Difference between revisions of "Team:Fudan"
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We make it compatible on laptop and mobile devices by using Materialize 1.0.0-rc.2. | We make it compatible on laptop and mobile devices by using Materialize 1.0.0-rc.2. | ||
--> | --> | ||
| + | <!-- LC check on 2018-10-18 --> | ||
<head> | <head> | ||
<meta charset="UTF-8"> | <meta charset="UTF-8"> | ||
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<!-- CSS --> | <!-- CSS --> | ||
<link rel="stylesheet" type="text/css" href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/css.css&action=raw&ctype=text/css" /> | <link rel="stylesheet" type="text/css" href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/css.css&action=raw&ctype=text/css" /> | ||
<!-- Font-awesome icons 4.7.0 --> | <!-- Font-awesome icons 4.7.0 --> | ||
| − | <link href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/font-awesome.css&action=raw&ctype=text/css" rel="stylesheet"> | + | <link href="https://2018.igem.org/wiki/index.php?title=Template:Fudan/font-awesome.css&action=raw&ctype=text/css" rel="stylesheet" /> |
<!-- Materialize 1.0.0-rc.2 (Material Design like) --> | <!-- Materialize 1.0.0-rc.2 (Material Design like) --> | ||
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<!-- Clear default CSS settings; CSS reset --> | <!-- Clear default CSS settings; CSS reset --> | ||
| − | <style | + | <style> |
*{margin: 0;padding: 0;list-style: none;} | *{margin: 0;padding: 0;list-style: none;} | ||
/* via: https://blog.csdn.net/weixin_41014370/article/details/79523637 */ | /* via: https://blog.csdn.net/weixin_41014370/article/details/79523637 */ | ||
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#highlight2 div,#highlight1 div{ | #highlight2 div,#highlight1 div{ | ||
margin-bottom: 150px; | margin-bottom: 150px; | ||
| − | color:#377893; | + | color:#377893; |
| − | font-weight:400; | + | font-weight:400; |
} | } | ||
| − | @media only screen and (max-width: 991px){ | + | @media only screen and (max-width: 991px) { |
#FudanBody #highlight1 .highlight{ | #FudanBody #highlight1 .highlight{ | ||
width: 33%;margin: 0 | width: 33%;margin: 0 | ||
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#highlight2{width:66%;margin: 20px auto 0 auto;} | #highlight2{width:66%;margin: 20px auto 0 auto;} | ||
} | } | ||
| − | @media only screen and (max-width: 600px){ | + | @media only screen and (max-width: 600px) { |
#FudanBody #pageContent .section p{ | #FudanBody #pageContent .section p{ | ||
| − | + | font-size: 18px; | |
| − | + | line-height: 30px; | |
| − | + | margin-top: 50px; | |
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} | } | ||
| − | #FudanBody # | + | #FudanBody .highlight{ |
| + | float: none; | ||
| + | } | ||
| + | #FudanBody #highlight1 .highlight, | ||
| + | #FudanBody #highlight1 .highlight{ | ||
width: 80%;margin: 0 auto; | width: 80%;margin: 0 auto; | ||
} | } | ||
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#highlight2{width:100%;} | #highlight2{width:100%;} | ||
} | } | ||
| − | #FudanBody #pageContent p.figureCaption{ | + | #FudanBody #pageContent p.figureCaption{ |
color: rgba(0,0,0,0.4); | color: rgba(0,0,0,0.4); | ||
font-size: 16px; | font-size: 16px; | ||
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bottom: -20px; | bottom: -20px; | ||
} | } | ||
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</style> | </style> | ||
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<script src="https://2018.igem.org/wiki/index.php?title=Template:Fudan/createjs20151126.js&action=raw&ctype=text/javascript"></script> | <script src="https://2018.igem.org/wiki/index.php?title=Template:Fudan/createjs20151126.js&action=raw&ctype=text/javascript"></script> | ||
<script src="https://2018.igem.org/wiki/index.php?title=Template:Fudan/mainpageDraw.js&action=raw&ctype=text/javascript"></script> | <script src="https://2018.igem.org/wiki/index.php?title=Template:Fudan/mainpageDraw.js&action=raw&ctype=text/javascript"></script> | ||
