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| − | <html lang="en">
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| − | <head>
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| − | <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.1.3/css/bootstrap.min.css" integrity="sha384-MCw98/SFnGE8fJT3GXwEOngsV7Zt27NXFoaoApmYm81iuXoPkFOJwJ8ERdknLPMO" crossorigin="anonymous">
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| − | <style>
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| − | .container {
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| − | align-items: center;
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| − | max-width: 960px;
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| − | a{
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| − | color:#7B84ED;
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| − | p{
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| − | font-size: 120%;
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| − | .shiny{
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| − | color:#7B84ED;
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| − | .headimage{
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| − | border-radius: 15px;
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| − | </style>
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| − | </head>
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| − | <body>
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| − | <div class="container">
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| − | <nav class="sticky-top py-3 navbar navbar-expand-lg navbar-light mr-auto">
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| − | <div class="container d-flex flex-column flex-md-row justify-content-between">
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| − | <div class="navbar-brand"><a href="https://2018.igem.org/Team:New_York_City/">HD Resolution</a></div>
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| − | <div class="collapse navbar-collapse" id="navbarSupportedContent">
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| − | <ul class="navbar-nav mr-auto">
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| − | <li class="nav-item dropdown">
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| − | <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarPR" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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| − | Project
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| − | </a>
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| − | <div class="dropdown-menu" aria-labelledby="navbarPR">
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| − | <a class="dropdown-item" href="https://2018.igem.org/Team:New_York_City/HD/">What is HD?</a>
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| − | <a class="dropdown-item" href="">Coming Soon</a>
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| − | </div>
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| − | </li>
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| − | <li class="nav-item dropdown">
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| − | <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarNB" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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| − | Notebook
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| − | </a>
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| − | <div class="dropdown-menu" aria-labelledby="navbarNB">
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| − | <a class="dropdown-item" href="">Coming Soon</a>
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| − | </div>
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| − | </li>
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| − | <li class="nav-item dropdown">
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| − | <a class="nav-link dropdown-toggle py-2 d-none d-md-inline-block" href="#" id="navbarHP" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
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| − | Human Practices
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| − | </a>
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| − | <div class="dropdown-menu" aria-labelledby="navbarHP">
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| − | <a class="dropdown-item" href="">Coming Soon</a>
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| − | </div>
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| − | </li>
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| − | <li class="nav-item">
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| − | <a class="nav-link" href="#">Team</a>
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| − | </li>
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| − | </ul>
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| − | </div>
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| − | </div>
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| − | </nav>
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| − | </div>
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| − | <div class="container bg-light py-1 align-middle">
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| − | <h2 align="center">What is Huntington's Disease?</h2>
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| − | </div>
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| − |
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| − | <div class="container">
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| − | <p class="lead">Huntington's disease (HD) is an inherited, autosomal dominant disorder that causes the progressive degeneration
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| − | of nerve cells in the basal ganglia, a part of the brain that is responsible for coordination and movement. It
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| − | is caused by a trinucleotide repeat of 40 or more CAG codons in the huntingtin protein. The exact function of
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| − | the huntingtin protein is unknown but it is critical in nerve cell function. Thus, there is a wide range of
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| − | symptoms and signs from cognitive, movement, and psychiatric disorders such as:</p>
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| − | <ul>
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| − | <li>Muscle problems, such as contraction or rigidity</li>
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| − | <li>Abnormal eye movements</li>
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| − | <li>Difficulty processing information</li>
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| − | <li>Fatigue, loss of energy</li>
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| − | <li>Social withdrawal</li>
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| − | <li>Mood swings and depression</li>
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| − | <li>Amnesia and handicapped judgement</li>
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| − | <li>Impaired speaking abilities and significant weight loss</li>
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| − | <li>Involuntary movement and loss of physical coordination</li>
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| − | </ul>
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| − | <br/>
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| − | <p class="lead">HD is adult-onset, usually affecting people in between their 30's to 50's. Symptoms typically worsen over a
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| − | 10 to 25 year period and greatly impact both mental and physical abilities. Eventually, they pass away due
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| − | to heart failure or other complications.</p>
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| − | </div>
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| − |
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| − | <div class="container bg-light py-1 align-middle">
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| − | <h2 align="center">Who is affected by Huntington's Disease?</h2>
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| − | </div>
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| − |
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| − | <div class="container">
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| − | <p class="lead">Huntington's disease affects all people regardless of their gender or ethnicity; however, some group is more
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| − | prone to the disease than others are. It occurs more frequently among people with European origin than among
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| − | any other population. In the United States, around 30,000 people are diagnosed with Huntington's disease. This
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| − | is only a small percentage of the US population, but it has the potential to grow quickly. 200,000 people are at
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| − | risk of inheriting HD, as the child of an affected parent has a 50-50% chance of having a gene that
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| − | causes the disease.</p>
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| − | </div>
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| − |
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| − | <div class="container bg-light py-1 align-middle">
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| − | <h2 align="center">Is There a Cure?</h2>
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| − | </div>
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| − |
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| − | <div class="container">
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| − | <p class="lead">Currently, the complications of Huntington's disease can be mitigated by medication for movement disorders and
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| − | psychiatric disorders (such as antidepressants), along with psychotherapy, speech therapy, physical therapy,
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| − | and occupational therapy. However, there exists no treatment to completely cure or slow the development of HD,
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| − | although there has been ongoing research and experimental therapies.</p>
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| − | <p class="lead">Our goal is to employ genetics to find an efficient resolution for HD, hence our name:
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| − | <span class="shiny"><strong>HD Resolution</strong></span></p>
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| − | </div>
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| − |
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| − | <div class="container">
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| − | <p class="lead">Sources:</p>
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| − | <ol>
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| − | <li><a href="http://hdsa.org/what-is-hd/">hdsa.org</a></li>
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| − | </ol>
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| − | </div>
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| − | <script src="https://code.jquery.com/jquery-3.3.1.slim.min.js" integrity="sha384-q8i/X+965DzO0rT7abK41JStQIAqVgRVzpbzo5smXKp4YfRvH+8abtTE1Pi6jizo" crossorigin="anonymous"></script>
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| − | <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.1.3/js/bootstrap.min.js" integrity="sha384-ChfqqxuZUCnJSK3+MXmPNIyE6ZbWh2IMqE241rYiqJxyMiZ6OW/JmZQ5stwEULTy" crossorigin="anonymous"></script>
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| − | </body>
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| − | </html>
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