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<html lang="en"> | <html lang="en"> | ||
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+ | <head> | ||
+ | |||
+ | <meta charset="utf-8"> | ||
+ | <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> | ||
+ | <meta name="description" content=""> | ||
+ | <meta name="author" content=""> | ||
+ | |||
+ | <title>OriginALS</title> | ||
+ | |||
+ | |||
+ | <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/bootstrap/4.1.0/css/bootstrap.min.css"> | ||
+ | |||
+ | |||
+ | |||
+ | |||
+ | <!-- Custom styles for this template --> | ||
+ | <style> | ||
+ | body, | ||
+ | html { | ||
+ | width: 100%; | ||
+ | height: 100%; | ||
+ | } | ||
+ | |||
+ | body { | ||
+ | font-family: 'Segoe UI Light'; | ||
+ | } | ||
+ | |||
+ | hr { | ||
+ | max-width: 60px; | ||
+ | border-width: 1px; | ||
+ | border-color: #0186ac; | ||
+ | } | ||
+ | |||
+ | hr.light { | ||
+ | border-color: #fff; | ||
+ | } | ||
+ | hr.dark { | ||
+ | border-color:#262626 | ||
+ | } | ||
+ | |||
+ | a { | ||
+ | color: #0186ac; | ||
+ | -webkit-transition: all 0.2s; | ||
+ | -moz-transition: all 0.2s; | ||
+ | transition: all 0.2s; | ||
+ | } | ||
+ | |||
+ | a:hover { | ||
+ | color: #0186ac; | ||
+ | text-decoration: none; | ||
+ | } | ||
+ | |||
+ | p{ | ||
+ | font-size:1.2rem; | ||
+ | } | ||
+ | ol { | ||
+ | font-size:1.2rem; | ||
+ | } | ||
+ | .justified { | ||
+ | text-align: justify; | ||
+ | } | ||
+ | h1, | ||
+ | h2, | ||
+ | h3, | ||
+ | h4, | ||
+ | h5, | ||
+ | h6 { | ||
+ | font-family: 'Segoe UI Light'; | ||
+ | |||
+ | } | ||
+ | |||
+ | .bg-primary { | ||
+ | background-color: #0186ac !important; | ||
+ | } | ||
+ | |||
+ | .bg-dark { | ||
+ | background-color: #212529 !important; | ||
+ | } | ||
+ | |||
+ | .text-faded { | ||
+ | color: rgba(255, 255, 255, 0.7); | ||
+ | } | ||
+ | .text-white { | ||
+ | color: rgba(255, 255, 255); | ||
+ | } | ||
+ | section { | ||
+ | padding: 8rem 0; | ||
+ | } | ||
+ | |||
+ | .section-heading { | ||
+ | margin-top: 0; | ||
+ | } | ||
+ | |||
+ | ::-moz-selection { | ||
+ | color: #fff; | ||
+ | background: #212529; | ||
+ | text-shadow: none; | ||
+ | } | ||
+ | |||
+ | ::selection { | ||
+ | color: #fff; | ||
+ | background: #212529; | ||
+ | text-shadow: none; | ||
+ | } | ||
+ | |||
+ | img::selection { | ||
+ | color: #fff; | ||
+ | background: transparent; | ||
+ | } | ||
+ | |||
+ | img::-moz-selection { | ||
+ | color: #fff; | ||
+ | background: transparent; | ||
+ | } | ||
+ | |||
+ | #mainNav { | ||
+ | border-bottom: 1px solid rgba(33, 37, 41, 0.1); | ||
+ | background-color: #fff; | ||
+ | font-family: 'Segoe UI', Calibri; | ||
+ | padding-left:0; | ||
+ | |||
+ | } | ||
+ | |||
+ | #mainNav .navbar-brand { | ||
+ | |||
+ | text-transform: uppercase; | ||
+ | color: #0186ac; | ||
+ | |||
+ | } | ||
+ | |||
+ | #mainNav .navbar-brand:focus, #mainNav .navbar-brand:hover { | ||
+ | color: #0186ac; | ||
+ | } | ||
+ | |||
+ | #mainNav .navbar-nav > li.nav-item > a.nav-link, | ||
+ | #mainNav .navbar-nav > li.nav-item > a.nav-link:focus { | ||
+ | font-size: 1.rem; | ||
+ | text-transform: uppercase; | ||
+ | color: #212529 !important; | ||
+ | font-weight:bold; | ||
+ | } | ||
+ | |||
+ | #mainNav .navbar-nav > li.nav-item > a.nav-link:hover, | ||
+ | #mainNav .navbar-nav > li.nav-item > a.nav-link:focus:hover { | ||
+ | color: #0186ac; | ||
+ | } | ||
+ | |||
+ | #mainNav .navbar-nav > li.nav-item > a.nav-link.active, | ||
+ | #mainNav .navbar-nav > li.nav-item > a.nav-link:focus.active { | ||
+ | color: #0186ac !important; | ||
+ | background-color: transparent; | ||
+ | } | ||
+ | |||
+ | #mainNav .navbar-nav > li.nav-item > a.nav-link.active:hover, | ||
+ | #mainNav .navbar-nav > li.nav-item > a.nav-link:focus.active:hover { | ||
+ | background-color: transparent; | ||
+ | } | ||
+ | |||
+ | @media (min-width: 992px) { | ||
+ | #mainNav { | ||
+ | border-color: transparent; | ||
+ | background-color: transparent; | ||
} | } | ||
− | + | #mainNav .navbar-brand { | |