<!-- init 2018-10-16 --> | <!-- init 2018-10-16 --> | ||
| + | <title>2018 iGEM Team:Fudan</title> | ||
</head> | </head> | ||
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<div class="nav-wrapper"> | <div class="nav-wrapper"> | ||
<div id="teamLogo" class="brand-logo"> | <div id="teamLogo" class="brand-logo"> | ||
| − | <a href="https://2018.igem.org/Team:Fudan" target="_self"><img src="https://static.igem.org/mediawiki/2018/c/c4/T--Fudan--teamLogo.svg"></a> | + | <a href="https://2018.igem.org/Team:Fudan" target="_self"><img alt="2018 team Fudan logo" src="https://static.igem.org/mediawiki/2018/c/c4/T--Fudan--teamLogo.svg"></a> |
</div> | </div> | ||
<ul id="nav-mobile" class="right blueBorder"> | <ul id="nav-mobile" class="right blueBorder"> | ||
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<!-- Dropdown and List elements in navigation bar --> | <!-- Dropdown and List elements in navigation bar --> | ||
<ul id="dropdown1" class="dropdown-content"> | <ul id="dropdown1" class="dropdown-content"> | ||
| − | <li><a href=" | + | <li><a href="./Demonstrate">Demonstration</a></li> |
| − | <li><a href=" | + | <li><a href="./Antigen_Receptors">Antigen, Receptors</a></li> |
| − | <li><a href=" | + | <li><a href="./Results">Transmembrane logic</a></li> |
</ul> | </ul> | ||
<ul id="dropdown2" class="dropdown-content"> | <ul id="dropdown2" class="dropdown-content"> | ||
| − | <li><a href=" | + | <li><a href="./Addon#ribo">Addon: ribo</a></li> |
| − | <li><a href=" | + | <li><a href="./Addon#TALE">Addon: TALE</a></li> |
| − | <li><a href=" | + | <li><a href="./Addon#T2">Addon: T2</a></li> |
| − | <li><a href=" | + | <li><a href="./Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> |
| − | <li><a href=" | + | <li><a href="./Model#NotchLigandKinetics">Model: Notch-ligand kinetics</a></li> |
| − | <li><a href=" | + | <li><a href="./Software">Software</a></li> |
</ul> | </ul> | ||
<ul id="dropdown3" class="dropdown-content"> | <ul id="dropdown3" class="dropdown-content"> | ||
| − | <li><a href=" | + | <li><a href="./InterLab">iGEM interLab</a></li> |
| − | <li><a href=" | + | <li><a href="./Notebook">Our notebook</a></li> |
| − | <li><a href=" | + | <li><a href="./Primers">Primers used</a></li> |
| − | <li><a href=" | + | <li><a href="./Protocols">Protocols</a></li> |
| − | <li><a href=" | + | <li><a href="./Safety">Safety</a></li> |
</ul> | </ul> | ||
<ul id="dropdown4" class="dropdown-content"> | <ul id="dropdown4" class="dropdown-content"> | ||
| − | <li><a href=" | + | <li><a href="./Basic_Parts">Basic parts</a></li> |
| − | <li><a href=" | + | <li><a href="./Composite_Parts">Composite parts</a></li> |
| − | <li><a href=" | + | <li><a href="./Optimization">Optimization</a></li> |
| − | <li><a href=" | + | <li><a href="./Parts_Collection">Parts collection</a></li> |
| − | <li><a href=" | + | <li><a href="./Improve">Parts improvement</a></li> |
| − | <li><a href=" | + | <li><a href="./Measurement">Quantification</a></li> |
</ul> | </ul> | ||
<ul id="dropdown5" class="dropdown-content"> | <ul id="dropdown5" class="dropdown-content"> | ||
| − | <li><a href=" | + | <li><a href="./Bio-Art">Bio-Art display</a></li> |
| − | <li><a href=" | + | <li><a href="./Collaborations">Collaborations</a></li> |
| − | <li><a href=" | + | <li><a href="./Design_Intention">Design intention</a></li> |
| − | <li><a href=" | + | <li><a href="./Human_Practices">Human practices</a></li> |
| − | <li><a href=" | + | <li><a href="./Public_Engagement">Public engagement</a></li> |
</ul> | </ul> | ||
<ul id="dropdown6" class="dropdown-content"> | <ul id="dropdown6" class="dropdown-content"> | ||
| − | <li><a href=" | + | <li><a href="./Acknowledgement">Acknowledgement</a></li> |
| − | <li><a href=" | + | <li><a href="./Attributions">Attributions</a></li> |
| − | <li><a href=" | + | <li><a href="./Heritage">Heritage</a></li> |
| − | <li><a href=" | + | <li><a href="./Team">Members</a></li> |
| − | <li><a href=" | + | <li><a href="./Sponsors">Sponsors</a></li> |
