Difference between revisions of "Team:BioIQS-Barcelona/Results"

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{{BioIQS-Barcelona}}
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<h1>Results</h1>
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<p>Here you can describe the results of your project and your future plans. </p>
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</div>
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    <title>BIO IQS</title>
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    <!-- Bootstrap core CSS -->
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    <link href="https://2018.igem.org/Template:BioIQS-Barcelona/css/bootstrapmin?action=raw&ctype=text/css" rel="stylesheet">
  
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    <script>
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        $(function () {
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            $('navigationbar').load('https://2018.igem.org/Template:BioIQS-Barcelona/header?action=raw&ctype=text/javascript');
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            $('footer').load('https://2018.igem.org/Template:BioIQS-Barcelona/footer?action=raw&ctype=text/javascript');
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<h3>What should this page contain?</h3>
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<ul>
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    <link href="https://2018.igem.org/Template:BioIQS-Barcelona/css/allmin?action=raw&ctype=text/css" rel="stylesheet"> <!-- canvio all.min per allmin-->
<li> Clearly and objectively describe the results of your work.</li>
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    <link rel="stylesheet" href="https://2018.igem.org/Template:BioIQS-Barcelona/css/simplelineicons?action=raw&ctype=text/css">     <!-- CANVI-->
<li> Future plans for the project. </li>
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<li> Considerations for replicating the experiments. </li>
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    <link href="https://fonts.googleapis.com/css?family=Catamaran:100,200,300,400,500,600,700,800,900" rel="stylesheet">
</ul>
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    <link href="https://fonts.googleapis.com/css?family=Muli" rel="stylesheet">    
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    <link rel="stylesheet" href="https://2018.igem.org/Template:BioIQS-Barcelona/css/new-age?action=raw&ctype=text/css">
  
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<h3>Describe what your results mean </h3>
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<li> Interpretation of the results obtained during your project. Don't just show a plot/figure/graph/other, tell us what you think the data means. This is an important part of your project that the judges will look for. </li>
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<li> Show data, but remember all measurement and characterization data must be on part pages in the Registry. </li>
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            overflow-wrap: break-word;
<li> Consider including an analysis summary section to discuss what your results mean. Judges like to read what you think your data means, beyond all the data you have acquired during your project. </li>
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</ul>
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<div class="column two_thirds_size" >
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    <!-- TREIEM AIXO PQ SENSE ESTIL ES PERD EL FORMAT I NO SERVEIX DE RES -->
<h3> Project Achievements </h3>
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    <navigationbar></navigationbar>
  
<p>You can also include a list of bullet points (and links) of the successes and failures you have had over your summer. It is a quick reference page for the judges to see what you achieved during your summer.</p>
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    <button id="myBtn" class="js-scroll-trigger" title="Go to top">Top</button>
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                <div class="col-lg-7 my-auto">
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                    <div class="header-content">
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                        <h1 class="mb-5">Project | Results</h1>
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                        <a href="https://2018.igem.org/Team:BioIQS-Barcelona/Results#first-steps" class="btn btn-outline btn-xl js-scroll-trigger">Have a look!</a>
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                </div>
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            </div>
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        </div>
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    </header>
  
