Difference between revisions of "Team:BGU Israel"

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<p>Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons.  
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Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach: (1) we identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them. (2) We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.
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In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.
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            <h1 class="section-heading  text-center animated fadeInLeft">Abstarct</h1>
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            <p style="margin:0px !important; padding:0!important;"  class="mb-4 justified animated fadeInRight">Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons. <br><br>
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Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach: </p>
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              <ol class="mb-4 justified animated fadeInRight">
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                <li> We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.</li>
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                <li>We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.</li>
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              </ol>
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              <p  class="mb-4 justified animated fadeInRight">
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In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.</p>
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            <h1 class="section-heading">Contact Us</h1>
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            <p class="mb-5 text-faded">Feel free to follow and contact us for more information on:</p>
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            <p>iGEM BGU</p></a>
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              @OrignialsBGU
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                <p>@iGEM_2018_BGU</p></a>
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            <p>
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              originalbgu@gmail.com
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            </p></a>
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                <a class="nav-link" href="#">Ben-Gurion University of the Negev<br>
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Ben Gurion 1, Beer Sheva 8410501, Israel</a>
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                <a class="nav-link" href="#">Copyright &copy; 2018 OriginALS. All Rights Reserved.</a>
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Revision as of 17:50, 28 July 2018

OriginALS

OriginALS

Abstarct

Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons.

Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach:

  1. We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.
  2. We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.

In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.

Contact Us

Feel free to follow and contact us for more information on:

iGEM BGU

@OrignialsBGU

@iGEM_2018_BGU

originalbgu@gmail.com