− | + | color: #434343; | |
− | + | ||
− | + | ||
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− | + | ||
} | } | ||
− | + | #mainNav .navbar-brand:focus, #mainNav .navbar-brand:hover { | |
− | + | color: #fff; | |
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} | } | ||
− | . | + | #mainNav .navbar-nav > li.nav-item > a.nav-link { |
− | + | padding: 0.5rem 1rem; | |
} | } | ||
− | . | + | #mainNav .navbar-nav > li.nav-item > a.nav-link, |
− | + | #mainNav .navbar-nav > li.nav-item > a.nav-link:focus { | |
+ | color: rgba(255, 255, 255, 0.7); | ||
} | } | ||
− | . | + | #mainNav .navbar-nav > li.nav-item > a.nav-link:hover, |
− | + | #mainNav .navbar-nav > li.nav-item > a.nav-link:focus:hover { | |
− | + | color: #fff; | |
} | } | ||
− | . | + | #mainNav.navbar-shrink { |
− | + | border-bottom: 1px solid rgba(33, 37, 41, 0.1); | |
− | + | background-color: #fff; | |
} | } | ||
− | . | + | #mainNav.navbar-shrink .navbar-brand { |
− | + | color: #0186ac; | |
− | + | ||
− | + | ||
} | } | ||
− | . | + | #mainNav.navbar-shrink .navbar-brand:focus, #mainNav.navbar-shrink .navbar-brand:hover { |
− | + | color: #0186ac; | |
− | + | ||
− | + | ||
} | } | ||
− | . | + | #mainNav.navbar-shrink .navbar-nav > li.nav-item > a.nav-link, |
− | + | #mainNav.navbar-shrink .navbar-nav > li.nav-item > a.nav-link:focus { | |
− | + | color: #212529; | |
} | } | ||
− | . | + | #mainNav.navbar-shrink .navbar-nav > li.nav-item > a.nav-link:hover, |
− | + | #mainNav.navbar-shrink .navbar-nav > li.nav-item > a.nav-link:focus:hover { | |
+ | color: #0186ac; | ||
} | } | ||
− | . | + | } |
− | + | ||
+ | header.masthead { | ||
+ | padding-top: 10rem; | ||
+ | padding-bottom: calc(10rem - 56px); | ||
+ | |||
+ | background-position: center center; | ||
+ | -webkit-background-size: cover; | ||
+ | -moz-background-size: cover; | ||
+ | -o-background-size: cover; | ||
+ | background-size: cover; | ||
+ | } | ||
+ | |||
+ | header.masthead hr { | ||
+ | margin-top: 30px; | ||
+ | margin-bottom: 30px; | ||
+ | } | ||
+ | |||
+ | header.masthead h1 { | ||
+ | font-size: 2rem; | ||
+ | } | ||
+ | |||
+ | header.masthead p { | ||
+ | font-weight: 300; | ||
+ | } | ||
+ | |||
+ | @media (min-width: 768px) { | ||
+ | header.masthead p { | ||
+ | font-size: 1.15rem; | ||
} | } | ||
− | . | + | } |
− | + | ||
− | + | @media (min-width: 992px) { | |
− | + | header.masthead { | |
− | + | height: 100vh; | |
− | + | min-height: 650px; | |
+ | padding-top: 0; | ||
+ | padding-bottom: 0; | ||
} | } | ||
− | . | + | header.masthead h1 { |
− | + | font-size: 3rem; | |
} | } | ||
− | + | } | |
− | + | ||
− | + | @media (min-width: 1200px) { | |
− | + | header.masthead h1 { | |
− | + | font-size: 4rem; | |
− | . | + | |
− | + | ||
} | } | ||
− | + | } | |
− | + | ||
− | + | .service-box { | |
− | + | max-width: 400px; | |
− | + | } | |
− | + | ||
− | + | .portfolio-box { | |
− | + | position: relative; | |
− | + | display: block; | |
− | + | max-width: 650px; | |
− | + | margin: 0 auto; | |
− | + | } | |
− | + | ||
− | + | .portfolio-box .portfolio-box-caption { | |
− | + | position: absolute; | |
− | + | bottom: 0; | |
− | + | display: block; | |
− | + | width: 100%; | |
− | + | height: 100%; | |
− | + | text-align: center; | |
− | + | opacity: 0; | |
− | + | color: #fff; | |
− | + | background: rgba(240, 95, 64, 0.9); | |
− | + | -webkit-transition: all 0.2s; | |
− | + | -moz-transition: all 0.2s; | |
− | + | transition: all 0.2s; | |
− | + | } | |
− | + | ||
− | + | .portfolio-box .portfolio-box-caption .portfolio-box-caption-content { | |
− | + | position: absolute; | |
− | + | top: 50%; | |
− | + | width: 100%; | |
− | + | transform: translateY(-50%); | |
− | + | text-align: center; | |
− | + | } | |
− | + | ||
− | + | .portfolio-box .portfolio-box-caption .portfolio-box-caption-content .project-category, | |
− | + | .portfolio-box .portfolio-box-caption .portfolio-box-caption-content .project-name { | |
− | + | padding: 0 15px; | |
