Difference between revisions of "Team:XJTU-China"

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<h3> Description</h3>
 
<h3> Description</h3>
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<p>One may say that our project, the project of XJTU-China 2018, is established from two distinct point-of-view. The design philosophy of synthetic biology: top-down and bottom-up meets and thus is how we come up with our idea. </p>
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<p>One may say that our project, the project of XJTU-China 2018, is established from two distinct point of views. The design philosophy of synthetic biology: top-down and bottom-up meets and thus is how we come up with our idea. </p>
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<p>The first idea comes from the dillema for those who want to lose weight, or especilly for those who suffer from diabetes: health and taste. Sugar are delightful but the energy it provides may lead to trouble. That's the reason why a variety of sugar substitutes emerges, but none without a clear record of health concerns. Here we introduce psicose, a rare sugar, the C-3 epimer of fructose, which is the ultimate solution of saccharose substitute: a perfect balance between sweetness and low energy (about 3% of that in saccharose).</p>
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<p>The first idea comes from the dillema for those who want to lose weight, or especilly for those who suffer from diabetes: health and taste. Sugar are delightful but the energy it provides may lead to trouble. That's the reason why a variety of sugar substitutes emerges, but none with a clear record of health concerns. Here we introduce psicose, a rare sugar, the C-3 epimer of fructose, which is the ultimate solution of saccharose substitute: a perfect balance between sweetness and low energy (about 3% of that in saccharose).</p>
 
<p>Chemical manufacturing of psicose is laborous and poses trouble in chiral separation. Biomanufacturing is promising but suffers severely from low enzymatic activity. The goal of our team is to find a reliable, robust and high throughput method in screening for enzymes with high activity.</p>
 
<p>Chemical manufacturing of psicose is laborous and poses trouble in chiral separation. Biomanufacturing is promising but suffers severely from low enzymatic activity. The goal of our team is to find a reliable, robust and high throughput method in screening for enzymes with high activity.</p>
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<p>The second idea emerges from the concerns about the instability of traditional continuous-culture-based directed evolution. Why a accelerated Darwinian evolution is never achieved with simple pressure-introducing tools such as toxic proteins or antibiotics? With this idea, we would manage to build up a Standard Framework for Directed Evolution with detailed data and standarized procedures.</p>
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<p>The second idea emerges from the concerns about the instability of traditional continuous-culture-based directed evolution. Why an accelerated Darwinian evolution is never achieved with simple pressure-introducing tools such as toxic proteins or antibiotics? With this idea, we would manage to build up a Standard Framework for Directed Evolution with detailed data and standarized procedures.</p>
 
<p>We are applying this exciting new method in searching for a more optimized enzyme for the biomanufacturing of psicose.</p>
 
<p>We are applying this exciting new method in searching for a more optimized enzyme for the biomanufacturing of psicose.</p>
 
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Revision as of 13:38, 28 June 2018

XJTU-China 2018

A Standard Framework for Directed Evolution

Know more about us

Our Twitter mainpage:

Wechat official public account:

E-mail address: XJTU-China

A mirror for synthetic biology hub (for mianland China users)

Description

One may say that our project, the project of XJTU-China 2018, is established from two distinct point of views. The design philosophy of synthetic biology: top-down and bottom-up meets and thus is how we come up with our idea.

The first idea comes from the dillema for those who want to lose weight, or especilly for those who suffer from diabetes: health and taste. Sugar are delightful but the energy it provides may lead to trouble. That's the reason why a variety of sugar substitutes emerges, but none with a clear record of health concerns. Here we introduce psicose, a rare sugar, the C-3 epimer of fructose, which is the ultimate solution of saccharose substitute: a perfect balance between sweetness and low energy (about 3% of that in saccharose).

Chemical manufacturing of psicose is laborous and poses trouble in chiral separation. Biomanufacturing is promising but suffers severely from low enzymatic activity. The goal of our team is to find a reliable, robust and high throughput method in screening for enzymes with high activity.

The second idea emerges from the concerns about the instability of traditional continuous-culture-based directed evolution. Why an accelerated Darwinian evolution is never achieved with simple pressure-introducing tools such as toxic proteins or antibiotics? With this idea, we would manage to build up a Standard Framework for Directed Evolution with detailed data and standarized procedures.

We are applying this exciting new method in searching for a more optimized enzyme for the biomanufacturing of psicose.

Gallery

Lab overview 1

Lab overview 2

Lab overview 3