</ul> | </ul> | ||
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<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Demonstrate">Demonstration</a></li> |
| − | <li><a href=" | + | <li><a href="./Antigen_Receptors">Antigen, Receptors</a></li> |
| − | <li><a href=" | + | <li><a href="./Results">Transmembrane logic</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Addon#ribo">Addon: ribo</a></li> |
| − | <li><a href=" | + | <li><a href="./Addon#TALE">Addon: TALE</a></li> |
| − | <li><a href=" | + | <li><a href="./Addon#T2">Addon: T2</a></li> |
| − | <li><a href=" | + | <li><a href="./Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> |
| − | <li><a href=" | + | <li><a href="./Model#NotchLigandKinetics">Model: Notch-ligand kinetics</a></li> |
| − | <li><a href=" | + | <li><a href="./Software">Software</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./InterLab">iGEM interLab</a></li> |
| − | <li><a href=" | + | <li><a href="./Notebook">Our notebook</a></li> |
| − | <li><a href=" | + | <li><a href="./Primers">Primers used</a></li> |
| − | <li><a href=" | + | <li><a href="./Protocols">Protocols</a></li> |
| − | <li><a href=" | + | <li><a href="./Safety">Safety</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Basic_Parts">Basic parts</a></li> |
| − | <li><a href=" | + | <li><a href="./Composite_Parts">Composite parts</a></li> |
| − | <li><a href=" | + | <li><a href="./Optimization">Optimization</a></li> |
| − | <li><a href=" | + | <li><a href="./Parts_Collection">Parts collection</a></li> |
| − | <li><a href=" | + | <li><a href="./Improve">Parts improvement</a></li> |
| − | <li><a href=" | + | <li><a href="./Measurement">Quantification</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Bio-Art">Bio-Art display</a></li> |
| − | <li><a href=" | + | <li><a href="./Collaborations">Collaborations</a></li> |
| − | <li><a href=" | + | <li><a href="./Design_Intention">Design intention</a></li> |
| − | <li><a href=" | + | <li><a href="./Human_Practices">Human practices</a></li> |
| − | <li><a href=" | + | <li><a href="./Public_Engagement">Public engagement</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<div class="collapsible-body"> | <div class="collapsible-body"> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Acknowledgement">Acknowledgement</a></li> |
| − | <li><a href=" | + | <li><a href="./Attributions">Attributions</a></li> |
| − | <li><a href=" | + | <li><a href="./Heritage">Heritage</a></li> |
| − | <li><a href=" | + | <li><a href="./Team">Members</a></li> |
| − | <li><a href=" | + | <li><a href="./Sponsors">Sponsors</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<main style="margin: 0"> | <main style="margin: 0"> | ||
<div style="position: relative;top:0;width: 100%;"> | <div style="position: relative;top:0;width: 100%;"> | ||
| − | <!-- 5/58/T | + | <!-- 5/58/T Fudan MainPageGIF_Half.gif , 0/06/T Fudan MainPageGIF.gif , 0/07/T Fudan mainpage2.gif --> |
<div id="animation_container" style="position:relative;background-color:rgba(255, 255, 255, 1.00); width:1920px; height:1080px"> | <div id="animation_container" style="position:relative;background-color:rgba(255, 255, 255, 1.00); width:1920px; height:1080px"> | ||
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<p>To survive, cells must identify and integrate various signals from the environment. Cells utilize their transmembrane receptors to recognize extracellular signals to execute a myriad of tasks ranging from cell-mediated immunity to tissue formation and regeneration. | <p>To survive, cells must identify and integrate various signals from the environment. Cells utilize their transmembrane receptors to recognize extracellular signals to execute a myriad of tasks ranging from cell-mediated immunity to tissue formation and regeneration. | ||
</p> | </p> | ||