− | padding | + | font-family: 'Open Sans', 'Helvetica Neue', Arial, sans-serif; |
− | + | } | |
− | + | ||
− | + | .portfolio-box .portfolio-box-caption .portfolio-box-caption-content .project-category { | |
− | + | font-size: 14px; | |
− | } | + | font-weight: 600; |
− | . | + | text-transform: uppercase; |
− | + | } | |
− | + | ||
+ | .portfolio-box .portfolio-box-caption .portfolio-box-caption-content .project-name { | ||
+ | font-size: 18px; | ||
+ | } | ||
+ | |||
+ | .portfolio-box:hover .portfolio-box-caption { | ||
+ | opacity: 1; | ||
+ | } | ||
+ | |||
+ | .portfolio-box:focus { | ||
+ | outline: none; | ||
+ | } | ||
+ | |||
+ | @media (min-width: 768px) { | ||
+ | .portfolio-box .portfolio-box-caption .portfolio-box-caption-content .project-category { | ||
+ | font-size: 16px; | ||
} | } | ||
− | . | + | .portfolio-box .portfolio-box-caption .portfolio-box-caption-content .project-name { |
− | + | font-size: 22px; | |
− | + | ||
} | } | ||
− | + | } | |
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− | + | ||
− | + | ||
− | + | .text-primary { | |
− | + | color: #0186ac !important; | |
− | + | } | |
− | + | ||
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− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | .btn { | |
− | + | font-weight: 700; | |
− | + | text-transform: uppercase; | |
+ | border: none; | ||
+ | border-radius: 300px; | ||
+ | font-family: 'Open Sans', 'Helvetica Neue', Arial, sans-serif; | ||
+ | } | ||
+ | .btn-xl { | ||
+ | padding: 1rem 2rem; | ||
+ | } | ||
+ | .btn-primary { | ||
+ | background-color: #0186ac; | ||
+ | border-color: #0186ac; | ||
+ | } | ||
− | + | .btn-primary:hover, .btn-primary:focus, .btn-primary:active { | |
− | + | color: #fff; | |
− | + | background-color: #ee4b28 !important; | |
− | + | } | |
− | + | ||
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− | + | ||
− | + | ||
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− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | .btn-primary:active, .btn-primary:focus { | |
− | + | box-shadow: 0 0 0 0.2rem rgba(240, 95, 64, 0.5) !important; | |
− | + | } | |
− | + | ||
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− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | /*parallax*/ | |
− | + | .parallax-window { | |
− | + | min-height: 400px; | |
− | + | background: transparent; | |
− | + | } | |
− | + | @media (min-width: 768px) { | |
− | + | #contact .container { | |
− | + | width:60%; | |
− | + | } | |
− | + | } | |
− | + | .footer-nav .navbar-brand { | |
− | + | padding-left:30px; | |
− | + | } | |
− | + | </style> | |
− | + | <link href="css/hover.css" rel="stylesheet"> | |
− | + | ||
− | + | </head> | |
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− | </ | + | |
− | + | ||
− | + | <body id="page-top"> | |
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− | < | + | |
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− | + | ||
− | <!-- | + | <!-- Navigation --> |
− | < | + | <nav class="navbar navbar-expand-lg navbar-light fixed-top" id="mainNav"> |
− | <div class=" | + | <div class="container"> |
− | < | + | <a class="navbar-brand js-scroll-trigger" href="#page-top">Start Bootstrap</a> |
+ | <button class="navbar-toggler navbar-toggler-right" type="button" data-toggle="collapse" data-target="#navbarResponsive" aria-controls="navbarResponsive" aria-expanded="false" aria-label="Toggle navigation"> | ||
+ | <span class="navbar-toggler-icon"></span> | ||
+ | </button> | ||
+ | <div class="collapse navbar-collapse" id="navbarResponsive"> | ||
+ | <ul class="navbar-nav ml-auto"> | ||
+ | <li class="nav-item"> | ||
+ | <a class="nav-link js-scroll-trigger" href="#about">Home</a> | ||
+ | </li> | ||
+ | <li class="nav-item"> | ||
+ | <a class="nav-link js-scroll-trigger" href="#services">Project</a> | ||
+ | </li> | ||
+ | <li class="nav-item"> | ||
+ | <a class="nav-link js-scroll-trigger" href="#portfolio">Team</a> | ||
+ | </li> | ||
+ | <li class="nav-item"> | ||
+ | <a class="nav-link js-scroll-trigger" href="#contact">Parts</a> | ||
