Difference between revisions of "Team:MIT"
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<div class = "subtitle" style="position: absolute; top: 34vw; left: 24vw;">Engineered Signal Transduction</div> | <div class = "subtitle" style="position: absolute; top: 34vw; left: 24vw;">Engineered Signal Transduction</div> | ||
</div> | </div> | ||
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<h3>92% of the World has Dental Caries</h3> | <h3>92% of the World has Dental Caries</h3> | ||
| − | < | + | <div class="text1" style ="position: absolute; |
| + | top: 73vw; | ||
| + | margin-right: 3vw; | ||
| + | left: 47vw;">As the world's most prevalent chronic disease, dental caries' (tooth decay) treatments are few and outdated. | ||
Our goal is to develop a novel preventative treatment that will function by inhibiting one of the key steps in | Our goal is to develop a novel preventative treatment that will function by inhibiting one of the key steps in | ||
| − | pathogenesis: biofilm formation mediated by Streptococcus mutans. </ | + | pathogenesis: biofilm formation mediated by Streptococcus mutans. </div> |
| − | < | + | <div class="text1" style =" position: absolute; margin-right: 3vw; |
| + | top: 90vw; | ||
| + | left: 47vw;">During biofilm formation, S. mutans communicate via a two-component quorum sensing pathway, known as the ComCDE | ||
system. This system allows them to sense the presence of other bacteria, and upon activation, secrete | system. This system allows them to sense the presence of other bacteria, and upon activation, secrete | ||
| − | adhesive proteins that are used to stick to the surface of the teeth.</ | + | adhesive proteins that are used to stick to the surface of the teeth.</div> |
</div> | </div> | ||
<div> | <div> | ||
<h4>Our Project:</h4> | <h4>Our Project:</h4> | ||
| − | < | + | <div class="text2" style ="position: absolute; |
| + | top: 126vw; | ||
| + | margin-right: 50vw; | ||
| + | left: 3vw;"> In order to create a highly specific sense-and-respond system, we ported the ComCDE system into mammalian cells. This grants | ||
them the ability to detect the presence of S. mutans and release anti-biofilm proteins preemptively. | them the ability to detect the presence of S. mutans and release anti-biofilm proteins preemptively. | ||
Our engineered cells will be encapsulated in a hydrogel that will be implanted in the gingival region of patients' | Our engineered cells will be encapsulated in a hydrogel that will be implanted in the gingival region of patients' | ||
| − | gums.</ | + | gums.</div> |
| − | < | + | <div class="text2" style ="position: absolute; |
| − | and modern. Please use the links above to learn more about our project!</ | + | margin-right: 50vw; |
| + | top: 148vw; | ||
| + | left: 3vw;"> We hope that our technology will help advance the field of dentistry and make dental care more effective, efficient, | ||
| + | and modern. Please use the links above to learn more about our project!</div> | ||
</div> | </div> | ||
Revision as of 03:19, 13 October 2018
C R E S T
Caries Reduction
Engineered Signal Transduction
92% of the World has Dental Caries
As the world's most prevalent chronic disease, dental caries' (tooth decay) treatments are few and outdated.
Our goal is to develop a novel preventative treatment that will function by inhibiting one of the key steps in
pathogenesis: biofilm formation mediated by Streptococcus mutans.
During biofilm formation, S. mutans communicate via a two-component quorum sensing pathway, known as the ComCDE
system. This system allows them to sense the presence of other bacteria, and upon activation, secrete
adhesive proteins that are used to stick to the surface of the teeth.
Our Project:
In order to create a highly specific sense-and-respond system, we ported the ComCDE system into mammalian cells. This grants
them the ability to detect the presence of S. mutans and release anti-biofilm proteins preemptively.
Our engineered cells will be encapsulated in a hydrogel that will be implanted in the gingival region of patients'
gums.
We hope that our technology will help advance the field of dentistry and make dental care more effective, efficient,
and modern. Please use the links above to learn more about our project!