Difference between revisions of "Team:New York City"

(Undo revision 109173 by Amars (talk))
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<body>
 
<body>
  
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<div class="column full_size" >
 
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<h1> Welcome to New York City 2018 iGEM Team! </h1>
 
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<p>A diverse team of mostly New York City area high school students! </p>
 
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<img src="https://i.imgur.com/otlUEQi.jpg" width = "350" height = "550">
 
  
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</div>  
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<div class="container">
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    <nav class="navbar navbar-expand-lg navbar-light mr-auto">
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        <a class="navbar-brand" href="index.html">HD Resolution</a>
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        <div class="collapse navbar-collapse" id="navbarSupportedContent">
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            <ul class="navbar-nav mr-auto">
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                <li class="nav-item dropdown">
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                    <a class="nav-link dropdown-toggle" href="#" id="navbarPR" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                        Project
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                    </a>
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                    <div class="dropdown-menu" aria-labelledby="navbarPR">
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                        <a class="dropdown-item" href="HD.html">What is HD?</a>
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                        <a class="dropdown-item" href="#">Coming Soon</a>
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                    </div>
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                </li>
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                <li class="nav-item dropdown">
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                    <a class="nav-link dropdown-toggle" href="#" id="navbarNB" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                        Notebook
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                    </a>
 +
                    <div class="dropdown-menu" aria-labelledby="navbarNB">
 +
                        <a class="dropdown-item" href="#">Coming Soon</a>
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                    </div>
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                </li>
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                <li class="nav-item dropdown">
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                    <a class="nav-link dropdown-toggle" href="#" id="navbarHP" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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                        Human Practices
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                    </a>
 +
                    <div class="dropdown-menu" aria-labelledby="navbarHP">
 +
                        <a class="dropdown-item" href="#">Coming Soon</a>
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                    </div>
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                </li>
 +
                <li class="nav-item">
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                    <a class="nav-link" href="#">Team (Coming Soon)</a>
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                </li>
 +
            </ul>
 +
        </div>
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    </nav>
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</div>
  
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<div class="column full_size" >
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<div class="container" align="center" width=50%>
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    <div class="row">
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<h3>Project Description</h3>
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        <div class="col-sm-4 vcl">
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<p> Huntington's Disease (HD) is an autosomal dominant disorder that leads to the progressive degeneration of neurons in the brain, which currently has no cure. HD is typically adult-onset and is characterized by a variety of symptoms including amnesia, involuntary movements, poor coordination, and impaired decision-making. Mutations in the huntingtin (HTT) gene causes HD, specifically a trinucleotide repeat of CAG that is abnormally repeated over 40 times. The goal of our project is to test the effectiveness of the plasmid that we generated last year, which targets and blocks endogenous faulty mRNA and releases a corrected RNA strand for proper protein synthesis of the HTT gene. The efficacy of this plasmid will be tested on Huntington cell lines. Since this plasmid has been designed with two different fluorophores to differentiate between the mutated and corrected strands, the effectiveness of this treatment will be tested by evaluating whether the intensity of the corrected fluorophore increases and the mutated fluorophore decreases in the Huntington cell lines.</p>
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            <h1 >Using genomics<br> to search for a <span class="shiny">Resolution</span> to Huntington's Disease (<span class="shiny">HD</span>)</h1>
 +
        </div>
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        <div class="col-sm-4">
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            <img src="brain.gif" width=200% style="border-radius: 15px">
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        </div>
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    </div>
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</div>
  
 +
<div class="container" align="center">
 +
    <div class="row">
 +
        <div class="col-sm-4">
 +
            <div class="container bg-light">
 +
                <h2>WHAT</h2>
 +
                <p align="left">Huntington's Disease (HD) is a genetic disorder that results in the breakdown of nerve cells in the
 +
                    brain. Although the disease affects the whole brain, the basal ganglia, which plays a critical role in
 +
                    motor functions and behavior, is most severely affected. Thus, symptoms of HD include involuntary
 +
                    movements, personality changes, and cognitive problems. Over time, the effects of HD is extremely
 +
                    debilitating, eventually rendering a patient unable to speak, walk, or even reason.</p>
 +
            </div>
 +
            <br>
 +
            <div class="container bg-light">
 +
                <h2>WHY</h2>
 +
                <p align="left">HD is a result of a specific mutation in the huntingtin (HTT) gene, which results in a faulty production
 +
                    of the HTT protein, mHTT. The mutation is a trinucleotide repeat of the codon CAG, where 40 or more will
 +
                    lead to the expression of HD.</p>
 +
            </div>
 +
        </div>
 +
        <div class="col-sm-4" align="center">
 +
            <img src="img/neuron.jpg" width=300>
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        </div>
 +
        <div class="col-sm-4">
 +
            <div class="container bg-light">
 +
                <h2>WHO</h2>
 +
                <p align="left">The most common form of HD is adult-onset, affecting people between their 30s and 40s.
 +
                    Many people form families and have children by the time they are diagnosed with HD, which automatically
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                    gives their children a 50% chance of inheriting the disease. HD affects about 1 in every 10,000
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                    people worldwide.</p>
 +
            </div>
 +
            <br>
 +
            <div class="container bg-light">
 +
                <h2>HOW</h2>
 +
                <p align="left">Our goal is to develop a cure to Huntington's Disease by employing RNA strand displacement
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                    technology to target erroneous mRNA within the affected cells and replace it with the corrected RNA
 +
                    strand for proper protein synthesis.
 +
                </p>
 +
            </div>
 +
        </div>
 +
    </div>
 
</div>
 
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Revision as of 19:32, 23 August 2018

Using genomics
to search for a Resolution to Huntington's Disease (HD)

WHAT

Huntington's Disease (HD) is a genetic disorder that results in the breakdown of nerve cells in the brain. Although the disease affects the whole brain, the basal ganglia, which plays a critical role in motor functions and behavior, is most severely affected. Thus, symptoms of HD include involuntary movements, personality changes, and cognitive problems. Over time, the effects of HD is extremely debilitating, eventually rendering a patient unable to speak, walk, or even reason.


WHY

HD is a result of a specific mutation in the huntingtin (HTT) gene, which results in a faulty production of the HTT protein, mHTT. The mutation is a trinucleotide repeat of the codon CAG, where 40 or more will lead to the expression of HD.

WHO

The most common form of HD is adult-onset, affecting people between their 30s and 40s. Many people form families and have children by the time they are diagnosed with HD, which automatically gives their children a 50% chance of inheriting the disease. HD affects about 1 in every 10,000 people worldwide.


HOW

Our goal is to develop a cure to Huntington's Disease by employing RNA strand displacement technology to target erroneous mRNA within the affected cells and replace it with the corrected RNA strand for proper protein synthesis.