+ | </li> | ||
+ | <li class="nav-item"> | ||
+ | <a class="nav-link js-scroll-trigger" href="#about">Practices</a> | ||
+ | </li> | ||
+ | <li class="nav-item"> | ||
+ | <a class="nav-link js-scroll-trigger" href="#services">Attributions</a> | ||
+ | </li> | ||
+ | |||
+ | </ul> | ||
+ | </div> | ||
</div> | </div> | ||
− | <div class=" | + | </nav> |
− | < | + | |
+ | <header class="masthead text-center parallax-window text-white d-flex" data-parallax="scroll" data-image-src="img/banner.png"> | ||
+ | <div class="container my-auto"> | ||
+ | <!--<div class="row"> | ||
+ | <div class="col-lg-10 mx-auto"> | ||
+ | <h1 class="text-uppercase"> | ||
+ | <strong>Your Favorite Source of Free Bootstrap Themes</strong> | ||
+ | </h1> | ||
+ | <hr> | ||
+ | </div> | ||
+ | <div class="col-lg-8 mx-auto"> | ||
+ | <p class="text-faded mb-5">Start Bootstrap can help you build better websites using the Bootstrap CSS framework! Just download your template and start going, no strings attached!</p> | ||
+ | <a class="btn btn-primary btn-xl js-scroll-trigger" href="#about">Find Out More</a> | ||
+ | </div> | ||
+ | </div>--> | ||
</div> | </div> | ||
− | + | </header> | |
− | + | ||
− | + | ||
− | </ | + | |
− | < | + | <section id="about"> |
− | + | <div class="container"> | |
− | + | <div class="row"> | |
− | + | <div class="col-lg-8 mx-auto"> | |
− | + | <h1 class="section-heading text-center animated fadeInLeft">Abstarct</h1> | |
− | + | <hr class="dark my-4 animated fadeInLeft"> | |
− | + | <p style="margin:0px !important; padding:0!important;" class="mb-4 justified animated fadeInRight">Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons. <br><br> | |
− | + | Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach: </p> | |
− | + | <ol class="mb-4 justified animated fadeInRight"> | |
− | + | <li> We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.</li> | |
− | </ | + | <li>We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.</li> |
+ | </ol> | ||
+ | <p class="mb-4 justified animated fadeInRight"> | ||
+ | In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.</p> | ||
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− | + | </div> | |
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</div> | </div> | ||
− | </div> | + | </div> |
− | </ | + | </section> |
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− | < | + | <section id="contact" class="bg-dark"> |
− | + | <div class="container"> | |
− | + | <div class="row"> | |
− | + | <div class="col-lg-8 mx-auto text-center text-white"> | |
− | + | <h1 class="section-heading">Contact Us</h1> | |
− | + | <hr class="my-4 light"> | |
− | + | <p class="mb-5 text-faded">Feel free to follow and contact us for more information on:</p> | |
− | + | </div> | |
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</div> | </div> | ||
− | <div class="col- | + | <div class="row"> |
− | < | + | <div class="col-lg-3 col-md-6 ml-auto text-center text-faded "> |
− | + | <a href="https://www.facebook.com/iGEMBGU/" target="_blank" class="text-faded"><i class="fa fa-facebook fa-3x mb-3 sr-contac hvr-bob"></i> | |
− | + | <p>iGEM BGU</p></a> | |
− | + | </div> | |
− | + | <div class="col-lg-3 col-md-6 mr-auto text-center text-faded "> | |
− | + | <a href="https://twitter.com/originalsbgu" target="_blank" class="text-faded"><i class="fa fa-twitter fa-3x mb-3 sr-contact hvr-bob"></i> | |
− | + | <p> | |
+ | @OrignialsBGU | ||
+ | </p></a> | ||
+ | </div> | ||
+ | <div class="col-lg-3 col-md-6 ml-auto text-center text-faded"> | ||
+ | <a href="https://www.instagram.com/igem_2018_bgu/" target="_blank" class="text-faded"><i class="fa fa-instagram fa-3x mb-3 sr-contact hvr-bob"></i> | ||
+ | <p>@iGEM_2018_BGU</p></a> | ||
+ | </div> | ||
+ | <div class="col-lg-3 col-md-6 mr-auto text-center text-faded"> | ||
+ | <a href="mailto:originalbgu@gmail.com" target="_blank" class="text-faded"><i class="fa fa-envelope-o fa-3x mb-3 sr-contact hvr-bob"></i> | ||
+ | <p> | ||
+ | originalbgu@gmail.com | ||
