Difference between revisions of "Team:SFLS Shenzhen/Description"

Breast cancer is the most common female malignancy in the world. According to the International Agency for Research on Cancer (IARC), the number of new cases of breast cancer in the world reached 1.38 million in 2008, and that is 22.9% of all female malignancies; 460,000 women died of breast cancer, which is 13.7% of all female malignant tumor deaths, and 1.7% of all female deaths [1] According to statistics, the annual incidence of female breast cancer in China is 169,000, which is the second most common malignant tumor in women; the death of female breast cancer in China is about 45,000; it is the sixth most common cause of malignant tumor death in women [2] The occurrence and development of breast cancer involves many factors, and the change of gene level expression is the most important regulatory factor [3]. In recent years, breast cancer has become a growing threat to people, and many well-known celebrities have died of breast cancer, which has also aggravated people’s panic about this type of cancer.
Beina Yao, a Chinese pop singer, was born in Wuhan, Hubei, in September 26, 1981. At 16:55 January 16, 2015, Yao died due to relapsed of breast cancer in Peking University of Shenzhen Hospital, and she was only 33 years old. This incident caused great sensation in China.
Small molecule miRNA is a class of endogenous single-stranded non-coding small RNAs of 21-24 nucleotides in length. miRNA not only plays an important role in the normal development, differentiation and apoptosis of the body, but also participates in the occurrence of various tumors including breast cancer, and regulates the occurrence and development of breast cancer at the microscopic level.
Serum MIRNA can be used as a sensitive marker for breast cancer, and its sensitivity and specificity are higher than the currently widely used carbohydrate antigens. [4] Studies have found that compared with healthy controls, miR-10b, miRNA-145 and miR-155 are up-regulated in the serum of breast cancer patients, and the expression levels of the three miRNAs are significantly correlated with tumor metastasis, but they have no correlation with age, histological features, and ER expression. Based on the sensitivity and specificity of microRNAs in serum, we use the Toehold switches, a tool for detecting MIRNA in synthetic biology, to construct a joint detection of miR-10b and miR-155 by constructing our gene loop.

Beina Yao, Chinese pop singer

1. FERLAY J, SHIN H R, BRAY F, et al. GLOBOCAN 2008v1.2, Cancer Incidence and Mortality Worldwide: IARCCancer Base No. 10 ［Internet］. Lyon, France: InternationalAgency for Research on Cancer; 2010［EB/OL］. http://globocan.iarc.fr, accessed on 10/05/2013.
2. 张敏璐, 黄哲宙, 郑莹. 中国2008年女性乳腺癌发病、死亡和患病情况的估计及预测［J］. 中华流行病学杂志,2012, 33(10): 1049-1051.
3. ＷａｎｇＹ，ＺｈａｎｇＨ，ＣｈｅｎＹ，ｅｔａｌ．ＬＳＤ１ｉｓａｓｕｂｕｎｉｔｏｆｔｈｅＮｕＲＤｃｏｍｐｌｅｘａｎｄｔａｒｇｅｔｓｔｈｅｍｅｔａｓｔａｓｉｓｐｒｏ－ｇｒａｍｓ ｉｎ ｂｒｅａｓｔｃａｎｃｅｒ［Ｊ］．Ｃｅｌｌ，２００９，１３８（４）：６６０－６７２．
4. 陆婉玲 王志刚.血清小分子RNA与乳腺癌关系研究进展。中国医药，2013，8（11）；1677-1679
5. 俞进友 仇建玲 朱正峰 周迎 谷文龙。ｍｉＲ－１０ｂ、ｍｉＲ１４５及ｍｉＲ１５５在乳腺癌患中的表达及临床意义【J】.贵州医药，2016，40（7）；683-685