| − | <div style="position: relative"><img class="figure" style="width: 100%" src="https://static.igem.org/mediawiki/2018/6/6e/T--Fudan--111111.png"><p class="figureCaption"> | + | <div style="position: relative"><img class="figure" style="width: 100%" src="https://static.igem.org/mediawiki/2018/6/6e/T--Fudan--111111.png" alt="frontpage image 1" /><p class="figureCaption">A cell using its specific transmembrane receptor, recognizes an external signal, integrates and output corresponding cellular decision.</p></div> |
<p> | <p> | ||
Therefore, in the field of synthetic biology, it would be especially impactful if cells could be programmed to recognize external environmental signals, generate contact-dependent signaling, and perform reliable logical computations. | Therefore, in the field of synthetic biology, it would be especially impactful if cells could be programmed to recognize external environmental signals, generate contact-dependent signaling, and perform reliable logical computations. | ||
</p> | </p> | ||
| − | <div style="position: relative"><img class="figure" style="width: 100%" src="https://static.igem.org/mediawiki/2018/7/7a/T--Fudan--2222222.png"><p class="figureCaption | + | <div style="position: relative"><img class="figure" style="width: 100%" src="https://static.igem.org/mediawiki/2018/7/7a/T--Fudan--2222222.png" alt="frontpage image 2" /><p class="figureCaption">Cells, armed with our transmembrane logic gates, can perform various tasks. We have made them even smarter.</p></div> |
<p> | <p> | ||
Our project ENABLE (ENgineered, Across membrane, Binary Logic in Eukaryotes) offers the first toolbox for mammalian cells to generate contact-dependent signaling from the external environment and Boolean output decisions. We believe this is a foundational advance for synthetic biology, and enables a wide range of opportunities. | Our project ENABLE (ENgineered, Across membrane, Binary Logic in Eukaryotes) offers the first toolbox for mammalian cells to generate contact-dependent signaling from the external environment and Boolean output decisions. We believe this is a foundational advance for synthetic biology, and enables a wide range of opportunities. | ||
</p> | </p> | ||
| − | <img style="width: 100%" src="https://static.igem.org/mediawiki/2018/7/71/T--Fudan--333333.png"> | + | <img style="width: 100%" src="https://static.igem.org/mediawiki/2018/7/71/T--Fudan--333333.png" alt="frontpage image 3" /> |
| + | </div> | ||
| + | </div> | ||
| + | <div class="section container"> | ||
| + | <p style="text-align:center">We gave the public presentation on #iGEM2018 between 9:00 and 9:25, | ||
| + | Oct 25<sup>th</sup> 2018, | ||
| + | Room 311, Hynes Convention Center in Boston, USA. This video was originally recorded by | ||
| + | <a href="https://v.douyu.com/show/GnzXvb8263zM462l" target=_blank>douyu</a>, | ||
| + | and later uploaded to <a href="https://youtu.be/hWuCCksK9d4" target=_blank>youtube</a>.</p> | ||
| + | <div style="width:560px;margin:0 auto;"> | ||
| + | <iframe width="560" height="315" src="https://www.youtube.com/embed/hWuCCksK9d4" frameborder="0" allow="autoplay; encrypted-media" allowfullscreen></iframe> | ||
| + | <!-- iframe src="https://v.douyu.com/video/share/index?vid=GnzXvb8263zM462l" frameborder="0" allowfullscreen="true" width="480" height="350"></iframe --> | ||
</div> | </div> | ||
</div> | </div> | ||
<div class="section" style="margin-bottom: 150px"> | <div class="section" style="margin-bottom: 150px"> | ||
| − | |||
<h2 style="font-weight: 900; margin-bottom: 30px;color:#377893;">Highlights</h2> | <h2 style="font-weight: 900; margin-bottom: 30px;color:#377893;">Highlights</h2> | ||
| − | |||
| − | |||
<div id="highlight1"> | <div id="highlight1"> | ||
<div class="highlight"> | <div class="highlight"> | ||
| − | <a href=" | + | <a href="./Demonstrate"><img src="https://static.igem.org/mediawiki/2018/6/65/T--Fudan--highlights_demonstration.png" alt="frontpage demonstration" /></a> |
Demonstration | Demonstration | ||
</div> | </div> | ||
<div class="highlight"> | <div class="highlight"> | ||