+ | </p></a> | ||
+ | </div> | ||
+ | |||
</div> | </div> | ||
+ | |||
</div> | </div> | ||
+ | |||
+ | </section> | ||
+ | <nav class="navbar navbar-expand-md navbar-dark bg-dark"> | ||
+ | <div class="navbar-collapse collapse w-100 order-1 order-md-0 dual-collapse2"> | ||
+ | <ul class="navbar-nav mr-auto"> | ||
+ | <li class="nav-item"> | ||
+ | <a class="nav-link" href="#">Ben-Gurion University of the Negev<br> | ||
+ | Ben Gurion 1, Beer Sheva 8410501, Israel</a> | ||
+ | </li> | ||
+ | |||
+ | </ul> | ||
+ | </div> | ||
+ | |||
+ | <div class="navbar-collapse collapse w-100 order-3 dual-collapse2"> | ||
+ | <ul class="navbar-nav ml-auto"> | ||
+ | <li class="nav-item"> | ||
+ | <a class="nav-link" href="#">Copyright © 2018 OriginALS. All Rights Reserved.</a> | ||
+ | </li> | ||
+ | |||
+ | </ul> | ||
</div> | </div> | ||
− | + | </nav> | |
− | </ | + | <link href="css/animate.css" rel="stylesheet"> |
− | <!-- | + | <!-- Bootstrap core JavaScript --> |
− | < | + | <script src="vendor/jquery/jquery.min.js"></script> |
− | + | <script src="vendor/bootstrap/js/bootstrap.bundle.min.js"></script> | |
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | </script> | + | |
− | <script src=" | + | |
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | < | + | <!-- Plugin JavaScript --> |
− | + | <script src="vendor/jquery-easing/jquery.easing.min.js"></script> | |
− | < | + | <script src="vendor/scrollreveal/scrollreveal.min.js"></script> |
− | + | <script src="vendor/magnific-popup/jquery.magnific-popup.min.js"></script> | |
− | + | <script> | |
− | + | /*! | |
+ | * parallax.js v1.5.0 (http://pixelcog.github.io/parallax.js/) | ||
+ | * @copyright 2016 PixelCog, Inc. | ||
+ | * @license MIT (https://github.com/pixelcog/parallax.js/blob/master/LICENSE) | ||
+ | */ | ||
− | + | ;(function ( $, window, document, undefined ) { | |
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | // Polyfill for requestAnimationFrame | |
− | + | // via: https://gist.github.com/paulirish/1579671 | |
− | // | + | (function() { |
− | // | + | var lastTime = 0; |
− | $(' | + | var vendors = ['ms', 'moz', 'webkit', 'o']; |
− | + | for(var x = 0; x < vendors.length && !window.requestAnimationFrame; ++x) { | |
− | }, | + | window.requestAnimationFrame = window[vendors[x]+'RequestAnimationFrame']; |
− | + | window.cancelAnimationFrame = window[vendors[x]+'CancelAnimationFrame'] || window[vendors[x]+'CancelRequestAnimationFrame']; | |
− | // | + | } |
− | + | ||
+ | if (!window.requestAnimationFrame) | ||
+ | window.requestAnimationFrame = function(callback) { | ||
+ | var currTime = new Date().getTime(); | ||
+ | var timeToCall = Math.max(0, 16 - (currTime - lastTime)); | ||
+ | var id = window.setTimeout(function() { callback(currTime + timeToCall); }, | ||
+ | timeToCall); | ||
+ | lastTime = currTime + timeToCall; | ||
+ | return id; | ||
+ | }; | ||
+ | |||
+ | if (!window.cancelAnimationFrame) | ||
+ | window.cancelAnimationFrame = function(id) { | ||
+ | clearTimeout(id); | ||
+ | }; | ||
+ | }()); | ||
+ | |||
+ | |||
+ | // Parallax Constructor | ||
+ | |||
+ | function Parallax(element, options) { | ||
+ | var self = this; | ||
+ | |||
+ | if (typeof options == 'object') { | ||
+ | delete options.refresh; | ||
+ | delete options.render; | ||
+ | $.extend(this, options); | ||
+ | } | ||
+ | |||
+ | this.$element = $(element); | ||
+ | |||
+ | if (!this.imageSrc && this.$element.is('img')) { | ||
+ | this.imageSrc = this.$element.attr('src'); | ||
+ | } | ||
+ | |||
+ | var positions = (this.position + '').toLowerCase().match(/\S+/g) || []; | ||
+ | |||
+ | if (positions.length < 1) { | ||
+ | positions.push('center'); | ||
+ | } | ||
+ | if (positions.length == 1) { | ||
+ | positions.push(positions[0]); | ||
+ | } | ||
+ | |||
+ | if (positions[0] == 'top' || positions[0] == 'bottom' || positions[1] == 'left' || positions[1] == 'right') { | ||
+ | positions = [positions[1], positions[0]]; | ||
+ | } | ||
+ | |||
