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| − | {{Utrecht/Navigation}}
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| − | <div class = "customelementM timeline" style = "background-color: blue">
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| − | <img style="z-index: 30" src="https://static.igem.org/mediawiki/2018/4/4e/T--Utrecht--2018-Graphic2-Home.svg">
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| − | <div class="customelementC3" style = "top: 3%;left: 10%;width: 80%;background-color: blue">
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| − | <video width = "100%" controls autoplay>
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| − | <source src="https://static.igem.org/mediawiki/2018/b/bb/T--Utrecht--2018--Home-Animation.mp4" type="video/mp4">
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| − | Your browser does not support the video tag :(
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| − | <div class="customelementC3" style = "top: 68.5%;left: 49%;width: 35%;text-align: center;font-size: 1.5vw">
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| − | Hello You!
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| − | </br></br>
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| − | Hello You!
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| − | Welcome to our wiki page. We are Team Utrecht 2018, a very diverse team from Utrecht University in the Netherlands. Want to know more about our team?
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| − | </br></br>
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| − | <a href = "https://2018.igem.org/Team:Utrecht/Team"> Click Here. </a>
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| − | <div class = "customelementM transparent timeline">
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| − | <div class="customelementC3" style = "top: 3.4%;left: 19%;width: 30%;">
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| − | Water is arguably our most precious resource.
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| − | Unfortunately, increased use of pharmaceuticals including antidepressants and chemotherapeutic medications are contaminating this valuable resource.
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| − | <div class="customelementC3" style = "top: 13.9%;left: 27.4%;width: 43%;">
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| − | After human use of these medications, remnants are disposed through the sewage systems and eventually contaminate surface waters, resulting in an increased pollutant concentration in the environment.
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| − | <div class="customelementC3" style = "top: 27.4%;left: 12%;width: 37%;">
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| − | These pharmaceutical waste products are still biologically active in vertebrates. For example, even low concentrations of antidepressants pose a threat to both society and ecological systems.
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| − | <div class="customelementC3" style = "top: 28.8%;left: 59.2%;width: 26%;">
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| − | We talked to water treatment companies, specialists and other stakeholders about how to improve current detection methods. Key requirements for our biosensor included safety, accuracy, high measurement rates and low costs.
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| − | See more on <a href = "https://2018.igem.org/Team:Utrecht/Human_Practices"> Integrated Human Practices.</a>
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| − | <div class="customelementC3" style = "top: 36.1%;left: 20%;width: 41%;">
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| − | Based on the input of experts and stakeholders, we developed the DeTaXion biosensor. DeTaXion improves identification of antidepressants in water, based on the chemotaxis pathway of E. coli.
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| − | For a more detailed discussion you can visit our <a href = "https://2018.igem.org/Team:Utrecht/Description"> Project Description.</a>
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| − | </div>
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| − | <div class="customelementC3" style = "top: 47.2%;left: 4.6%;width: 44%;">
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| − | The chemotaxis pathway was adjusted in such a manner that E. coli can detect antidepressants. Upon recognition of the antidepressant agents, the light signal produced by the E. coli changes.
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| − | <div class="customelementC3" style = "top: 52.6%;left: 65.6%;width: 26%;">
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| − | To achieve the detection of antidepressants, we set up a three step approach <a href = "https://2018.igem.org/Team:Utrecht/Design"> Project Design</a>.
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| − | </br></br>
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| − | Next, we performed these steps in the lab, which resulted into interesting <a href = "https://2018.igem.org/Team:Utrecht/Results">Findings</a>.
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| − | <div class="customelementC3" style = "top: 65.2%;left: 56%;width: 32%;">
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| − | Since we wanted to enlighten others about biotechnology, water safety and valorisation, we engaged the public at several outreach event, including our <a href = "https://2018.igem.org/Team:Utrecht/Conference"> biotechnology conference </a> and “Weekend of Science”, establishing an open discussion. More about this topic can be found in <a href = "https://2018.igem.org/Team:Utrecht/Public_Engagement">Public Engagement</a>.
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| − | </br></br>
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| − | Furthermore, we <a href = "https://2018.igem.org/Team:Utrecht/Collaborations">collaborated</a> with other iGEM teams to get valuable insights.</div>
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| − | <div class="customelementC3" style = "top: 75.8%;left: 34%;width: 30%;">
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| − | We also had to find the means to fund our project.
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| − | Luckily, some parties were willing to invest
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| − | their time and capital in us.
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| − | </br></br></br>
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| − | We are very grateful to our <a href = "https://2018.igem.org/Team:Utrecht/Sponsors">Sponsors</a> and other <a href = "https://2018.igem.org/Team:Utrecht/Attributions">Contributors</a>.
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| − | A special thank you for your help!
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| − | </div>
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| − | <div class="customelementC3" style = "top: 88%;left: 54%;width: 38%">
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| − | After a lot of late nights, long hours in the laboratory, insightful conversations with stakeholders, sweat (maybe some tears) and a massive amount of laughter and joy.
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| − | </br></br>
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| − | We, Team Utrecht 2018, proudly present you our applied product:
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| − | </br></br>
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| − | <a href = "https://2018.igem.org/Team:Utrecht/Applied_Design"><i style = "font-size: 1.6vw"><u><b>DeTaXion</a>: A biosensor to rapidly identify harmful water-based pharmaceuticals in surface waters.</i>
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| − | {{Utrecht/Footer}}
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