<ul>
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<li>A list of linked bullet points of the successful results during your project</li>
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        <section class="first-steps text-center" id="first-steps">
<li>A list of linked bullet points of the unsuccessful results during your project. This is about being scientifically honest. If you worked on an area for a long time with no success, tell us so we know where you put your effort.</li>
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</ul>
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                <div class="col-md-9 mx-auto">
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                    <h2 class="section-heading orange" id="cuttheword">Achievements of our project</h2>
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                </div>
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                <div class="col-md-12 mx-auto block-sept">
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                    <a class="js-scroll-trigger a-arrow" href="https://2018.igem.org/Team:BioIQS-Barcelona/Results#cl-description"><span class="arrow down"></span></a>
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</div>
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                        <h1 class="book orange"><i>1.</i></h1>
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                    </div>
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                                <div class="col-md-12">
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                                    <h4 class="book orange-medium">Computationally <a href="https://2018.igem.org/Team:BioIQS-Barcelona/Standardization">demonstrated</a> that primer binding regions are perfectly conserved or slightly different for both DQ2 and DQ8 celiac haplotypes separately. This means that either the same primer can be used for amplifying all genotypes, or a specific HLA-DQ2- or HLA-DQ8-primer can be designed, reducing the cost of the sensor.</h4>
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                        <div class="col-md-6 left">
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                            <div class="row block-sept">
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                              <div class="col-md-auto">
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                        <h1 class="book orange"><i>2.</i></h1>
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                    </div>
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                                <div class="col-md-12">
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                                    <h4 class="book orange-medium">Successfully <a href="https://2018.igem.org/Team:BioIQS-Barcelona/Basic_Part">designed</a> a simple and cheap way to extract the extracellular domain of both alpha and beta chains of the HLA-DQ protein from the human genome. This would make the extraction of all HLA-DQ existing variants possible using only one protocol.</h4>
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        </div>
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    </section>
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                  <section class="st-description block-desc" id="cl-description">
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                        <h1 class="book orange"><i>3.</i></h1>
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                    </div>
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                                <div class="col-md-12">
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                                    <h4 class="book orange-medium">Thoroughly designed and characterized multiple <a href="https://2018.igem.org/Team:BioIQS-Barcelona/Composite_Part">composite parts</a> to ensure the correct expression of the human HLA-DQ presenting protein in a bacterial or yeast host. This would enable us to determine the best way to produce the elements needed for the sensor.</h4>
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                                </div>
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<div class="highlight decoration_A_full">
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<h3>Inspiration</h3>
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                              <div class="col-md-auto">
<p>See how other teams presented their results.</p>
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                        <h1 class="book orange"><i>4.</i></h1>
<ul>
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                    </div>
<li><a href="https://2014.igem.org/Team:TU_Darmstadt/Results/Pathway">2014 TU Darmstadt </a></li>
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                                <div class="col-md-12">
<li><a href="https://2014.igem.org/Team:Imperial/Results">2014 Imperial </a></li>
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                                    <h4 class="book orange-medium">Correctly cloned one of the constructs into the desired expression vector and prepared it for further expression experiments. Cloning is a tedious work and not always results as one would expect so this is an important achievement!</h4>
<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Results">2014 Paris Bettencourt </a></li>
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                                </div>
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                        <h1 class="book orange"><i>5.</i></h1>
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                    </div>
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                                <div class="col-md-12">
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                                    <h4 class="book orange-medium">Carefully built a <a href="https://2018.igem.org/Team:BioIQS-Barcelona/Model">theoretical model</a> to illustrate the essential detection mechanism of the sensor. Modeling has become one of the most important jobs in this project and have allowed us to better understand the role of the sensor.</h4>
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                            </div>
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                        </div>
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    </section>
  
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    <footer></footer>
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Latest revision as of 18:56, 17 December 2018

BIO IQS

Project | Results

Have a look!

Achievements of our project

1.

Computationally demonstrated that primer binding regions are perfectly conserved or slightly different for both DQ2 and DQ8 celiac haplotypes separately. This means that either the same primer can be used for amplifying all genotypes, or a specific HLA-DQ2- or HLA-DQ8-primer can be designed, reducing the cost of the sensor.

2.

Successfully designed a simple and cheap way to extract the extracellular domain of both alpha and beta chains of the HLA-DQ protein from the human genome. This would make the extraction of all HLA-DQ existing variants possible using only one protocol.

3.

Thoroughly designed and characterized multiple composite parts to ensure the correct expression of the human HLA-DQ presenting protein in a bacterial or yeast host. This would enable us to determine the best way to produce the elements needed for the sensor.

4.

Correctly cloned one of the constructs into the desired expression vector and prepared it for further expression experiments. Cloning is a tedious work and not always results as one would expect so this is an important achievement!

5.

Carefully built a theoretical model to illustrate the essential detection mechanism of the sensor. Modeling has become one of the most important jobs in this project and have allowed us to better understand the role of the sensor.