+ | if (this.positionX !== undefined) positions[0] = this.positionX.toLowerCase(); | ||
+ | if (this.positionY !== undefined) positions[1] = this.positionY.toLowerCase(); | ||
+ | |||
+ | self.positionX = positions[0]; | ||
+ | self.positionY = positions[1]; | ||
+ | |||
+ | if (this.positionX != 'left' && this.positionX != 'right') { | ||
+ | if (isNaN(parseInt(this.positionX))) { | ||
+ | this.positionX = 'center'; | ||
+ | } else { | ||
+ | this.positionX = parseInt(this.positionX); | ||
+ | } | ||
+ | } | ||
+ | |||
+ | if (this.positionY != 'top' && this.positionY != 'bottom') { | ||
+ | if (isNaN(parseInt(this.positionY))) { | ||
+ | this.positionY = 'center'; | ||
+ | } else { | ||
+ | this.positionY = parseInt(this.positionY); | ||
+ | } | ||
+ | } | ||
+ | |||
+ | this.position = | ||
+ | this.positionX + (isNaN(this.positionX)? '' : 'px') + ' ' + | ||
+ | this.positionY + (isNaN(this.positionY)? '' : 'px'); | ||
+ | |||
+ | if (navigator.userAgent.match(/(iPod|iPhone|iPad)/)) { | ||
+ | if (this.imageSrc && this.iosFix && !this.$element.is('img')) { | ||
+ | this.$element.css({ | ||
+ | backgroundImage: 'url(' + this.imageSrc + ')', | ||
+ | backgroundSize: 'cover', | ||
+ | backgroundPosition: this.position | ||
+ | }); | ||
+ | } | ||
+ | return this; | ||
+ | } | ||
+ | |||
+ | if (navigator.userAgent.match(/(Android)/)) { | ||
+ | if (this.imageSrc && this.androidFix && !this.$element.is('img')) { | ||
+ | this.$element.css({ | ||
+ | backgroundImage: 'url(' + this.imageSrc + ')', | ||
+ | backgroundSize: 'cover', | ||
+ | backgroundPosition: this.position | ||
+ | }); | ||
+ | } | ||
+ | return this; | ||
+ | } | ||
+ | |||
+ | this.$mirror = $('<div />').prependTo(this.mirrorContainer); | ||
+ | |||
+ | var slider = this.$element.find('>.parallax-slider'); | ||
+ | var sliderExisted = false; | ||
+ | |||
+ | if (slider.length == 0) | ||
+ | this.$slider = $('<img />').prependTo(this.$mirror); | ||
+ | else { | ||
+ | this.$slider = slider.prependTo(this.$mirror) | ||
+ | sliderExisted = true; | ||
+ | } | ||
+ | |||
+ | this.$mirror.addClass('parallax-mirror').css({ | ||
+ | visibility: 'hidden', | ||
+ | zIndex: this.zIndex, | ||
+ | position: 'fixed', | ||
+ | top: 0, | ||
+ | left: 0, | ||
+ | overflow: 'hidden' | ||
+ | }); | ||
+ | |||
+ | this.$slider.addClass('parallax-slider').one('load', function() { | ||
+ | if (!self.naturalHeight || !self.naturalWidth) { | ||
+ | self.naturalHeight = this.naturalHeight || this.height || 1; | ||
+ | self.naturalWidth = this.naturalWidth || this.width || 1; | ||
+ | } | ||
+ | self.aspectRatio = self.naturalWidth / self.naturalHeight; | ||
+ | |||
+ | Parallax.isSetup || Parallax.setup(); | ||
+ | Parallax.sliders.push(self); | ||
+ | Parallax.isFresh = false; | ||
+ | Parallax.requestRender(); | ||
+ | }); | ||
+ | |||
+ | if (!sliderExisted) | ||
+ | this.$slider[0].src = this.imageSrc; | ||
+ | |||
+ | if (this.naturalHeight && this.naturalWidth || this.$slider[0].complete || slider.length > 0) { | ||
+ | this.$slider.trigger('load'); | ||
+ | } | ||
+ | |||
+ | } | ||
+ | |||
+ | |||
+ | // Parallax Instance Methods | ||
+ | |||
+ | $.extend(Parallax.prototype, { | ||
+ | speed: 0.2, | ||
+ | bleed: 0, | ||
+ | zIndex: -100, | ||
+ | iosFix: true, | ||
+ | androidFix: true, | ||
+ | position: 'center', | ||
+ | overScrollFix: false, | ||
+ | mirrorContainer: 'body', | ||
+ | |||
+ | refresh: function() { | ||
+ | this.boxWidth = this.$element.outerWidth(); | ||
+ | this.boxHeight = this.$element.outerHeight() + this.bleed * 2; | ||
+ | this.boxOffsetTop = this.$element.offset().top - this.bleed; | ||
+ | this.boxOffsetLeft = this.$element.offset().left; | ||
+ | this.boxOffsetBottom = this.boxOffsetTop + this.boxHeight; | ||
+ | |||
+ | var winHeight = Parallax.winHeight; | ||
+ | var docHeight = Parallax.docHeight; | ||
+ | var maxOffset = Math.min(this.boxOffsetTop, docHeight - winHeight); | ||
+ | var minOffset = Math.max(this.boxOffsetTop + this.boxHeight - winHeight, 0); | ||