| − | <a href=" | + | <a href="./Public_Engagement"><img src="https://static.igem.org/mediawiki/2018/0/02/T--Fudan--highlights_education.png" alt="frontpage education" /></a> |
Public engagement | Public engagement | ||
</div> | </div> | ||
<div class="highlight"> | <div class="highlight"> | ||
| − | <a href=" | + | <a href="./Model"><img src="https://static.igem.org/mediawiki/2018/b/b9/T--Fudan--highlights_model.png" alt="frontpage model" /></a> |
Model | Model | ||
</div> | </div> | ||
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<div id="highlight2"> | <div id="highlight2"> | ||
<div class="highlight"> | <div class="highlight"> | ||
| − | <a href=" | + | <a href="./Human_Practices"><img src="https://static.igem.org/mediawiki/2018/3/3b/T--Fudan--highlights_integrated.png" alt="frontpage human practices" /></a> |
Human practices | Human practices | ||
</div> | </div> | ||
<div class="highlight"> | <div class="highlight"> | ||
| − | <a href=" | + | <a href="./Parts_Collection"><img src="https://static.igem.org/mediawiki/2018/e/e3/T--Fudan--highlights_parts.png" alt="frontpage parts" /></a> |
Parts collection | Parts collection | ||
| − | + | </div> | |
</div> | </div> | ||
</div> | </div> | ||
| − | |||
| − | |||
| − | |||
</div> | </div> | ||
</main> | </main> | ||
| − | |||
<!--Abstract on content page--> | <!--Abstract on content page--> | ||
<div id="abstractContent" class="z-depth-2"> | <div id="abstractContent" class="z-depth-2"> | ||
| − | <a href="#!"><img src="https://static.igem.org/mediawiki/2018/9/96/T--Fudan--X.svg"></a> | + | <a href="#!"><img alt="2018 team Fudan abstract" src="https://static.igem.org/mediawiki/2018/9/96/T--Fudan--X.svg"></a> |
<div class="container"> | <div class="container"> | ||
<h2 style="margin: 0;padding: 10px 0;">Abstract</h2> | <h2 style="margin: 0;padding: 10px 0;">Abstract</h2> | ||
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</div> | </div> | ||
| − | <!-- Floating Btns | + | <!-- Floating Btns |
| − | + | ||
<div class="floatingBtn"> | <div class="floatingBtn"> | ||
<a href="#FudanWrapper" class="btn"> | <a href="#FudanWrapper" class="btn"> | ||
<i class="fa fa-angle-up" style="font-size: 48px;line-height: 45px"></i> | <i class="fa fa-angle-up" style="font-size: 48px;line-height: 45px"></i> | ||
</a> | </a> | ||
| − | </div>--> | + | </div> --> |
<!-- Footer with sponsors and contact methods --> | <!-- Footer with sponsors and contact methods --> | ||
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<div class="row"> | <div class="row"> | ||
<div id="sponsor" class="col m3 s12 row"> | <div id="sponsor" class="col m3 s12 row"> | ||
| − | <a href="https://2018.igem.org/Team:Fudan" target="_blank"><img class="col s3 m6 l3" style="position:relative; padding: 0 0.3rem; margin:-0.15rem 0; left: -0.45rem;" src="https://static.igem.org/mediawiki/2018/7/73/T--Fudan--teamLogoWhite.png"> | + | <a href="https://2018.igem.org/Team:Fudan" target="_blank"><img alt="2018 Team:Fudan logo white" class="col s3 m6 l3" style="position:relative; padding: 0 0.3rem; margin:-0.15rem 0; left: -0.45rem;" src="https://static.igem.org/mediawiki/2018/7/73/T--Fudan--teamLogoWhite.png"> |
</a><a href="http://www.fudan.edu.cn/en/" target="_blank"><img class="col s3 m6 l3" alt="Fudan University" src="https://static.igem.org/mediawiki/2018/f/f7/T--Fudan--schoolLogo.png"> | </a><a href="http://www.fudan.edu.cn/en/" target="_blank"><img class="col s3 m6 l3" alt="Fudan University" src="https://static.igem.org/mediawiki/2018/f/f7/T--Fudan--schoolLogo.png"> | ||
</a><a href="http://life.fudan.edu.cn/" target="_blank"><img class="col s3 m6 l3" style="margin-bottom: 4%;/* 该图比其他小一点，排版需要 */" alt="School of Life Sciences, Fudan University" src="https://static.igem.org/mediawiki/2018/1/1d/T--Fudan--schoolOfLifeSciencesIcon.png"> | </a><a href="http://life.fudan.edu.cn/" target="_blank"><img class="col s3 m6 l3" style="margin-bottom: 4%;/* 该图比其他小一点，排版需要 */" alt="School of Life Sciences, Fudan University" src="https://static.igem.org/mediawiki/2018/1/1d/T--Fudan--schoolOfLifeSciencesIcon.png"> | ||
