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Protein

For this year’s iGEM competition, we have chosen to submit Rev protein for the award of iGEMers can export their RNA sequences containing an RRE to the cytoplasm if they express Rev protein simultaneously.

How Rev works

Rev recruits CRM1, a principal nuclear export factor in cells which mediates export of cellular RNAs including snRNA and all 4 ribosomal RNAs to the cytoplasm.

Key advantage

Rev protein makes it possible to export complex RNA structures from the nucleus to the cytoplasm, which otherwise cannot be achieved effectively.