+ | var imageHeightMin = this.boxHeight + (maxOffset - minOffset) * (1 - this.speed) | 0; | ||
+ | var imageOffsetMin = (this.boxOffsetTop - maxOffset) * (1 - this.speed) | 0; | ||
+ | var margin; | ||
+ | |||
+ | if (imageHeightMin * this.aspectRatio >= this.boxWidth) { | ||
+ | this.imageWidth = imageHeightMin * this.aspectRatio | 0; | ||
+ | this.imageHeight = imageHeightMin; | ||
+ | this.offsetBaseTop = imageOffsetMin; | ||
+ | |||
+ | margin = this.imageWidth - this.boxWidth; | ||
+ | |||
+ | if (this.positionX == 'left') { | ||
+ | this.offsetLeft = 0; | ||
+ | } else if (this.positionX == 'right') { | ||
+ | this.offsetLeft = - margin; | ||
+ | } else if (!isNaN(this.positionX)) { | ||
+ | this.offsetLeft = Math.max(this.positionX, - margin); | ||
+ | } else { | ||
+ | this.offsetLeft = - margin / 2 | 0; | ||
+ | } | ||
+ | } else { | ||
+ | this.imageWidth = this.boxWidth; | ||
+ | this.imageHeight = this.boxWidth / this.aspectRatio | 0; | ||
+ | this.offsetLeft = 0; | ||
+ | |||
+ | margin = this.imageHeight - imageHeightMin; | ||
+ | |||
+ | if (this.positionY == 'top') { | ||
+ | this.offsetBaseTop = imageOffsetMin; | ||
+ | } else if (this.positionY == 'bottom') { | ||
+ | this.offsetBaseTop = imageOffsetMin - margin; | ||
+ | } else if (!isNaN(this.positionY)) { | ||
+ | this.offsetBaseTop = imageOffsetMin + Math.max(this.positionY, - margin); | ||
+ | } else { | ||
+ | this.offsetBaseTop = imageOffsetMin - margin / 2 | 0; | ||
+ | } | ||
+ | } | ||
+ | }, | ||
+ | |||
+ | render: function() { | ||
+ | var scrollTop = Parallax.scrollTop; | ||
+ | var scrollLeft = Parallax.scrollLeft; | ||
+ | var overScroll = this.overScrollFix ? Parallax.overScroll : 0; | ||
+ | var scrollBottom = scrollTop + Parallax.winHeight; | ||
+ | |||
+ | if (this.boxOffsetBottom > scrollTop && this.boxOffsetTop <= scrollBottom) { | ||
+ | this.visibility = 'visible'; | ||
+ | this.mirrorTop = this.boxOffsetTop - scrollTop; | ||
+ | this.mirrorLeft = this.boxOffsetLeft - scrollLeft; | ||
+ | this.offsetTop = this.offsetBaseTop - this.mirrorTop * (1 - this.speed); | ||
+ | } else { | ||
+ | this.visibility = 'hidden'; | ||
+ | } | ||
+ | |||
+ | this.$mirror.css({ | ||
+ | transform: 'translate3d('+this.mirrorLeft+'px, '+(this.mirrorTop - overScroll)+'px, 0px)', | ||
+ | visibility: this.visibility, | ||
+ | height: this.boxHeight, | ||
+ | width: this.boxWidth | ||
}); | }); | ||
− | } | + | |
+ | this.$slider.css({ | ||
+ | transform: 'translate3d('+this.offsetLeft+'px, '+this.offsetTop+'px, 0px)', | ||
+ | position: 'absolute', | ||
+ | height: this.imageHeight, | ||
+ | width: this.imageWidth, | ||
+ | maxWidth: 'none' | ||
+ | }); | ||
+ | } | ||
}); | }); | ||
− | |||
− | |||
− | |||
− | |||
− | var | + | |
− | if ( | + | // Parallax Static Methods |
− | $(this). | + | |
+ | $.extend(Parallax, { | ||
+ | scrollTop: 0, | ||
+ | scrollLeft: 0, | ||
+ | winHeight: 0, | ||
+ | winWidth: 0, | ||
+ | docHeight: 1 << 30, | ||
+ | docWidth: 1 << 30, | ||
+ | sliders: [], | ||
+ | isReady: false, | ||
+ | isFresh: false, | ||
+ | isBusy: false, | ||
+ | |||
+ | setup: function() { | ||
+ | if (this.isReady) return; | ||
+ | |||
+ | var self = this; | ||
+ | |||
+ | var $doc = $(document), $win = $(window); | ||
+ | |||
+ | var loadDimensions = function() { | ||
+ | Parallax.winHeight = $win.height(); | ||
+ | Parallax.winWidth = $win.width(); | ||
+ | Parallax.docHeight = $doc.height(); | ||
+ | Parallax.docWidth = $doc.width(); | ||
+ | }; | ||
+ | |||
+ | var loadScrollPosition = function() { | ||
+ | var winScrollTop = $win.scrollTop(); | ||
+ | var scrollTopMax = Parallax.docHeight - Parallax.winHeight; | ||
+ | var scrollLeftMax = Parallax.docWidth - Parallax.winWidth; | ||
+ | Parallax.scrollTop = Math.max(0, Math.min(scrollTopMax, winScrollTop)); | ||
+ | Parallax.scrollLeft = Math.max(0, Math.min(scrollLeftMax, $win.scrollLeft())); | ||
+ | Parallax.overScroll = Math.max(winScrollTop - scrollTopMax, Math.min(winScrollTop, 0)); | ||
+ | }; | ||
+ | |||
