Difference between revisions of "Team:Paris Bettencourt"

 
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<h2>Protein scaffolds for star-shaped antimicrobial peptides</h2>
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<h1> STAR CORES: Protein scaffolds for star-shaped AMPs </h1>
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<p><b>StarCores</b> are these novel, biologically-synhesized, star-shaped Antimicrobial Peptide (AMP). Like antibiotics, AMPs can be used to kill harmful bacteria. Since AMPs attack bacteria differently than conventional antibiotics, <b>the resistance evolution occurs at a much slower rate.</b></br>
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<p> Antibiotic resistance is responsible for an estimated 25 000 deaths per year in the EU and 1.5 billion € per year in healthcare costs. A promising alternative to antibiotics is antimicrobial peptides (AMPs), a diverse class of naturally occurring proteins. Similar to antibiotics, AMPs have a broad action spectrum and high efficiency, but resistance to AMPs evolves much more slowly. These compounds are usually produced using chemical synthesis, which requires specialized equipment and personnel and has limited yield. Our project will employ E. coli based cell-free expression platform to produce naturally occurring or artificially designed AMPs. These AMPs are fused to self-assembling star-shaped scaffold proteins to improve their bactericidal efficiency against various infection-causing bacteria. Our aim is to screen various AMPs and scaffold protein complexes, followed by a selection of the best AMP+scaffold combinations in terms of bactericidal property and bio-compatibility.</p>
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<p> For more details, email us at : paris-bettencourt-2018@cri-paris.org </p>
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<p>We designed StarCores in response to the specific needs of veterinarians, farmers, and policymakers in France. Our goal was to provide a specific solution for killing Gram-negative bacteria on pig farms. Over the summer, we successfully designed, produced, tested, and optimized a novel class of bacteria-killing peptides with <b>high activity and reduced toxicity.</b></br>
  
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<p>The story of our project unfolds sequentially. For the best experience of our wiki, we invite you to read the sections below in order, starting with <b>Integrated Human Practices (Human Practices I)</b>.</p>
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                <div>Human Practices I </div>
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                <div>Modeling</div>
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                <div>Optimization</div>
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                <div>Human Practices II (Public Engagement)</div>
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                <div>BioBricks</div>
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  <h3>Giant Jamboree 2018 Results!</h3>
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  <b>Gold Medal </b><br>
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  Nominations for <b>Best New Composite Part </b> and <b>Best Software</b><br><b><a href="https://synbiobeta.com/cell-free-expression-platforms-enable-new-possibilities-at-igem-and-beyond/">Synbiobeta wrote an article on us! </b>
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Latest revision as of 00:50, 8 December 2018

Protein scaffolds for star-shaped antimicrobial peptides

StarCores are these novel, biologically-synhesized, star-shaped Antimicrobial Peptide (AMP). Like antibiotics, AMPs can be used to kill harmful bacteria. Since AMPs attack bacteria differently than conventional antibiotics, the resistance evolution occurs at a much slower rate.

We designed StarCores in response to the specific needs of veterinarians, farmers, and policymakers in France. Our goal was to provide a specific solution for killing Gram-negative bacteria on pig farms. Over the summer, we successfully designed, produced, tested, and optimized a novel class of bacteria-killing peptides with high activity and reduced toxicity.

The story of our project unfolds sequentially. For the best experience of our wiki, we invite you to read the sections below in order, starting with Integrated Human Practices (Human Practices I).

Human Practices I
Design
Production
Testing
Modeling
Optimization
Human Practices II (Public Engagement)
Team
Lab Notebook
BioBricks
Medal Criteria



Giant Jamboree 2018 Results!


Gold Medal
Nominations for Best New Composite Part and Best Software
Synbiobeta wrote an article on us!

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
paris-bettencourt-2018@cri-paris.org