-sm-4"> | ||
<div class="container"> | <div class="container"> | ||
− | <h2>WHO</h2> | + | <h2 class="display-4">WHO</h2> |
− | <p align="left">The most common form of HD is adult-onset, affecting people between their 30s and 40s. | + | <p align="left" class="lead">The most common form of HD is adult-onset, affecting people between their 30s and 40s. |
Many people form families and have children by the time they are diagnosed with HD, which automatically | Many people form families and have children by the time they are diagnosed with HD, which automatically | ||
gives their children a 50% chance of inheriting the disease. HD affects about 1 in every 10,000 | gives their children a 50% chance of inheriting the disease. HD affects about 1 in every 10,000 | ||
Line 85: | Line 175: | ||
<br> | <br> | ||
<div class="container"> | <div class="container"> | ||
− | <h2>HOW</h2> | + | <h2 class="display-4">HOW</h2> |
− | <p align="left">Our goal is to develop a cure to Huntington's Disease by employing RNA strand displacement | + | <p align="left" class="lead">Our goal is to develop a cure to Huntington's Disease by employing RNA strand displacement |
technology to target erroneous mRNA within the affected cells and replace it with the corrected RNA | technology to target erroneous mRNA within the affected cells and replace it with the corrected RNA | ||
strand for proper protein synthesis. | strand for proper protein synthesis. | ||
Line 94: | Line 184: | ||
</div> | </div> | ||
</div> | </div> | ||
− | < | + | <br /> |
− | < | + | <div align="center"> |
− | < | + | <video height="320" width="auto" controls> |
+ | <source src="https://static.igem.org/mediawiki/2018/0/06/T--New_York_City--Video.mp4" type="video/mp4"> | ||
+ | </video> | ||
+ | </div> | ||
+ | <br/> | ||
+ | <div class="container" align="center"> | ||
+ | <div class="row" align="center"> | ||
+ | <div class="col-sm-4"> | ||
+ | <a href="https://hdsa.org/"><img class="sponsor" src="https://static.igem.org/mediawiki/2018/a/a4/T--New_York_City--hdsa.png"/></a> | ||
+ | </div> | ||
+ | <div class="col-sm-4"> | ||
+ | <a href="http://www.hdfoundation.org/"><img class="sponsor" src="https://static.igem.org/mediawiki/2018/8/86/T--New_York_City--hdf.png"/></a> | ||
+ | </div> | ||
+ | <div class="col-sm-4"> | ||
+ | <a href="https://www.cerebralpalsy.org.au/"><img class="sponsor" src="https://static.igem.org/mediawiki/2018/0/03/T--New_York_City--cpa.png"/></a> | ||
+ | </div> | ||
+ | </div> | ||
+ | <br/> | ||
+ | </div> | ||
+ | <div class="container" align="center"> | ||
+ | <div class="row" align="center"> | ||
+ | <div class="col-sm-4"> | ||
+ | <a href="https://www.steptember.us/"><img class="sponsor" src="https://static.igem.org/mediawiki/2018/3/38/T--New_York_City--step.png"/></a> | ||
+ | </div> | ||
+ | <div class="col-sm-4"> | ||
+ | <a href="https://nya.hdsa.org//"><img class="sponsor" src="https://static.igem.org/mediawiki/2018/6/61/T--New_York_City--ya.png"/></a> | ||
+ | </div> | ||
+ | <div class="col-sm-4"> | ||
+ | <a href="https://hdsa.donordrive.com/index.cfm?fuseaction=donorDrive.participant&participantID=48528"><img class="sponsor" src="https://static.igem.org/mediawiki/2018/1/11/T--New_York_City--hope.png"/></a> | ||
+ | </div> | ||
+ | </div> | ||
+ | <br/> | ||
+ | <div class="container" align="center"> | ||
+ | <div class="row" align="center"> | ||
+ | <div class="col-sm-3"> | ||
+ | </div> | ||
+ | <div class="col-sm-2"> | ||
+ | <a href="https://www.facebook.com/HDResolution/"><img class="social" src="https://static.igem.org/mediawiki/2018/6/61/T--New_York_City--fb.png"></a> | ||
+ | </div> | ||
+ | <div class="col-sm-2"> | ||
+ | <a href="https://twitter.com/HDNYC_iGEM"><img class="social" src="https://static.igem.org/mediawiki/2018/4/46/T--New_York_City--twit.png"></a> | ||
+ | </div> | ||
+ | <div class="col-sm-2"> | ||
+ | <a href="https://www.instagram.com/nyc_igem/"><img class="social" src="https://static.igem.org/mediawiki/2018/0/0a/T--New_York_City--ig.png"></a> | ||
+ | </div> | ||
+ | <div class="col-sm-3"> | ||
+ | </div> | ||
+ | </div> | ||
+ | <br /> | ||
+ | </div> | ||
</body> | </body> | ||
+ | </html> |
Latest revision as of 00:10, 5 December 2018
Testing the efficacy of mRNA displacement technique in huntingtin cell lines to treat Huntington's Disease
WHAT
Huntington's Disease (HD) is a genetic disorder that results in the breakdown of nerve cells in the brain. Although the disease affects the whole brain, the basal ganglia, which plays a critical role in motor functions and behavior, is most severely affected. Thus, symptoms of HD include involuntary movements, personality changes, and cognitive problems. Over time, the effects of HD is extremely debilitating, eventually rendering a patient unable to speak, walk, or even reason.
WHY
HD is a result of a specific mutation in the huntingtin (HTT) gene, which results in a faulty production of the HTT protein, mHTT. The mutation is a trinucleotide repeat of the codon CAG, where 40 or more will lead to the expression of HD.
WHO
The most common form of HD is adult-onset, affecting people between their 30s and 40s. Many people form families and have children by the time they are diagnosed with HD, which automatically gives their children a 50% chance of inheriting the disease. HD affects about 1 in every 10,000 people worldwide.
HOW
Our goal is to develop a cure to Huntington's Disease by employing RNA strand displacement technology to target erroneous mRNA within the affected cells and replace it with the corrected RNA strand for proper protein synthesis.