+ | $win.on('resize.px.parallax load.px.parallax', function() { | ||
+ | loadDimensions(); | ||
+ | self.refresh(); | ||
+ | Parallax.isFresh = false; | ||
+ | Parallax.requestRender(); | ||
+ | }) | ||
+ | .on('scroll.px.parallax load.px.parallax', function() { | ||
+ | loadScrollPosition(); | ||
+ | Parallax.requestRender(); | ||
+ | }); | ||
+ | |||
+ | loadDimensions(); | ||
+ | loadScrollPosition(); | ||
+ | |||
+ | this.isReady = true; | ||
+ | |||
+ | var lastPosition = -1; | ||
+ | |||
+ | function frameLoop() { | ||
+ | if (lastPosition == window.pageYOffset) { // Avoid overcalculations | ||
+ | window.requestAnimationFrame(frameLoop); | ||
+ | return false; | ||
+ | } else lastPosition = window.pageYOffset; | ||
+ | |||
+ | self.render(); | ||
+ | window.requestAnimationFrame(frameLoop); | ||
+ | } | ||
+ | |||
+ | frameLoop(); | ||
+ | }, | ||
+ | |||
+ | configure: function(options) { | ||
+ | if (typeof options == 'object') { | ||
+ | delete options.refresh; | ||
+ | delete options.render; | ||
+ | $.extend(this.prototype, options); | ||
+ | } | ||
+ | }, | ||
+ | |||
+ | refresh: function() { | ||
+ | $.each(this.sliders, function(){ this.refresh(); }); | ||
+ | this.isFresh = true; | ||
+ | }, | ||
+ | |||
+ | render: function() { | ||
+ | this.isFresh || this.refresh(); | ||
+ | $.each(this.sliders, function(){ this.render(); }); | ||
+ | }, | ||
+ | |||
+ | requestRender: function() { | ||
+ | var self = this; | ||
+ | self.render(); | ||
+ | self.isBusy = false; | ||
+ | }, | ||
+ | destroy: function(el){ | ||
+ | var i, | ||
+ | parallaxElement = $(el).data('px.parallax'); | ||
+ | parallaxElement.$mirror.remove(); | ||
+ | for(i=0; i < this.sliders.length; i+=1){ | ||
+ | if(this.sliders[i] == parallaxElement){ | ||
+ | this.sliders.splice(i, 1); | ||
} | } | ||
+ | } | ||
+ | $(el).data('px.parallax', false); | ||
+ | if(this.sliders.length === 0){ | ||
+ | $(window).off('scroll.px.parallax resize.px.parallax load.px.parallax'); | ||
+ | this.isReady = false; | ||
+ | Parallax.isSetup = false; | ||
+ | } | ||
+ | } | ||
+ | }); | ||
+ | |||
+ | |||
+ | // Parallax Plugin Definition | ||
+ | |||
+ | function Plugin(option) { | ||
+ | return this.each(function () { | ||
+ | var $this = $(this); | ||
+ | var options = typeof option == 'object' && option; | ||
+ | |||
+ | if (this == window || this == document || $this.is('body')) { | ||
+ | Parallax.configure(options); | ||
+ | } | ||
+ | else if (!$this.data('px.parallax')) { | ||
+ | options = $.extend({}, $this.data(), options); | ||
+ | $this.data('px.parallax', new Parallax(this, options)); | ||
+ | } | ||
+ | else if (typeof option == 'object') | ||
+ | { | ||
+ | $.extend($this.data('px.parallax'), options); | ||
+ | } | ||
+ | if (typeof option == 'string') { | ||
+ | if(option == 'destroy'){ | ||
+ | Parallax.destroy(this); | ||
+ | }else{ | ||
+ | Parallax[option](); | ||
+ | } | ||
+ | } | ||
}); | }); | ||
+ | } | ||
+ | |||
+ | var old = $.fn.parallax; | ||
+ | |||
+ | $.fn.parallax = Plugin; | ||
+ | $.fn.parallax.Constructor = Parallax; | ||
+ | |||
+ | |||
+ | // Parallax No Conflict | ||
+ | |||
+ | $.fn.parallax.noConflict = function () { | ||
+ | $.fn.parallax = old; | ||
+ | return this; | ||
+ | }; | ||
+ | |||
+ | |||
+ | // Parallax Data-API | ||
+ | |||
+ | $( function () { | ||
+ | $('[data-parallax="scroll"]').parallax(); | ||
}); | }); | ||
− | |||
− | |||
− | </body> | + | }(jQuery, window, document)); |
+ | |||
+ | </script> | ||
+ | |||
+ | <!-- Custom scripts for this template --> | ||
+ | <script src="js/creative.min.js"></script> | ||
+ | |||
+ | </body> | ||
+ | |||
</html> | </html> |
Revision as of 06:49, 29 July 2018
Abstarct
Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons.
Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach:
- We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.
- We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.
In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.
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