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<span>Project</span> | <span>Project</span> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Demonstrate">Demonstration</a></li> |
| − | <li><a href=" | + | <li><a href="./Antigen_Receptors">Antigen, Receptors</a></li> |
| − | <li><a href=" | + | <li><a href="./Results">Transmembrane logic</a></li> |
<li><a href="https://2017.igem.org/Team:Fudan">2017.iGEM</a></li> | <li><a href="https://2017.igem.org/Team:Fudan">2017.iGEM</a></li> | ||
</ul> | </ul> | ||
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<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Addon#ribo">Addon: ribo</a></li> |
| − | <li><a href=" | + | <li><a href="./Addon#TALE">Addon: TALE</a></li> |
| − | <li><a href=" | + | <li><a href="./Addon#T2">Addon: T2</a></li> |
| − | <li><a href=" | + | <li><a href="./Model#Transcriptional_Amplifer">Model: transcriptional amplifer</a></li> |
| − | <li><a href=" | + | <li><a href="./Model#NotchLigandKinetics">Model: Notch-ligand kinetics</a></li> |
| − | <li><a href=" | + | <li><a href="./Software">Software</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<span>Wet lab</span> | <span>Wet lab</span> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./InterLab">iGEM interLab</a></li> |
| − | <li><a href=" | + | <li><a href="./Notebook">Our notebook</a></li> |
| − | <li><a href=" | + | <li><a href="./Primers">Primers used</a></li> |
| − | <li><a href=" | + | <li><a href="./Protocols">Protocols</a></li> |
| − | <li><a href=" | + | <li><a href="./Safety">Safety</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<span>Toolbox</span> | <span>Toolbox</span> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Basic_Parts">Basic parts</a></li> |
| − | <li><a href=" | + | <li><a href="./Composite_Parts">Composite parts</a></li> |
| − | <li><a href=" | + | <li><a href="./Optimization">Optimization</a></li> |
| − | <li><a href=" | + | <li><a href="./Parts_Collection">Parts collection</a></li> |
| − | <li><a href=" | + | <li><a href="./Improve">Parts improvement</a></li> |
| − | <li><a href=" | + | <li><a href="./Measurement">Quantification</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<span>Outreach</span> | <span>Outreach</span> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Bio-Art">Bio-Art display</a></li> |
| − | <li><a href=" | + | <li><a href="./Collaborations">Collaborations</a></li> |
| − | <li><a href=" | + | <li><a href="./Design_Intention">Design intention</a></li> |
| − | <li><a href=" | + | <li><a href="./Human_Practices">Human practices</a></li> |
| − | <li><a href=" | + | <li><a href="./Public_Engagement">Public engagement</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<span>Team</span> | <span>Team</span> | ||
<ul> | <ul> | ||
| − | <li><a href=" | + | <li><a href="./Acknowledgement">Acknowledgement</a></li> |
| − | <li><a href=" | + | <li><a href="./Attributions">Attributions</a></li> |
| − | <li><a href=" | + | <li><a href="./Heritage">Heritage</a></li> |
| − | <li><a href=" | + | <li><a href="./Team">Members</a></li> |
| − | <li><a href=" | + | <li><a href="./Sponsors">Sponsors</a></li> |
</ul> | </ul> | ||
</div> | </div> | ||
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<div class="footer-copyright"> | <div class="footer-copyright"> | ||
<div class="container"> | <div class="container"> | ||
| − | + | <div class="contactUS row"> | |
| − | + | <div class="col s12 m6 l4"><i class="fa fa-location-arrow"></i> Life Sci Bldg E301, 2005 Songhu Rd, Shanghai | |
| − | + | </div><div class="col s12 m6 l2"><i class="fa fa-fax"></i> +86-21-31246727 | |
| − | + | </div><div class="col s12 m6 l2"><i class="fa fa-envelope-o"></i> igem@fudan.edu.cn | |
| − | + | </div><div class="col s12 m6 l4"><i class="fa fa-twitter"></i> <i class="fa fa-wechat"></i> Fudan_iGEM | |
| − | + | </div> | |
| − | + | </div> | |
| − | + | </div> | |
</div> | </div> | ||
</footer> | </footer> | ||
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}); | }); | ||
| − | //ScrollSpy Init | + | //ScrollSpy Init, not the frontpage or pages without sidebar |
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//Init slide-out nav | //Init slide-out nav | ||
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$('.parallax').parallax(); | $('.parallax').parallax(); | ||
}); | }); | ||
| + | |||
| + | // @@@@ <!DOCUTYPE html> required for .fadeIn .fadeOut | ||
| + | //hide the nav | ||
| + | var $topNav=$("#topNav"); | ||
| + | var footerHeight=$("#FudanFooter").height(); | ||
| + | var pageHeight=$("#FudanWrapper").height(); | ||
| + | scrollTop=$(document).scrollTop(); | ||
| + | if(scrollTop>pageHeight-footerHeight-$(window).height() && $(window).width()>991){ | ||
| + | $topNav.fadeOut(200); | ||
| + | } | ||
| + | else { | ||
| + | $topNav.fadeIn(200); | ||
| + | } | ||
| + | $(document).on("scroll",function () { | ||
| + | footerHeight=$("#FudanFooter").height(); | ||
| + | pageHeight=$("#FudanWrapper").height(); | ||
| + | scrollTop=$(document).scrollTop(); | ||
| + | if(scrollTop>pageHeight-footerHeight-$(window).height() && $(window).width()>991){ | ||
| + | $topNav.fadeOut(200); | ||
| + | } | ||
| + | else { | ||
| + | $topNav.fadeIn(200); | ||
| + | } | ||
| + | }); | ||
| + | |||
//show caption | //show caption | ||
if($(window).width()>991){ | if($(window).width()>991){ | ||
Revision as of 17:53, 6 November 2018
- Addon: ribo
- Addon: TALE
- Addon: T2
- Model: transcriptional amplifer
- Model: Notch-ligand kinetics
- Software
ENABLE
To survive, cells must identify and integrate various signals from the environment. Cells utilize their transmembrane receptors to recognize extracellular signals to execute a myriad of tasks ranging from cell-mediated immunity to tissue formation and regeneration.
A cell using its specific transmembrane receptor, recognizes an external signal, integrates and output corresponding cellular decision.
Therefore, in the field of synthetic biology, it would be especially impactful if cells could be programmed to recognize external environmental signals, generate contact-dependent signaling, and perform reliable logical computations.
Cells, armed with our transmembrane logic gates, can perform various tasks. We have made them even smarter.
Our project ENABLE (ENgineered, Across membrane, Binary Logic in Eukaryotes) offers the first toolbox for mammalian cells to generate contact-dependent signaling from the external environment and Boolean output decisions. We believe this is a foundational advance for synthetic biology, and enables a wide range of opportunities.
We gave the public presentation on #iGEM2018 between 9:00 and 9:25, Oct 25th 2018, Room 311, Hynes Convention Center in Boston, USA. This video was originally recorded by douyu, and later uploaded to youtube.
Highlights
Demonstration
Public engagement
Model
Human practices
Parts collection
Abstract
Contact-dependent signaling is critical for multicellular biological events, yet customizing contact-dependent signal transduction between cells remains challenging. Here we have developed the ENABLE toolbox, a complete set of transmembrane binary logic gates. Each gate consists of 3 layers: Receptor, Amplifier, and Combiner. We first optimized synthetic Notch receptors to enable cells to respond to different signals across the membrane reliably. These signals, individually amplified intracellularly by transcription, are further combined for computing. Our engineered zinc finger-based transcription factors perform binary computation and output designed products. In summary, we have combined spatially different signals in mammalian cells, and revealed new potentials for biological oscillators, tissue engineering, cancer treatments, bio-computing, etc. ENABLE is a toolbox for constructing contact-dependent signaling networks in mammals. The 3-layer design principle underlying ENABLE empowers any future development of transmembrane logic circuits, thus contributes a foundational advance to Synthetic Biology.